Gene 26549 (Tetrahymena)
26549
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 26549.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26549.AA | Ciliate-E2 | 144-346 | 14 | 1.7e-13 | 42.64 | In-house | 119-286 (365) | Show / Hide |
Range on Protein: 144-346
Range on HMM: 119-286/365
Sequence Identity: 14% (40 aa)
MNLQQFLDER-LK-------QNLPIQFKELVSIMRQSIS---------------ALANLQEEK-IAHNDIKLANILVFRKPIAQLAQQQTNKNNEQMKQN
..|.... .. .| . ... || ||.| .. || | ... | | |||. |||.
GDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------------------
KKQPLLPNQLQFDQSATFSPNKSARLSSQKNNKIAPNKFLFNEYDKNQCSMQEEKEANQNQTNQQDSQCIDYEIEIKFCDIGSSQ--------------A
|| .| | |. .
---------------------------------------------------------------------------IKIIDFGLSKKYDDDNQNRTHKQQC
NQSTFKK---TKKPG----------------TDSYLAPEEFLGDKI--------HIYKYDVYSLGLCF
. .| | .. || | |.||| . | |. . || |..||| ..
KWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
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| Kinase | 26549.AA | Ciliate-C8 | 139-346 | 18 | 1.2e-12 | 41.96 | In-house | 93-238 (238) | Show / Hide |
Range on Protein: 139-346 Range on HMM: 93-238/238 Sequence Identity: 18% (40 aa) MEKGEMN--LQQFLDERLKQNLPIQFKELVSIMRQSISALANLQEEKIAHNDIKLANILVFRK----PIAQLAQ--QQTNKNNEQMKQNKKQPLLPNQLQ ||| . | |.|..|. |.... . .. |. | | ...| | | |||. |.|| |. |. .| . MEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQ--------------------CD FDQSATFSPNKSARLSSQKNNKIAPNKFLFNEYDKNQCSMQEEKEANQNQTNQQDSQCIDYEIEIKFCDIGSSQANQSTFKKTKKPGTDSYLAPEEFLG- |.... . ||| .|.............| |. | ||| . FGFASQLPKNKSHYHSKKFKGTDQYIEMYF-------------------------------------------------------CGNWGYFAPEVEKKQ --DKIHIYK--YDVYSLGLCF .. |. |.||.||.. SRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 26549.AA | Ciliate-E4 | 136-196 | 31 | 1.9e-10 | 31.51 | In-house | 80-140 (150) | Show / Hide |
Range on Protein: 136-196 Range on HMM: 80-140/150 Sequence Identity: 31% (19 aa) YILMEKGEMNLQQFLDERLKQNLPIQFKELVSIMRQSISALANLQEEKIAHNDIKLANILV |..|| .||| . . .|... |. | ..|.|...|| |.|.|.| ||.. YWFMEYLQKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFF |
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| Kinase | 26549.AA | Ciliate-E2-Unclassified | 136-346 | 15 | 4.3e-10 | 31.23 | In-house | 97-260 (352) | Show / Hide |
Range on Protein: 136-346
Range on HMM: 97-260/352
Sequence Identity: 15% (39 aa)
YILMEKGEM-NLQQFLD-------------ERLKQNLPIQFKELV-----SIMRQSISALANLQEEK-IAHNDIKLANILVFRKPIAQLAQQQTNKNNEQ
|| ||. | .|.|.. ...||. .. .. . ...| ...| | ... | | |||. |||. .
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--------------
MKQNKKQPLLPNQLQFDQSATFSPNKSARLSSQKNNKIAPNKFLFNEYDKNQCSMQEEKEANQNQTNQQDSQCIDYEIEIKFCDIGSSQANQST------
.|| .| |.| .|.
----------------------------------------------------------------------------NYYIKIIDFGISKKYQQNNNCDTN
---------FKKTKKP-GTDSYL----APEEFLGDKIHI---YKYDVYSLGLCF
..... || .|. ||| . | . || |..||| ..
QQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
|
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| Kinase | 26549.AA | S_TKc | 80-429 | 12 | 5.7e-10 | -30.69 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 80-429
Range on HMM: 19-231/231
Sequence Identity: 12% (46 aa)
KQNSQSKKLILKELFGQDIKQEIEFVKTIRQLNYRIPGLIYMINYAIYQTESLEVGYILMEKGEM---NLQQFLDERLKQNLP--IQFKELVSIMRQSIS
. .. .. .|.. ..|..||. | . | .. .. . . |. || . .| .....| .. |. . . ..|.| ..
RHKKTGRIVAIKIIK-EHIRREIQILKK------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC
ALANLQEEKIAHNDIKLANILVFRKPI--------AQLAQQQTNKNNEQMKQNKKQPLLPNQLQFDQSATFSPNKSARLSSQKNNKIAPNKFLFNEYDKN
||. . . .| | |.| .|||. . | .||
ALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------------------------------------------------------------
QCSMQEEKEANQNQTNQQDSQCIDYEIEIKFCDIGSSQANQSTFKKTKKPGTDSYLAPEEFLGDKIHIY-KYDVYSLGLCFINLIIQKTSNFHVYMKNSN
| || |.||| . . . | |..|.| ... .. ..
----------------------------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--------
WNNLMSKKDWLEILQDILEEWIRIASLRMNNQDVKTILTKMLIIDINSRPDFIELRN----IFDDLFK
. .... |. ...| .. |.| | . || |. . | . .
--------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 26549.AA | C8 | 291-346 | 32 | 4.7e-08 | 24.17 | In-house | 162-226 (226) | Show / Hide |
Range on Protein: 291-346 Range on HMM: 162-226/226 Sequence Identity: 32% (21 aa) YEIEIKFCDIGSSQA---NQSTFKKTKK--PGTDSYLAPEEFLG----DKIHIYKYDVYSLGLCF | ||| ||.| . . |.| . | ||. |.||| . |. . |..|.|| YGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 26549.AA | Ciliate-E2a | 152-195 | 29 | 1e-07 | 18.79 | In-house | 88-134 (275) | Show / Hide |
Range on Protein: 152-195 Range on HMM: 88-134/275 Sequence Identity: 29% (14 aa) ERLKQNLPIQFK--ELVSIMRQSIS-ALANLQEEKIAHNDIKLANIL ...||. .... | .||.| .. .|.... .| | |.|. ||| DKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENIL |
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| Kinase | 26549.AA | Ciliate-A7 | 137-205 | 31 | 2e-06 | 19.47 | In-house | 94-180 (360) | Show / Hide |
Range on Protein: 137-205 Range on HMM: 94-180/360 Sequence Identity: 31% (27 aa) ILMEKGEMNLQQFLDERLKQ-NLPIQ----------FKELVSIMRQSISALANLQEE-KIAHNDIKLANILVFRKPI------AQLA ||||..|..| |.. . || .. .. .. || .||. | .| .|||||||. ||..| . . ..|| ILMEQAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLA |
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| Kinase | 26549.AA | Ciliate-A5 | 401-424 | 29 | 5e-06 | 16.91 | In-house | 252-275 (275) | Show / Hide |
Range on Protein: 401-424 Range on HMM: 252-275/275 Sequence Identity: 29% (7 aa) TILTKMLIIDINSRPDFIELRNIF ... .||... | ||||.... .. NFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 26549.AA | C8 | 139-196 | 34 | 7e-06 | 16.57 | In-house | 99-156 (226) | Show / Hide |
Range on Protein: 139-196 Range on HMM: 99-156/226 Sequence Identity: 34% (20 aa) MEKGEMNLQQFLDERLKQNLPIQFKELVSIMRQSISALANLQEEKIAHNDIKLANILV || | ||.|. ||| ....... .. | | | . ... .| | |||. |.|| MELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLV |
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| Kinase | 26549.AA | Ciliate-E1 | 68-260 | 15 | 2.5e-05 | 13.81 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 68-260 Range on HMM: 1-202/202 Sequence Identity: 15% (33 aa) LSLSSPNSNQQEKQNSQS---KKLILKELFGQDIKQEIEFVKTIRQ-LNYRIPGLIYMINYAIYQT-ESLEVGYILMEKGEMNLQQFLD---------ER .. .| . ||.... ..... .. ... ........ . . . . .| |.. |. ... . .|..|. ...|.. |. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC LKQNLPIQFKELVSIMRQSISALANLQEEKIAHNDIKLANILVFRKPIAQLAQQQTNKNNEQMKQNKKQPLLPNQLQFDQSATFSPNKSARLSSQKNNKI ... .|.....|. | | .|. |. .| | ||| .|||. .. . ....... |. | |..| .. . . . | . .||.|| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKF---LKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKI APNKFLF . .. NYKSDIY |
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| Kinase | 26549.AA | TKL | 291-424 | 13 | 5.7e-05 | 13.85 | In-house | 189-364 (364) | Show / Hide |
Range on Protein: 291-424
Range on HMM: 189-364/364
Sequence Identity: 13% (26 aa)
YEIEIKFCDIGSSQANQSTF--------------------KKTKKPGTDSYLAPEEFLGD---------------KIHIYKYDVYSLGLCFINLIIQKTS
... .| || | |. .. .. .. .. || ..||| . |. . | |||| |... .. ..
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-
NFHVYMKNSNWNNLMSKKDWLEILQDILE---------EWIRIASLR-------------MNNQD----VKTILTKMLIIDINSRPDFIELRNIF
. .. . . ... .|| ... | .| .... | ..|| | |. ..
------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 26549.AA | TKL | 150-199 | 18 | 0.000208 | 11.8 | In-house | 125-176 (364) | Show / Hide |
Range on Protein: 150-199 Range on HMM: 125-176/364 Sequence Identity: 18% (11 aa) LDERLKQNLPIQFKELVSIMRQSISALANLQEEK--------IAHNDIKLANILVFRK | ..| . ....... .... | .. |.| |.| .||||... LLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN |
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| Kinase | 26549.AA | Ciliate-E1 | 289-340 | 24 | 0.006817 | 5.81 | In-house | 142-202 (202) | Show / Hide |
Range on Protein: 289-340 Range on HMM: 142-202/202 Sequence Identity: 24% (15 aa) IDYEIEIKFCDIGSSQ--ANQSTFKKTKKPGTDSYLAPEEF-------LGDKIHIYKYDVY |. . . ..||.| |. |... . .| |..| ||. ... ||.|.| INNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 26549.AA | Ciliate-A5 | 145-196 | 35 | 0.04265 | 3.18 | In-house | 79-132 (275) | Show / Hide |
Range on Protein: 145-196 Range on HMM: 79-132/275 Sequence Identity: 35% (19 aa) NLQQFLDERLKQNLPIQFKE--LVSIMRQSISALANLQEEKIAHNDIKLANILV ||.| . .| .. . |...| |. || ||... ||. .| | ||. .||.. NLEQEMQMRKQCQKDIFYNEQELWYIMDCLISVCMYLQQNNICHGDIRPQNICL |
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| Kinase | 26549.AA | Ciliate-A7 | 335-352 | 33 | 0.090549 | 2.15 | In-house | 254-271 (360) | Show / Hide |
Range on Protein: 335-352 Range on HMM: 254-271/360 Sequence Identity: 33% (6 aa) YKYDVYSLGLCFINLIIQ .|.||...|..| ....| KKCDVFAFGVSFFQILFQ |
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