Gene 24856 (Tetrahymena)
24856
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 24856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24856.AA | TKL | 1104-1288 | 19 | 3.1e-26 | 91.48 | In-house | 119-364 (364) | Show / Hide |
Range on Protein: 1104-1288
Range on HMM: 119-364/364
Sequence Identity: 19% (49 aa)
FYSMGS-YAYYHNSIMSLNKRVQMVLQVAQGVKFLQSID--------IYHLDLKPPNILLDGEQN--------------IKICDFGESYCIQNIGEQG--
... || . |.| ...|....|..|.|. .| | . | | |||..|||.| . .|||||| | .... |..
YCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT
---------------VFQRAGRTLPYSPIESLSGN----------------TFSPASDVYSIGAIISEIIFDKKLIE-FKRINQQ---------KLQSKL
. . |. . . | | |. ..|...|||| | .. ||. .. . .. . .. .. ..
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDK
NQRNYRL-----IYSDLVVKEFGIKQIMKILKVLMLKCVNPDPNCRPHIEYLIAIL
..| . . . ..... .| || .| ..||. || . .. .|
GLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 24856.AA | TKL-Unique | 1118-1217 | 32 | 4.6e-19 | 64.0 | In-house | 107-222 (290) | Show / Hide |
Range on Protein: 1118-1217 Range on HMM: 107-222/290 Sequence Identity: 32% (38 aa) MSLNKRVQMVLQVAQGVKFLQSID--IYHLDLKPPNILLDGE-----QNIKICDFGESYCIQNIGEQGVF--------QRAGRTLPYSPIESLSG--NTF .....||.|....||| .| . . |.|.|||..|.|.| . |||||||| | .| . . | | .. ... | |.. ... LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFR-WMAPEVLRMNFCQY SPASDVYSIGAIISEII | ||||| |.. ||. SEKSDVYSFGIVLWEIA |
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| Pkinase | 24856.AA | Pkinase | 1017-1220 | 23 | 1.3e-17 | 63.39 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 1017-1220 Range on HMM: 1-209/293 Sequence Identity: 23% (52 aa) EKKLKKISAGGFSDIFQTELNFISKSTEQTSCQNFAIKVQKKDPQARDTEKIEK----EVNVIKHIVPRSNFITRYYFDVETKDRLYMDLYFYSMG---- ....|| .|.|. | ... ... .|.|. ||. ... ..... |. . |.. .. .| |.| .|.||..|| . . .| YHIGRKIGSGSFGCV--------YKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL--NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM SYA---Y--YHNSI-MSLNKRVQMVLQVAQGVKFLQSIDIYHLDLKPPNILLDGEQNI----KICDFGESYCIQNIGEQGVFQRAGRTLPYSPIESLS-G . . .|... .| . ...|...|.... | | | |||| |||.| . .| |||||| . ... . .. .. |..| . | . | DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGG NTFSPASDVYSIGAIISEIIFDK . .|..|..|.| |. | .. . QYYGPKVDMWSCGCILYEMLCGR |
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| S_TKc | 24856.AA | S_TKc | 1017-1290 | 19 | 3.7e-16 | 60.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1017-1290 Range on HMM: 1-231/231 Sequence Identity: 19% (58 aa) EKKLKKISAGGFSDIFQTELNFISKSTEQTSCQNFAIKVQKKDPQARDTEKIEKEVNVIKHIVPRSNFITRYYFDVETKDRLYMDLYFYSM---GSYAYY ..|.|| |.|. .. . . . .|||. | |.|..|... |. . .| ..| .. |.||| . . . . | YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK--------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI HNSI-------MSLNKRVQMVLQVAQGVKFLQSIDIYHLDLKPPNILLDGEQNIKICDFGESYCIQNIGEQGVFQRAGRTLPYSPIESLSGNTFSP-ASD .. .. .. |........ | | | |||| ||||| .||||||| . . |. | . | | ... ..| KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCD VYSIGAIISEIIFDKKLIEFKRINQQKLQSKLNQRNYRLIYSDLVVKEFGIKQIMKILKVLMLKCVNPDPNCRPHIEYLIA-------ILYL ..|.| |. | . . . . ..|.. |. . .| .. || . ||. || . . . .. WWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 24856.AA | Ciliate-E3 | 1142-1217 | 38 | 4.2e-16 | 46.96 | In-house | 124-202 (202) | Show / Hide |
Range on Protein: 1142-1217 Range on HMM: 124-202/202 Sequence Identity: 38% (31 aa) IYHLDLKPPNILLDGEQN---IKICDFGESYCIQNIGEQGVFQRA--GRTLPYSPIESLSGNTFSPASDVYSIGAIISEII | | |.|| |||.| ..| ||||||||| .. . | . | | |.. | . . .| || ||.||.. ... IIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRK--NKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | 24856.AA | Ciliate-B2 | 1121-1210 | 32 | 1.5e-14 | 30.52 | In-house | 104-197 (197) | Show / Hide |
Range on Protein: 1121-1210 Range on HMM: 104-197/197 Sequence Identity: 32% (32 aa) NKRVQMVLQVAQGVKFLQSIDIYHLDLKPPNILLDGEQNIKICDFGESYCIQNIGEQGVFQRAGRTLPYSPIESLSGN---TFSPA----SDVYSIG .| .||. | | . . .| |||.|| |||. . | . |||| | .| . .. . | | | . | . ||.. ||.||.| QKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS-SIKK--DNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 24856.AA | RIPK | 1126-1166 | 44 | 1.6e-14 | 45.86 | In-house | 112-154 (290) | Show / Hide |
Range on Protein: 1126-1166 Range on HMM: 112-154/290 Sequence Identity: 44% (19 aa) MVLQVAQGVKFLQSID--IYHLDLKPPNILLDGEQNIKICDFG |. ... |. .| |.. | |.|||| |||.|.. ..|| ||| MIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFG |
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| Kinase | 24856.AA | DAPK | 1124-1166 | 44 | 3.9e-14 | 35.03 | In-house | 106-152 (264) | Show / Hide |
Range on Protein: 1124-1166 Range on HMM: 106-152/264 Sequence Identity: 44% (21 aa) VQMVLQVAQGVKFLQSIDIYHLDLKPPNILLDG--EQN--IKICDFG .. . |. .||..| | .| |||||| ||.| . .. |||.||| TRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFG |
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| Kinase | 24856.AA | CAMK | 1129-1168 | 36 | 3.9e-14 | 41.24 | In-house | 187-243 (425) | Show / Hide |
Range on Protein: 1129-1168 Range on HMM: 187-243/425 Sequence Identity: 36% (21 aa) QVAQGVKFLQSIDIYHLDLKPPNILLDGEQ-----------------NIKICDFGES |....|... | .| |.|||| ||||| ||||.||| . QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 24856.AA | DRAK | 1129-1173 | 54 | 3e-13 | 36.94 | In-house | 107-154 (259) | Show / Hide |
Range on Protein: 1129-1173 Range on HMM: 107-154/259 Sequence Identity: 54% (26 aa) QVAQGVKFLQSIDIYHLDLKPPNILLDGEQ---NIKICDFGESYCIQN |. .||..| . .| |||||| |||| .|. ||||||| | |.| QILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICN |
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| Kinase | 24856.AA | TK | 1115-1208 | 15 | 2.1e-12 | 37.16 | In-house | 229-379 (486) | Show / Hide |
Range on Protein: 1115-1208
Range on HMM: 229-379/486
Sequence Identity: 15% (24 aa)
NSIMSLNKRVQMVLQVAQGVKFLQSIDI------YHLDLKPPNILLDGEQN-----------IKICDFG--------ESYCIQNIGEQGVFQ--------
...... .. | .|.|.| .| | . | || |.|.. . . .||.||| . |.. .. . .
KHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM
----------------RAGRTLPYSPIESLSGNT---------FSPASDVYS
.. . . . |.| ... |...|||.|
WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWS
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| Kinase | 24856.AA | MLK | 1117-1217 | 28 | 8.1e-12 | 37.41 | In-house | 120-230 (291) | Show / Hide |
Range on Protein: 1117-1217 Range on HMM: 120-230/291 Sequence Identity: 28% (32 aa) IMSLNKRVQMVLQVAQGVKFLQSID---IYHLDLKPPNILLD------GEQNIKICDFGESYCIQNIGEQGVFQRAGRTLPYSPIESL---SGNTFSPAS .... .. ||.|.|. .| | . | | |||..|||.| .. . ||||||.| ..... . . .|| |. . | . ....| .. VYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAG-TYAWMAPEVIQQFRCEKYSEKC DVYSIGAIISEII ||.|.| .. |.. DVWSWGVVLWEML |
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| TyrKc | 24856.AA | TyrKc | 1017-1288 | 18 | 4.1e-11 | -43.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1017-1288 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) EKKLKKISAGGFSDIFQTELNFISKSTEQTSCQNFAIKVQKKDPQARDTEKIEKEVNVIKHIVPRSNFITRYYFDVETK-------DRLYMDLYFYSMGS ...||. | | ... ... .. |.|. |.| | . .| .. ... .. | | | . .. . |.. . . . |. ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD ---YAYYHNSIMSLNKRVQMVLQVAQGVKFLQSIDIYHLDLKPPNILLDGEQNIKICDFGESYCIQNI------GEQGVFQR--AGRT-LPY--SPIESL | .| .. . ... .|.|.| .| | . | || |.|.. .. .||.||| | | . .. . . |.| ||. ..|.. LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI SGNTFSPASDVYSIGA----IISEIIFDKKLIEFKRINQQKLQSKLNQRNYRLIYSDLVVKEFGIKQIM------KILKVLMLKCVNPDPNCRPHIEYLI ..|...|||.| | | . .... .. | . .. |.... . . | . . .|..| . ||..|| . .. NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-------P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH AIL .. ECF |
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| Kinase | 24856.AA | TK | 1260-1288 | 25 | 0.000158 | 10.25 | In-house | 447-486 (486) | Show / Hide |
Range on Protein: 1260-1288 Range on HMM: 447-486/486 Sequence Identity: 25% (10 aa) M-----------KILKVLMLKCVNPDPNCRPHIEYLIAIL | ... ||..| ..||. || . | | MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | 24856.AA | MLK | 1261-1288 | 35 | 0.001468 | 8.37 | In-house | 264-291 (291) | Show / Hide |
Range on Protein: 1261-1288 Range on HMM: 264-291/291 Sequence Identity: 35% (10 aa) KILKVLMLKCVNPDPNCRPHIEYLIAIL ...| || .| |.||. || . . .| EHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 24856.AA | Pkinase_Tyr | 1263-1288 | 30 | 0.004014 | 11.2 | Pfam | 245-270 (270) | Show / Hide |
Range on Protein: 1263-1288 Range on HMM: 245-270/270 Sequence Identity: 30% (8 aa) LKVLMLKCVNPDPNCRPHIEYLIAIL . ||..| ..||. || .... .| IYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 24856.AA | Pkinase_Tyr | 1119-1166 | 37 | 0.088517 | 6.65 | Pfam | 109-156 (270) | Show / Hide |
Range on Protein: 1119-1166 Range on HMM: 109-156/270 Sequence Identity: 37% (18 aa) SLNKRVQMVLQVAQGVKFLQSIDIYHLDLKPPNILLDGEQNIKICDFG .. .|| .|.|.| .| |. . | || |.|.. . .|||||| TMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG |
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| Kinase | 24856.AA | Pkinase_Tyr | 1191-1208 | 33 | 0.823169 | 3.37 | Pfam | 182-199 (270) | Show / Hide |
Range on Protein: 1191-1208 Range on HMM: 182-199/270 Sequence Identity: 33% (6 aa) PIESLSGNTFSPASDVYS . |... . |. .|||.| APECINYGKFTTKSDVWS |
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