Gene 26666 (Tetrahymena)
26666
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 26666.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26666.AA | Ciliate-E2 | 604-781 | 18 | 2.8e-17 | 55.83 | In-house | 144-357 (365) | Show / Hide |
Range on Protein: 604-781
Range on HMM: 144-357/365
Sequence Identity: 18% (44 aa)
EKQKI-IFAQQIS--------------QTIKNLHENN-SYHGNLKPSNILMDATHKAYLSDWEFSSKMYHKDK----ISQSMILKSQSEKAQISPNIEDD
||. . |..|... . .. ||..| | ..||.|||. ..|. .| | . . .|. ... . . ..| . |
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-
DSIDKNPL-----------YSFGYIAPEIFQNPQ-----KAKFQGAAADVYSLGMIFYFLFTSQDPSFCGIVQEQQLYNNNDLKISRER-----------
. .. || ||||... . | | . ..|..|||.|.|.. . . | || ....... .
-------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCK
---IKNDRLR--ELIQN----MVKFDPYKRCS-IQ
|. . ||.. | . || || . ..
WKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE
|
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| S_TKc | 26666.AA | S_TKc | 506-791 | 14 | 7.3e-13 | 11.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 506-791
Range on HMM: 1-231/231
Sequence Identity: 14% (42 aa)
FDILQFIAKREIGSTSIAKINYNLLDEKENIILQTQNNFAYPSTLSTKIQRLINGEGLLQQKGFCIKQISDIAFELWIVYPQLEY---NLYAVLKQNLL-
..||. | | |. . . .. . .. | . .| . . . . . .... .|..| .. .|. ..|..
YEILRKIGK---GAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRH
-----IMEKQKIIFAQQISQTIKNLHENNSYHGNLKPSNILMDATHKAYLSDWEFSSKMYHKDKISQSMILKSQSEKAQISPNIEDDDSIDKNPLYSFGY
. | . ...|| . .. .|... | |||.|||.| ..| .. .. . . |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------TTFCGTPWY
IAPEIFQNPQKAKFQGAAADVYSLGMIFYFLFTSQDPSFCGIVQEQQLYNNNDLKISRERIKNDRLRELIQNMVKFDPYKRCSIQNTCE-----NLNHLL
.|||.. .. ....|..|.| |.| ... | |. |.|..... . ....|... ..|| || .. . .. .
MAPEVL------GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 26666.AA | Ciliate-E2-Unclassified | 604-781 | 21 | 1.4e-12 | 39.98 | In-house | 136-344 (352) | Show / Hide |
Range on Protein: 604-781
Range on HMM: 136-344/352
Sequence Identity: 21% (48 aa)
EKQKII------FAQQISQTIKNLHENN-SYHGNLKPSNILMDATH---KAYLSDWEFSSKMY----------HKDKISQSMILKSQSEKAQISPNIEDD
. |... .. || | .. ||..| | ..||.|||.| . . ..|. .|.| | .| ......... . |
TEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q---
DSIDKNPLYSFGYIAPEIFQNPQKA--KFQGAAADVYSLGMIFYFLFTSQDPSFCGIVQEQ---------------QLYNNN-DLKISRERIKN------
| |||..|. . |. ..|..|||.|.|.. . . . | . .|| |||.| . .|. ..
------------YTAPEVLQGQNYDHSKA--YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKH
------DRLRELIQNMVKFDPYKRCSIQ
| ...|.| | | .| || ...
WSPEAKDFINDLLQKMLKKNPNKRITFE
|
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| Kinase | 26666.AA | Pkinase | 631-790 | 15 | 2.3e-10 | 37.72 | Pfam | 134-293 (293) | Show / Hide |
Range on Protein: 631-790 Range on HMM: 134-293/293 Sequence Identity: 15% (30 aa) LKPSNILMDATHKA----YLSDWEFSSKMYHKDKISQSMILKSQSEKAQISPNIEDDDSIDKNPLYSFGYIAPEIFQNPQKAKFQGAAADVYSLGMIFYF |||.|||.| . ..|. .. ... . .| . . . .|.|||. . ... | ..|..|.| |.| LKPENILIDNNGHIDACVKICDFGLAKQFD------------------------Y-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYE LFTSQDPSFCGI-----VQEQQLYNNNDL-KISRERIKN---------------------DRLRELIQNMVKFDPYKRCSIQNTCENLNH--L ... | |.| . ..|..... ...... . . ....| .. ..||.||.. . |.| . MLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF |
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| Kinase | 26666.AA | TKL-Unique | 591-725 | 20 | 5.3e-10 | 31.64 | In-house | 86-219 (290) | Show / Hide |
Range on Protein: 591-725
Range on HMM: 86-219/290
Sequence Identity: 20% (31 aa)
NLYAVLK----------QNLLIMEKQKIIFAQQISQTIKNLHENN--SYHGNLKPSNILMDAT-----HKAYLSDWEFSSKMYHKDKISQSMILKSQSEK
.|| || .|. . .|.. .|..|.| .|| .. .|..||.||.| | .. ..| ..| .| . ... .
SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR---
AQISPNIEDDDSIDKNPLYSFGYIAPEIFQNPQKAKFQGAAADVYSLGMIFY
. .. || ..|||.. .. .... .|||| |.. .
-------------NQTRCGSFRWMAPEVLRMNF-CQYS-EKSDVYSFGIVLW
|
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| Kinase | 26666.AA | ULK | 696-781 | 21 | 5.8e-10 | 31.05 | In-house | 217-321 (329) | Show / Hide |
Range on Protein: 696-781 Range on HMM: 217-321/329 Sequence Identity: 21% (23 aa) YIAPEIFQNP-QKAKFQGAAADVYSLGMIFYFLFTSQDPSFCGIVQEQQLYNNNDL---------KISRERIK----------NDRLRELIQNMVKFDPY | ||.|.|. . .. . .|..|||.||| . . . | .. ..|.|.....| .| . .. . ...||. | ..|. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK KRCSIQ .|.|.. DRISWE |
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| Kinase | 26666.AA | C8 | 597-724 | 19 | 3.8e-09 | 28.01 | In-house | 115-226 (226) | Show / Hide |
Range on Protein: 597-724 Range on HMM: 115-226/226 Sequence Identity: 19% (26 aa) KQNLLIMEKQKIIFAQQISQTIKNLHENNSYHGNLKPSNILMDATHKAY----LSDWEFSSKMYHKDKISQSMILKSQSEKAQISPNIEDDDSIDKNPLY .... . ...| | | |. . ..| | | .||.|.|. . . |.| |.|. . || .. . NKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT---------------------CG SFGYIAPEIFQN-PQKAKFQGAAADVYSLGMIF ..|.|||| . .. |. |..|.|.. TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 26666.AA | ULK | 696-781 | 24 | 1.2e-08 | 26.92 | In-house | 213-316 (324) | Show / Hide |
Range on Protein: 696-781 Range on HMM: 213-316/324 Sequence Identity: 24% (26 aa) YIAPEIFQNP-QKAKFQGAAADVYSLGMIFYFLFTSQDPSFCGIVQEQQLYNNNDLK---------ISRERI-KN---------DRLRELIQNMVKFDPY | ||.|.|. . .. . .|..|||.||| . . . | |. ..|.|| . .|. | . | .. . ...||. | ..|. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEK KRCSIQ .|.|.. DRISWE |
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| Kinase | 26666.AA | Ciliate-C3 | 606-649 | 40 | 2.4e-08 | 26.3 | In-house | 97-140 (140) | Show / Hide |
Range on Protein: 606-649 Range on HMM: 97-140/140 Sequence Identity: 40% (18 aa) QKIIFAQQISQTIKNLHENNSYHGNLKPSNILMDATHKAYLSDW ||. ..|| | | ||| | || .|.||||. . .. . |. QKLQISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 26666.AA | Ciliate-C8 | 597-724 | 18 | 2.9e-07 | 22.43 | In-house | 111-238 (238) | Show / Hide |
Range on Protein: 597-724
Range on HMM: 111-238/238
Sequence Identity: 18% (26 aa)
KQNLLIMEKQKIIFAQQISQTIKNLHENNSYHGNLKPSNILMDATHKA----YLSD------WEFSSKMYHKDK-ISQSMILKSQSEKAQISPNIEDDDS
|... ...|.| | |. . .|| .| | ||.|.| . |.| |.|.. .. . . ... ..
KKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYF--------
IDKNPLYSFGYIAPEIFQNPQKAKFQGAA--ADVYSLGMIF
. .||.|||. .. .. . . |.||.| ..
-----CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
|
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| Kinase | 26666.AA | Ciliate-E6 | 583-653 | 24 | 4.4e-07 | 18.97 | In-house | 27-101 (154) | Show / Hide |
Range on Protein: 583-653 Range on HMM: 27-101/154 Sequence Identity: 24% (18 aa) IVYPQLEYNLYAVLKQNLLIME-KQK---IIFAQQISQTIKNLHENNSYHGNLKPSNILMDATHKAYLSDWEFSS || . .|.||.....|. .. .|. . |..|... . || .| ...|... || | .. ..| |.. IVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQ |
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| Kinase | 26666.AA | Ciliate-E2a | 693-727 | 40 | 5.6e-07 | 16.6 | In-house | 173-209 (275) | Show / Hide |
Range on Protein: 693-727 Range on HMM: 173-209/275 Sequence Identity: 40% (15 aa) SFGYIAPEIFQNPQ--KAKFQGAAADVYSLGMIFYFL . ||.|||.. |.. | |. . |. |.| |||.| TPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYIL |
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| Kinase | 26666.AA | Ciliate-E6 | 676-721 | 17 | 0.0019 | 7.25 | In-house | 103-154 (154) | Show / Hide |
Range on Protein: 676-721 Range on HMM: 103-154/154 Sequence Identity: 17% (9 aa) ISPNIEDDDSIDKNPLYSFGYIAPEIFQ------NPQKAKFQGAAADVYSLG | ||.. .. . . . |..|| | .. .. . .| .|.. IIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
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| Kinase | 26666.AA | ULK | 604-638 | 42 | 0.011107 | 5.41 | In-house | 125-159 (324) | Show / Hide |
Range on Protein: 604-638 Range on HMM: 125-159/324 Sequence Identity: 42% (15 aa) EKQKIIFAQQISQTIKNLHENNSYHGNLKPSNILM |.. |.| .|| . | ||..| | .||.|||. EQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI |
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| Kinase | 26666.AA | ULK | 604-639 | 41 | 0.012866 | 5.06 | In-house | 129-164 (329) | Show / Hide |
Range on Protein: 604-639 Range on HMM: 129-164/329 Sequence Identity: 41% (15 aa) EKQKIIFAQQISQTIKNLHENNSYHGNLKPSNILMD |.. |.| .|| . | ||..| | .||.|||.. EQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH |
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