Gene 29013 (Tetrahymena)
29013
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 29013.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 29013.AA | Ciliate-E2-Unclassified | 1152-1292 | 19 | 7.9e-10 | 30.3 | In-house | 148-265 (352) | Show / Hide |
Range on Protein: 1152-1292
Range on HMM: 148-265/352
Sequence Identity: 19% (30 aa)
IASYICDSLQNLHASS-IFHLNLKPSNILFDSKK---HPYLSGWEIRKKEKIQQAEENID---------DDEQDDKY-QVSYG--YTPPEVVNSINTQKP
.. .|.. |. || . | | ..||.|||||... .. .... | || . .. .. . ....... .| ||.||| . | ..
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHS
QVAMANNFSTPQKSQLASYATNSNPSFGPLNTVQALSQFGPNSDVWSLGMIFHYLFF
.|.||||.|.... |
KA--------------------------------------YKCDIWSLGVILYEMLF
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| S_TKc | 29013.AA | S_TKc | 1016-1359 | 12 | 3e-09 | -41.32 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1016-1359
Range on HMM: 1-231/231
Sequence Identity: 12% (46 aa)
MISADKLSK------FRSYKKHMNISPEDQLILDGEPVVVKQFLISNPREVDEMFYFIESQEKKLMNQSSSINNQSTNVNSLAYQQHLAQVFLGQSLIYI
.|. | .. ..|. .|. | .|. . |. .|
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK--------------------------------------EHIRREIQILKK-HHPNI
KGFSYQPVSNDAISLYLFYPAQSY---NLYGAMRKNL-------FSLLDKLLIASYICDSLQNLHASSIFHLNLKPSNILFDSKKHPYLSGWEIRKKEKI
. . .. .||.. . .|. ..|. |. . .. ||. |. .| | | |||.|||.|. | .. . ..
VKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--
QQAEENIDDDEQDDKYQVSYGYTPPEVVNSINTQKPQVAMANNFSTPQKSQLASYATNSNPSFGPLNTVQALSQFGP-NSDVWSLG-----MIFHYLFFR
. . .. | .|||. ..|. .|.||.| |. | |.
-------------TTFCGTPWYMAPEVL---------------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP
IDSGEGNFCRDKRVYAGFNLIITEYAIGSNYFLDKIKELIEDMVKSNPDQRATLSHVKD----LLQKLYI
... |..| . |..|. . . .|..| | . . ..
------------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 29013.AA | TKL | 1156-1354 | 11 | 1.9e-07 | 22.91 | In-house | 141-364 (364) | Show / Hide |
Range on Protein: 1156-1354 Range on HMM: 141-364/364 Sequence Identity: 11% (29 aa) ICDSLQNLHASS--------IFHLNLKPSNILFDSKKH--------------PYLSGWEIRKKEKIQQAEENIDDDEQ----------DDKYQV-SYGYT |. .. ||.. | | .||..||| |.. . . .. . . . . . . ... |. .... IARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWM PPEVVNSINTQKPQVAMANNFSTPQKSQLASYATNSNPSFGPLNTVQALSQFGPNSDVWSLGMIFHYLFFRIDSGEGNFCR------------DKRVYAG .||| . . . | . .. ... . .||.| |... .. | ... .. .... | APEVLRGQMNYTEKVGI-------------------------DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKG FNLIITEYAIG------SNYFLDKIKELIEDMVKSNPDQRATLSHVKDLL . | . ..... .|.|..| ...|..| . . ... | LRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 29013.AA | Ciliate-C1 | 1158-1182 | 44 | 2.3e-07 | 14.57 | In-house | 140-164 (328) | Show / Hide |
Range on Protein: 1158-1182 Range on HMM: 140-164/328 Sequence Identity: 44% (11 aa) DSLQNLHASSIFHLNLKPSNILFDS ...| .| ..|.|. ||| |||.|. NVIQYIHQNNICHRDLKPENILLDE |
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| Kinase | 29013.AA | Ciliate-E1 | 1141-1243 | 22 | 1e-06 | 18.39 | In-house | 103-202 (202) | Show / Hide |
Range on Protein: 1141-1243 Range on HMM: 103-202/202 Sequence Identity: 22% (24 aa) KNLFSLLDKLLIASYICDSLQNLHASSIFHLNLKPSNILFDSKKHPYLSGWEIRKKEKIQQAE--ENIDDDEQDDKYQVSYGYTPPEVVN----SINTQK .| |. . |. |. . | |. ||. | |...||.|||..... .. ..... | ...... |.. .| | |||..| . | .. QNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------DFGISKFLKNNQNQQCQYKGYTHY-YYPPEQYNCPEQEHNKNQ PQVAMANNF . . . . KINYKSDIY |
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| Kinase | 29013.AA | Ciliate-B2 | 1158-1180 | 47 | 2e-06 | 11.17 | In-house | 115-137 (197) | Show / Hide |
Range on Protein: 1158-1180 Range on HMM: 115-137/197 Sequence Identity: 47% (11 aa) DSLQNLHASSIFHLNLKPSNILF | | .. | || .||.|||| DGLIQFRMYNILHLDIKPQNILF |
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| Kinase | 29013.AA | MLCK | 1156-1184 | 37 | 3e-06 | 11.98 | In-house | 106-134 (257) | Show / Hide |
Range on Protein: 1156-1184 Range on HMM: 106-134/257 Sequence Identity: 37% (11 aa) ICDSLQNLHASSIFHLNLKPSNILFDSKK ||. .. .| | ||.||| ||.. ... ICEGVHHMHWQNIVHLDLKPENIMCQTRT |
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| Kinase | 29013.AA | TKL-Sp1 | 1163-1182 | 40 | 5e-06 | 14.4 | In-house | 114-133 (263) | Show / Hide |
Range on Protein: 1163-1182 Range on HMM: 114-133/263 Sequence Identity: 40% (8 aa) LHASSIFHLNLKPSNILFDS .||. | || ||.|.. .. MHACNILHLDIKPANVMVER |
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| Kinase | 29013.AA | CAMK | 1156-1183 | 42 | 5.7e-05 | 11.18 | In-house | 188-215 (425) | Show / Hide |
Range on Protein: 1156-1183 Range on HMM: 188-215/425 Sequence Identity: 42% (12 aa) ICDSLQNLHASSIFHLNLKPSNILFDSK ||. .. .| | |. ||| |||.|.. ICSAVHYCHSHNIVHRDLKPENILLDDN |
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| Kinase | 29013.AA | Pkinase | 1215-1359 | 11 | 0.000472 | 15.41 | Pfam | 171-293 (293) | Show / Hide |
Range on Protein: 1215-1359 Range on HMM: 171-293/293 Sequence Identity: 11% (19 aa) YQVSYGYTPPEVVNSINTQKPQVAMANNFSTPQKSQLASYATNSNPSFGPLNTVQALSQFGPNSDVWSLGMIFHYLFFRIDSGEGNFCRDK------RVY . ....| .|||.. . || .|.||.| |....... .... . . FCGTPWYMAPEVIR-----------------------------------------GGQYYGPKVDMWSCGCILYEMLCGR-----PPFPGHCWHDNHDQM AGFNLIITEYAIGSNYFL---------------------DKIKELIEDMVKSNPDQRATLSHVKDLLQKLYI . ...| . . . . |..|... . .| .| | ...|| .. QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF |
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| Kinase | 29013.AA | ULK | 1156-1179 | 41 | 0.001734 | 8.14 | In-house | 139-162 (329) | Show / Hide |
Range on Protein: 1156-1179 Range on HMM: 139-162/329 Sequence Identity: 41% (10 aa) ICDSLQNLHASSIFHLNLKPSNIL |. .. || | | .||.||| ILNGFKELHKHNIIHRDIKPQNIL |
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| Kinase | 29013.AA | ULK | 1156-1179 | 45 | 0.001757 | 8.29 | In-house | 135-158 (324) | Show / Hide |
Range on Protein: 1156-1179 Range on HMM: 135-158/324 Sequence Identity: 45% (11 aa) ICDSLQNLHASSIFHLNLKPSNIL || .. || | | .||.||| ICNGFKELHKHNIIHRDIKPQNIL |
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| Kinase | 29013.AA | ULK | 1278-1292 | 46 | 0.003302 | 7.15 | In-house | 237-251 (329) | Show / Hide |
Range on Protein: 1278-1292 Range on HMM: 237-251/329 Sequence Identity: 46% (7 aa) SDVWSLGMIFHYLFF .|.||||.||... . CDIWSLGCIFYEMLY |
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| Kinase | 29013.AA | ULK | 1278-1292 | 46 | 0.003577 | 7.18 | In-house | 233-247 (324) | Show / Hide |
Range on Protein: 1278-1292 Range on HMM: 233-247/324 Sequence Identity: 46% (7 aa) SDVWSLGMIFHYLFF .|.||||.||... . CDIWSLGCIFYEMLY |
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| Kinase | 29013.AA | Ciliate-B2 | 1278-1284 | 57 | 0.023709 | 1.22 | In-house | 191-197 (197) | Show / Hide |
Range on Protein: 1278-1284 Range on HMM: 191-197/197 Sequence Identity: 57% (4 aa) SDVWSLG ||..|.| SDIYSMG |
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| Pkinase | 29013.AA | Pkinase | 1138-1189 | 27 | 0.446042 | 4.89 | Pfam | 97-154 (293) | Show / Hide |
Range on Protein: 1138-1189 Range on HMM: 97-154/293 Sequence Identity: 27% (16 aa) AMRKNLF--SLLDKLLIASYICDSLQNLHASSIFHLNLKPSNILFDSKKHP----YLS ..|.. | | . .. |. |. .|. .| | |||.|||.|.. |. .. TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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