Gene 22157 (Tetrahymena)
22157
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 22157.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22157.AA | Ciliate-B2 | 186-367 | 35 | 1.1e-68 | 160.6 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 186-367 Range on HMM: 1-197/197 Sequence Identity: 35% (69 aa) YALGSQIGKGGESLIYEDQ------NNQEQIIKIIFS---STNELIENQKKIFAKLINFKKFIQLVEHIKIDDNLHIFIHKKYQQSLWQELLQFNQNENK | |. |.|||. .|.| |. ..|| | . | |.. || . . .....||.|. . ...| | . || ||| . .. . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKC FTDEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGNYIYIDFGISQIYENGKNMVVRGISDKYSSYEQKNDT------NNISYKSDVYSLG |. .|....||.|| ||| .....||||||||.|||. |||.| ||||| | .. . ..| || | || .. || ..||.||.| FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 22157.AA | Ciliate-E1 | 192-364 | 34 | 2.2e-46 | 148.87 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 192-364 Range on HMM: 1-202/202 Sequence Identity: 34% (70 aa) IGKGGESLIYED--QNNQ-----EQIIKIIFSST----NELIENQKKIFAKLINFKKFIQLVEHIKIDDN-LHIFIHKKYQQSLWQELL---------QF ||.|..|.... |||. ..||...| .. ...|....||. ... .. ||... ||||.| ..|.| ....|| ..| |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC NQNENKFTDEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGNYIYIDFGISQ--IYENGKNMVVRGISDKYSSYEQKN-------DTNNISYKS .||.|.||......|||.||.|||.|... |.|.||||.||||.. |||.| |||||. .... ......| ..|...||.| ....|.||| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS DVY |.| DIY |
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| Kinase | 22157.AA | C8 | 260-370 | 24 | 1.1e-11 | 36.93 | In-house | 103-226 (226) | Show / Hide |
Range on Protein: 260-370 Range on HMM: 103-226/226 Sequence Identity: 24% (30 aa) QQSLWQELLQFNQNENKFTDEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGNYI----YIDFGISQIYENGKN-MVVRGI----SDKYSSYEQ .| | | ... ... .|..|. .| .| |. ...|.|.| ||||.|.|. .||. |||.. . |. . . . ..|. |. EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEI KND----TNNISYKSDVYSLGRTL .. . .||..|.| | EKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 22157.AA | Ciliate-E3 | 186-374 | 29 | 4.1e-11 | 31.2 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 186-374
Range on HMM: 1-202/202
Sequence Identity: 29% (62 aa)
YALGSQIGKGGESLIY---EDQNNQEQIIKIIFSSTNEL---IENQKKIFAKLINFKKF-----IQLVEHIKIDDNLHIFIHKKYQQS-LWQELLQFNQN
| ..|.|. .. | ||||. || |. . |. .| . .|.... . . . ..| ||| .| .. .. ||
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIK-QQN
ENKFTDEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGN--YIYI-DFGIS-QIYENG--KNMVVRGISDKYSSYEQKNDTNNISYKSDVYSLG
| . ..|. .|||.|.. | | | ||||||||.| . | | | ||| | | . | . | . |.. || || ..|| || ||.|
K---TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ-NDQQQISKESDYYSVG
RTLQQVI
. |..
AVFCQLC
|
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| Kinase | 22157.AA | S_TKc | 186-436 | 15 | 3.1e-09 | -41.42 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 186-436
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)
YALGSQIGKGGESLIYEDQN---NQEQIIKIIFSSTNELIENQKKIFAKLINFKKFIQLVEHIKIDDNLHIFIHKKYQ--QSLWQELLQFNQNENK--FT
| .. .||||. . | .. ... |||| | |.. .| | . . ..| ... |.|... . .| . . . . . .. |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP
DEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGNYIYIDFGISQIYENGKNMVVRG---------ISDKYSSYEQKNDTNNISY-KSDVYSLGR
... ....| . . |.| |.||.|||.|. . .|||.. .. . . | . .. |.|..|.|
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCGC
TLQQVIEKFEYLNPQSQIKEFVQKFIKNIVNNQMVKEAIHQRSDCQLIHYLFS---EQLLNIQDKLD-------RTFI
.| . . . | |... .| .. ...| .. |. . . . | ..
ILYEMLC-GYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 22157.AA | DAPK | 299-335 | 41 | 2e-08 | 19.01 | In-house | 122-162 (264) | Show / Hide |
Range on Protein: 299-335 Range on HMM: 122-162/264 Sequence Identity: 41% (17 aa) KEILHLDIKPDNILIDDRGNYI----YIDFGISQIYENGKN ..| |||.|| ||. ||. ||||.| . .|| . RNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEE |
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| Kinase | 22157.AA | Ciliate-A1 | 186-367 | 25 | 4.2e-08 | 23.6 | In-house | 1-215 (301) | Show / Hide |
Range on Protein: 186-367 Range on HMM: 1-215/301 Sequence Identity: 25% (55 aa) YALGSQIGKGGESLI---YEDQNNQ-EQIIKIIFSSTNELIEN--QKKIFAKLINFKKFIQLVEHIKIDDN--LHIFIHKKYQQSLWQELLQFNQNENKF | |.||. . . |. ||.. .||| ...| | | |.|| . | . .. .| . || | | | .. . . YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQY--GNLFNYCYQNDYM TDEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGNYIYIDFGISQIYENGK-------------------NMVVRGISDKYSSYEQ-------- | . | .|.|..|. . |||.|.||.|||| . . .|.|.|.. | . . . .| . | | || KKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQ KNDTNNISYKSDVYSLG . |.|. .||.|||| MFIENKIYKQSDMYSLG |
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| Kinase | 22157.AA | CAMK | 301-335 | 32 | 5.8e-08 | 20.99 | In-house | 200-251 (425) | Show / Hide |
Range on Protein: 301-335 Range on HMM: 200-251/425 Sequence Identity: 32% (17 aa) ILHLDIKPDNILIDDR-----------------GNYIYIDFGISQIYENGKN | |.|.||.|||.||. .| |||| ..... |.| IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGEN |
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| Kinase | 22157.AA | TKL-Unique | 271-367 | 26 | 5.9e-08 | 24.34 | In-house | 101-215 (290) | Show / Hide |
Range on Protein: 271-367 Range on HMM: 101-215/290 Sequence Identity: 26% (31 aa) NQNENKFTDEKFIKIIFDLIQGLIDLKIKE--ILHLDIKPDNILIDDR-----GNYIYIDFGISQIYENGKNMVVRGI------SDK----YSSYEQKND | |..|.. ....|.. | ||.. | .| |.|.|.|. |.|.| . | .|||.| . . .| .... . . ... | .. NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM T-NNISYKSDVYSLG . .| |||||| | NFCQYSEKSDVYSFG |
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| Kinase | 22157.AA | Pkinase | 301-367 | 31 | 8.8e-08 | 28.59 | Pfam | 129-199 (293) | Show / Hide |
Range on Protein: 301-367 Range on HMM: 129-199/293 Sequence Identity: 31% (23 aa) ILHLDIKPDNILIDDRGNY----IYIDFGISQI--YENGKNMVVRGISDKYSSYEQKNDTNNISYKSDVYSLG |.| |.||.|||||..|. .|||.. | |. | .. . | . | .. . ...|.|..|.| IIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG |
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| Kinase | 22157.AA | Ciliate-E5 | 288-397 | 25 | 1e-07 | 20.97 | In-house | 111-184 (271) | Show / Hide |
Range on Protein: 288-397 Range on HMM: 111-184/271 Sequence Identity: 25% (30 aa) DLIQGLIDLKIKEILHLDIKPDNILIDDRGNYIYIDFGIS----QIYENGKNMVVRGISDKYSSYEQKNDTNNISYKSDVYSLGRTLQQVIEKFEYLNPQ .|..|| |. | |.|||||| ||| |||.||| . . . .| QLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRD---------------------------------------------KQVSEQ SQ-----IKEFVQKFIKNI .| | | . |||| | RQNSSETIEENMIKFIKII |
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| Kinase | 22157.AA | NZAK | 276-329 | 37 | 1.4e-07 | 20.99 | In-house | 101-154 (329) | Show / Hide |
Range on Protein: 276-329 Range on HMM: 101-154/329 Sequence Identity: 37% (20 aa) KFTDEKFIKIIFDLIQGLIDLKIKEILHLDIKPDNILIDDRGNYIYIDFGISQI .| . . ||.| |. ... | ..|.| |||. |.. | ..| |||| | | RFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDFGSSII |
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