Gene 23447 (Tetrahymena)
23447
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 23447.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 23447.AA | Ciliate-E1 | 559-729 | 20 | 2.2e-25 | 79.8 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 559-729 Range on HMM: 1-202/202 Sequence Identity: 20% (42 aa) IKKGGEADIFTN-------QNIAYKVIKLNGDDDLKKQEKELLRIQELQEQNILNINTSHVIEDIV-NHTKYIIHVMQKCQMSLYDEIL----------- |..|.....| ...| |.|.... .. ....|. ...... . .... .|. | . .| ....|..||.|.. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --SKKVFSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQ-----QIDFIDPFCGYQMYTPGFKPK------NRERNLPFYH .. |. ..... | ... || |.|. |.|.|||| |||. ...||...||| |. |.. .. .. ..| | . . |.. . . QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DIY ||| DIY |
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| Kinase | 23447.AA | Ciliate-B2 | 553-694 | 29 | 9.5e-16 | 33.42 | In-house | 1-151 (197) | Show / Hide |
Range on Protein: 553-694 Range on HMM: 1-151/197 Sequence Identity: 29% (45 aa) FKLGHHIKKGGEADIFTNQ---------NIAYKVIKLNGDDDLKKQEKELLRIQELQEQNILNINTSHVIEDIVNHTKYIIHVMQKCQMSLYDEIL---- . |. | |||. |. ..|.|. | | . ..| . | . |.|| . . .|. .| | .. .|.||. || .|. YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHE-IKIMKMFEYNINVVKYIDHIQ--INETIDVL-IMEKCECSLKQELQKIQK SKKVFSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGAS .| | . ... | . || .| . | | |||| |||. .|| ..||| | QQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS |
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| Kinase | 23447.AA | Ciliate-C6 | 629-698 | 37 | 5.1e-12 | 38.89 | In-house | 117-188 (306) | Show / Hide |
Range on Protein: 629-698 Range on HMM: 117-188/306 Sequence Identity: 37% (27 aa) KCQMSLYDEILSKKVFSLKEILRFISTAFHLLIVLRQ-KYIYHSDIKPGNILKIDD-NNYQLSDFGASQQID | ..... .. |. .||. | . .| .. | | |||| ||| .|| ||| |||||..||.. KQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLF |
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| Kinase | 23447.AA | S_TKc | 553-797 | 16 | 4.8e-08 | -58.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 553-797
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)
FKLGHHIKKGGEA------DIFTNQNIAYKVIKLNGDDDLKKQEKELLRIQELQEQNILNINTSHVIEDIVNHTKYIIHVMQKCQM---SLYDEILSKKV
.... .| ||. . .. |.. | |.|| . ..| ..|. . || .. . . ... || | .|.| | ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK---HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR
------FSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQQIDFIDPFCG---------YQMYTPGFKPKNRERNLPFYH--
|. .. ... . | . .. | | |.|| ||| .|. . ..||| . |. . ||| .. .
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL-LDE-HIKICDFGLARQL---TTFCGTPWYMAPEVL----------------GYGKCK
-DIYSFGKTIQKLLM-----KLENQSKISKCLNEFIDEEICKDDEISIKVDCFEFPRKFIN--TLMRFTNDEVIE-------IELY
|..|.| .. .| .. .. | . .. .| || . | | |. . .
CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 23447.AA | Ciliate-A1 | 626-699 | 24 | 4.9e-07 | 19.92 | In-house | 79-153 (301) | Show / Hide |
Range on Protein: 626-699 Range on HMM: 79-153/301 Sequence Identity: 24% (18 aa) VMQKCQMSLYDEILSKKV-FSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNILKIDDNNYQLSDFGASQQIDF .| .|| . . . . || . . . .. . . | |.|.||.||| .|. . . |.| |.| . IMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQ |
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| Kinase | 23447.AA | DYRK2 | 631-679 | 37 | 1.2e-05 | 14.0 | In-house | 84-134 (318) | Show / Hide |
Range on Protein: 631-679 Range on HMM: 84-134/318 Sequence Identity: 37% (19 aa) QMSLYDEILSKKV--FSLKEILRFISTAFHLLIVLRQKYIYHSDIKPGNIL .|.||. | .. |||... ||. . | |.. | | | || ||| SMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL |
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| Kinase | 23447.AA | LKB | 668-703 | 38 | 1.7e-05 | 12.37 | In-house | 125-160 (265) | Show / Hide |
Range on Protein: 668-703 Range on HMM: 125-160/265 Sequence Identity: 38% (14 aa) IYHSDIKPGNILKIDDNNYQLSDFGASQQIDFIDPF . | ||||||.| || ..||| |.. .. VVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRD |
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| Kinase | 23447.AA | RAN | 668-692 | 62 | 2.2e-05 | 13.89 | In-house | 170-195 (324) | Show / Hide |
Range on Protein: 668-692 Range on HMM: 170-195/324 Sequence Identity: 62% (17 aa) IYHSDIKPGNILKID--DNNYQLSDFG ||| |||| ||| || | | | |.| IYHCDIKPENIL-IDGIDWNIYLCDWG |
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| Kinase | 23447.AA | FRAY | 670-694 | 56 | 2.7e-05 | 12.05 | In-house | 130-154 (277) | Show / Hide |
Range on Protein: 670-694 Range on HMM: 130-154/277 Sequence Identity: 56% (14 aa) HSDIKPGNILKIDDNNYQLSDFGAS | ||| |||| .| . |..||| | HRDIKAGNILIGEDGTIQIADFGVS |
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| Kinase | 23447.AA | PHK | 668-697 | 50 | 4.4e-05 | 12.98 | In-house | 130-159 (273) | Show / Hide |
Range on Protein: 668-697 Range on HMM: 130-159/273 Sequence Identity: 50% (15 aa) IYHSDIKPGNILKIDDNNYQLSDFGASQQI | | | || ||| .|. | .|||| . |. IVHRDLKPENILCDDNMNIKISDFGFACQL |
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| Kinase | 23447.AA | C8 | 663-697 | 43 | 4.6e-05 | 13.64 | In-house | 139-177 (226) | Show / Hide |
Range on Protein: 663-697 Range on HMM: 139-177/226 Sequence Identity: 43% (17 aa) LRQKYIYHSDIKPGNILKIDDNNYQ----LSDFGASQQI . .| | | |||| |.| |.|| |.||| . |. IHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQV |
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