Gene 8053 (Tetrahymena)

8053

Species: Tetrahymena
Alias: 8053, 3716.m00083, TTHERM_00502140, 393, PreTt08053, 63.m00231
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
8053.AA Protein None 460 None Fasta, JSON
8053.kin_dom Protein Kinase Domain None 152 None Fasta, JSON
8053.NA RNA None 1383 None Fasta, JSON

Protein domain

Protein domains of 8053.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8053.AA S_TKc 178-428 15 3.4e-11 -12.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 178-428
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)

FVKIQLLGKGACGIVEKQLFKPLEQEVAMKKYLMEENLDEFDSEVFIMKSKQSEFIPKLIFYQRESQQIYMELGMITL---ETYDLYLRRNHLD----IS
. .....|||| | | |   |   ..||.|.       . . .|. |.|. . ..| ||. . .. . .|| . ..     . .|.  .|..      ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EKFAVWILKQLLIINKYMFNEGFHHSDIKPGNIIITFNELQNMKIKLIDFGASSIFPEDYWIQYTPLFQCPDLFKKVEQSQHLNR------------QEI
|  |  ...|..   .|. . |. | |.|| || ..        ||..||| . ..   . .  || .  | ..       . ..             | 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEM

LFAEF-FASCRSVQLLTLANHPKRKQLFLLESIDEYLSDQVIGEKYNYLRVILQYMFKLK-----SLKSMDE-------KDFT
|  .  |      |. .. .. .                         .. ... ...       .     .         . 
LCGYPPFP-----QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase 8053.AA Pkinase 178-326 25 1.8e-09 34.61 Pfam 1-162 (293) Show / Hide 
Range on Protein: 178-326
Range on HMM: 1-162/293
Sequence Identity: 25% (42 aa)

FVKIQLLGKGACGIVEKQLFKPLEQE-VAMKKYLMEENLDEFD------SEVFIMKSKQSEFIPKLIFYQRESQQIY--MELGMITLETYDLY--LR-RN
..... .|.|. | | ..  .  ... ||.|.   ... ...|      ||. |||. ....| .|. . .... ||  ||. . .|.  ||.  .. ..
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

HLDI--SEKFAVWILKQLLIINKYMFNEGFHHSDIKPGNIIITFNELQN-MKIKLIDFGASSIF
|  .  ||. .  ...|.|   .|. ..|. | |.|| || |  |. ..  ..|..||| .  |
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQF
Kinase 8053.AA STE 178-326 18 1.1e-08 26.99 In-house 1-197 (359) Show / Hide 
Range on Protein: 178-326
Range on HMM: 1-197/359
Sequence Identity: 18% (39 aa)

FVKIQLLGKGACG-IVEKQLFK-----PLEQE---------VAMKKYLMEEN-------------------LDEFDSEVFIMKSKQ--SEFIPKLIFYQR
. .|. .||||.|  . .   |     .  ..         .|.|.  .|..                   ....  |. |||  .  ...| | . .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------ESQQIYMELGM-ITLE-TYD-LYLRRNHLD--------ISEKFAVWILKQLLII-NKYMFNEGFHHSDIKPGNIIITFNELQNMKIKLIDF
         ..  |.||.    .|.  ..  | . . |.        ..|.   .|..|.|    .|  . .  | ||||.|| .         .||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GASSIF
| ....
GVCGQL
Kinase 8053.AA Ciliate-E8 295-323 48 3.8e-07 18.41 In-house 112-138 (138) Show / Hide 
Range on Protein: 295-323
Range on HMM: 112-138/138
Sequence Identity: 48% (14 aa)

HSDIKPGNIIITFNELQNMKIKLIDFGAS
|.|.|  ||..  |     |||.|||| |
HCDFKLNNILVQRND--DTKIKIIDFGFS
Kinase 8053.AA Ciliate-A4 295-329 40 5.1e-07 18.63 In-house 240-284 (284) Show / Hide 
Range on Protein: 295-329
Range on HMM: 240-284/284
Sequence Identity: 40% (18 aa)

HSDIKPGN-----IIITFNEL----Q-NMKIKLIDFGASSIFPED
|||||| |     |..|        | . .  |||||  |   ||
HSDIKPQNKIQLQIMLTVKKSKEDQQSQIQLMLIDFGGASFQLED
Kinase 8053.AA Ciliate-E9 270-323 34 5.5e-07 17.95 In-house 109-159 (298) Show / Hide 
Range on Protein: 270-323
Range on HMM: 109-159/298
Sequence Identity: 34% (19 aa)

SEKFAVWILKQLLIINKYMFNEG-FHHSDIKPGNIIITFNELQNMKIKLIDFGAS
.|. | .. |||.    || ...   | |.|| |..|     .|  .|..||| |
NENVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLID----KNYNMKICDFGMS
Kinase 8053.AA CAMK 295-329 31 6.3e-07 17.58 In-house 202-249 (425) Show / Hide 
Range on Protein: 295-329
Range on HMM: 202-249/425
Sequence Identity: 31% (15 aa)

HSDIKPGNIIITFNE-------------LQNMKIKLIDFGASSIFPED
| |.|| || .. |.             ..| .||.|||| . .|...
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG
Kinase 8053.AA CDK-Unclassified 287-323 39 9.5e-07 18.08 In-house 136-173 (324) Show / Hide 
Range on Protein: 287-323
Range on HMM: 136-173/324
Sequence Identity: 39% (15 aa)

YMFNEGFHHSDIKPGNIIITFNE-LQNMKIKLIDFGAS
|.   ...| |||| || || |      ..|..||| .
YLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQA
Kinase 8053.AA STE7 178-208 35 1e-06 20.39 In-house 1-31 (288) Show / Hide 
Range on Protein: 178-208
Range on HMM: 1-31/288
Sequence Identity: 35% (11 aa)

FVKIQLLGKGACGIVEKQLFKPLEQEVAMKK
...|  ||.|..|.|.| ..||  .  |.|.
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKR
Kinase 8053.AA Ciliate-A4 213-256 36 1e-06 17.23 In-house 147-190 (284) Show / Hide 
Range on Protein: 213-256
Range on HMM: 147-190/284
Sequence Identity: 36% (16 aa)

ENLDEFDSEVFIMKSKQSEFIPKLIFYQRESQQIYMELGMITLE
....||  | .||   |.|. ||| .|  . |  .||.|   |.
KTQEEFIRELYIMQTVQCEYMPKLFYYDIDQQILFMEMGLCSLY
Kinase 8053.AA ROCK 178-321 28 2e-06 17.53 In-house 1-143 (263) Show / Hide 
Range on Protein: 178-321
Range on HMM: 1-143/263
Sequence Identity: 28% (42 aa)

FVKIQLLGKGACGIVEKQLFKPLEQEVAMKKYLMEENLDEFDSEVF-----IMKSKQSEFIPKLIFYQRESQQIYMELGMITLETYDLYLRRNHLDISEK
|  |...|.|| | |.    |  ..  |||     | .   ||  |     ||    ||.| .| .   . . .||   |  .   ||       |..||
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMV--MDYMPGGDLVNLMSNYDVPEK

FAVWILKQLLIINKYMFNEGFHHSDIKPGNIIITFNELQNMKIKLIDFG
.| .    .      . . || | |.|| |...     .   .|| |||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLD----KYGHLKLADFG
Kinase 8053.AA Ciliate-E2 283-341 18 2e-06 18.41 In-house 154-256 (365) Show / Hide 
Range on Protein: 283-341
Range on HMM: 154-256/365
Sequence Identity: 18% (21 aa)

IIN-----------------KYMFNEG-FHHSDIKPGNIIITFNELQNMKIKLIDFGASSIFPEDYW---------------------------------
|..                 .|. ...   | |||| ||..         ||.|||| | .. .|.                                  
ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMF

--IQYTPLFQCP
  | .|| ...|
NTICGTPGYMAP
Kinase 8053.AA Ciliate-A1 295-327 39 4e-06 16.96 In-house 124-152 (301) Show / Hide 
Range on Protein: 295-327
Range on HMM: 124-152/301
Sequence Identity: 39% (13 aa)

HSDIKPGNIIITFNELQNMKIKLIDFGASSIFP
|.|.||.||.| | .    |.|..|.| | . .
HRDLKPQNILIHFDD----KWKICDLGMSKQLE
Kinase 8053.AA Ciliate-E2 178-248 16 0.002587 7.21 In-house 1-111 (365) Show / Hide 
Range on Protein: 178-248
Range on HMM: 1-111/365
Sequence Identity: 16% (18 aa)

FVKIQLLGKGACG-----IV--EKQLF--------KPLEQ----EVAMKKYLMEEN----LDEFDSEVFIMK----------------SKQSEFIPKLIF
. .|...|.|. |      |  ....|        .   |    .|..|.| |. .    . .. .|  ||.                . .. .| |.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

YQR--ESQQIYM
.      . ||.
CFQEKDDNNIYL
Kinase 8053.AA CAMK 183-227 16 0.067923 1.08 In-house 1-87 (425) Show / Hide 
Range on Protein: 183-227
Range on HMM: 1-87/425
Sequence Identity: 16% (14 aa)

LLGKGACGIVEKQLFKPLE------------QEVAMKKYL------------------------------MEENLDEFDSEVFIMKS
 ||.|. |.| .   |               |.||.| .                                ....... .|. |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKK
Kinase 8053.AA Ciliate-A1 178-194 35 0.160939 0.86 In-house 1-17 (301) Show / Hide 
Range on Protein: 178-194
Range on HMM: 1-17/301
Sequence Identity: 35% (6 aa)

FVKIQLLGKGACGIVEK
.   ||..||  |.| .
YHVVQLIDKGSFGVVMR