Gene 25965 (Tetrahymena)

25965

Species: Tetrahymena
Alias: 3688.m00110, 25965, PreTt25965, 616, 26.m00317, TTHERM_00289330
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
25965.AA Protein None 735 None Fasta, JSON
25965.kin_dom Protein Kinase Domain None 200 None Fasta, JSON
25965.NA RNA None 2208 None Fasta, JSON

Protein domain

Protein domains of 25965.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25965.AA S_TKc 13-287 20 1.3e-32 115.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-287
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

EDKLTLIARGGFSQIFVTQCNLTKQPIVVKKMKSDDPSTLNFLTQEANCIKKLNDENPNIKNIIKIYSNHQRGNCIYIAMEYCPL--GSLEKILQQKQK-
 ..| .| .|.|.. .  . . |..   .|..|       . . .| .. ||     ||| ... .. .    ...|. ||||.   |.| ........ 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LSHYEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQNEYVLTDWGSAQQLNHQHSTTLRDNTYFTPGYQAPELQNENLISSNMKFNYFIAD
     ..  ..  ...|...|| | |..| .| ||||||.|. |  .  ..| |.| ||         .    || | |||.          ..... .|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---------GYGKCKCD

IYSLGMMLLRCTG--PTFREIRTISSEADQGDHDWKINKLFKTYIYQKEYQDGVIDKIIAGFLNYSKSSRMKLEEALK----TINTTYP
..|.| .|  .    | |.             .. .. |. .         . ..| .| . |..  . |.   |||.      .  . 
WWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG--------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25965.AA CAMK 18-186 16 5.8e-31 96.45 In-house 1-291 (425) Show / Hide 
Range on Protein: 18-186
Range on HMM: 1-291/425
Sequence Identity: 16% (48 aa)

LIARGGFSQIFVTQCNLTK------------QPIVVKKMKSD----------------------------DPSTLNFLTQEANCIKKLND-----ENPNI
 . ||.|.. .  .  .|.            |   .| .. .                            .|... .. .| .. |||..       |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

KNIIKIYSNHQ---------RGNC--------IYIAM---EYCPLG----S-LEKILQQKQ--------------KLSHYEILIFAKQMISALIYAHRLG
 ... .| ...           ..        .|. |   |||. |      ...| ....              ...  |   . .|..||. | | ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LVHSDLKPENVLIREQ-----------------NEYVLTDWGSAQQLN----------HQHSTTLRDN-------------TYFTPGYQA-PEL
 || ||||||.|. .                  |   ..|.| |....          ... . . .|                ||.| | ||.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase 25965.AA Ciliate-E2 13-212 20 5.7e-29 96.56 In-house 1-286 (365) Show / Hide 
Range on Protein: 13-212
Range on HMM: 1-286/365
Sequence Identity: 20% (61 aa)

EDKLTLIARGGFSQIFVTQCNLT--------------------KQPIVVKKMKSDDPSTLNFLTQEANCIKKLND-----------ENPNIKNIIKIYSN
 ... .| .|.|....  .  ..                    |. |  . ||.  .. .... || . ....|.           |. | .||||.|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HQ--RGNCIYIAMEYCPLGSLEKILQQK-----------QKLSHYEILIFAKQMIS---------------ALIYAHRLG-LVHSDLKPENVLIREQNEY
 |    |.||. ||||  |.|.......           ......||. . || ..               || | |  .  .| |.||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

VLTDWGSAQQLNHQ------------------HSTTLRDN-----------TYFTPGYQAPELQNENLIS--SNMKFNYFIADIYSLGMML
 ..|.| ..... .                   |.| ...           .. ||||.|||  |   ..  .. |   . .||.|||..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 25965.AA Ciliate-E2-Unclassified 13-212 18 2.5e-26 88.37 In-house 1-260 (352) Show / Hide 
Range on Protein: 13-212
Range on HMM: 1-260/352
Sequence Identity: 18% (49 aa)

EDKLTLIARGGFSQIFVTQCNLTKQP-----------IVVKKMKSDDPSTLNFLTQEANCIKKLNDEN----------PNIKNIIKIYSNHQRG--NCIY
  ..  | .|||....  |.. .||            . .|.... |   ...  .| |..|| .. .           |........  ..    ..||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD--EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

IAMEYCPLGSLEKILQQKQK-----------------LSHYEIL-----IFAKQMISALIYAHRLG-LVHSDLKPENVLIREQN---EYVLTDWGSAQQL
| ||||. |.|....... |                 .. ....      ...| ...| | |. .  .| |.||||.|. ...   .  ..|.|.. ..
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

NHQHSTTLRDN--------------TYFTPGYQ----APELQNENLIS---SNMKFNYFIADIYSLGMML
. .   .  ..              .  ||.|.    |||.  ..  .   .      . .||.|||. |
QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVIL
Kinase 25965.AA Pkinase 13-212 24 5.3e-25 89.48 Pfam 1-202 (293) Show / Hide 
Range on Protein: 13-212
Range on HMM: 1-202/293
Sequence Identity: 24% (53 aa)

EDKLTLIARGGFSQIFVTQCNLTKQPIVVKKMKSDDPSTLNFLTQ----EANCIKKLNDENPNIKNIIKIYSNHQRGNCIYIAMEYCPLG----SLEKIL
  ..  | .|.|.. .  .   | .  .||..| .. .     |     |.   |.||      .||...|   .... ||. ||||. |    .|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

Q--QKQKL--SHYEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQNEY----VLTDWGSAQQLNHQHSTTLRDNTYFTPGYQAPELQNENLISSN-
.  .. ..  |  |.  ...|....| | |. | .| ||||||.|| ....      ..|.|.| |... ... . . .  ||.| |||.        . 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEV-------IRG

MKFNYFIADIYSLGMML
 .     .|..|.| .|
GQYYGPKVDMWSCGCIL
Kinase 25965.AA ULK 11-212 22 8.7e-23 76.43 In-house 1-246 (329) Show / Hide 
Range on Protein: 11-212
Range on HMM: 1-246/329
Sequence Identity: 22% (56 aa)

FSEDKLTLIARGGFSQIFVTQCNLTK---QPIVVKKMKS---DDPSTLN--------FLTQEANCIKKLNDE--NPN-IKNIIKIYSNHQRG--NCIYIA
.. ..   .  | | . .   .. ||   . .|. || .    . .  .        .|..|   .|||...  ..|  .||.| |   .    |.||| 
YCLNH--CLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYCPLGSLEKILQQKQK----------LSHYEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQNEYV------------LTDWGSAQQLNHQ-HS
||||. | ||.......|          ||  |...| || .... . |  . .| |.||.|.|| . ...             ..| | |....    .
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

TTLRDNTY------FTPGYQAPELQNENLISSNMKFNYFIADIYSLGMML
  .   .        || | ||.. ....   ..... . .||.|||...
QQMMMTCVNEKRLCGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIF
Kinase 25965.AA STE 13-185 20 1.7e-22 76.37 In-house 1-232 (359) Show / Hide 
Range on Protein: 13-185
Range on HMM: 1-232/359
Sequence Identity: 20% (50 aa)

EDKLTLIARGGFSQIFVTQCNL---------------TKQPIVVKKMKSDDP-----------------STLNFLTQEANCIKKLNDENPNIKNIIKIYS
 ...  | .|.| . .   ..                |.. . .|.|. ..                  . .. . .| .  ||.|.     .||.| | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH--M-HPNIVKYYG

NHQRG-------NCIYIAMEYCPLGSLEKILQQK----QKLSHY--------EILI--FAKQMISA-LIYAHRLGLVHSDLKPENVLIREQNEYVLTDWG
 . ..       . ..|.|||.. |||..|...|    . |.|         | .|  ...| . . | | |... .| |.|| |.|.       |.| |
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFG

SAQQLNHQHS------------TTL-RDNTYF-TPGYQAPE
 . ||.. ..            |.  . ||   || . |||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 25965.AA ULK 11-212 21 1.7e-21 73.04 In-house 1-242 (324) Show / Hide 
Range on Protein: 11-212
Range on HMM: 1-242/324
Sequence Identity: 21% (53 aa)

FSEDKLTLIARGGFS-QIFVTQCNLT---KQPIVVKKMK----SDDPST------LNFLTQEANCIKKLN---DENPNIKNIIKIYSNHQRG--NCIYIA
.. ..   .  | |  . .   .. |   .| . .|..     .....       ...| .| . .|||.    .| .  .|.| |   .    | ||| 
YCLNH--CLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPN-H--HIVKLYDWFETSNHNNIYII

MEYCPLGSLEKILQQKQK---------LSHYEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQNEYV------------LTDWGSAQQLNH-QHST
||||. | ||.......|         ||  |...| || .... . |  . .| |.||.| || . ...             ..| | |....  . . 
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

TLRDNTY------FTPGYQAPELQNENLISSNMKFNYFIADIYSLGMML
...  .        || | ||.......   ..... . .||.|||...
QMCQTCVNEKRIKGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIF
Kinase 25965.AA Ciliate-E1 19-206 23 7e-21 64.98 In-house 1-202 (202) Show / Hide 
Range on Protein: 19-206
Range on HMM: 1-202/202
Sequence Identity: 23% (48 aa)

IARGGFSQIFVTQCNLTK----QPIVVKKMKSDDPSTLNFLTQEANCIKKLNDENPNIKNIIKIYSNHQRGNCIYIAMEYCPLGSLEKILQ---------
|..|.||..|   .. ..    . ....    ..  .......| ..|.|   .. .| .||...   |  .|| | ...|   ||.. ||         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCC--CSLKDYLQNHNRLEYWQ

----QKQKLSHYEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQNEYVLTDWGSAQQLNHQHSTTLRDNTYFTPGYQAPELQNENLISSNMKFNYF
    ......  ...  ..|.| .||. | ... |.|.||.|.||  |..||..| | ...|.  ...   . ...|  |. ||  |...   ... |. 
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLK-NNQNQQCQYKGYTHYYYPPEQYNCPEQ--EHNKNQK

I---ADIY
|    |||
INYKSDIY
Kinase 25965.AA CAMKL 39-150 27 2.2e-20 61.6 In-house 32-164 (297) Show / Hide 
Range on Protein: 39-150
Range on HMM: 32-164/297
Sequence Identity: 27% (37 aa)

IVVKKMKSDDPSTLNF-----------LTQEANCIKKLNDE-NPNIKNIIKIY--SNH--QRGNCIYIAMEYCPLGS--LEKILQQK----QKLSHYEIL
|. || ...|| ...            ...|... |.||    |||  .  ..  ..|  .  ..||. ||||. |.  |   ....    ....  |  
IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEAR

IFAKQMISALIYAHRLGLVHSDLKPENVLIREQN
 . .|..||. | |..| || |.||||.|. |..
RYFRQIVSAVNYCHSHGIVHRDIKPENILLDENG
Kinase 25965.AA TKL 19-212 17 2.8e-19 66.1 In-house 1-279 (364) Show / Hide 
Range on Protein: 19-212
Range on HMM: 1-279/364
Sequence Identity: 17% (52 aa)

IARGGFSQIFVTQCNLTK--------QPIVVKKMKS--DDPSTL-------------------------NFLTQEANCIKKLNDENPNIKNIIKIYS--N
| .|||....  ... .         ....|||.||  || .|.                          |. .|......|     .  ||....   .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRL-----RHPNIVQFMGYCC

HQRGNC-----------IYIAMEYCPLGSLEKILQQKQKLSHYEILIFAKQMISALIYAHRLG--------LVHSDLKPENVLIREQNE-----------
  ...|           ..| ||||| |||. .|.      .  .. .|... ... | |  .        ..| |||..|.|. | ..           
CPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---YVLTDWGSAQQLNHQHSTTL-----------------RDNTYFTPGYQAPELQNENLISSN--------MKFNYFIA-DIYSLGMML
     ..| | .. ...  . .                  . .   ||.. |||. ....  ..        ..| |. . |.|| |..|
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 25965.AA MELK 14-186 28 2.3e-18 59.09 In-house 2-170 (254) Show / Hide 
Range on Protein: 14-186
Range on HMM: 2-170/254
Sequence Identity: 28% (50 aa)

DKLTLIARGGFSQIFVTQCNLTKQPIVVKKM-KSDDPSTLNFLTQEANCIKKLNDENPNIKNIIKIYSNHQRGNCIYIAMEYCPLGSLEKILQQKQKLSH
.    |  |||... .    || | . .| | |    . |  .  | . .|.|       ..| ..|   .  . |.. ||||| | .   . ....|. 
EVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRH-----QHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEE

YEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQNEYVLTDWGSAQQLNHQHSTTLRDNTYFTPGYQAPEL
 |   | .|..||. | |  |  | ||||||.|. |. .  | |.|   .   .      .     | | ||||
EETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPEL
Kinase 25965.AA TyrKc 13-227 16 1.8e-08 -85.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-227
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

EDKLTLIARGGFSQIFVTQCNLTKQPIVVKKMKSDDPSTLNFLTQEANCIKKL--NDENPNIKNIIKIYSNHQRG-------NCIYIAMEYCPLGSLEKI
  ..  . .| | ...  . .   ..  ||..|.|    .  . .||.  .||  . .     ||...|     .         ..| |||.|.|.| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LQQKQK-LSHYEILIFAKQMISALIYAHRLGLVHSDLKPENVLIREQN----------EYVLTD--WGSAQQLNHQ----HST-----------TLRDNT
|. ... |.. . | |. |  .   | |. ...| ||   |.|. |..           ..  |  .| ...  ..    ..            ......
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

Y----------------FTPGYQAPE------LQNENLIS------SNMKFNY--------FIADIYSLGMMLLRCTG-----PTFREIRTIS
.                || | | ..      . |. .|         ..  .          ...|.  .|.  .       |||.||. . 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEIHECF