Gene 7822 (Tetrahymena)
7822
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 7822.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7822.AA | Ciliate-E2 | 84-244 | 17 | 1.8e-16 | 53.0 | In-house | 11-253 (365) | Show / Hide |
Range on Protein: 84-244
Range on HMM: 11-253/365
Sequence Identity: 17% (44 aa)
NFSQVYICKLDKQEQQS----------------SNDAQQFQDKSYVLKRVELTGDYQSEL----------LEPSFQFILKHENIASIIDYQV--INNQLE
||..|| || .|. .|. ...... |.. . .| . .... | . ...|.| || .... .| .
NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIY
ILMDYYPEGSIVNYLQKNQEWP-----------WLERLKIFVNITN---------------CVQFIHYNE-LIHKDLKLLNILIDSKGKPSITDFGISE-
. |.|. |. |...|. . . |...|. |.. .....| . || |.|. |||. . |.|||.|
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKK
----------LQACKQIQQNK----------------------YGTAKY
.| || ... | .||. |
YDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGY
|
|||||||||
| Kinase | 7822.AA | NuaK | 156-228 | 34 | 3.6e-16 | 38.48 | In-house | 76-148 (252) | Show / Hide |
Range on Protein: 156-228 Range on HMM: 76-148/252 Sequence Identity: 34% (25 aa) ILMDYYPEGSIVNYLQKNQEWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKPSITDFGISEL | | | | .|. . .. | | ..| |. | . | .. .| |||| ||| | .. | ||| | . IVMEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNY |
|||||||||
| Kinase | 7822.AA | TKL | 136-273 | 19 | 4.6e-14 | 47.05 | In-house | 82-282 (364) | Show / Hide |
Range on Protein: 136-273 Range on HMM: 82-282/364 Sequence Identity: 19% (41 aa) LKHENIASIIDYQVINNQ-------------LEILMDYYPEGSIVNYLQKNQEWPWLERLKIFVNITNCVQFIHYNE--------LIHKDLKLLNILIDS |.|.|| ... | ... | | |.|.| || .||. | |... | ... | .. .|| ||| |||.|. LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDE KGK--------------PSITDFGISELQACKQ--------------------IQQNKYGTAKYSGKEF---QLDSN-----------MNLDDRSDIYSI ... . |.|||.| .. .. || . | |.. . . ..|.|| NWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSF AVILVEL ...| |. GIVLWEI |
|||||||||
| Kinase | 7822.AA | Ciliate-B2 | 137-267 | 26 | 1.8e-13 | 27.97 | In-house | 58-197 (197) | Show / Hide |
Range on Protein: 137-267 Range on HMM: 58-197/197 Sequence Identity: 26% (38 aa) KHENIASIIDYQVINNQLEILMDYYPEGSIVNYLQ---KNQ-EWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKPSITDFGISELQACK ...|. .||. ||.. ..| | | . || | | . . .... . . .. .. .| |.| |||. ..|. .||||| . YNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDN QIQQNKYGTAKYSGKEFQLDSN------MNLDDRSDIYSIA | .. | | || .| |.. |.|..|||||. QQIKIKGFTKKYASPE-QMECDHNQTFVTNIDFQSDIYSMG |
|||||||||
| Kinase | 7822.AA | Ciliate-E1 | 132-264 | 25 | 3.7e-13 | 39.57 | In-house | 49-202 (202) | Show / Hide |
Range on Protein: 132-264 Range on HMM: 49-202/202 Sequence Identity: 25% (40 aa) FQFILKHENIASIIDYQV-INNQLEILMDYYPEGSIVNYLQ-------------KNQEWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGK .. . |...| ||||. .|...|. . . | .||| ..... .. ..|.... .. .|.. .|| |.| ||||...|. MK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN PSITDFGISELQACKQIQQN--KYGTAKYSGKEFQL------DSNMNLDDRSDIY ..||||| .. .|.|| |. | .|. .| . | . . |||| YVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
|||||||||
| S_TKc | 7822.AA | S_TKc | 74-327 | 19 | 1.3e-12 | 7.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 74-327 Range on HMM: 1-231/231 Sequence Identity: 19% (52 aa) VKDQTLLMKTNFSQVYICKLDKQEQQSSNDAQQFQDKSYVLKRVELTGDYQSELLEPSFQFILKHENIASIIDYQVINNQLEILMDYYPE--GSIVNYLQ . .. | |..|| |. | .. . .|.. .. . | . .|.|| ..|. . . | . |.| . |. |.. YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK KNQE------WPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKPSITDFGISELQACKQIQQNKYGTAKYSGKEFQLDSNMNLDD-RSDIY |.. | . ... | . ....| . || ||| |||.|. |.|||.. . || | | . ..|.. KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWW SIAVILVELTLQRGIYQKEVSQSVDLTKEKGLLSDDALDFLKGMIDYSSKQVRPNSQEVNS---------FF |. .|| |. . .. .... .| . |..|.||.... .. .. || |. .| SCGCILYEMLCGYPPFP-----QMQMMFKKIG-SPEAKDFIRKCLQKDPEK-RPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 7822.AA | GIN4 | 135-248 | 28 | 3.1e-11 | 31.72 | In-house | 90-204 (293) | Show / Hide |
Range on Protein: 135-248 Range on HMM: 90-204/293 Sequence Identity: 28% (33 aa) ILKHENIASIIDYQVINNQLEILMDYYPEGSIVNYLQKNQEWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGK-PSITDFGISELQACKQ .. | |. .. | ||.| ....| .| . ||| . . | | ...| | | . | ...|.||| |.|.|.| . | |||. |. . LISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNK IQQNKYGTAKYSGKE . . | | | LLETSCGSPHYAAPE |
|||||||||
| Kinase | 7822.AA | Ciliate-E2-Unclassified | 182-244 | 27 | 4.5e-11 | 34.67 | In-house | 146-228 (352) | Show / Hide |
Range on Protein: 182-244 Range on HMM: 146-228/352 Sequence Identity: 27% (23 aa) LKIFVNITNCVQFIHYNE-LIHKDLKLLNILIDSKG---KPSITDFGIS-ELQAC---------------KQIQQNKYGTAKY ...| | .. ...|.. || |.|. |||.|..| .. |.||||| ..| . .|... . || | KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNY |
|||||||||
| Kinase | 7822.AA | C8 | 171-270 | 22 | 1.8e-10 | 32.65 | In-house | 115-226 (226) | Show / Hide |
Range on Protein: 171-270 Range on HMM: 115-226/226 Sequence Identity: 22% (25 aa) QKNQEWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKPS----ITDFGISEL--QACKQIQQNKY---GTAKYSGKEFQLD---SNMNLD .|.|. . ....| . . .| .|| . .|.|.|. |.|. ... . |||.. . ...||. |. || .|. | . . NKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYR DRSDIYSIAVIL .||..|. ..| IQSDLFSVGLVL |
|||||||||
| Kinase | 7822.AA | Ciliate-E3 | 156-274 | 26 | 2.3e-10 | 28.85 | In-house | 81-202 (202) | Show / Hide |
Range on Protein: 156-274 Range on HMM: 81-202/202 Sequence Identity: 26% (34 aa) ILMDYYPEGSIVNYLQKNQEWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKG---KPSITDFGISELQACKQIQQNK-----Y---GTAKY | ..| |. .|.. |. . ..|. .|. . || .|| |.| |||.|. | ||| | || ..|| . | | IVQEYCSNGDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGES-----KQLRKNKGHTHTQYQGWTPFY SGKEFQLDSNMNLDDRSDIYSIAVILVELT . .| .. . ||.||. ... .| AAPEQNDQQQISKE--SDYYSVGAVFCQLC |
|||||||||
| Kinase | 7822.AA | Kin4 | 156-224 | 33 | 4.9e-10 | 26.37 | In-house | 87-155 (273) | Show / Hide |
Range on Protein: 156-224 Range on HMM: 87-155/273 Sequence Identity: 33% (23 aa) ILMDYYPEGSIVNYLQKNQEWPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKPSITDFG | ..| | |.|. . ..| . |...|| |.|.|||| |.|.| . ||||| IVLEYVCGGEFYKYIQRKRRLKEMNACRLFAQLISGVHYMHYKGLVHRDLKLENLLLDKHENLVITDFG |
|||||||||
| Kinase | 7822.AA | Pkinase | 136-228 | 25 | 5.8e-10 | 36.31 | Pfam | 57-161 (293) | Show / Hide |
Range on Protein: 136-228 Range on HMM: 57-161/293 Sequence Identity: 25% (27 aa) LKHENIASIIDYQVINNQLEILMDYYPEG----SIVNYLQ--KNQEW--PWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKP----SITDF |.|.|| ..|. .. . . |.| . | . |.. .. .. | ... | ....| . || |||. |||||..| . |.|| LNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF GISEL |.... GLAKQ |
|||||||||
| TyrKc | 7822.AA | TyrKc | 74-327 | 17 | 9.9e-07 | -113.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 74-327
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)
VKDQTLLMKTNFSQVYICKLDKQEQQSSNDAQQFQDKSYVLKRV---ELTGDYQSELLEPSFQFI--------L--KHENIASIIDYQVIN-------NQ
.. | .| .|| .... | | | |. | .|.|| .. . . .
ITLGKKLGEGAFGEVYKGTWK--------------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP
LEILMDYYPEGSIVNYLQKNQE-WPWLERLKIFVNITNCVQFIHYNELIHKDLKLLNILIDSKGKPSITDFGISELQACK---QIQQNKYGTAKY--SGK
| |.| | | |. .||.|... .. . |.. . | . ...| . .|| || |.|..... |.||| | . .| ..| .||
LMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGK
----------EFQLDSNMNLDDR-----SDIYSIAVILVEL-----TLQRG-----IYQKEVSQSVD----LTKEKGL-------LSDDALDFLKGMIDY
| .... ||..| | . |. . | . .|| . |. . . . .|. . | ..
TMLPIRWMAPE-------CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
SSKQVRPNSQEVNSFF
.. ||. .|. ..|
DPED-RPTFSEIHECF
|
|||||||||
| Kinase | 7822.AA | Pkinase | 260-327 | 15 | 1.223863 | 3.34 | Pfam | 192-293 (293) | Show / Hide |
Range on Protein: 260-327 Range on HMM: 192-293/293 Sequence Identity: 15% (16 aa) RSDIYSIAVILVELTLQRGIYQKE-----VSQSVDLTKEKG----------------------------LLSDDALDFLKGMIDYSSKQVRPNSQEVNSF ..|..|. .|| |. . | ... . ..| . . . .| ..|....||.|..... |. ||. ... KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK-RPTAEQILQH --F | PWF |
|||||||||