Gene 19973 (Tetrahymena)

19973

Species: Tetrahymena
Alias: 19973, TTHERM_01406900, PreTt19973, 370, 372.m00011
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
19973.AA Protein None 472 None Fasta, JSON
19973.kin_dom Protein Kinase Domain None 248 None Fasta, JSON
19973.NA RNA None 1419 None Fasta, JSON

Protein domain

Protein domains of 19973.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19973.AA Ciliate-C5 88-347 92 5e-197 654.49 In-house 1-260 (260) Show / Hide 
Range on Protein: 88-347
Range on HMM: 1-260/260
Sequence Identity: 92% (241 aa)

VYLTSYIAQGGYGCVFEAKYNGEIVAVKCSKPKFDKIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQSFFDQKKTLPLNQIVG
.||||||.|||.||||||||| ||||||||||.|.|||||||||||||||||||||||||.|||.||||||||.||||||||||||||||||||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEITDDNGLFNIKYDIYGLGIILLELTLGKFLEDG
|||||||||||||||||||||.||||||||||||||||||||||||||||||||.||||||||||||||||||.|||||||||||||||||||||||||.
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCTFIRNGKLPKYMSKNALYQDINQIIIKMLEKMPQNRIDSFGLAKQLNELRLKLENQFI
|||||||||||.|.||||||||||||||||||||||||||||.|.|||||||||||.|||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 19973.AA Ciliate-E1 94-269 26 4.3e-30 95.28 In-house 1-202 (202) Show / Hide 
Range on Protein: 94-269
Range on HMM: 1-202/202
Sequence Identity: 26% (54 aa)

IAQGGYGCVFEA---KYN-----GEIVAVKC--SKPKFDKIKEEEK-IMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQ---------SF
|..|... ||.|   ..|       |. ...  .. .|.....|.. ||| .|   |... |. .. ..|  ...|  ...|.||| .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKT-YNLKGFTRKYAAPEIT-------DDNGLFNIK
  ... .   |..  ..|.   .. ..|.|.||.||||.|||...| . ...|| | || .|  ..  .. ||.| .|. ||         ..|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 19973.AA Ciliate-B2 89-272 28 1.1e-19 42.88 In-house 2-197 (197) Show / Hide 
Range on Protein: 89-272
Range on HMM: 2-197/197
Sequence Identity: 28% (58 aa)

YLTSYIAQGGYGCVFEAKYNGEI------VAVKCSKP----KFDKIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQSFFDQKK
||. ||..|| | ..|  |  ..      .|.|          . | .| ||||..    .| | |. .  ... .   |  |  | ||. .|    |.|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

TLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEITDDN------GLFNIKYDIYGLG
  . . ..    |.     ..  .| .| ||||.|||  .|.  . .||.| | | |      . |||| ||| ||  ..          . . ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 19973.AA CMGC 88-255 14 8.2e-18 54.25 In-house 1-296 (513) Show / Hide 
Range on Protein: 88-255
Range on HMM: 1-296/513
Sequence Identity: 14% (44 aa)

VYLTSYIAQGGYGCVFEAKY----------------NGEIVAVKCSKPKFDKIK---------------EEEKIMKLLK----------------DTPYV
    ..| .| || |....                 ..||||.|  | .|...                 | ||.| |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKSIEEFFNEKNS---------------KYYQISKKYSCNLKDIMQSFF------------------------DQKKTLPLNQIVGFAIQMSTVFE--KI
 | .. |  ...                . | .     ..|......                           ..| ... .|  .. |. .  .   .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QQNN--LIHSDIKPENILYDSQEKCF-------------------NLCDYGESKSFKDG---------------------SKTYNLKGFTRKYAAPEI
 ...   || |.|||||| ... ...                    .|| | .... .                      ...|     || | ||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 19973.AA Pkinase 94-326 21 6.6e-17 60.86 Pfam 7-282 (293) Show / Hide 
Range on Protein: 94-326
Range on HMM: 7-282/293
Sequence Identity: 21% (62 aa)

IAQGGYGCVFEAKYNGE--IVAVKCSKPKFDKIKE--------EEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQSF----FDQKKT
| .|..|||....  |.  |||||. | . .| ..        | .||| | . |..   . ..| . ....| .     . |.  |  |     .....
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNI-VRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGC

L--PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKC---FNLCDYGESKS--FKDGSKTYNLKGFTRKYAAPEITDDNGLFNIKYDIYGLG
.  . ...  .. |.    | . ... || |.||||||.|..  .   . .|| | .|      .| .. . | |. |.|||.  ..     | |....|
FYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCG

IILLELTLGKFLEDGD--------CTFIRNGKLPKYMSKNALY---------------------QDINQIIIKMLEKMPQNRI
.|| |. .|... .|.           |.. . |....                          ..  ..| ..|.| |. |.
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase 19973.AA Ciliate-E3 201-279 37 3.3e-16 47.32 In-house 121-202 (202) Show / Hide 
Range on Protein: 201-279
Range on HMM: 121-202/202
Sequence Identity: 37% (31 aa)

QNNLIHSDIKPENILYDSQEK--CFNLCDYGESKSFKDGS-KTYNL-KGFTRKYAAPEITDDNGLFNIKYDIYGLGIILLELT
. |.|||||||.||| |. .       || ||||  .     |  .  |.|  |||||. .|....    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC
Kinase 19973.AA Ciliate-E2-Unclassified 90-283 20 6.7e-16 51.66 In-house 3-268 (352) Show / Hide 
Range on Protein: 90-283
Range on HMM: 3-268/352
Sequence Identity: 20% (56 aa)

LTSYIAQGGYGCVFEAKYNGE-------------IVAVKCSKPKFDKIKEEEKIMKLLK------------------DTPYVFKSIEEFFNEKNSKYYQI
.   | |||.|.|.... . .             |...|  . |   |. |.|.|. .|                  . |.. | ...| ...|   | .
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IYIV

SKKY-SCNLKDIMQSF----------FDQKKT---LPLNQIV-----GFAIQMSTVFEKIQQNN-LIHSDIKPENILYDSQEK--CFNLCDYGESKSFKD
  .    .|.......          |...|.   .. .|..      .. |    .|.. ..|  || ||||||||.|.. |  .  ..|.| ||  ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------GSKTYNLKGFTRKYA----APEITDDNGLFN---IKYDIYGLGIILLELTLGKF
                .. .. .  |  |     |||. . ..  .   .| ||..||.|| |.  |..
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase 19973.AA S_TKc 88-333 20 8.4e-16 54.85 SMART 1-220 (231) Show / Hide 
Range on Protein: 88-333
Range on HMM: 1-220/231
Sequence Identity: 20% (53 aa)

VYLTSYIAQGGYGCVFEAKYNG--EIVAVKCSKPKFDKIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSC---NLKDIMQSFFDQK--KTL
  .   | .|..|.|. .. ..  .|||.|. |   ..|. | .|.|   . |.. | .. | .   ...| .    .    .|.|....   ..  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEITDDNGLFNI-KYDIYGLGIILLELT
|  ..  .. |.    | . ... || |.|||||| |.   .  .|| | .. .       .    |. | |||.      ..  | |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKFLEDGDCTFIRNGKLPKYMSKNALYQDINQIIIKMLEKMPQNRIDSFGLAK
 |. . . .   . .  .          ..  ..| |.|.| |..|.    . .
CGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase 19973.AA C8 88-275 22 2.1e-15 50.04 In-house 1-226 (226) Show / Hide 
Range on Protein: 88-275
Range on HMM: 1-226/226
Sequence Identity: 22% (51 aa)

VYLTSYIAQGGYGCVFEAKYNGE--IVAVKCSKPKFD-KIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKK----YS-----------CNLKD-
.    |. .|.|| | .||   .   .. |  | . . .|...|.||| .. .| ||.  . . ||.. .| . ..      |           | ... 
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

---------IMQSFFDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENIL-YDSQEKC--FNLCDYGESKSFKDGSKTYNLKGF----TRKYAA
         . . . .... .. ..    ||||    . |.. | .| ||||.|.| . .|..     ||| |..   ..  . .  | .    | .| |
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEITDD----NGLFNIKYDIYGLGIIL
|||  .    .  ..|. |.. .|..|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 19973.AA TKL 203-282 20 1.2e-13 45.56 In-house 160-286 (364) Show / Hide 
Range on Protein: 203-282
Range on HMM: 160-286/364
Sequence Identity: 20% (26 aa)

NLIHSDIKPENILYDS-------------QEKCFNLCDYGESKSFK-------------------DGSKTYNLKGFTRKYAAPEITDDN-----------
..|| |.|..||| |.              . |  .||.| |....                   ...|| . .. |  . |||. ...           
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

----GLFNIKYDIYGLGIILLELTLGK
    . .. | |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 19973.AA Ciliate-E2 88-338 18 1.8e-13 42.59 In-house 1-365 (365) Show / Hide 
Range on Protein: 88-338
Range on HMM: 1-365/365
Sequence Identity: 18% (70 aa)

VYLTSYIAQGGYGCVFEA-------------------------KYNGEIVAVKCSKPK-FDKIKEEEKIMKLLK---------------DTPYVFKSIEE
  .   | ||..|.|...                         |... |.|.|. |..    || |..||. ..               . |.. | .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FFNEKNSKYYQISKKYSC-NLKDIMQ---SFFDQK----KTLPLNQIVGFAIQMSTVF---------------EKIQQNN-LIHSDIKPENILYDSQEKC
| .......| .   ..  .|.|...    .....    | . ...|  .  |   .|               | . ..|  || ||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGESKSFKDG---------SKTYNLKG-----------------------FTRKYAAPEITDDNGL--------FNIKYDIYGLGIILLELTLGK
  ..| | || ..|          .| |   .                        |  | ||||    .          . | ||. ||.|| |.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FLEDGDCTFIRNGKLPKYMSKNALYQDIN----------------------------QIIIK----MLEKMPQNRIDSFGLAKQLNEL
.                   .. . ..|.                            ..| |    ||.| |..||...  ...   .
PPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19973.AA STE 89-140 18 9.7e-08 23.53 In-house 1-92 (359) Show / Hide 
Range on Protein: 89-140
Range on HMM: 1-92/359
Sequence Identity: 18% (17 aa)

YLT-SYIAQGGYGCVFEAKYN-----------------GEIVAVKCSK---------------------PKFDKIKEEEKIMKLLKD-TPYV
.   . | .|..| |. |...                 |||.|.|  .                      ....|..| |||| ...  |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNI
Kinase 19973.AA TyrKc 88-335 15 1.4e-07 -100.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 88-335
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

VYLTSYIAQGGYGCVFEAKYNGEIVAVKCSK--PKFDKIKEEEKIMKLL-KDTPYVFK----SIEEF-----------------------FNEKNSKYYQ
. |   .  | .| |...... . ||||. |       . .| .||. | .. | . .     ....                       .  |. .   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ISKKYSCNLKDIMQSFFDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDG------SKTY------NLKG
                      |.. . . |..| .   | . ..|.|| |.   |.|....  .   .| | |.  .|.      ...|      . |.
----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-FTRKYAAPEITDDNGLFNIKYDIYGLGIILLEL-TLGKFLEDGD----------CTFIRNGKLPKYMSKNA------LYQDINQIIIKMLEKMPQNRID
 .  .  |||   . | |..| |..  |. . |. |.|.    |.            ....|. .. .  .         ... ||. .  .  | .|  
MLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

SFGLAKQL
   . ...
FSEIHECF
Kinase 19973.AA STE 201-278 25 1.4e-07 22.97 In-house 170-261 (359) Show / Hide 
Range on Protein: 201-278
Range on HMM: 170-261/359
Sequence Identity: 25% (25 aa)

QNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKD-----------------GSKTYNLKGFTRKYAAPEITDD-----NGLFNIKYDIYGLGIILLEL
... || |||| |||         ||| | .... |                 ..|.. . |    . |||. .      ..  ..| ||. ||. ..|.
SHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 19973.AA TKL 94-135 19 1.5e-07 23.3 In-house 1-83 (364) Show / Hide 
Range on Protein: 94-135
Range on HMM: 1-83/364
Sequence Identity: 19% (16 aa)

IAQGGYGCVFEAKYNG----------EIVAVKCSKP-------------------------------KFDKIKEEEKIMKLLK
| .||.|.|. .|..|          . ||||  |                                 .....|| ..|. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR
Kinase 19973.AA Ciliate-E2-Unclassified 310-338 34 0.188938 0.82 In-house 325-352 (352) Show / Hide 
Range on Protein: 310-338
Range on HMM: 325-352/352
Sequence Identity: 34% (10 aa)

INQIIIKMLEKMPQNRIDSFGLAKQLNEL
||... |||.| | .|| .|  ...   .
INDLLQKMLKKNPNKRI-TFEQILNHPWF