Gene 25269 (Tetrahymena)
25269
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 25269.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 25269.AA | CK1-Unclassified | 26-174 | 33 | 2.4e-52 | 152.79 | In-house | 1-158 (244) | Show / Hide |
Range on Protein: 26-174 Range on HMM: 1-158/244 Sequence Identity: 33% (54 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLEDEIRILKDLSNIE-------GVPKIISYGNN--SSYQYVAMTLLDKDLGFYFAFCQ .|. | .|||| ....| .. ..|||.|. |. .| .| |..|...| | . |.||.. .| . . |... |.||...| .| .|. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCN KRFSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMG--KGKDERLYVVDFGMSKAY ..||.|||||. ... |..| ..||||.||.| .|| .. ..| .||| || | RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRY |
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Kinase | 25269.AA | CK1 | 26-174 | 34 | 1.5e-46 | 158.24 | In-house | 1-159 (271) | Show / Hide |
Range on Protein: 26-174 Range on HMM: 1-159/271 Sequence Identity: 34% (56 aa) FRIMNIINSGSFGTVFQAIEKNLKME---VAVKVLKNPDKDTLMMLEDEIRILKDLSN------IEGVPKIISYGNN--SSYQYVAMTLLDKDLGFYFAF .|. |..|||| ....| ..| ||.|. || | .| .|..|.| | . .|.|... .| . . | .. |.|| ..| .| | YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF CQKRFSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGK-GKDE-RLYVVDFGMSKAY |...||.|||||. ... .| .| ..||||.||.| .|| ||.. ..|..|||..| | CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRY |
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Kinase | 25269.AA | CK1 | 26-172 | 25 | 1.3e-40 | 139.36 | In-house | 1-196 (339) | Show / Hide |
Range on Protein: 26-172 Range on HMM: 1-196/339 Sequence Identity: 25% (49 aa) FRIMNIINSGSFG-TVFQA-----IEKNLK-----MEVAVKVLKNPDKDTLMMLEDEIRILKDLSNI-------------------EGVPKIISYGNNSS ... | .|.|| ... . . .. . |.|.|| .. .. ...|..|....| | .. .. |... |. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --YQYVAMTLLDKDLGFYFA---FCQKRFSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGKGKD--------E------RLYVVDFGMSK | |. |||| ..|. ... .|...||.||.||. | .| |..||.|.||||.||.|..|| ... | ..|..||||.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMAR |
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Kinase | 25269.AA | CK1-A | 26-172 | 35 | 8.3e-33 | 113.19 | In-house | 1-146 (261) | Show / Hide |
Range on Protein: 26-172 Range on HMM: 1-146/261 Sequence Identity: 35% (52 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLEDEIRILKDLSNIEGVPKIISYGNNSSYQYVAMTLLDKDLGFYFAFCQKRFSVKTVL .|.. | ||||| .. .|. . |||.|. .| . .. | .. . |. |.|.. ||.. | . | || | | ||..||..|||| YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIY--EAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVL MLSIDLLTIMEQIHDAGYIHRDLKPENMMMGKGKD-ERLYVVDFGMSK || ... .| .| ..||||.||.| .|| |. .|...|||..| MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAK |
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Kinase | 25269.AA | CK1-D | 26-172 | 36 | 1.9e-30 | 104.54 | In-house | 1-146 (261) | Show / Hide |
Range on Protein: 26-172 Range on HMM: 1-146/261 Sequence Identity: 36% (54 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLEDEIRILKDLSNIEGVPKIISYGNNSSYQYVAMTLLDKDLGFYFAFCQKRFSVKTVL .|| | ||||| .. . . |||.|. . | |. | .. | .. |.|.| .|.. | . | || | | .|...||.|||| YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKL--ECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVL MLSIDLLTIMEQIHDAGYIHRDLKPENMMMGKGKDERL-YVVDFGMSK ||. ... .| || .||||.||.| .|| || . |..|||..| MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAK |
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Kinase | 25269.AA | CK1 | 177-254 | 42 | 4.8e-30 | 100.73 | In-house | 185-271 (271) | Show / Hide |
Range on Protein: 177-254 Range on HMM: 185-271/271 Sequence Identity: 42% (37 aa) ITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRK----EYVQNMKQTIKLEELTKG-LPSIFLEYMKYARL----QEPNYL | .| | ||||.||.|||||.|.||..|.|||||. | | ..|... .|.| || .|. | .|..|.| ..|.| INTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 25269.AA | TTBKL | 26-172 | 28 | 8e-30 | 97.91 | In-house | 1-157 (288) | Show / Hide |
Range on Protein: 26-172 Range on HMM: 1-157/288 Sequence Identity: 28% (45 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVL-KNP-DKDTLMMLEDEIRILKDLS--NIEGVPKIISYGNNSSYQYVAMTLLDKDLG-FYFAFCQKR-F ..| .| .| ||.|.... .. | ..|... || .... | . |. .|. |. . .||.. .|.. .|....|||. ..|. . ..|. | WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKM-EVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRF SVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGKGKD-----ERLYVVDFGMSK |. |.. ..| .| . |.||.|.||||.|| |...| .. ..|..||||.. SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMAR |
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Kinase | 25269.AA | CK1-Unclassified | 177-232 | 55 | 7.9e-29 | 82.22 | In-house | 185-244 (244) | Show / Hide |
Range on Protein: 177-232 Range on HMM: 185-244/244 Sequence Identity: 55% (33 aa) ITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRK----EYVQNMKQTIKLEELT | || | ||||.||||||||.||||.||.||||.| | | .||... .|.| INAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 25269.AA | CK1-G | 26-174 | 33 | 5.9e-25 | 81.45 | In-house | 1-151 (266) | Show / Hide |
Range on Protein: 26-174 Range on HMM: 1-151/266 Sequence Identity: 33% (52 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLEDEIRILKDLSNI-EGVPKIISYGNNSSYQYVAMTLLDKDLGFYFAFCQKRFSVKTV .|. | |.|| .| ||. . | . | | | || | | |. ||.|.. .| | | || | | .| .|||||| YRVGKKIGCGNFGELFEG--KNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTV LMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGK---GKDERLYVVDFGMSKAY .|..| ... ||..|. | || ||.| . |. ... ....|||| | | CMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQY |
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Kinase | 25269.AA | CK1-D | 174-256 | 45 | 9.8e-25 | 84.09 | In-house | 171-261 (261) | Show / Hide |
Range on Protein: 174-256 Range on HMM: 171-261/261 Sequence Identity: 45% (41 aa) YCAITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRK----EYVQNMKQTIKLEELTKGLPSIFLEYMKYARL----QEPNYLVQ | .| |.| ||||.||||||||.|.||..| |||||. . | | . . | .|...| ||.|| | .|| |.| . |.|. YASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 25269.AA | CK1 | 174-256 | 32 | 1.1e-23 | 79.57 | In-house | 237-339 (339) | Show / Hide |
Range on Protein: 174-256 Range on HMM: 237-339/339 Sequence Identity: 32% (34 aa) YCAITAHHGNEQSRKDDLESLGYILIYFAKGK--LPWQGINSTRK----EYVQNMKQTIKLEELTKG------------LPSIFLEYMKYARLQ----EP || | .| | ||.|.|||.|..| ||.. ||. ||||.... | . |. ||. .. | . . .|. | ..||| | . .| YCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRP NYLVQ .| DYEMI |
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Kinase | 25269.AA | Worm6 | 26-172 | 28 | 3e-22 | 76.78 | In-house | 1-160 (279) | Show / Hide |
Range on Protein: 26-172 Range on HMM: 1-160/279 Sequence Identity: 28% (46 aa) FRIMNIINSGSFGTVFQAIEKNLKM--EVAVKVLKNPDKDTLMMLEDEIRILKDLSNIE--GVPKIISYGNNSS--YQYVAMTLLDKDLGFYFAFC-QKR . . | .|.||.|... .| | ..|.|. | . || |. .|| . .. ...||. .|. . . |. |||. |.|. . ... ... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGK------GKDERLYVVDFGMSK ||. | | ..| | |. | .|.||||.|| | | .. ..| .||||.. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCR |
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Kinase | 25269.AA | CK1-A | 174-247 | 47 | 3.2e-22 | 75.19 | In-house | 171-248 (261) | Show / Hide |
Range on Protein: 174-247 Range on HMM: 171-248/261 Sequence Identity: 47% (37 aa) YCAITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRK----EYVQNMKQTIKLEELTKGLPSIFLEYMKYAR | .| || | ||||.||.||.||...|| .|||||||. | | . | .. .|.| || |. | ||.|.| YASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCR |
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Kinase | 25269.AA | CK1-G | 177-247 | 38 | 2.9e-18 | 58.41 | In-house | 177-253 (266) | Show / Hide |
Range on Protein: 177-247 Range on HMM: 177-253/266 Sequence Identity: 38% (30 aa) ITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGI----NSTRKEYVQNMKQTIKLEELTKG--LPSIFLEYMKYAR | | | |||| ||.|.|| . .|| |.||||| | | . . . |. . | | .. .| | |..|.| INTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVR |
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Kinase | 25269.AA | TTBK | 26-170 | 29 | 7.1e-16 | 52.62 | In-house | 1-147 (257) | Show / Hide |
Range on Protein: 26-170 Range on HMM: 1-147/257 Sequence Identity: 29% (44 aa) FRIMNIINSGSFGTVFQAIEKNLK-MEVAVKVLKNPDKDTLMMLEDEIRILKDLSNIEGVPKIISYGNNSSYQYVAMTLLDKDLG-FYFAFCQKRFSVKT ... | | || ...| . . .||.|| . . . . |. .|| | . | . | | | . |. |.|. | | . . ||. | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKM--EVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST VLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGK--GKDERLYVVDFGM | | . .| .|.||. |. ||| || | ||. . . | .|||. TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGL |
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Kinase | 25269.AA | S_TKc | 26-261 | 19 | 2.9e-15 | 47.02 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-261 Range on HMM: 1-231/231 Sequence Identity: 19% (52 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLEDEIRILKDLSNIEGVPKIISYGNNSSYQYVAMTLLDK---DLGFYFAFCQKR---- ..|...| .|.||.|.....|. . .||.|..| ... ||.||| . . . |.. . . .. |. | ..| || | .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -FSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGKGKDERLYVVDFGMSKAYCAITAHHGNEQ--------------SR-KDDLESLGYILIYFA |. .. . .. .| .|. | ||||||||| .. . .. . |||... . . . .. | | |.| ||. .. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEML KGKLPWQGINSTRKEYVQNMKQTIKLEELTKGLPSIFLEYMKYARLQEPNYLV-----QKHDEV |. |.. . .. .... . | . . |.. |. | .| . CGYPPFP----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 25269.AA | VRK | 83-175 | 31 | 2.2e-14 | 42.91 | In-house | 86-184 (284) | Show / Hide |
Range on Protein: 83-175 Range on HMM: 86-184/284 Sequence Identity: 31% (31 aa) GVPKIISYG----NNSSYQYVAMTLLDKDLGFYFA-FCQKRFSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGK-GKDERLYVVDFGMSKAYC |.|... | | .| . | .. || . .||| |||| |.. .| . | .|. .| | |.| .| . |. . .. | ||.| . || GIPYCWGFGYHDFNGEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYC |
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Kinase | 25269.AA | TTBKL | 174-245 | 35 | 6.9e-13 | 39.92 | In-house | 195-269 (288) | Show / Hide |
Range on Protein: 174-245 Range on HMM: 195-269/288 Sequence Identity: 35% (28 aa) YCAITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRKEYVQNMKQTIKLEELTKG------LPSIFLEYMKY || . .| . ||.|.||| |. |..|....| |||..... |. . ||. |.| | |. .|| |.. ||. YCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMED--KMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKH |
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Kinase | 25269.AA | TTBK | 174-256 | 34 | 8.2e-13 | 41.65 | In-house | 173-257 (257) | Show / Hide |
Range on Protein: 174-256 Range on HMM: 173-257/257 Sequence Identity: 34% (30 aa) YCAITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRKEYVQNMKQTIKLEELTKGLPSIFLEYMKYAR----LQEPNYLVQ | .|.|| | |.||| || |.|. |..| ||| | |. | .||. . | | .|. | .|. . |.| . YASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIKD--KDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 25269.AA | Worm6 | 174-224 | 31 | 5.2e-11 | 36.05 | In-house | 187-237 (279) | Show / Hide |
Range on Protein: 174-224 Range on HMM: 187-237/279 Sequence Identity: 31% (16 aa) YCAITAHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINSTRKEYVQNMKQ |... .| | ||.||||.|| | .. . .|.|||.... . . .. ... YAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWC |
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Kinase | 25269.AA | VRK | 179-224 | 42 | 2e-08 | 23.59 | In-house | 211-257 (284) | Show / Hide |
Range on Protein: 179-224 Range on HMM: 211-257/284 Sequence Identity: 42% (20 aa) AHHGNEQSRKDDLESLGYILIYFAKGKLPWQGINS-TRKEYVQNMKQ || |. || |||.||| ... . |.||| |.|| || AHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQ |
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Kinase | 25269.AA | TyrKc | 26-235 | 15 | 2.9e-08 | -89.07 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 26-235 Range on HMM: 1-280/280 Sequence Identity: 15% (44 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLEDEIRILKDL-SNIEGVPKIISYGNNS-------SYQYVAMTLLDK-DLGFYFAFCQ . .. .| ||.|.... | ..||||.||. .... .|.||.. | . . . ... . . .. | . .. || | .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR KRFSVKTVLMLSIDLLTIMEQIHDAGYIHRDLKPENMMMGKGKDERLYVVDFGMSKAYCAI-------TAHHGNEQSRKDD--------LESL-GY---- .....|. | ... || .|. ..||||| | . |... . . |||.|.. . | . ... .|.. . PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT --------ILIY--FAKGKLPWQG-----INSTR-KEYVQNMKQTIKLEE---------------------------------LTKGL .... | |. |. | .. .. |||.. . . .. . . . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 25269.AA | Pkinase_Tyr | 26-80 | 25 | 6.5e-08 | 27.42 | Pfam | 1-63 (270) | Show / Hide |
Range on Protein: 26-80 Range on HMM: 1-63/270 Sequence Identity: 25% (16 aa) FRIMNIINSGSFGTVFQAIEK----NLKMEVAVKVL--KNPDKD--TLMMLEDEIRILKDL-SN ... . .|.||.|.... | | |..||||.| . ... .... |..|.| | .. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHH |
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Kinase | 25269.AA | Pkinase | 26-79 | 32 | 4.8e-07 | 25.99 | Pfam | 1-58 (293) | Show / Hide |
Range on Protein: 26-79 Range on HMM: 1-58/293 Sequence Identity: 32% (19 aa) FRIMNIINSGSFGTVFQAIEKNLKMEVAVKVLKNPDKDTLMMLED----EIRILKDLS ..| .| |||||.|.....|. .||||..| .... . .. ||.|.| |. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN |
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Kinase | 25269.AA | Pkinase | 138-172 | 39 | 8.2e-05 | 18.1 | Pfam | 124-160 (293) | Show / Hide |
Range on Protein: 138-172 Range on HMM: 124-160/293 Sequence Identity: 39% (15 aa) IHDAGYIHRDLKPENMMMGKGKDER---LYVVDFGMSK .|. | ||||||||| .. ... . . ||| .| CHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAK |
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Kinase | 25269.AA | Pkinase | 181-230 | 22 | 0.000625 | 14.98 | Pfam | 185-237 (293) | Show / Hide |
Range on Protein: 181-230 Range on HMM: 185-237/293 Sequence Identity: 22% (12 aa) HGNEQSRKDDLESLGYILIYFAKGKLPWQGI----NSTRKEYVQNMKQTIKLEE .|.. ..| | |.| ||.... |..|..| | .. .. ... .|.. GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHF |