Gene 26552 (Tetrahymena)
26552
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 26552.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26552.AA | CAMK | 663-766 | 21 | 2.2e-20 | 61.72 | In-house | 175-321 (425) | Show / Hide |
Range on Protein: 663-766 Range on HMM: 175-321/425 Sequence Identity: 21% (32 aa) YFNEVEVVEFMKSMIDVHYHLQKNNIAHRDIKPQNILIVEDDDQNI-------------VYKVCDVGSGVGLESSSQYT--------------------- .|.| |. ... ... .. ..||.|||.|| |||.....| . |..| | ........ RFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ RTRTVAGTEVYMS-PEVYTGI------YNTVT----QYNPFKSDVFSLG .|. || ||. ||| | . | .| ..|.|. |.| KMKTFCGTPEYMAAPEVLNGKGHCNMQN-A-TDEEKPYYGPKCDMWSCG |
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| Kinase | 26552.AA | C8 | 676-769 | 34 | 3.7e-20 | 66.73 | In-house | 132-226 (226) | Show / Hide |
Range on Protein: 676-769 Range on HMM: 132-226/226 Sequence Identity: 34% (33 aa) MIDVHYHLQKNNIAHRDIKPQNILIVEDDDQNIVYKVCDVGSGVGLESSSQYTRTRTV--AGTEVYMSPEVYTGIYNTVTQYNPFKSDVFSLGLVF ||| .. || ||||||.|.|. .| .. | || | .... . .. . || |. ||. .. | . ||. .||.||.||| MIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYR-IQSDLFSVGLVL |
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| Kinase | 26552.AA | Pkinase | 557-837 | 17 | 5.5e-19 | 68.21 | Pfam | 28-293 (293) | Show / Hide |
Range on Protein: 557-837
Range on HMM: 28-293/293
Sequence Identity: 17% (55 aa)
CVKQVRITERDCTYEQ-FIN--ECNILEKTKLFPHENMIKFYGYFITKENNDSQILIGNIVMERGKQ-----SLKMFMQQRQNQNKKQQEELSISQVETT
.||... .... .| .. |. |. . . |.| ...|..| . .. | .||| .|. ...
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED----KDHIY---MVMEYCEGGLYVMDLFDYIST--------------------
KSKQIQNQSEIDGAY-FNEVEVVEFMKSMIDVHYHLQKNNIAHRDIKPQNILIVEDDDQNIVYKVCDVGSGVGLESSSQYTRTRTVAGTEVYMSPEVYTG
. .|.. | | |. .|. .. ... ...| |||.||.||||..... . |.|| |. .. .. . |..|| ||.|||
---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV---
IYNTV-TQYNPFKSDVFSLGLVFLEFLTFKLVDKDK---KVRLDKDKYMAEVKELRHEAKKRYKYI-------------------FGLNKILKQMLVYNQ
|| . |.|..|.|... |.|. .. ... . .|... ...... . . ... . ...| .| ..
---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP
NDRVTFQDLYQQ--V
..| |.... | .
KKRPTAEQILQHPWF
|
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| Kinase | 26552.AA | Ciliate-C8 | 676-769 | 29 | 1.2e-18 | 63.68 | In-house | 128-238 (238) | Show / Hide |
Range on Protein: 676-769 Range on HMM: 128-238/238 Sequence Identity: 29% (33 aa) MIDVHYHLQKNNIAHRDIKPQNILIVEDDDQNIVYKVCD------VGSGVGLESSSQYTRTRTVAGTEVY-----------MSPEVYTGIYNTVTQYNPF |||. | .|| ||||||.|.| .|.... | || | |. . . .... ||. | . |||..... . . MIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSK KSDVFSLGLVF |||..|.|||. KSDSYSVGLVL |
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| Kinase | 26552.AA | STE | 543-774 | 20 | 1.4e-18 | 62.33 | In-house | 15-263 (359) | Show / Hide |
Range on Protein: 543-774
Range on HMM: 15-263/359
Sequence Identity: 20% (60 aa)
VYEARNRLNDSLT--------------ECVKQVRITERD----------------CTYEQFINECNILEKTK-LFPHENMIKFYGYFITK---ENNDSQI
|| |.|. |. .. .||... . . .|...| .|. | . |.| .|.||... . ..||...
VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM--HPNIVKYYGCYFKEGHNHKNDDEL
LIGNIVMERGK-QSLKMFMQ------QRQNQNKKQQEELSISQVETTKSKQIQNQSEIDGAYFNEVEVVEFMKSMIDV-HYHLQKNNIAHRDIKPQNILI
.|.|| || ... ...|.|.. . .|.| .. . .. . |.| ...| ||||||.|||.
---WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ-----------------------H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL
VEDDDQNIVYKVCDVGSGVGLESS--------------SQYTRTRTVAGTEVYMSPEVYTGIYNT-VTQYNPFKSDVFSLGLVFLEFLT
| || | |..| .. .. |..|| .|.||| .. .. . .|. .|.|. |||.. .| .|
---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMAT
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| Kinase | 26552.AA | Ciliate-C6 | 664-774 | 35 | 2.7e-18 | 61.43 | In-house | 132-248 (306) | Show / Hide |
Range on Protein: 664-774 Range on HMM: 132-248/306 Sequence Identity: 35% (43 aa) FNEVEVVEFMKSMIDVHYHLQK-NNIAHRDIKPQNILIVEDDDQNIVYKVCDVGSGVGLESSSQYTRTRTVAGTEVYMSPEVYTGIY--------NTVTQ |.| |.| | | . .. |||||||||.|||| .|.. |. | | | |... .. || |||| .. | | FDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDEN---NYYLSDFGCAQQLFQSEFTRNNDIHMGTLKWMSPELREMKKQYNQHQDDNSNQQ YNPFKSDVFSLGLVFLEFLT . ||.|.||||.. | || IDYFKCDIFSLGMILLYMLT |
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| Kinase | 26552.AA | Ciliate-E2-Unclassified | 681-839 | 23 | 9.3e-18 | 58.19 | In-house | 158-352 (352) | Show / Hide |
Range on Protein: 681-839 Range on HMM: 158-352/352 Sequence Identity: 23% (48 aa) YHLQKNNIAHRDIKPQNILIVEDDDQ-NIVYKVCDVGSGVGLESSSQYTRTR--------------TVAGTEVYM----SPEVYTG-IYNTVTQYNPFKS | .|||| ||||||.|||. |... | |..| |. ........ |. |..|| || .|||. | |.. . .|. YLHHKNNIIHRDIKPENILF--DNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKC DVFSLGLVFLEFLTFKL--VDKDKKV---------------RLDKDKYMAEVKELRHE-----AKKRYKYIFGLNKILKQMLVYNQNDRVTFQDLYQQVF |..||| .. |.|. .. |.... | .... ... .. . ... .|..|..||..|.| | ||... . . DIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPW E F |
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| Kinase | 26552.AA | Ciliate-A5 | 626-771 | 25 | 1.4e-17 | 57.52 | In-house | 84-210 (275) | Show / Hide |
Range on Protein: 626-771 Range on HMM: 84-210/275 Sequence Identity: 25% (40 aa) MQQRQNQNKKQQEELSISQVETTKSKQIQNQSEIDGAYFNEVEVVEFMKSMIDVHYHLQKNNIAHRDIKPQNILIVEDDDQNIVYKVCDVG----SGVGL ||.|... | ...|| | . |.. | | . ||.||| |.||.||||.. .| .|. |.. . . MQMRKQCQKD--------------------------IFYNEQELWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQ----VKLMDMNESKDFFYQI ESSSQYTRTRTVAGTE-VYMSPEVYTGIYNT------VTQYNPFKSDVFSLGLVFLE . || . . .. . | ||. ... .| .|||||.||.. || NWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSDVFCLGMICLE |
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| Kinase | 26552.AA | TKL | 681-837 | 20 | 5.9e-17 | 57.61 | In-house | 146-364 (364) | Show / Hide |
Range on Protein: 681-837 Range on HMM: 146-364/364 Sequence Identity: 20% (46 aa) YHLQKNN--------IAHRDIKPQNILIVEDDD----------QNIVYKVCDVG-SGVGLESS----------------SQYTRTRTVAGTEVYMSPEVY ..| .| |.|||.|..|||. |. ... |.|| | | . .|. .. ..| |. || .|.||| NYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVL TGI--YNTVT---------QYNPFKSDVFSLGLVFLEFLTFKLVDKDKKVRLDKDK-------YMAEVKELRHEAKKRYK----------YIFGLNKILK | |. .|.. |.||.| |.|. | || ... .| . . . .|. .| || . . . . .. |... RGQMNYTEKVGIDEFCKGFEYSE-KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQ QMLVYNQNDRVTFQDLYQQV . .. ..| .||.. .. DCWDHDPEKRPSFQEILKRL |
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| S_TKc | 26552.AA | S_TKc | 530-838 | 18 | 6.1e-16 | 56.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 530-838
Range on HMM: 1-231/231
Sequence Identity: 18% (60 aa)
YSLEKCFAK-SNSYVYEARNRLNDSLTECVKQVRITERDCTYEQFINECNILEKTKLFPHENMIKFYGYFITKENNDSQILIGNIVMERGKQ---SLKMF
| . . | . . || .|.. . .|... |....| .||.| |.| .|.|..| . .||| . .|. .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDY
MQQRQNQNKKQQEELSISQVETTKSKQIQNQSEIDGAYFNEVEVVEFMKSMIDVHYHLQKNNIAHRDIKPQNILIVEDDDQNIVYKVCDVGSGVGLESSS
...|. . ... .|.| .. .|. ... .. ...| |||.||.|||. | . |.|| |. |
IKKRGRHGLRF--------------------------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----
QYTRTRTVAGTEVYMSPEVYTGIYNTVTQYNPFKSDVFSLGLVFLEFLT----FKLVDKDKKVRLDKDKYMAEVKELRHEAKKRYKYIFGLNKILKQMLV
.|. || ||.||| .|...|.|. |.| .. |.|. | . .. . .. . .....|.
-----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG------------SPEAKDFIRKCLQ
YNQNDRVTFQDLYQ--------QVF
.. ..| | .. | . |
KDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 26552.AA | ULK | 682-769 | 31 | 2.3e-15 | 51.06 | In-house | 141-242 (324) | Show / Hide |
Range on Protein: 682-769 Range on HMM: 141-242/324 Sequence Identity: 31% (33 aa) HLQKNNIAHRDIKPQNILIVEDDDQ--------NIVYKVCDVGSGVGLES-SSQYTRTRTVA------GTEVYMSPEVYTGIYNT--VTQYNPFKSDVFS .|.|.|| ||||||||||| ... . |.|.|..| | . ... . . . . | || ||.|.. . . .|. .|.|..| ELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQI---LQGQGEQKPYYDYKCDIWS LGLVF || .| LGCIF |
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| Kinase | 26552.AA | ULK | 682-769 | 32 | 2.7e-15 | 49.91 | In-house | 145-246 (329) | Show / Hide |
Range on Protein: 682-769 Range on HMM: 145-246/329 Sequence Identity: 32% (34 aa) HLQKNNIAHRDIKPQNILIVEDDDQ--------NIVYKVCDVGSGVGLESS--SQYTRTRTVA-----GTEVYMSPEVYTGIYNT--VTQYNPFKSDVFS .|.|.|| ||||||||||| ... . |.|.|..| | . .... .| . .| || ||.|.. . . .|. .|.|..| ELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQI---LQGQGEQKPYYDYKCDIWS LGLVF || .| LGCIF |
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| TyrKc | 26552.AA | TyrKc | 530-837 | 17 | 1e-06 | -114.04 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 530-837 Range on HMM: 1-280/280 Sequence Identity: 17% (62 aa) YSLEK-----CFAKSNSYVYEARNRLNDSLTEC-VKQVRITERDCTYEQFINECNILEKTKLF--PHENMIKFYGYFITKENN---DSQILIGNIVMERG .|.| .| . ||... . ... || .. | |..| .|. | . |.| ...||. .... | . ...| |. | ITLGKKLGEGAFGE----VYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCK---LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG KQSLKMFMQQRQNQNKKQQEELSISQVETTKSKQIQNQSEIDGAYFNEVEVVEFMKSMIDV----HYHLQKNNIAHRDIKPQNILIVEDDDQNIVYKVCD .|| . . .... . . .. . .... | | ..|. |||. |.|. |. . |..| --DLKDYLRKHRPK----------------------------------LCMKDLLSFCWQIACGMEY-LHSKNCIHRDLAARNCLVGENH----TVKISD VGSGVGLESS------SQYTRTRT-VAGTEV----YMSPEVY-TGIYNTVTQYNPFKSDVFSLGLVFLEFLTFKLVDKDKKVRLDKDKYMAEVKELRHEA | ... ..| |... | . |.||. .|...| ||||.| | . | .|. . | . .|... FGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-------KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYV KKRYKYIFGLN--------------KILKQMLVYNQNDRVTFQDLYQQV |..| | .| || .. .|| ||...... KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 26552.AA | Ciliate-A5 | 803-837 | 34 | 2e-06 | 18.15 | In-house | 241-275 (275) | Show / Hide |
Range on Protein: 803-837 Range on HMM: 241-275/275 Sequence Identity: 34% (12 aa) KKRYKYIFGLNKILKQMLVYNQNDRVTFQDLYQQV .|. || . . ..||||. . |.| .| ..||.. MKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 26552.AA | ULK | 815-839 | 20 | 3.1e-05 | 14.61 | In-house | 300-324 (324) | Show / Hide |
Range on Protein: 815-839 Range on HMM: 300-324/324 Sequence Identity: 20% (5 aa) ILKQMLVYNQNDRVTFQDLYQQVFE ....||.|...|| ....... . LIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 26552.AA | ULK | 815-839 | 24 | 3.2e-05 | 14.29 | In-house | 305-329 (329) | Show / Hide |
Range on Protein: 815-839 Range on HMM: 305-329/329 Sequence Identity: 24% (6 aa) ILKQMLVYNQNDRVTFQDLYQQVFE ....||.|...|| ....|.. . LIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 26552.AA | ULK | 571-604 | 35 | 0.02757 | 3.99 | In-house | 55-91 (324) | Show / Hide |
Range on Protein: 571-604 Range on HMM: 55-91/324 Sequence Identity: 35% (13 aa) EQFINECNILEKTKLFPHEN--MIKFYGYFITKE-NN ....|| .|. | | |.| .|.| .| |. || QLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN |
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| Kinase | 26552.AA | STE | 812-839 | 20 | 0.323529 | 0.2 | In-house | 330-359 (359) | Show / Hide |
Range on Protein: 812-839 Range on HMM: 330-359/359 Sequence Identity: 20% (6 aa) LNKILKQMLVYNQNDRVTFQDLYQ--QVFE .. ... |... |.| | ..| . | FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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