Gene 12561 (Tetrahymena)
12561
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 12561.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12561.AA | Ciliate-E1 | 87-265 | 26 | 2.8e-49 | 158.38 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 87-265 Range on HMM: 1-202/202 Sequence Identity: 26% (55 aa) LSEGGQARVYIVRQINTNKKYAMKVFFQNQIQNG--------KQEYEICQRFEKTIYTKEIKEFIIHTN--FSFLISEYYDQDLSDEIE--------DIK ...|....|.. .|.|.|.. ...... ... |..|.|.. |.| .|. .| ..|.. . .. .| |.... | |... ... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC HYKGANFTFQKLLLMIFNIIDGYSFLRIYNIIHLDIKTSNILKNETTAIYIISDHGCSLIYKPNQLVNYNQRCFTEKYAPEELKK-------GTKEIGPK ... .||||... .||..|||.. |..|||||.||| .|||.| .|...|.|.|...| ||. .......|..|.|.| .. ...|. | QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK TDIY .||| SDIY |
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| Kinase | 12561.AA | Ciliate-B2 | 81-268 | 32 | 2e-34 | 78.33 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 81-268 Range on HMM: 1-197/197 Sequence Identity: 32% (65 aa) YKIEKFLSEGGQARVYIVRQINTNKKY---AMKVFFQ---NQIQNGKQEYEICQRFEKTIY-TKEIKEFIIHTNFSFLISEYYDQDLSDEIEDIKHYKGA | . |.. .||. .. . ...| |.|. |. . .. .|..| . ||. |. | | . | . || | .| .|.. |. . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQ-K NFTFQKLLLMIFNIIDGYSFLRIYNIIHLDIKTSNILKNETTAIYIISDHGCSLIYKPNQLVNYNQRCFTEKYA-PEELKKG-----TKEIGPKTDIYSL .|. |||. |||. ||| .|.|||.||||| .|||. . |. .| | | | | || .. . || ||| || ... .| . ||||. CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGN-YVYCDFGISSIKKDNQQIKIKG--FTKKYASPEQMECDHNQTFVTNIDFQSDIYSM G | G |
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| Kinase | 12561.AA | S_TKc | 81-320 | 20 | 5.7e-14 | 27.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 81-320
Range on HMM: 1-231/231
Sequence Identity: 20% (53 aa)
YKIEKFLSEGGQARVYIVRQINTNKKYAMKVFFQNQIQNGKQEYEICQRFEKTIYTKEIKEFIIHTNFSFLISEYYDQ---DLSDEIEDIKH-YKGANFT
|.| . . .|. ..|| .| ..|....|.|. .. ..| .|... . . ..... . .. ... || |. || | |.. .. .. |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP
FQKLLLMIFNIIDGYSFLRIYNIIHLDIKTSNILKNETTAIYIISDHGCSLIYKPNQLVNYNQRCFTEKY-APEELKKGTKEIGP-KTDIYSLGKTFQEI
.. |... .. .||| |.| .||| .| |.| | . .. . | | | ||| | |. | |..|.| .. |
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEM
FE---------QLKEFIVGDSFSFAKQFIQIIHEKMIQTSIDKRVDIQELHR--------LFF
. .. . |. ......| .|. | .|| . |. . .|
LCGYPPFPQMQMMFKKIG------SPEAKDFI-RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 12561.AA | Ciliate-E2-Unclassified | 81-268 | 22 | 2.6e-11 | 35.49 | In-house | 1-257 (352) | Show / Hide |
Range on Protein: 81-268 Range on HMM: 1-257/352 Sequence Identity: 22% (57 aa) YKIEKFLSEGGQARVYIVRQINTNKKYAMKVFFQNQIQN-GKQEYEICQRFEKTIYTKEIK--------------------EFIIHTNFSF-------LI ||| | . .||.. || .........|||| ..||.. ...... . . . ...| .||.. . | .. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV SEYYDQ-DLSDEIEDIKH------------YKGANFTFQKLL-----LMIFNIIDGYSFLRIYN-IIHLDIKTSNILKNETTA--IYIISDHGCSLIYKP || .. ||.. |.. |. ... || |. . .. |..| ..| | ||| ||| .||| .. |.| | | |. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ N--------------QLVNYNQRCFTEKYA----PEELKKGTKEIGP---KTDIYSLG | . .....| | | . |. .| . .. | ||.||| NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG |
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| Kinase | 12561.AA | AGC | 81-111 | 35 | 7.2e-10 | 20.18 | In-house | 1-37 (395) | Show / Hide |
Range on Protein: 81-111 Range on HMM: 1-37/395 Sequence Identity: 35% (13 aa) YKIEKFLSEGGQARVYIVRQI------NTNKKYAMKV ... | ...|. .|| || |.| ||||| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV |
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| Kinase | 12561.AA | Ciliate-E2 | 81-303 | 20 | 7.5e-09 | 26.49 | In-house | 1-306 (365) | Show / Hide |
Range on Protein: 81-303
Range on HMM: 1-306/365
Sequence Identity: 20% (67 aa)
YKIEKFLSEGGQARVYIVRQINTNKK-----------------------YAMKVFFQNQIQNGKQEYEICQRFEKTIYTK-----------------EIK
||. | . .|... || .......|. ||||.. .|||.. ||| |... . | | ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY-KKINEKNILEQLNHPNIIKMY
EFII--HTNFSFLISEYYDQ-DLSDEIEDIKHY-------KGANFTFQKLLLMIFNIIDGY---------------SFLRIYN-IIHLDIKTSNILKNET
|. . .| .|. ||... || | |.. |. . .|| .. . .. |..|. .| | ||| ||| .|||
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
TAIYIISDHGCSLIYKPN----------QLVNYNQ---------------------RCFTEKYAPEELKKGTKE--------IGPKTDIYSLGKTFQEIF
|.| | | .|... .. . . | | | . | .| |. . | ||.||| .. |
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML
EQLKEFIVGDSFSFAKQFIQIIHEKMIQ
| .|.|... |.
FGKPPF------------QQQIKQCKID
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| Kinase | 12561.AA | CMGC | 81-210 | 16 | 1.1e-08 | 23.72 | In-house | 1-216 (513) | Show / Hide |
Range on Protein: 81-210 Range on HMM: 1-216/513 Sequence Identity: 16% (37 aa) YKIEKFLSEGGQARVYIVRQ--------------INTNKKYAMKVFFQNQIQNGKQ--------------EYEICQRFEKT-------------IYTK-- |.| | . || . || | ..||...|.| ..... ..... | .| ... |. . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI -EIKEFIIHTNFS-----------------FLISEYYDQDLSDEIEDIKH-YKG----------------------ANFTFQKLLLMIFNIIDGYS--FL ..... | | .|. || |.|| . |.. .. |.| .|. ... |. | .. VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC RIYN--IIHLDIKTSNIL . ||| |.| .||| HSHWGNIIHRDLKPENIL |
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| Kinase | 12561.AA | Ciliate-E2a | 81-125 | 31 | 6e-08 | 19.51 | In-house | 1-44 (275) | Show / Hide |
Range on Protein: 81-125 Range on HMM: 1-44/275 Sequence Identity: 31% (14 aa) YKIEKFLSEGGQARVYIVRQINTNKKYAMKVFFQNQIQNGKQEYE ||..| . .| ..||......|.|..|||.| . ... |...| YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKE |
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| Kinase | 12561.AA | Ciliate-C5 | 198-268 | 35 | 7.8e-08 | 21.61 | In-house | 116-185 (260) | Show / Hide |
Range on Protein: 198-268 Range on HMM: 116-185/260 Sequence Identity: 35% (25 aa) NIIHLDIKTSNILKNETTAIYIISDHGCSLIYKPNQLVNYNQRCFTEKYAPEELKKGTKEIGPKTDIYSLG |.|| |.| ||| . ....|.| | .| . |. . || ||| |.. | ||| || NLIHSDVKPENILYDSQEKCFNLCDYGESKSFK-DGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLG |
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| Kinase | 12561.AA | NAK | 81-130 | 26 | 2.6e-07 | 20.39 | In-house | 1-63 (299) | Show / Hide |
Range on Protein: 81-130 Range on HMM: 1-63/299 Sequence Identity: 26% (17 aa) YKIEKFLSEGGQARVYIVR---------QINTNKKYAMKVFFQNQ----IQNGKQEYEICQRF |..|| | ||| . || |. ... .||| | . . ... |.| |..... YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKL |
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| Kinase | 12561.AA | CAMK | 198-268 | 20 | 6e-06 | 14.28 | In-house | 199-321 (425) | Show / Hide |
Range on Protein: 198-268
Range on HMM: 199-321/425
Sequence Identity: 20% (25 aa)
NIIHLDIKTSNILKNETT----------------AIYIISDHGCSLIYKPNQLVN----------------------YNQRCFTEKYA--PEELKK-G--
||.|.|.| ||| .. . |.| | . ...|.. . .. .| | |. || |.. |
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC
---------TKEIGPKTDIYSLG
. .|||.|. |.|
NMQNATDEEKPYYGPKCDMWSCG
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| Kinase | 12561.AA | Pkinase | 81-127 | 23 | 6.1e-05 | 18.55 | Pfam | 1-52 (293) | Show / Hide |
Range on Protein: 81-127 Range on HMM: 1-52/293 Sequence Identity: 23% (12 aa) YKIEKFLSEGGQARVYIVRQINTNKKYAMKVFFQNQIQNGKQEY-----EIC |.|.. . .|. ..||. . ..|.|..|.|.. . .|... ||. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQ |
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| Kinase | 12561.AA | Pkinase | 198-268 | 33 | 0.000282 | 16.2 | Pfam | 128-199 (293) | Show / Hide |
Range on Protein: 198-268 Range on HMM: 128-199/293 Sequence Identity: 33% (26 aa) NIIHLDIKTSNILKNETTAI----YIISDHGCSLIY-KPNQLVNYNQRCFTEKY-APEELKKGTKEIGPKTDIYSLG .||| |.| .||| ... | |. | |.. . |. .. .| | | ||| .. | ...||| |..|.| GIIHRDLKPENILIDNNGHIDACVKIC-DFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCG |
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| Kinase | 12561.AA | CAMK | 86-129 | 13 | 0.000719 | 7.56 | In-house | 1-87 (425) | Show / Hide |
Range on Protein: 86-129 Range on HMM: 1-87/425 Sequence Identity: 13% (12 aa) FLSEGGQARVYIVRQINTN------------KKYAMKVFF-------------------------------QNQIQNGKQEYEICQR | .|. . |. ....||. .|.|.|. .. .| ..|.||... TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKK |
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