Gene 8538 (Tetrahymena)

8538

Species: Tetrahymena
Alias: 132.m00097, 8538, TTHERM_00787110, PreTt08538, 284, 3755.m00457
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
8538.AA Protein None 618 None Fasta, JSON
8538.kin_dom Protein Kinase Domain None 158 None Fasta, JSON
8538.NA RNA None 1857 None Fasta, JSON

Protein domain

Protein domains of 8538.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8538.AA Ciliate-E1 40-192 23 3.6e-15 46.2 In-house 1-150 (202) Show / Hide 
Range on Protein: 40-192
Range on HMM: 1-150/202
Sequence Identity: 23% (37 aa)

IGQSPFSLIFSAYNIRKF-RREAIKIVNFEPR--KLEILQVVRKEAIPIKNIQKHPNIVQIYDEQFIEKEGNTFLVIVMEQYEIQIKIKCFFQMLLENLD
||.. ||..| |...    .  |.||.| .    . ..... ...  . | ..|. .|.||.| ..|..  .. ...   ... . ...       . | 
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH-----NRL-

EIMEEMRVKGQRFEFNQMIHLVITLLDGLTAIHQAGSVHRNIKASNIVL-KDGVYKY
|.. ... . . | | |...... |.||| ..|| .  ||.|| .||.  ..| |.|
EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVY
Kinase 8538.AA S_TKc 34-378 16 4.6e-10 -29.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-378
Range on HMM: 1-231/231
Sequence Identity: 16% (58 aa)

YEEIKFIGQSPFSLIFSAYNIRKFRREAIKIVNFEPRKLEILQVVRKEAIPIKNIQKHPNIVQIYDEQFIEKEGNTFLVIVMEQYEIQIKIKCFFQMLLE
|| .. ||.  |.  . .....  |. ||||..         . .|.|    |.  .|||||..||         ..| .|||  .            | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGD----------LG

NLDEIMEEMRVKGQR--FEFNQMIHLVITLLDGLTAIHQAGSVHRNIKASNIVLKD-------GVYKYFLSPSHNQFTQIIKKLITHSLTFVTLSLNQEQ
.| ....... .| |  |   .  ...  ....|  .|. | .|| .| .|| | .       |. . .                               
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------------------------------

TNLIIQLHIQIFCGDYIYSLSYQLFIYKMQKQYGTPMFIGPEVMKNEGYKQQYTNISMILSNIK-QTDIYCLGFLLMKMDNISLMNYNIHQGEQEEKNKL
                               . ||| .. |||.                .  |   |.. .| .|  |    |  |   .    . ...
-----------------------------TTFCGTPWYMAPEVL----------------GYGKCKCDWWSCGCILYEM----LCGYPPFP----QMQMM

IMRIHYDAFSKNKLPEDFAINKDSFFYPFIMSMIQSNFTLRKNTKFYME-----KLLIYL
. .|                  ...   ||. . | . . |      ..     |.  ..
FKKIG----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8538.AA Ciliate-E2-Unclassified 145-299 16 6.7e-08 23.51 In-house 131-260 (352) Show / Hide 
Range on Protein: 145-299
Range on HMM: 131-260/352
Sequence Identity: 16% (30 aa)

KGQRFEFNQMI-----HLVITLLDGLTAIHQAG-SVHRNIKASNIVLKDGVYKYFLSPSHNQFTQIIKKLITHSLTFVTLSLNQEQTNLIIQLHIQIFCG
....|. .|..     ..   .|.||  .|. .  .||.|| .||..... .                                           .|   
QRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----------------------------------------NYYIKII

DYIYSLSYQLFIYK---------------MQKQYGTPMFI----GPEVMKNEGYKQQYTNISMILSNIKQTDIYCLGFLL
|.  |  || ....               |. . |||...     |||.....| ..           .. ||..|| .|
DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---------YKCDIWSLGVIL
Kinase 8538.AA CAMK-Unique 34-99 18 7e-08 21.89 In-house 1-83 (363) Show / Hide 
Range on Protein: 34-99
Range on HMM: 1-83/363
Sequence Identity: 18% (15 aa)

YEEIKFIGQSPFSLIFSAYNIRKFRREAIKIVNFEPRKLEILQV-----------------VRKEAIPIKNIQKHPNIVQIYD
|. .. ||.  |.... . ..      |.|.|...  . ... .                   |... |   ..||||...||
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYD
Kinase 8538.AA C8 34-186 19 6.9e-07 20.06 In-house 1-157 (226) Show / Hide 
Range on Protein: 34-186
Range on HMM: 1-157/226
Sequence Identity: 19% (32 aa)

YEEIKFIGQSPFSLIFSAYNIRKFRREAIKIVNFEPRKLEILQVVRKEAIPIKNIQKHPNIVQIYDEQFIEKEGNTFLVIVMEQYEIQ------IKIKCF
 .. ... .  .... .|.|... |  ..|.   .  .       ... . |.   . | ..| ||   .|..       |.|. . .       . | .
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQD------IQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSC

FQML----LENLDEIMEEMRVKGQRFEFNQMIHLVITLLDGLTAIHQAGSVHRNIKASNIVLK
| |      .|| .. .|.| | | |. ..   . | ..||.  ||.   .|| || .|. ..
FVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVC
Kinase 8538.AA SgK071 135-185 29 3e-06 17.87 In-house 87-137 (283) Show / Hide 
Range on Protein: 135-185
Range on HMM: 87-137/283
Sequence Identity: 29% (15 aa)

LDEIMEEMRVKGQRFEFNQMIHLVITLLDGLTAIHQAGSVHRNIKASNIVL
.|..|.| | |..  .   |  .   .|. .. .|. . .||. | |||.|
FDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHHRNIIHRDLKPSNIYL
Kinase 8538.AA STE 34-119 24 6e-06 17.16 In-house 1-120 (359) Show / Hide 
Range on Protein: 34-119
Range on HMM: 1-120/359
Sequence Identity: 24% (29 aa)

YEEIKFIGQSPFSLIFSAYNIR---------------KFRREAIKIVNFEPRK---------------LEILQVVRKEAIPIKNIQK-HPNIVQIYDEQF
.| |..||.  |   . |.|.                . .. |||..|.|. .                |..| . ||    |. .. |||||. |.  |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KEGNTFLVIVMEQYE
 |   .. .. | |.||  .
KEGHNHKNDDELWICMEYMD
Kinase 8538.AA CK1 129-185 26 1.6e-05 15.37 In-house 109-165 (339) Show / Hide 
Range on Protein: 129-185
Range on HMM: 109-165/339
Sequence Identity: 26% (15 aa)

QMLLENLDEIMEEMRVKGQRFEFNQMIHLVITLLDGLTAIHQAGSVHRNIKASNIVL
..| .||.....  |  ...|  .  ... | .|..|  .| .| .||.||..|...
TLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCM
Kinase 8538.AA Ciliate-C8 43-187 20 3.4e-05 14.94 In-house 1-154 (238) Show / Hide 
Range on Protein: 43-187
Range on HMM: 1-154/238
Sequence Identity: 20% (31 aa)

SPFSLIFSAYNIRKFRREAIKIVNF-EPRKLEILQVVRKEAIPIKNIQKHPNIVQIYDEQFIEKEGNTFL-----VIVMEQYEIQIKIKCFFQMLLE-N-
  |... .|.|... |  |.|..             . || . |    . | .|| ||  ....| .         || .|  |.     . . . . | 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LDEIMEEMRVKGQRFEFNQMIHLVITLLDGLTAIHQAGSVHRNIKASNIVLKD
 |..  ...| | . .  .. . ..|  .|..  .|.   .|| || .|. . .
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCF
Kinase 8538.AA KHS 34-95 27 0.000174 10.86 In-house 1-59 (258) Show / Hide 
Range on Protein: 34-95
Range on HMM: 1-59/258
Sequence Identity: 27% (17 aa)

YEEIKFIGQSPFSLIFSAYNIRKFRREAIKIVNFEPRKLEILQVVRKEAIPIKNIQKHPNIV
|| .. .|   .  .. | .|.     |.|.. .||   . ..|. .| . .|.  .|||||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPG--DDFAVIQQEIMMMKDC-RHPNIV
Kinase 8538.AA FRAY 161-187 44 0.000323 8.63 In-house 116-142 (277) Show / Hide 
Range on Protein: 161-187
Range on HMM: 116-142/277
Sequence Identity: 44% (12 aa)

LLDGLTAIHQAGSVHRNIKASNIVLKD
.| ||   |. | .|| ||| || . .
VLKGLCYFHKNGQIHRDIKAGNILIGE
Kinase 8538.AA STE 135-189 28 0.000371 10.72 In-house 124-186 (359) Show / Hide 
Range on Protein: 135-189
Range on HMM: 124-186/359
Sequence Identity: 28% (19 aa)

LDEIMEEMRVKGQ----------RFEFNQMIHLVITLLDG-LTAIHQAGSVHRNIKASNIVLKDGV
||.|...   .|.          ||. .| .. .  .| | |  .|. . .|| ||..|| |   |
LDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---V
Kinase 8538.AA KHS 162-187 50 0.000949 8.34 In-house 106-131 (258) Show / Hide 
Range on Protein: 162-187
Range on HMM: 106-131/258
Sequence Identity: 50% (13 aa)

LDGLTAIHQAGSVHRNIKASNIVLKD
| ||  .|. | .|| ||  ||.| |
LQGLHYLHSMGKMHRDIKGANILLTD
Kinase 8538.AA FRAY 34-98 29 0.002084 6.07 In-house 1-64 (277) Show / Hide 
Range on Protein: 34-98
Range on HMM: 1-64/277
Sequence Identity: 29% (19 aa)

YEEIKFIGQSPFSLIFSAYNIRKFRREAIKIVNFEPRKLEILQVVRKEAIPIKNIQKHPNIVQIY
|| .  ||.    ... || | .  . |||..| |  .   .  ..|| |   .  .|||.|. .
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKE-IQAMCQCHHPNVVHYH
Kinase 8538.AA CAMK-Unique 169-186 38 0.028555 3.07 In-house 174-191 (363) Show / Hide 
Range on Protein: 169-186
Range on HMM: 174-191/363
Sequence Identity: 38% (7 aa)

HQAGSVHRNIKASNIVLK
|. . |||..|. ||...
HSQDIVHRDLKLENIMVC
Kinase 8538.AA CAMK-Unique 253-276 28 0.03344 2.84 In-house 232-269 (363) Show / Hide 
Range on Protein: 253-276
Range on HMM: 232-269/363
Sequence Identity: 28% (11 aa)

MQKQYGTPMFIGP--------------EVMKNEGYKQQ
||.  |||... |              || .. .| ||
MQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQ
Kinase 8538.AA CK1 34-113 12 0.138785 1.4 In-house 1-108 (339) Show / Hide 
Range on Protein: 34-113
Range on HMM: 1-108/339
Sequence Identity: 12% (14 aa)

YEEIKFIGQSPFS-LIFSA-----YNIRKF-----RREAIKIVNFEPRKLEILQVVRKEAIPIKNIQKH--------------------PNIVQIYDEQF
.. .| ||.  |   |. .     ...  .      . |.|.   ||.| .  . ...|.. .... ..                      .. .|.  .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKV---EPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHG

IEKEGNTFLVI
 |.... ..|.
EEDDYYNYMVM
Kinase 8538.AA C8 288-299 33 0.199932 0.85 In-house 215-226 (226) Show / Hide 
Range on Protein: 288-299
Range on HMM: 215-226/226
Sequence Identity: 33% (4 aa)

KQTDIYCLGFLL
.| |.. .| .|
IQSDLFSVGLVL