Gene 5379 (Tetrahymena)
5379
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 5379.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 5379.AA | Ciliate-C1 | 15-264 | 28 | 3.4e-60 | 154.79 | In-house | 12-328 (328) | Show / Hide |
Range on Protein: 15-264 Range on HMM: 12-328/328 Sequence Identity: 28% (93 aa) TADVHLCSTPKNT---AIKIFK--------------------------KEVAFKMELKSLTFLEKIPNVIKMKG------FIDEL----PTQAIFLEYAS |..| .|. | | |.|.|| . . | |.|. | ||.. | .. . | .||.| TCKVFYCKMPNNQKVYAVKQFKNEYTSQQQLTFKDSSSPRENTHHSESCMQDHNNEIKHLQELKNHPNIVNMVQIIREIQYDKKNGQTYCFMCIVFEYCS NGTLFKFVANNNG-LTEEGAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENYNAYLCDFGNAIF----------LKQIHDLEFIP------------ || || ..|. .|| | | |.| | |.. .|.. | |||.|.||||||||.| . ||| | | .|| .. NGELFDYIAHKGPLFNEELARYYFHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGFAQFLNSASSQNTLSKQKDGEKMNHNTSSTECSDASS --------SAGTQCCRAPELIRQKSDNLLVPRKPDAIDLKKADVFSLGVLLFTMVFCKQPFSK-ADSSDFFFQTL-TKSKSKFWNLFAIEP------SPL . || ||||.... . ...| | |..|| || || ||.| |. || ... . .. ...| . | DESHWLYVCMGTEGYMAPELHEKQ-----------RYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYWQCHQKNYGQHNFFSNE LKDLINQLIAPNPSDRLTIQEILSHQWI ..|||||. |.|| .|.|.|||..| | FMDLINQMLAYNPQKRITLQEIKCHPWY |
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Kinase | 5379.AA | CAMK | 9-264 | 18 | 1.3e-52 | 167.43 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 9-264 Range on HMM: 1-425/425 Sequence Identity: 18% (78 aa) LLSSSETADVHLCSTPKNT---------------AIKIFKK---------------------------------EVAFKMELKSLTFLEK------IPNV | . . |.|| ..| |||| .| . .. |.. . | . ||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IKMKGFID------------ELPT--------QAIFL---EYASNG----TLFKFVANNNG---------------LTEEGAHYFFKQIIKVVEILHSSQ ||. ... . ... ||.|.| || .. . . .||. |...|.||. |. .|| IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKLENILLDEN-----------------YNAYLCDFGNAIFLKQIH----------------------DLEFIPSAGTQCCRA-PELIRQ--KSD |||||.|.||||||.| .| ..||| |..... . . . . || . | ||.... ... IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN NLLVPRKPDAI-------DLKKADVFSLGVLLFTMVFCKQPFSKADSSDFF---------FQTLTK-SKSKFW-NLFAIEPSP----------------- . . . .|.|. |.||.|..|. . || . .. . ... | | |.. . . |.. MQ------N-ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH ----LLKDLINQLIAPNPSDRLTIQEILSHQWI ||||... ..|..|.||...|.|.|. FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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S_TKc | 5379.AA | S_TKc | 4-264 | 24 | 9.6e-52 | 179.13 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-264 Range on HMM: 1-231/231 Sequence Identity: 24% (69 aa) YELQTLL---SSSETADVHLCSTPKNTAIKIFKKEVAFKMELKSLTFLEKIPNVIKMKGFIDELPTQAIFLEYASN--GTLFKFVANNNG------LTEE ||. .. . .. .. .| . |||| | .. |.. | . ||..|....... ...||... |.||.. .... ..| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- GAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENYNAYLCDFGNAIFLKQIHDLEFIPSAGTQCCRAPELIRQKSDNLLVPRKPDAIDLKKADVFSLG | ....||.. .| .|| .|.|||.| ||||||| . .|||| | .| || .|||.. . .|.|. |.| HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCG VLLFTMVFCKQPFSKADSSDFFFQTLTKSKSKFWNLFAIEPSPLLKDLINQLIAPNPSDRLTIQEILS-------HQWI ..|. |. . ||. . |. . || .||.|... .|..|.|. |.| |.|. CILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 5379.AA | Ciliate-E2 | 4-264 | 21 | 8.6e-45 | 151.68 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 4-264 Range on HMM: 1-365/365 Sequence Identity: 21% (83 aa) YELQTLLSSSETADVHLC---STPKN-----------------------TAIKIFKKE--VAFKMELKSLTFLE----KIPN------------VIKMKG |... .. . ..| .| ...|. |.||.|| ..|.|.. . .. || | .|||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE FID--ELPTQAIFLEYASNGTLFKFVANN-----------NGLTEEGAHYFFKQIIK---------------VVEILHSSQ-IVHRDIKLENILLDENYN . . . .||.. |.||.. || . .||. . |..|||.. .| ||| |.|||||.||||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AYLCDFGNAIFLKQI----------------HDLEFIPS--------------AGTQCCRAPELIR-QKSDNLLVPRKPDAIDLKKADVFSLGVLLFTMV ..|||.. .... | . |. .|| ||| .. .| || . .|.|..||||.|. |. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----QKQKGYDYKCDIWSLGVILYEML FCKQPFSKADSSDFFFQTLTKSKSKFWNLFAIE-----------------PSPLLKDLINQ----LIAPNPSDRLT-IQEILSHQWI | | || . . | . .... | |. ||||.. .. .|. |.| ...|| |.|. FGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 5379.AA | Pkinase | 22-264 | 23 | 1.3e-44 | 158.79 | Pfam | 22-293 (293) | Show / Hide |
Range on Protein: 22-264 Range on HMM: 22-293/293 Sequence Identity: 23% (67 aa) STPKNTAIKIFKKEVAFK---------MELKSLTFLEKIPNVIKMKGFIDELPTQAIFLEYASNG----TLFKFVA--NNNGL--TEEGAHYFFKQIIKV .|.| |.||.||. . . .|.. . | . ||....... . . . .||. .| || .. ..... .|. . ...||.. GTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRG VEILHSSQIVHRDIKLENILLDENYNA----YLCDFGNAIFLKQIHDLEFIPSAGTQCC----RAPELIRQKSDNLLVPRKPDAIDLKKADVFSLGVLLF .| .|| |.|||.|.||||.|.|.. .|||| | ... . . . | |. .|||.|| . . .|.|..|.|..|. LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIR-----------GGQYYGPKVDMWSCGCILY TMVFCKQPFSKA------DSSDFFFQTLTKSKSKFWN-----------------LFAIEPSPLLKDLINQLIAPNPSDRLTIQEILSHQWI |.. . ||. . | ..... . . | .| .. |. .||.|. .....|..|.|...|| | |. EMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 5379.AA | Ciliate-E2-Unclassified | 4-264 | 20 | 2.2e-44 | 151.88 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 4-264 Range on HMM: 1-352/352 Sequence Identity: 20% (74 aa) YELQTLLSSSETADVHLCSTPKNT-------AIKIFKKEVAFKME----------LKSLT-------------FLEKIPNVIKMKGFIDE--LPTQAIFL |... . . ..|..| |. ..|| .. . .|. .... | .|. ...| | . . | . YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EYASNGTLFKFVANNNG-----------------LTEEGAH-----YFFKQIIKVVEILHSSQ-IVHRDIKLENILLDENY---NAYLCDFGNAIFLK-- ||. .|.|... .... .||. | ..|.||.. | ||... |.|||||.||||.|.| . ..|||...... EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN ------------QIHDLEFIPSAGTQCCR----APELIRQ-KSDNLLVPRKPDAIDLKKADVFSLGVLLFTMVFCKQPFSKADSSD------------FF .. . .. .|| . |||.... . |. .|.|..||||.|. |.| . ||. .. . . NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYR FQTLTKSKSKFWNLFAIEP-------SPLLKDLIN----QLIAPNPSDRLTIQEILSHQWI .| . . | | .. . .. || ||.|| ... ||. |.|...|| |.|. KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 5379.AA | TKL | 25-262 | 17 | 1.2e-30 | 107.52 | In-house | 27-364 (364) | Show / Hide |
Range on Protein: 25-262 Range on HMM: 27-364/364 Sequence Identity: 17% (59 aa) KNTAIKIFKKEV-----------------------------AFKMELKSLTFLEK--IPNVIKMKGFIDELPT-------------QAIFLEYASNGTLF | |.|.||.. ... | . . . . ||.....|. . | .| ||...|.|. KDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLL KFVANNNGLTEEGAHYFFKQIIKVVEILHSSQ--------IVHRDIKLENILLDENYN--------------AYLCDFGNAIFLKQIHDLEFIP------ .. . . . ..| . .. |||.. |.|||.| .|||.|||.. . .|||| . |..| . . . HYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMES ------------SAGTQCCRAPELIRQKSDNL-----LVPRKPDAIDLKKADVFSLGVLLFTMVFCKQPFSKADSS---------DFFFQTLTKSKSKFW || . |||..|.. .. . . . .|.||.| |..|. .. ...|... ... ..| . |.. AEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPI NLFAIE------PSPL---LKDLINQLIAPNPSDRLTIQEILSHQ . ... .|.|. . ...|..|.. ||||.. PPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 5379.AA | CAMKL | 52-137 | 38 | 1.1e-29 | 91.85 | In-house | 75-174 (297) | Show / Hide |
Range on Protein: 52-137 Range on HMM: 75-174/297 Sequence Identity: 38% (38 aa) PNVIKMKGFIDELPT------QAIFLEYASNGT--LFKFVANNNG----LTEEGAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENY--NAYLCDFG ||.||. |. . ...||.|.| || .. .. . ..|. |. .|.||. |. .|| |||||||.|||||||| |. ..||| PNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG |
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Kinase | 5379.AA | Ciliate-E9 | 68-137 | 47 | 4.2e-26 | 80.17 | In-house | 86-157 (298) | Show / Hide |
Range on Protein: 68-137 Range on HMM: 86-157/298 Sequence Identity: 47% (34 aa) AIFLEYASNGTLFKFV-ANNNGLTEEGAHYFFKQIIKVVEILHSSQ-IVHRDIKLENILLDENYNAYLCDFG .| |||.|| ||... |. | |.|||.| .| .| | | |||.|.||.|.|.||| .|||| YIVMEYANNGCLFDLISMHTEKFNENVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFG |
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Kinase | 5379.AA | TSSK | 69-137 | 40 | 2.8e-23 | 73.22 | In-house | 94-168 (289) | Show / Hide |
Range on Protein: 69-137 Range on HMM: 94-168/289 Sequence Identity: 40% (30 aa) IFLEYASNGTLFKFVANN------NGLTEEGAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENYNAYLCDFG ...|||..|.|. .. .. ..|.|| | .|.|... |. .|| .||||.|.||||||.. | | ||| MVMEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFG |
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Kinase | 5379.AA | MARK | 71-137 | 47 | 4.8e-23 | 72.31 | In-house | 81-151 (262) | Show / Hide |
Range on Protein: 71-137 Range on HMM: 81-151/262 Sequence Identity: 47% (34 aa) LEYASNGTLFKFVANN--NGLTEEGAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENY--NAYLCDFG .||||.| |. .. . |.|| |. .|.||. |. .|| |||||||.||||.||| |. ..||| MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG |
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Kinase | 5379.AA | CAMKL | 184-264 | 27 | 8.2e-18 | 53.29 | In-house | 215-297 (297) | Show / Hide |
Range on Protein: 184-264 Range on HMM: 215-297/297 Sequence Identity: 27% (24 aa) KKADVFSLGVLLFTMVFCKQPFSKADS---SDFFFQTLTKSKSKFWNLFAIE--PSPLLKDLINQLIAPNPSDRLTIQEILSHQWI .|.|. |.||.|..||. . || .. .. . .| . . . . | .| ..||| .. .||..| ||..|..| | PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 5379.AA | ULK | 69-137 | 31 | 1.6e-16 | 55.24 | In-house | 94-183 (324) | Show / Hide |
Range on Protein: 69-137 Range on HMM: 94-183/324 Sequence Identity: 31% (28 aa) IFLEYASNGTLFKFVANNNG---------LTEEGAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENYNAY------------LCDFG |..|| |.|... .|.. |.|. | |||||. ||. .|.|||||..|||. .. . ..||| IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG |
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Kinase | 5379.AA | ULK | 184-264 | 25 | 1e-14 | 48.68 | In-house | 231-324 (324) | Show / Hide |
Range on Protein: 184-264 Range on HMM: 231-324/324 Sequence Identity: 25% (24 aa) KKADVFSLGVLLFTMVFCKQPFSKADSSDFF------------FQTLTKSKSKFWNL--FAIEPSPLLKDLINQLIAPNPSDRLTIQEILSHQWI .|.|..|||.... |.. | ||.. .| . |.. | . ... .. || .|||| ... ...|| ...||..| |. YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 5379.AA | Ciliate-E9 | 184-264 | 27 | 1.7e-14 | 42.39 | In-house | 204-298 (298) | Show / Hide |
Range on Protein: 184-264 Range on HMM: 204-298/298 Sequence Identity: 27% (26 aa) KKADVFSLGVLLFTMVFCKQPFSKADSSDF-----------FFQTLTKSKSKFWNLFAIEPSP---LLKDLINQLIAPNPSDRLTIQEILSHQWI .| |.||.|..|| ||. || ... | .. || .|. | .|..|. | | .|||| .| |. QKFDIFSAGCILFMMVMNQYPFFHTNCYNDTTIDKIWQYYRIFFFCMDNCQNFWDQFIYNYRPEEQEFIDMMNWMLQQDPQNRISIQEIRMHPWM |
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Kinase | 5379.AA | MARK | 234-264 | 41 | 8.6e-12 | 35.0 | In-house | 232-262 (262) | Show / Hide |
Range on Protein: 234-264 Range on HMM: 232-262/262 Sequence Identity: 41% (13 aa) SPLLKDLINQLIAPNPSDRLTIQEILSHQWI |. ...||..|. .||..| ||.||..| |. SKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | 5379.AA | TyrKc | 4-264 | 18 | 6.2e-10 | -62.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 4-264 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) YELQTLLSSSETADVHLCSTPKNTAIKIFKKEVAFKMELKS-LTFLEKI----PNVIKMKGFIDEL-------PTQAIFLEYASNGTLFKFVANNNG-LT .| | . . |... . |.| |.. .... . . . |. ||.... | . . . | .||...| | .. .. . |. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC EEGAHYFFKQIIKVVEILHSSQIVHRDIKLENILLDENYNAYLCDFGNAIFLKQI------HDLEFIPSAGTQCCR--------APELIRQKSDNLLVPR . ..| || . | ||| ...|||. |.|..||. . .||| . ... .| . ........ ||| | MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDY--YRKKEHKGGKTMLPIRWMAPECI----------- KPDAIDL---KKADVFSLGVLLF-TMVFCKQPFSK-----ADSSDFFFQTLTKSKSKFWNL-----FAIEPSPLLKDLINQLIAPNPSDRLTIQEILSHQ . | ||.| ||... . ...|| . . .. . . . . | . .. . ... | . .|.|| | .|| |. ----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE WI . CF |
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Kinase | 5379.AA | TSSK | 238-264 | 44 | 8.7e-09 | 24.95 | In-house | 263-289 (289) | Show / Hide |
Range on Protein: 238-264 Range on HMM: 263-289/289 Sequence Identity: 44% (12 aa) KDLINQLIAPNPSDRLTIQEILSHQWI |||| .. .|.|. |..|.||..| |. KDLIRHMLQPHPCNRPHINEICHHCWM |
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Kinase | 5379.AA | MARK | 182-199 | 55 | 4.3e-05 | 12.78 | In-house | 183-200 (262) | Show / Hide |
Range on Protein: 182-199 Range on HMM: 183-200/262 Sequence Identity: 55% (10 aa) DLKKADVFSLGVLLFTMV | .|.|. ||||.|..|| DGPKVDIWSLGVVLYFMV |
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Kinase | 5379.AA | TSSK | 184-205 | 50 | 0.001552 | 7.45 | In-house | 208-229 (289) | Show / Hide |
Range on Protein: 184-205 Range on HMM: 208-229/289 Sequence Identity: 50% (11 aa) KKADVFSLGVLLFTMVFCKQPF |..|| |.|| |..||. . || KWYDVWSMGVILYIMVCGCMPF |