Gene 22819 (Tetrahymena)
22819
Sequence
Protein domains of 22819.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22819.AA | Ciliate-B2 | 388-569 | 38 | 1.8e-75 | 176.96 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 388-569 Range on HMM: 1-197/197 Sequence Identity: 38% (75 aa) YALGSCIEQGGESFIYEDI---I---NKNVIIKIIYV---QMNQTIDMQKKIFDILKDEKNFLQLIDHIKIYDNLHIFIHEKFQKNLQQELENFNKDKNI | |. | .||. ||.| . .....|| .. . |. || .. . | ..||||.| . ...| ||.. |.|||. .| . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKC FTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQ-EGNMQIRGKTDNYSSQEQRNQD-----VNKISYKSDVYSLG |..|.|..|||.|| ||| .. .|||||||||.|||. . |||.|.||||| | . . . .|.| | | | || ..| | .| ..||.||.| FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 22819.AA | Ciliate-E1 | 394-566 | 35 | 4.6e-46 | 147.83 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 394-566 Range on HMM: 1-202/202 Sequence Identity: 35% (72 aa) IEQGGESFIYEDIINKN----VIIKIIYVQMNQT-------IDMQKKIFDILKDEKNFLQLIDHIKIYDN-LHIFIHEKFQKNLQQELE---------NF |..|..|.... ....| |..||| .. |.. | ..||.. .| |.. .|.|| ||| .| ..|.| |. ...|...|. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC NKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQ---EGNMQIRGKTDNYSSQEQRN------QDVNKISYKS ....| ||.|.....||.||.|||.|...||.|.||||.|||..| |||.|.||||| ... . ..|..| |..|...|| | .. .||.||| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DVY |.| DIY |
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| Kinase | 22819.AA | Ciliate-E3 | 438-576 | 30 | 4.1e-13 | 37.51 | In-house | 62-202 (202) | Show / Hide |
Range on Protein: 438-576 Range on HMM: 62-202/202 Sequence Identity: 30% (44 aa) KNFLQLIDHIKIYDNLHIFIHEKFQKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGN---YIYTDFGISEIYQE .| .. | . .| ||| .. | .| .. | . |.. ..... ..| |.|.. ||| | |||| |||||.. | ||| | . QNVVKCHDQYYDQQNKMIFIVQEYCSN--GDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRK GN--MQIR--GKTDNYSSQEQRNQDVNKISYKSDVYSLGKTLLKVI . . | | |.. || | ..|| || ||.| .. .. NKGHTHTQYQGWTPFYAAPEQNDQ--QQISKESDYYSVGAVFCQLC |
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| Kinase | 22819.AA | Ciliate-A1 | 456-569 | 25 | 8.9e-13 | 39.76 | In-house | 78-215 (301) | Show / Hide |
Range on Protein: 456-569 Range on HMM: 78-215/301 Sequence Identity: 25% (36 aa) FIHEKFQKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQEGN------------------- .| |. |..... |. . .. . . . .| |..|. .||||.|.|| |||. . . |.|.| . . IIMEYCQYGNLF---NYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHY MQI-RGKTDNYSSQEQ-----RNQDV--NKISYKSDVYSLG . .| . | | || | | |||. .||.|||| HTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLG |
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| Kinase | 22819.AA | C8 | 462-572 | 25 | 2e-12 | 39.57 | In-house | 103-226 (226) | Show / Hide |
Range on Protein: 462-572 Range on HMM: 103-226/226 Sequence Identity: 25% (31 aa) QKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYI----YTDFGISEIYQEGNMQIRGKT------DNYSSQEQ ..||.| . . . . |.... .. .| |. .. |||.| ||||.|.|| .||. |||.. .. .| | . |. |. EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEI RNQ---DVNKISYKSDVYSLGKTL .. .. . . .||..|.| | EKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 22819.AA | TKL | 501-569 | 20 | 9.1e-10 | 31.36 | In-house | 159-276 (364) | Show / Hide |
Range on Protein: 501-569
Range on HMM: 159-276/364
Sequence Identity: 20% (24 aa)
KNILHLDIKPKNILVDNRGN--------------YIYTDFGISEIYQEGN---------------------MQIRGKTDNYSSQEQRNQDVN--------
..|.| |.|.||||||. .. .|||.| .. . .. | .. . | ... |
PPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGID
------KISYKSDVYSLG
. | |.|||| |
EFCKGFEYSEKCDVYSFG
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| Kinase | 22819.AA | S_TKc | 388-626 | 17 | 6.7e-09 | -46.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 388-626 Range on HMM: 1-231/231 Sequence Identity: 17% (47 aa) YALGSCIEQG--GESFIYEDII-NKNVIIKIIYVQMNQTIDMQKKIFDILKDEKNFLQLIDHIKIYDNLHIFIHEKFQKNL-------QQ---ELENFNK | .. | .| |. . .. .. | |||| . .. | . |. .| | . .| . ..| . .| . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIK DKNI------FTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQEGNMQIRGKTDNYSSQEQRNQDVNKISY-KSDVYS ... |.| ... .. .| . ...|.| |.|| |||.|. . .|||.. .. | .| . | . .. |.|..| KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWS LGKTLLKVIE-----RFKELNGQSKFIKFAKSIQDIVKKSMVQEDINQRDDCYLIHS----QFSDQLF .| .| . . ... | |. .. | . . | | ..| . . ... | CGCILYEMLCGYPPFP--QMQMMFKKIG-SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 22819.AA | STE | 479-569 | 21 | 1.7e-08 | 26.28 | In-house | 148-255 (359) | Show / Hide |
Range on Protein: 479-569 Range on HMM: 148-255/359 Sequence Identity: 21% (25 aa) FTEQNLIKMIFNLIHG-LIDLKNKNILHLDIKPKNILVDNRGNYIYTDFGISEIYQE-------------------GNMQIRGKTDNYSSQEQRNQD--- | |. ...... ...| | | ...| | |||| |||. .|||.. . .. . . | . . | .|. FPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQG -VNKISYKSDVYSLG ... ..|.|..||| RDKGYDTKCDIWSLG |
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| Kinase | 22819.AA | Ciliate-E4 | 462-517 | 33 | 2.7e-08 | 24.24 | In-house | 87-142 (150) | Show / Hide |
Range on Protein: 462-517 Range on HMM: 87-142/150 Sequence Identity: 33% (19 aa) QKNLQQELENFNKDKNIFTEQNLIKMIFNLIHGLIDLKNKNILHLDIKPKNILVDN ||.|||.. . .. |.|. . . | .| .. | .|| | |.|| ||..|. QKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQ |
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| Kinase | 22819.AA | Ciliate-E2-Unclassified | 388-569 | 22 | 5.5e-08 | 23.81 | In-house | 1-257 (352) | Show / Hide |
Range on Protein: 388-569
Range on HMM: 1-257/352
Sequence Identity: 22% (58 aa)
YALGSCIEQGG--ESFIYEDIINK--------NVIIKIIYVQMNQT-------IDMQKK-------IFDILKDEKNFLQLIDHIKIYDNLHIF-------
| .. .| ||| . . ... .| ..|... |... . |..| . .|... |. ..|. |. ...|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQ---ILLNHPHPFIVKMFYCFQDKQNIY
-IHEKF-QKNLQQELENFNKDK-------------NIFTEQNLI-----KMIFNLIHGL-IDLKNKNILHLDIKPKNILVDNRG---NYIYTDFGISE--
. |.. ...|.| .....| | .|||||. . ... .. || ...||.| |||| |||.|| | . .|||||
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
---------------IYQEGNMQIRGKTDNYS----SQEQRNQDVNKIS--YKSDVYSLG
|... .|. . | || . | . . | ||.|..|||
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
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| Kinase | 22819.AA | CAMK | 500-536 | 27 | 1.5e-07 | 19.66 | In-house | 197-250 (425) | Show / Hide |
Range on Protein: 500-536 Range on HMM: 197-250/425 Sequence Identity: 27% (15 aa) NKNILHLDIKPKNILVDNR-----------------GNYIYTDFGISEIYQEGN ..|| |.|.|| |||.|.. .| .||| . ....|. SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE |
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| Kinase | 22819.AA | Pkinase | 500-569 | 28 | 2e-06 | 23.48 | Pfam | 126-199 (293) | Show / Hide |
Range on Protein: 500-569 Range on HMM: 126-199/293 Sequence Identity: 28% (22 aa) NKNILHLDIKPKNILVDNRGNY----IYTDFGISE---IYQEGNMQIRGKTDNYSSQEQRNQDVNKISYKSDVYSLG ...|.| |.|| |||.||.|. .|||... . . |. . | .| . | .. .....|.|..|.| SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWSCG |
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