Gene 7789 (Tetrahymena)

7789

Species: Tetrahymena
Alias: PreTt07789, 963, 7789, 3759.m00402, 140.m00104, TTHERM_00822360
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
7789.AA Protein None 304 None Fasta, JSON
7789.kin_dom Protein Kinase Domain None 199 None Fasta, JSON
7789.NA RNA None 912 None Fasta, JSON

Protein domain

Protein domains of 7789.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7789.AA RCK 21-211 46 2.8e-122 389.88 In-house 98-298 (298) Show / Hide 
Range on Protein: 21-211
Range on HMM: 98-298/298
Sequence Identity: 46% (95 aa)

KYLNPNK--VKNYIFQLLKAIEFMHRNNIFHRDIKPENILLLG----------EHIKLADFGSCKRINSEHPYTEYISTRWYRAPECLLTDGYYDYKMDL
|||. |.  .||...|.|.....||....||||.|||||.. |          .|||.||||.|. | |..|||.|.||||||||||||...||...||.
KYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDI

WGVGCVMFEIIGLHPLFPGNNELDQVHKIHNILGTPPKEILDRFKKHATHMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRINANQAINH
|.|||.|.|.  |.|||||..|.|| .||....||| |.... ..|.|..|.|.|.. .|.....|. |  .|..||.|..|.| .||. ||.|.||..|
WAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN--CSQDCIELMEKMLQWDPQKRITAQQALQH

EYF
 ||
PYF
Kinase 7789.AA MOK 22-211 57 2.3e-112 353.6 In-house 96-283 (283) Show / Hide 
Range on Protein: 22-211
Range on HMM: 96-283/283
Sequence Identity: 57% (109 aa)

YLNPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLLGEHIKLADFGSCKRINSEHPYTEYISTRWYRAPECLLTDGYYDYKMDLWGVGCVMFEIIGL
||  .|...|..||.|... |||| |||||.||||||.  .|.||||||||. . |  ||||||||||||||||||||||| |.||.| |||| .||. |
YLPQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASL

HPLFPGNNELDQVHKIHNILGTPPKEILDRFKKHATHMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRINANQAINHEYF
|||||| ||.||. ||| ..||| ..|| .||...  |..||  . | ||.||.  .|... |.....|.  |||| || | |.| | ||
HPLFPGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLT--PNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 7789.AA CMGC 13-211 21 5.5e-86 282.44 In-house 140-513 (513) Show / Hide 
Range on Protein: 13-211
Range on HMM: 140-513/513
Sequence Identity: 21% (79 aa)

TLHEILQN----------KYLNPNK------------VKNYI------FQLLKAIE--FMHRNN--IFHRDIKPENILLLGE------------------
.|.....|          ..|.. .            .|...      .|.|....  ..|...  |.|||.||||||.  .                  
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ

---HIKLADFGSCKRINSE----------------------HPYTEYISTRWYRAPECLLTDGYYD---------YKMDLWGVGCVMFEIIG--------
   ..|..|||... ....                      .|||.|..|||||||| || ...|.         ...| |.|||...|..         
KNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFR

LHPLFPGNNE-----------LDQVHKIHNILGTPP---------------KE-------------------------ILDRFKKHATHMEFDFQPQHGT
..|||||..|           .|| .|| ..||||.               .|                         ... | ... .. ..|..... 
GKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPK

GIDKLLVNAN---------------------------------ASPECIDLIKKLLIYDPDQRINANQAINHEYF
 . .|  ...                                 ..|..|||.||.|.||||.|| | || .|.||
PWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 7789.AA MAK 20-211 35 1.3e-76 243.35 In-house 124-352 (352) Show / Hide 
Range on Protein: 20-211
Range on HMM: 124-352/352
Sequence Identity: 35% (82 aa)

NK-YLNPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLLG------------------EHIKLADFGSCKRINSEHPYTEYISTRWYRAPECLLTDG
.. ..    ..| ..| | .. |||... ||||.|||||.. |                  | ||.||||    | |  ||| |.||||||||| ||  .
DRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRST

YYDYKMDLWGVGCVMFEIIGLHPLFPGNNELDQVHKIHNILGTPPKEI----------------LDRFKKHATHMEFDFQPQHG---TGIDKLLVNANAS
||   .|.| |||.| |.  . ||||| .| ||. ||  .|||| |.                  .   . |  | | |.   .   . ...|. |.. |
YYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNFRFPQCVPPSIMPLKHLIPNCSQS

PECIDLIKKLLIYDPDQRINANQAINHEYF
 . |.|.|..| .||. | .|.|.  . ||
-DAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 7789.AA CDK 2-211 30 1.7e-67 214.96 In-house 62-284 (284) Show / Hide 
Range on Protein: 2-211
Range on HMM: 62-284/284
Sequence Identity: 30% (79 aa)

LRRLSPHEHIITLHEILQNK---------------------------YLNPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLL--GE----HIKLAD
|. |  |..|..||..   |                           |.    .|.|..|||......|.|.| |||.|| |||.   ||    ..|.||
LKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIAD

FGSCKRINS-------EHPYTEYISTRWYRAPECLLTDGYYD--YKMDLWGVGCVMFEIIG---LHPLFPGNNELDQVHKIHNILGTPPKEILDRFKKHA
||  .  ..         .||  . |.|||||| || .  |.     |.|.|||.. |..      |||||..|.|| .|| .|.|||  ..   ..|  
FGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLP

THMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRINANQAINHEYF
 .                           ||. |.| |||..||.| || .|.||
DY---------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 7789.AA CDC2 19-211 36 2.4e-60 183.94 In-house 96-301 (301) Show / Hide 
Range on Protein: 19-211
Range on HMM: 96-301/301
Sequence Identity: 36% (75 aa)

QNKYLNPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLLGE-HIKLADFGSCKRINSEH-PYT--EYISTRWYRAPECLLTDGYYDYKMDLWGVGCV
.||.. |..||.|..|.|....| |.. |.|||.|| |||.  .  ||.||||  . ..  . .||    . |.|||||| || . .|.   |.| .||.
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

MFEI---IGLHPLFPGNNELDQVHKIHNILGTPPKEILDRFKKHATHMEFDFQPQHGTGIDKLLVN-------ANASPECIDLIKKLLIYDPDQRINANQ
. |.   .  .|||.|  | ||  ||  |||||  ...   ..  ..   .|   . ... |.. |         . ||.|||....|.||| .||.| .
FAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQ-LPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

AINHEYF
|..| ||
ALQHPYF
Kinase 7789.AA Pkinase 9-211 30 4.6e-59 207.34 Pfam 87-293 (293) Show / Hide 
Range on Protein: 9-211
Range on HMM: 87-293/293
Sequence Identity: 30% (67 aa)

EHIITLHEILQ---NKYL--NPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLL-GEHI----KLADFGSCKR--INSEHPYTEYISTRWYRAPECL
.  . |.....   .. .   .. .|.|. |.|...|..|...| |||.||||||.    ||    |..|||..|   . . . .| .  |.||.||| .
Y-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI

LTDGYYDYKMDLWGVGCVMFEIIGLHPLFPGN----NELDQVHKIHNILGTPPKEILDRFKKHATHMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLL
... ||..| | |..||...| .  .|.|||     | .|| ..| .|.|.|...  .      . . | . . |   .   ..  |.|.||.|.||..|
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCL

IYDPDQRINANQAINHEYF
 .|| .|..| |. .|..|
CKDPKKRPTAEQILQHPWF
Kinase 7789.AA CDKL 23-211 38 8.8e-58 196.12 In-house 95-286 (286) Show / Hide 
Range on Protein: 23-211
Range on HMM: 95-286/286
Sequence Identity: 38% (74 aa)

LNPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLL--GEHIKLADFGSCKRIN-SEHPYTEYISTRWYRAPECLLTDGYYDYKMDLWGVGCVMFEII
.....|..|..|.||||.| | .|. ||||||||||.      .|| |||  . .. .   ||.|  |||||||| |. |  |    |.| .|||| | |
VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMI

GLHPLFPGNNELDQVHKIHNILGTPPKEILDRFKKHATHMEFDF-QPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRINANQAINHEYF
  .||.|| ...|| ..|   ||.   .    |.|.       | ...|   . | . |..  .. .|..||.|  |||.|... |. .|.||
DGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSN-KKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 7789.AA GSK 13-211 30 7.5e-55 165.67 In-house 98-328 (328) Show / Hide 
Range on Protein: 13-211
Range on HMM: 98-328/328
Sequence Identity: 30% (70 aa)

TLHEILQ-----NKYLNPNKVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLL--GEHIKLADFGSCKRINS--EHPYTEYISTRWYRAPECLLTDGYYD
||....      .. .  . .| | .|..... . |  .| ||||||.|||.       |..|||| |.. .   .| . || .| ||||| ..   .|.
TLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYT

YKMDLWGVGCVMFEIIGLHPLFPGNNELDQVHKIHNILGTPPKEILDRFKKHATHMEFD---FQPQHGTGIDK-------------------LLVNANAS
 . | | .||||.| .  .|||||....||   | ..||||.|| .. .. . ....|.   ||   .. . |                   .. ...  
CQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTD

PE-CIDLIKKLLIYDPDQRINANQAINHEYF
..  ||||.|.|.||| .|... .|. |..|
MQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 7789.AA MAPK 14-211 33 2.7e-51 175.57 In-house 102-328 (328) Show / Hide 
Range on Protein: 14-211
Range on HMM: 102-328/328
Sequence Identity: 33% (77 aa)

LHEILQNKY-LNPNKVKNYIFQLLKA--IEFMHRNNIFHRDIKPENILLLGE-HIKLADFGSCKRINSE--HPY-------------TEYISTRWYRAPE
|| |..    |.   ..  ..|.|..  . ..|  |. |||.||.|||.  .   |..|||    | .|  |..             |||..||||||||
LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPE

CLLTD--GYYDYKMDLWGVGCVMFEIIG-LHPLFPGNNELDQVHKIHNILGTPPKEILDRFK--KHATHMEFDF---QPQHGTGIDKLLVNAN--ASPEC
 .|      |. ..| | ||| . | ..  .|||||.. .||  .| ..||||..| . . .  .|| ..   .   ... .   .|.. |||  |.|..
IMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQA

IDLIKKLLIYDPDQRINANQAINHEYF
|||..|.|  |||.||.. .|..|.||
IDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 7789.AA ERK7 32-211 36 7.9e-51 171.92 In-house 106-292 (292) Show / Hide 
Range on Protein: 32-211
Range on HMM: 106-292/292
Sequence Identity: 36% (69 aa)

IFQLLKAIEFMHRNNIFHRDIKPENILLLGE-HIKLADFGSCKRINSEH-------PYTEYISTRWYRAPECLLTDGYYDYKMDLWGVGCVMFEIIGLHP
..|||.|| .||  |. |||.|| ||||  | ..|..|||    | .           |||. |||||||| ||    |    |.|..||.. |..   |
MYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKP

LFPGNNELDQVHKIHNILGTPPKEILDRFKKH-ATHMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRINANQAINHEYF
.|||.  ..|. || .... | .| .   . | |  |    . |.   .|...   ..... |||.|.||.. |..|. |.||..| | 
MFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 7789.AA S_TKc 3-211 22 3.8e-34 120.68 SMART 19-231 (231) Show / Hide 
Range on Protein: 3-211
Range on HMM: 19-231/231
Sequence Identity: 22% (61 aa)

RRLS-----------------------PHEHIITLHEILQ------------------------NKY------LNPNKVKNYIFQLLKAIEFMHRNNIFH
|  .                        |..|..|... |                        ...      ...  .. |. |...|.|..|...| |
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH

RDIKPENILLLGEHIKLADFGSCKRINSEHPYTEYISTRWYRAPECLLTDGYYDY-KMDLWGVGCVMFEIIGLHPLFPGNNELDQVHKIHNILGTPPKEI
||.|||||||   |||..|||.....      | .. |.||.||| |     |.. | | | .||...| .   |.||      |.... ...|      
RDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------

LDRFKKHATHMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRINANQAIN-------HEYF
                                |||..|.|.|.| .||..|. | .| .       |..|
--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7789.AA TyrKc 2-211 14 2e-06 -118.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-211
Range on HMM: 1-280/280
Sequence Identity: 14% (45 aa)

LRRLS--------------------------------------------PHEHIIT-----------------------------LHEILQNKY--LNPN
.. .                                              |..|.                              |.. |...   |.. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

KVKNYIFQLLKAIEFMHRNNIFHRDIKPENILLLGEH-IKLADFGSCKRINSE------HPYT-------EY--ISTRWYRAPECLLTDGYYDYKMDLWG
.  .. .|  .  |. |..|. |||.   |.|.  .| .| .||| .. | ..      . |        .   .  ||. ||||.  .| .  | | | 
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVWS

VGCVMFEIIGLHPLFPGN-----NELDQVHKIHNILGTPPKEIL----DRFKKHATHMEFDFQPQHGTGIDKLLVNANASPECIDLIKKLLIYDPDQRIN
 | .|.||  .    . .      . ..|..     . .|.                                     ...|  ...|.   .||..| .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-VCCPDEMYQIMKQCWHEDPEDRPT

ANQAINHEYF
 ..   ||.|
FSEI--HECF
Kinase 7789.AA RCK 1-20 45 3.2e-05 12.22 In-house 50-69 (298) Show / Hide 
Range on Protein: 1-20
Range on HMM: 50-69/298
Sequence Identity: 45% (9 aa)

ALRRLSPHEHIITLHEILQN
.||.|.||..|| |.|....
SLRKLNPHPNIIKLKEVIRD
Kinase 7789.AA MOK 1-18 55 0.002969 5.48 In-house 50-67 (283) Show / Hide 
Range on Protein: 1-18
Range on HMM: 50-67/283
Sequence Identity: 55% (10 aa)

ALRRLSPHEHIITLHEIL
|.|||.||  |. |||..
AMRRLNPHPNILMLHEVV