Gene 27070 (Tetrahymena)
27070
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 27070.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| N-Term_TEN | 27070.AA | N-Term_TEN | 4-191 | 100 | 2.6e-164 | 556.98 | Pfam | 1-188 (188) | Show / Hide |
Range on Protein: 4-191 Range on HMM: 1-188/188 Sequence Identity: 100% (188 aa) INNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNK |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| INNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNK QNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNN |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| QNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNN |
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| Kinase | 27070.AA | Ciliate-A5 | 302-315 | 28 | 0.223908 | 0.65 | In-house | 262-275 (275) | Show / Hide |
Range on Protein: 302-315 Range on HMM: 262-275/275 Sequence Identity: 28% (4 aa) EIYRKNCAELSQYQ | .|.. ...||. ENKRPDFHQIYQYL |
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| Telomerase_RBD | 27070.AA | Telomerase_RBD | 355-490 | 25 | 8.9e-45 | 154.49 | Pfam | 1-142 (142) | Show / Hide |
Range on Protein: 355-490 Range on HMM: 1-142/142 Sequence Identity: 25% (36 aa) KQITNFLRQIIQNCV-PNQL-LG---KKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIV .|...|.. ...... |... .| |.|.|.|. ... ||.. |||.... .... |.|.|..|. ..... |... .. .|..| .. .....|| WQVYSFCWACLRKIFWPKDFMWGGQSKHNWKIFFKNIHKFVKLRRFEKMHLHECMWGMKVNDCPWLGPSCSNCCKQYQSDFRKRRQMLHRWMYWLFDHIV IPVLRYNFYITEKHKEGSQIFYYRKPIWKLVSKLTIVK-VRI || .| .||.||.... ..|||||...|. .....|.. . IPLIRSFFYCTESQFHRNRIFYYRHDVWRRLVRPWIRWHYKK |
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| RVT_1 | 27070.AA | RVT_1 | 538-629 | 18 | 6.7e-05 | 19.36 | Pfam | 1-87 (223) | Show / Hide |
Range on Protein: 538-629 Range on HMM: 1-87/223 Sequence Identity: 18% (20 aa) IPKK----GSFRPIM----TFLRKDKQKNIKLNLNQILMDSQLVFRNLKDMLGQKIGYSVFDNKQISEKFAQFIEK-----------WKNKGRPQLYYVT |||| |..||. ... | .| .|..|.... .. ... |. .. .. .... IPKKDKRMGKWRPCHISICNCDYKILNKIMKKRLEPHY------------------------EPIFHYPQHGFRPGRSCHDALVIHCLNKWKGCYWWFIK LDIKKCYDSID ||||||.|.|. LDIKKCFDQIP |
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| RVT_1 | 27070.AA | RVT_1 | 744-870 | 16 | 9e-06 | 22.54 | Pfam | 116-223 (223) | Show / Hide |
Range on Protein: 744-870 Range on HMM: 116-223/223 Sequence Identity: 16% (22 aa) YNVISFNK---VKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLKNAEQVNGSINLLMRLTDDYLFISDS-QQN-ALNLIVQLQNCANNNGFMFNDQK ..|. ... .. | || |||. .| |. | .| .. . . | || |. ... . ..... ..... ..|. .| | FSVYINGWKHPGGHYQWRGMPQGCPNSPYLFNIYMHELDRPIRKRF--------PGCTYCRYMDDILIFCKGSPEESHQQHLEEVCQWCKEWGLKINPEK ITTNFQFPQEDYNLEHFKISVQNECQWIGKSI . | |... | | CQIMH----------------QDEVKFLGYTI |
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| Kinase | 27070.AA | Ciliate-C6 | 1711-1844 | 27 | 5.3e-17 | 56.8 | In-house | 69-231 (306) | Show / Hide |
Range on Protein: 1711-1844 Range on HMM: 69-231/306 Sequence Identity: 27% (45 aa) LSKYEGVVKLLHYCIIPEQMAYIITDVPNKTLQSQIEQQIAI------------------LEQFDDKIILKIAQEVINCLLLIQKELDLPHRDIKPSSIV | ||| |.|. | | |.. .||. | |||..| . .| .|.||.. |.... . . | .|. | ||||||| | LKKYENVIKMQNYFIEPNRQTYIVLDLAESTLQDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNIL LASD-GQYKLTNFRPSQ-FNLASNYMLI-LSQGSIAFMSPEVRFQIE----VQ----MSNVNY . | |.|. | .| .... . . |.. |||| | .. | . ..| IMDDENNYYLSDFGCAQQLFQSEFTRNNDIHMGTLKWMSPELREMKKQYNQHQDDNSNQQIDY |
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| S_TKc | 27070.AA | S_TKc | 1680-1956 | 15 | 1.2e-08 | -49.88 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1680-1956
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)
YEIY-------------VDQFNHNKAYLVKNQDYVQEYINTHLQLSK--YEGVVKLLHYCIIPEQMAYIITDVPNK---TLQSQIEQQIAIL--EQFDDK
||| . . .. . .| . | | .|. | . .|||. .. . |.... . .| . |... .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-
IILKIAQEVINCLLLIQKELDLPHRDIKPSSIVLASDGQYKLTNFRPSQFNLASNYMLILSQGSIAFMSPEVRFQIEVQMSNVNYDPEEEEVGQSYEIYK
. ........ | . . |||.||. | | . . |.. | || . |. .|.|||
HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICD-----FGLARQL--TTFCGTPWYMAPEVL---------------------------
KSLDQNINVLDYIKNEEEIHLYDQYKADIFSLGLTLLLATT-KMGIDGLNINKELLSERILKLKSNTNFSDKTKDLIESMLKWEEDERPTYEQLLS----
|. |.|. |.| .| . . . . ... ..|. |. ||.|. .|... ..||| ..|
--------------------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD
-----MI
.
IKCHPWF
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| Kinase | 27070.AA | Ciliate-E2-Unclassified | 1755-1831 | 20 | 1.4e-08 | 25.86 | In-house | 134-237 (352) | Show / Hide |
Range on Protein: 1755-1831 Range on HMM: 134-237/352 Sequence Identity: 20% (21 aa) QFDDKIIL-----KIAQEVINCL-LLIQKELDLPHRDIKPSSIVLASDG---QYKLTNFRPSQFNLASN--------------YMLILSQ-GSIAFM--- .|... .. ... .....| |..| . ||||||. |.. ..| . |.. | | .. .| .... .. |.. .| IFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQY -SPEV .||| TAPEV |
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| Kinase | 27070.AA | ULK | 1877-1958 | 19 | 7.8e-07 | 20.34 | In-house | 217-324 (324) | Show / Hide |
Range on Protein: 1877-1958 Range on HMM: 217-324/324 Sequence Identity: 19% (21 aa) EIHL-------YDQYKADIFSLGLTLLLATT-K-----MGIDGLNI-NKELLSE----------RILKLK---SNTNFSDKTKDLIESMLKWEEDERPTY .| |. ||.||.||| . . | . . ... ...|. . .. . .. ..|...|||| ||. .|..| . QILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISW EQLLSMIQE |..... EEIFNHPWF |
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| Kinase | 27070.AA | ULK | 1877-1958 | 22 | 2e-06 | 18.35 | In-house | 221-329 (329) | Show / Hide |
Range on Protein: 1877-1958 Range on HMM: 221-329/329 Sequence Identity: 22% (24 aa) EIHL-------YDQYKADIFSLGLTLLLATTKM------GIDGL-NINKELLSE----------RILKLK---SNTNFSDKTKDLIESMLKWEEDERPTY .| |. ||.||.||| . . | .|...|. . |. . .. ..|...|||| ||. .|..| . QILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISW EQLLSMIQE |.|... EELFNHPWF |
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| Kinase | 27070.AA | Ciliate-C6 | 1882-1956 | 29 | 2e-06 | 18.45 | In-house | 230-306 (306) | Show / Hide |
Range on Protein: 1882-1956 Range on HMM: 230-306/306 Sequence Identity: 29% (23 aa) DQYKADIFSLGLTLLLATTKMGIDGLNINKELLSERILKLKSNTNFSD--KTKDLIESMLKWEEDERPTYEQLLSMI | .| ||||||..|| | |.. | . .. . .| .| . . |.. || . |.|| | | DYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMSILIQTI |
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| Kinase | 27070.AA | Ciliate-E2 | 1754-1831 | 15 | 3e-06 | 17.68 | In-house | 140-258 (365) | Show / Hide |
Range on Protein: 1754-1831
Range on HMM: 140-258/365
Sequence Identity: 15% (19 aa)
EQFDDKIILKIAQEVIN---------------CLLLIQKELDLPHRDIKPSSIVLASDGQYKLTNFRPSQFNLAS----------NYMLILS--------
..|..| |..| ..... .| . .. ||||||. |.. |.. | |... . . .. .
KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPG
--------------QGSIAFMSPEV
|. .|.||.
YMDQIIQQNMFNTICGTPGYMAPEI
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| Kinase | 27070.AA | STE | 1884-1956 | 18 | 3e-06 | 18.1 | In-house | 247-359 (359) | Show / Hide |
Range on Protein: 1884-1956 Range on HMM: 247-359/359 Sequence Identity: 18% (21 aa) YKADIFSLGLTL--------LLAT-TKMGIDGLNINKELLSE----------RILKLKS-----------------NTNFSDKTKDLIESMLKWEEDERP .|.|| |||.|. ... . | . ... .. . .|.. ...|.. || |. |. . ..|| TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP TYEQLLS----MI |..|||. | TASQLLKSEHPFI |
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| Kinase | 27070.AA | Ciliate-A5 | 1783-1802 | 55 | 7e-06 | 16.39 | In-house | 122-141 (275) | Show / Hide |
Range on Protein: 1783-1802 Range on HMM: 122-141/275 Sequence Identity: 55% (11 aa) HRDIKPSSIVLASDGQYKLT |.||.|..| | |||.||. HGDIRPQNICLTQDGQVKLM |
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| Kinase | 27070.AA | Ciliate-E2 | 1908-1953 | 26 | 1.7e-05 | 14.79 | In-house | 312-360 (365) | Show / Hide |
Range on Protein: 1908-1953 Range on HMM: 312-360/365 Sequence Identity: 26% (14 aa) NINKELLSERILKLK--SNTNFSDKTKDLIES----MLKWEEDERPT-YEQLL .... .. . . .| |. . |...|||| ||. ....|.| .||.| WQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL |
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| Kinase | 27070.AA | Ciliate-B2 | 1869-1892 | 20 | 2.1e-05 | 8.55 | In-house | 175-197 (197) | Show / Hide |
Range on Protein: 1869-1892 Range on HMM: 175-197/197 Sequence Identity: 20% (5 aa) LDYIKNEEEIHLYDQYKADIFSLG .. ..| . . . ....||.|.| MECDHN-QTFVTNIDFQSDIYSMG |
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| Kinase | 27070.AA | NAK | 1923-1956 | 32 | 2.9e-05 | 13.44 | In-house | 266-299 (299) | Show / Hide |
Range on Protein: 1923-1956 Range on HMM: 266-299/299 Sequence Identity: 32% (11 aa) SNTNFSDKTKDLIESMLKWEEDERPTYEQLLSMI .|...|.. .||| ||. . ..||. .|.|. . DNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | 27070.AA | STE7-Unclassified | 1921-1956 | 28 | 5.8e-05 | 13.53 | In-house | 260-301 (301) | Show / Hide |
Range on Protein: 1921-1956 Range on HMM: 260-301/301 Sequence Identity: 28% (12 aa) LKSNT---NFSDKTKDLIESMLKWEEDERPTYEQLLS---MI |.... ..| .|.|. .| .. |||.. ||| .| LPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI |
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| Kinase | 27070.AA | Ciliate-B2 | 1697-1804 | 19 | 0.000108 | 6.85 | In-house | 42-148 (197) | Show / Hide |
Range on Protein: 1697-1804 Range on HMM: 42-148/197 Sequence Identity: 19% (21 aa) NQDYVQEYINTHLQLSKYEGVVKLLHYCIIPEQMAYIITDVPNKTLQSQIEQQIAILEQFDDKIILKIAQEVINCLLLIQKELDLPHRDIKPSSIVLASD ... .|. |. . ... |||.. . | |. .|.. |.. ... ..| . .... . |. | . . | ||||. | . . DKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMY-NILHLDIKPQNILFMQN GQYKLTNF |.|....| GNYVYCDF |
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| Kinase | 27070.AA | Ciliate-E2-Unclassified | 1881-1953 | 24 | 0.000166 | 11.57 | In-house | 243-347 (352) | Show / Hide |
Range on Protein: 1881-1953 Range on HMM: 243-347/352 Sequence Identity: 24% (26 aa) YDQ---YKADIFSLGLTL-LLATTKMGIDGLNINK---------------ELLSERILK----LKSNT-----NFSDKTKDLIE----SMLKWEEDERPT ||. ||.||.||| | . . . .. | .. .|... . | |.. . |.. ||.|. .|||. ..|.| YDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRIT YEQLL .||.| FEQIL |
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| Kinase | 27070.AA | Ciliate-A5 | 1881-1956 | 25 | 0.000199 | 11.37 | In-house | 194-275 (275) | Show / Hide |
Range on Protein: 1881-1956 Range on HMM: 194-275/275 Sequence Identity: 25% (21 aa) YDQYKADIFSLGLTLL-LAT----TKMGI--DGLNINKELLSERILKLKSNTNFSDKTKDLIESMLKWEEDERPTYEQLLSMI .. || |.|.||...| ..| | . . . | .. | . .. .|. |. ..| || || ||. .|. HNWYKSDVFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKK-YSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 27070.AA | STE7-Unclassified | 1755-1804 | 36 | 0.003027 | 7.41 | In-house | 115-164 (301) | Show / Hide |
Range on Protein: 1755-1804 Range on HMM: 115-164/301 Sequence Identity: 36% (18 aa) QFDDKIILKIAQEVINCLLLIQKELDLPHRDIKPSSIVLASDGQYKLTNF ... ... ||| ||. | . ... . ||||||. | . |.|| |.. | WIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDF |
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| Kinase | 27070.AA | NAK | 1783-1801 | 54 | 0.003572 | 6.35 | In-house | 146-167 (299) | Show / Hide |
Range on Protein: 1783-1801 Range on HMM: 146-167/299 Sequence Identity: 54% (12 aa) HRDIKPSSIVLAS---DGQYKL |||||. | | . ||.||| HRDIKIENILLSESHHDGNYKL |
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| Kinase | 27070.AA | STE | 1756-1831 | 23 | 0.005364 | 6.57 | In-house | 148-233 (359) | Show / Hide |
Range on Protein: 1756-1831 Range on HMM: 148-233/359 Sequence Identity: 23% (22 aa) FDDKIILKIAQEVINCLLLIQKELDLPHRDIKPSSIVLASDGQYKLTNFRPSQFNLASNY----------------MLILSQGSIAFMSPEV |. ..| .|..... || .. ||||||. | | ||..| . |. . |. .|.||| FPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEV |
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| Kinase | 27070.AA | ULK | 1783-1831 | 20 | 0.03057 | 3.73 | In-house | 153-222 (329) | Show / Hide |
Range on Protein: 1783-1831 Range on HMM: 153-222/329 Sequence Identity: 20% (14 aa) HRDIKPSSIVLASD------------GQYKLTNF---RPSQFNLASNYMLILSQ------GSIAFMSPEV ||||||. | . . |..|.. | . . .. .. |. |. .|.|.. HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQI |
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| Kinase | 27070.AA | Ciliate-E2 | 1877-1895 | 33 | 0.057461 | 2.52 | In-house | 257-286 (365) | Show / Hide |
Range on Protein: 1877-1895 Range on HMM: 257-286/365 Sequence Identity: 33% (10 aa) EIHLYDQ-----------YKADIFSLGLTL ||. . . ||.||.||| .| EILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | 27070.AA | ULK | 1783-1804 | 29 | 0.165537 | 1.19 | In-house | 149-182 (324) | Show / Hide |
Range on Protein: 1783-1804 Range on HMM: 149-182/324 Sequence Identity: 29% (10 aa) HRDIKPSSIVLASD------------GQYKLTNF ||||||. | . . |..|.. | HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF |
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