Gene 7400 (Tetrahymena)

7400

Species: Tetrahymena
Alias: 87.m00180, PreTt07400, n.7400, 1169, TTHERM_00624120, 7400
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
7400.AA Protein None 1039 None Fasta, JSON
7400.kin_dom Protein Kinase Domain None 245 None Fasta, JSON
7400.NA RNA None 1617 None Fasta, JSON

Protein domain

Protein domains of 7400.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7400.AA Ciliate-E2 38-246 19 1.6e-22 74.14 In-house 84-361 (365) Show / Hide 
Range on Protein: 38-246
Range on HMM: 84-361/365
Sequence Identity: 19% (57 aa)

NILQRVVHPNVVQFEEHFN--SSHVFFMQMEYCPN-NLRQLLKEK------------SLSQQEQFHYAMQVIR---------------GVQAIHSVN-HS
|||... |||.... |.|   . . ... ||||   .|....|..            ... .|  ..  |...               ... .|| |   
NILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNII

HKELKTQNILVNQQGNLVIGDFGLDREDDIFYQKCQS------------------------QDDLVNSQRW---YVAPEIQMGQP---GILQN-INQPAD
|  .| .|||.     . | |||| .. |...|...                         |....|.. .   |.|||| .|..    ..|.  .  .|
HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD

IWSLGIIILEIFGLKYVSNFQSIEQLQLTLDLLYNQDFSFINF------------------IDKFLTDIIKQ----LLNSEPSKRPI-IDDVKK
|||||.|. |    |.             ..   .....| ..                  ...   |.||.    .|. .|.||.  ......
IWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 7400.AA CMGC 39-187 19 3.1e-19 59.01 In-house 74-329 (513) Show / Hide 
Range on Protein: 39-187
Range on HMM: 74-329/513
Sequence Identity: 19% (49 aa)

ILQRVV-----------------HPNVVQFEEHFNSSH-----------------VFFMQMEYCPNNLRQLLKEKS----------LSQQE---------
||...                  |.|.|.  ..| ...                  ... .||....| |..|...          ||. .         
ILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP

---QFHYA------MQVIRGVQ--AIHSVN--HSHKELKTQNILVNQQ--------------------GNLVIGDFGLDREDDIFYQKCQSQ--------
     ..        |..||.    .|| .    |  || .|||.|..                    |.| |.|||| |  ..   ....|        
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNV

---------DDLVNSQRWYVAPEIQMGQP-----GILQNINQPADIWSLGIIILEIF
              . ||| |||| .| .      . .. ..| |.||.| |. |..
NKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMY
Kinase 7400.AA CDK 38-130 27 1.6e-17 52.44 In-house 60-159 (284) Show / Hide 
Range on Protein: 38-130
Range on HMM: 60-159/284
Sequence Identity: 27% (30 aa)

NILQRVVHPNVVQFEEHFNSS-----------HVFFMQMEYCPNNLRQLLKEKSLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGN----
..|.   |||.|.  . . ..           . ..| .||..  | ....          .| .| .||.  .|| .  |  ||.||||.| .|.    
SLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCG

-LVIGDFGL
 | |.||||
RLKIADFGL
Kinase 7400.AA CAMK 38-182 17 1.6e-17 52.33 In-house 83-323 (425) Show / Hide 
Range on Protein: 38-182
Range on HMM: 83-323/425
Sequence Identity: 17% (42 aa)

NILQRVV-------HPNVVQFEEHFNSSHV-------------------FFMQM---EYCPNN------LRQLLKEKS---------------LSQQEQF
.|....        |||.... |.. ..|.                   ..| |   |||..       .  . . ..               .. .|  
EIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREAR

HYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQ-----------------GNLVIGDFGLDREDDI-----FYQKCQSQDDLVNSQRW------------
.|  |.. .|. .|| |  |  ||  |||...                  .|. | |||. .. |      . .....   . ..| |            
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQ-WTTPTEGQKMKTF

-----YVA-PEIQMGQP---------GILQNINQPADIWSLGII
     |.| ||.  |..         .  . .....|.||.|.|
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase 7400.AA ULK 38-130 26 2.4e-16 54.53 In-house 62-184 (324) Show / Hide 
Range on Protein: 38-130
Range on HMM: 62-184/324
Sequence Identity: 26% (32 aa)

NILQRVV---HPN--VVQFEEHFNSSHV--FFMQMEYCPN-NLRQLLKEK----------SLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQ
.|..      |||  .|.. . |..|.   ... ||||.  .|.|..|..           ||.||  .. .| . | ...|. |  |  .| ||||.. 
QIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHN

QGNLV------------IGDFGL
                 |.|||.
GQPKTDSKKVHPNGVLKIADFGF
Kinase 7400.AA Pkinase 37-130 30 3.4e-16 58.34 Pfam 51-158 (293) Show / Hide 
Range on Protein: 37-130
Range on HMM: 51-158/293
Sequence Identity: 30% (33 aa)

ANILQRVVHPNVVQFEEHFNSSHVFFMQMEYCPN-----NLRQLLK---EKSL--SQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNL---
. |..|. |||.|.. . | ..    | ||||..      |  ...   ....  | .|  .|. |..||.. .|| .  |  || .|||....|..   
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDAC

-VIGDFGL
  |.||||
VKICDFGL
S_TKc 7400.AA S_TKc 2-257 20 3.5e-16 60.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-257
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

KDINRVI-----------IATKDSRQVAFKVRHFQSKLQLKEYQDQANILQRVVHPNVVQFEEHFNSSHVFFMQMEYCPN---NLRQLLKEKS-------
 .| |.|           . .|. |.|| |. .       .  .   .||..  |||.|.. ..| . . ..| ||||..   .|....|..        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNLVIGDFGLDREDDIFYQKCQSQDDLVNSQRWYVAPEIQMGQPGILQNINQ-PADIWSL
..  .  .|. |...... .|| .  |  || .|||...  .. |.|||| |.           . .. . .||.|||.           .  ..|.||.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGT-PWYMAPEVL--------GYGKCKCDWWSC

GIIILEIFGLKYVSNFQSIEQLQLTLDLLYNQDFSFINFIDKFLTDIIKQLLNSEPSKRPIIDDVKKMIQKEIDVRFV
|.|. | .  .         |.|......           .. . |.|...|. .|.||| . .. .. ..     ..
GCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7400.AA ULK 39-130 25 3.9e-16 52.88 In-house 63-188 (329) Show / Hide 
Range on Protein: 39-130
Range on HMM: 63-188/329
Sequence Identity: 25% (32 aa)

ILQRVV--------HPNVVQFEEHFNSSHV--FFMQMEYCPN-NLRQLLKEK-----------SLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNIL
|...          |||.|.. . |..|.   ... ||||.  .|.|..|..            ||.||  .. .| . | ...|. |  |  .| ||||
IMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL

VNQQGNLV------------IGDFGL
..                  |.|||.
IHNGQPKTDSKKVHPNGVLKIADFGF
Kinase 7400.AA Ciliate-E2-Unclassified 12-246 17 8.5e-16 51.3 In-house 22-348 (352) Show / Hide 
Range on Protein: 12-246
Range on HMM: 22-348/352
Sequence Identity: 17% (60 aa)

KDSRQV-----AFKVRHFQSKLQ------------LKEYQ-DQAN--------ILQRVVHPNVVQFEEHFNSSHVFFMQMEYCPN-NLRQLLKE------
|.  |.     . |.... .|..            ... . .. .        ||.   ||..| ....|..   ... ||||.. .|.| .|.      
KQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQ

------------KSLSQQEQF-----HYAMQVIRGVQAIHSVNHS-HKELKTQNILVNQQG---NLVIGDFGLDR---EDDIFYQKC------QSQDDLV
            | .. |.       .|. |.. | . .|. |.  |  .| .|||....|   .. | |||. .   ... .. .       . .... 
KGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMM

NSQ---RWYV----APEIQMGQPGILQNINQP----ADIWSLGIIILE-IFGLKYVSNFQSIEQLQ------------LTLDLLYNQDFSFINFID----
...     |     |||. .|     || ...    .||||||.|. | .||    .  ..... |              ..  ......| .|      
WTFCGTPNYMPQYTAPEVLQG-----QNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIP

--------KFLTDIIKQLLNSEPSKRPIIDDVKK
         |..|.....|.  |.||. ......
KHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 7400.AA Ciliate-A2 30-249 22 1.9e-15 50.33 In-house 42-272 (272) Show / Hide 
Range on Protein: 30-249
Range on HMM: 42-272/272
Sequence Identity: 22% (54 aa)

LKEYQDQANILQRVVHPNVVQFEEHFNSSHVFFMQMEYC-PNNLRQLLK-----EKSLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGN-
|.| ...| .|. . |||.|. .. |      | |||.|   .| .  .     .|.....   |.| |.. ... .|. |  . .|. .||| .|... 
LQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQI

LVIGDFGLDREDDIFYQKCQSQDDLVNSQRWYVAPEI-QM---------GQPGILQNINQPADIWSLGIIILEIFGLKYVSNFQSIEQLQLT-LDLLYNQ
..  |||| .. .   .  . ..  ...   |  ||. ..         ... | |. .  .||| .||  . . |...      .. ..||     .. 
IKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFM--GDIWAFGICLYQLGGADQ------QHCYKLTQCNQKKWW

DFSFINFIDKFLTDIIKQLLNSEPSKRP-IIDDVKKMIQ
 ..  .. |. . .||.|.||..| ||| .|.  .. ..
QYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH
Kinase 7400.AA TKL 45-248 18 5.5e-15 50.41 In-house 84-364 (364) Show / Hide 
Range on Protein: 45-248
Range on HMM: 84-364/364
Sequence Identity: 18% (52 aa)

HPNVVQFEEHFNSSHV-------------FFMQMEYCPNNL-RQLLKEKSLSQQEQFHYAMQVIRGVQAIHS--------VNHSHKELKTQNILVNQQGN
|||.|||    ...               ... |||||.   . .|       .  .. |... ||..  ||         .  |  ||..||||.. ..
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

--------------LVIGDFGLDR-EDDIFYQKCQS-----------QDDLVNSQR---WYVAPEIQMGQPGILQ-----------NINQPADIWSLGII
              . |.|||| |  .  . .....           ..   ..|.    . |||. .||.   .             .. .|..| ||.
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

ILEIFG--LKY--VSNFQSI------EQLQLTLDLLYNQDFSFI----------NFIDKFLTDIIKQLLNSEPSKRPIIDDVKKMI
. ||.   . |    ... |      | . .  |  .      |          . ... . .....  ...|.|||  ....| .
LWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 7400.AA GCN2 35-130 31 8.6e-15 47.84 In-house 252-354 (511) Show / Hide 
Range on Protein: 35-130
Range on HMM: 252-354/511
Sequence Identity: 31% (32 aa)

DQANILQRVVHPNVVQFEEH----FNSSHVFFMQMEYCP-NNLRQLLKEKSLSQQEQ--FHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNLVIGD
.|  ... . |.|.| .. .    . ..|. . |||||.  .|||.... .. ....  . |. |.. |.. ||| . .|. || .||.. ..||  |||
QQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGD

FGL
|||
FGL
TyrKc 7400.AA TyrKc 6-248 20 9e-09 -80.84 SMART 14-280 (280) Show / Hide 
Range on Protein: 6-248
Range on HMM: 14-280/280
Sequence Identity: 20% (56 aa)

RVIIATKDSRQVAFKVRHFQSKLQLKEYQDQANILQRV--VHPNVVQF----EEH---FNSSHVFFMQMEYCPN-NLRQLLKEKS--LSQQEQFHYAMQV
.|  .| . .||| |. .  .   ...  . |.|. ..   |||.|..     ..   | ...  .. |||.|. .|.. |...   |. ..  ... |.
EVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQI

IRGVQAIHSVNHSHKELKTQNILVNQQGNLVIGDFGLDREDDIF--------YQKCQS--QDDLVNSQRWYVAPEIQMGQPGILQNI-NQPADIWSLGII
 .| . .|| |  |  | . |.||. ..   |.|||| |. .          | . ..  . . .   ||. |||       |  .. .   |.|| |. 
ACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APEC------INYGKFTTKSDVWSFGVC

ILEIFGLKYVSNFQS----IEQLQLTLDLLYNQDFSFINF--------IDKFLTDIIKQLLNSEPSKRPIIDDVKKMI
. ||| .            ..  ..  ..                     . . .|.||  . .|..||   .... .
MWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 7400.AA Pkinase 152-248 18 2e-06 24.16 Pfam 175-293 (293) Show / Hide 
Range on Protein: 152-248
Range on HMM: 175-293/293
Sequence Identity: 18% (24 aa)

RWYVAPEIQMGQPGIL--QNINQPADIWSLGIIILEIFGLKYVSNFQSI------EQLQLTLDLLYNQDFSFINFID--------------------KFL
.||.|||.      |.  | . ...|.||.|.|. | .  .    |..       .|.|.    .. .  . .   .                    . .
PWYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGR--PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

TDIIKQLLNSEPSKRPIIDDVKKM--I
 |.|| .|.  |.||| ......   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 7400.AA GCN2 154-187 37 0.000394 9.88 In-house 419-447 (511) Show / Hide 
Range on Protein: 154-187
Range on HMM: 419-447/511
Sequence Identity: 37% (13 aa)

YVAPEIQMGQPGILQNINQPADIWSL-GIIILEIF
|..||.|          || .|..|| |||..|..
YMCPEQQ------KSHYNQKVDMYSLGGIIFFEMW
Kinase 7400.AA ULK 154-238 25 0.000445 10.23 In-house 217-317 (329) Show / Hide 
Range on Protein: 154-238
Range on HMM: 217-317/329
Sequence Identity: 25% (26 aa)

YVAPEIQMGQPGILQNIN-QPADIWSLGIIILEIFGLKYV--SNFQSIEQLQLTLDLLYN------------QDFS---FINFIDKFLTDIIKQLLNSEP
| ||.| .|| |  .. .   .||||||.|. |.   |.   ..  . ..||   .|. |             .|     .. | . . |.|...|  ..
YMAPQILQGQ-GEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDE

SKR
..|
KDR
Kinase 7400.AA ULK 154-238 25 0.001182 8.91 In-house 213-312 (324) Show / Hide 
Range on Protein: 154-238
Range on HMM: 213-312/324
Sequence Identity: 25% (26 aa)

YVAPEIQMGQPGILQNIN-QPADIWSLGIIILEIFGLKYV---SNFQSIE----QL------QLTLDLLYNQDFS---FINFIDKFLTDIIKQLLNSEPS
| ||.|..|| |  .. .   .||||||.|. |.   ||    . |.. .    .|      |...    . .|     .. | . . |.|...|  ...
YMAPQILQGQ-GEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEK

KR
.|
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