Gene 3618 (Tetrahymena)
3618
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 3618.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3618.AA | Ciliate-B2 | 142-224 | 28 | 4.4e-11 | 22.21 | In-house | 63-148 (197) | Show / Hide |
Range on Protein: 142-224 Range on HMM: 63-148/197 Sequence Identity: 28% (25 aa) VRIIEYSNIKKYDISYMIMELCEDNLESLIK----QNIKYSLQEAVNITMKLIGMLIDIHSSNLVHLSIEPRKILIDAENNFKLIGF |..|.. |.. .| .||| || |.. .. | ... | ... || || ... | .|| | |. ||. ..|... | VKYIDHIQINE-TIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDF |
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| Kinase | 3618.AA | Ciliate-E1 | 112-271 | 17 | 5.2e-10 | 29.23 | In-house | 27-202 (202) | Show / Hide |
Range on Protein: 112-271 Range on HMM: 27-202/202 Sequence Identity: 17% (31 aa) IKFIDQTEKQYKEQYEKLEA-FLQVQDTYSLVRIIEYSNIKKYDISYMIMELCEDNLESLIK-------------QNIKYSLQEAVNITMKLIGMLIDIH |. ... ........ | . ..... ... ||.| |... |.. |.|.|...|. .. ...... |. ..|.. || ||..| INCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELH SSNLVHLSIEPRKILIDAENNFKLIGFPCQR--IKSSKKEKKMDFIDGDKYSTFKAP-QQLHNYEKVQQVSFISNVS . |. |. | | .|||. ..|... | . . ......... . |.. . .. . .| |.... |.. QYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | 3618.AA | Ciliate-A1 | 155-222 | 30 | 8.8e-08 | 22.51 | In-house | 75-143 (301) | Show / Hide |
Range on Protein: 155-222 Range on HMM: 75-143/301 Sequence Identity: 30% (21 aa) ISYMIMELCE-DNLESLIKQNIKYSLQEAVNITMKLIGMLIDIHSSNLVHLSIEPRKILIDAENNFKLI . ..||| |. || ...|| . | . | ...| ..|||. | .|. . | ||| .. .|.. CMFIIMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKIC |
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| S_TKc | 3618.AA | S_TKc | 86-370 | 15 | 2.3e-07 | -68.78 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 86-370
Range on HMM: 1-231/231
Sequence Identity: 15% (49 aa)
HRVIDPIDSEN--NVYKIEDIDTGLFFAIKFIDQTEKQYKEQYEKLEAFLQVQDTYSLVRIIEYSNIKKYDISYMIMELCED---NLESLIKQNIK----
.....| . ||| ...|| .||| |. . . | . .. .|..... | ||.||.|. .| ..||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--YSLQEAVNITMKLIGMLIDIHSSNLVHLSIEPRKILIDAENNFKLIGFPCQRIKSSKKEKKMDFIDGDKYSTFK------APQQLHNYEKVQQVSFIS
.. .| .. .. | .|| . .| . | ||.| . |.. | |. .|| || |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL-------------
NVSGDEFKIQSQNLSINSQKDGQEDFKE-EIDIFSMGLVILSVIG-VNINYRTADEIRTGNFNNIIDMNELNPLVSFVIHTMLQTEPQHRYSALKLQAEI
. ..|. | | .. . . . . .... | . | .|| .|..|..| .. ..
------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDE
-----LIYF
.|
WDIKCHPWF
|
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| Kinase | 3618.AA | ULK | 157-214 | 33 | 4.4e-05 | 13.79 | In-house | 96-164 (329) | Show / Hide |
Range on Protein: 157-214 Range on HMM: 96-164/329 Sequence Identity: 33% (23 aa) YMIMELCED-NLESLIKQNIK----------YSLQEAVNITMKLIGMLIDIHSSNLVHLSIEPRKILID |.|||.|.. .||..||.| | | |||... . .. . ..|. | .| | | |||. YIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH |
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| Kinase | 3618.AA | Ciliate-E3 | 159-218 | 31 | 6e-05 | 11.69 | In-house | 82-141 (202) | Show / Hide |
Range on Protein: 159-218 Range on HMM: 82-141/202 Sequence Identity: 31% (19 aa) IMELCED-NLESLIKQNIKYSLQEAVNITMKLIGMLIDIHSSNLVHLSIEPRKILIDAENN ..|.|. .| || .... | ...| .|.||. |. | | | ||.| .|| VQEYCSNGDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNN |
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| Kinase | 3618.AA | Ciliate-C3 | 196-224 | 37 | 6.3e-05 | 14.02 | In-house | 112-140 (140) | Show / Hide |
Range on Protein: 196-224 Range on HMM: 112-140/140 Sequence Identity: 37% (11 aa) IHSSNLVHLSIEPRKILIDAENNFKLIGF .| |.|| | .. ||| .... |.| | LHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 3618.AA | PLK | 98-130 | 33 | 7.2e-05 | 11.91 | In-house | 15-47 (258) | Show / Hide |
Range on Protein: 98-130 Range on HMM: 15-47/258 Sequence Identity: 33% (11 aa) VYKIEDIDTGLFFAIKFIDQTEKQYKEQYEKLE .|...||.|. .||| ... |.. |.||.. CYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMK |
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| Kinase | 3618.AA | NEK | 342-368 | 29 | 0.000326 | 11.19 | In-house | 260-286 (286) | Show / Hide |
Range on Protein: 342-368 Range on HMM: 260-286/286 Sequence Identity: 29% (8 aa) SFVIHTMLQTEPQHRYSALKLQAEILI . .|. ||| .|..|.|. .. . .| QNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | 3618.AA | CK1 | 157-203 | 31 | 0.000519 | 9.98 | In-house | 105-155 (339) | Show / Hide |
Range on Protein: 157-203 Range on HMM: 105-155/339 Sequence Identity: 31% (16 aa) YMIMELCEDNLESLIK---Q-NIKYSLQEAVNITMKLIGMLIDIHSSNLVH ||.|.|. |||.| | . | | |. ...| . .. | ..|. . .| YMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIH |
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| Kinase | 3618.AA | Ciliate-E3 | 291-311 | 28 | 0.009315 | 4.77 | In-house | 182-202 (202) | Show / Hide |
Range on Protein: 291-311 Range on HMM: 182-202/202 Sequence Identity: 28% (6 aa) QEDFKEEIDIFSMGLVILSVI | .. | |. |.| |.. .. QQQISKESDYYSVGAVFCQLC |
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| Kinase | 3618.AA | Ciliate-A1 | 298-369 | 20 | 0.229073 | 0.33 | In-house | 209-301 (301) | Show / Hide |
Range on Protein: 298-369 Range on HMM: 209-301/301 Sequence Identity: 20% (20 aa) IDIFSMGLVILSVIG-----------VNINYRTADE------------IRTGNFNNII--DMNELNPLVSFVIHTMLQTEPQHRYSALKLQAEILIY .|..|.|..|. . ||| . | ..| . ||. | | |.| ||. | | .. . |. SDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNL----IFKMMQYEPNNRCSLQQCIDCLYIF |
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| TPR | 3618.AA | TPR | 527-560 | 14 | 1.077483 | 0.3 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 527-560 Range on HMM: 1-34/34 Sequence Identity: 14% (5 aa) VDSLNSLATSLIYSYESQSSIQYLLAALNLRKVI .. .. |. .. . . |... || | AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR | 3618.AA | TPR | 570-603 | 26 | 0.000117 | 22.72 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 570-603 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AYTLSDLGEAYCQGKDYEQALQYHIQSLEMRKQL | ... ||..| . .||..|... ..||. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 3618.AA | TPR_1 | 570-603 | 23 | 0.000717 | 17.5 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 570-603 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) AYTLSDLGEAYCQGKDYEQALQYHIQSLEMRKQL | ... || .| . ..|..|... . ||.. . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 3618.AA | TPR_2 | 570-603 | 26 | 0.010152 | 13.71 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 570-603 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) AYTLSDLGEAYCQGKDYEQALQYHIQSLEMRKQL |. . ||..| . .||..|..| ..|. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 3618.AA | TPR | 613-646 | 26 | 0.315401 | 4.99 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 613-646 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) ADSLFNLSKIYYLTNDMDQSIKLNTEGLQMSASI |. ..|| .||. .| |. |. .. |.. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 3618.AA | TPR_2 | 613-635 | 34 | 1.912339 | 5.66 | Pfam | 1-23 (34) | Show / Hide |
Range on Protein: 613-635 Range on HMM: 1-23/34 Sequence Identity: 34% (8 aa) ADSLFNLSKIYYLTNDMDQSIKL |. ..|| ..|| .| |. |.. AEAWYNLGQCYYKQGDYDEAIEY |
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| TPR_1 | 3618.AA | TPR_1 | 613-646 | 23 | 7.794422 | 3.41 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 613-646 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) ADSLFNLSKIYYLTNDMDQSIKLNTEGLQMSASI |. ..|| .|| .. |. |. . |.. . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| LRR_RI | 3618.AA | LRR_RI | 779-806 | 32 | 0.222142 | 3.15 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 779-806 Range on HMM: 1-28/28 Sequence Identity: 32% (9 aa) NLSNLTLQFPSNQIGAIGASDLGSGLAN | | ..|. .| .|. |. | .||. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 809-836 | 39 | 0.002586 | 16.8 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 809-836 Range on HMM: 1-28/28 Sequence Identity: 39% (11 aa) NLSNLTLKLGQNQIGDEGASVLGSALAN | | ..| |..| .||||. .| ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 839-866 | 46 | 0.015156 | 11.38 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 839-866 Range on HMM: 1-28/28 Sequence Identity: 46% (13 aa) NLSNLTLDLCANQIGDEGASGLCSGLAN | | ..|.| | .||||. ||.||. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 916-943 | 32 | 0.068642 | 6.75 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 916-943 Range on HMM: 1-28/28 Sequence Identity: 32% (9 aa) NLSNLTLNLRFNQIGAMGASGLGQALAK | | ..|.|. | .|. |. | ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 946-973 | 39 | 0.008154 | 13.28 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 946-973 Range on HMM: 1-28/28 Sequence Identity: 39% (11 aa) NLSNLTLKLGYNQIGDAGALGLGSGLAN | | ..| |..| .||.|. | .||. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 976-1003 | 32 | 0.05812 | 7.26 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 976-1003 Range on HMM: 1-28/28 Sequence Identity: 32% (9 aa) NLSNLTLDLWFNQIGAMGASGLGQALAK | | ..|.|. | .|. |. | ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 1064-1091 | 32 | 0.583358 | 0.19 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1064-1091 Range on HMM: 1-28/28 Sequence Identity: 32% (9 aa) NLSNLTLYLTANLIGAMGASGLGSALAN | | ..|.| | .|. |. | ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 1094-1121 | 39 | 0.007203 | 13.66 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1094-1121 Range on HMM: 1-28/28 Sequence Identity: 39% (11 aa) NLSNLTLGLYGNQIGDEGASGLGSALAN | | ..| | .| .||||. | ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 3618.AA | LRR_RI | 1124-1151 | 42 | 0.017325 | 10.97 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1124-1151 Range on HMM: 1-28/28 Sequence Identity: 42% (12 aa) NLSNLTLDLDFNKIGDEGASGLGSALAK | | ..|.| ||.||||. | ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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