24136

Species: Tetrahymena
Alias: TTHERM_00590210, PreTt24136, 3726.m00069, 24136, 348, 81.m00193
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
24136.AA Protein None 689 None Fasta, JSON
24136.kin_dom Protein Kinase Domain None 144 None Fasta, JSON
24136.NA RNA None 2070 None Fasta, JSON

Protein domain

Protein domains of 24136.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24136.AA CAMK 17-159 21 3.2e-33 103.87 In-house 201-425 (425) Show / Hide
Range on Protein: 17-159
Range on HMM: 201-425/425
Sequence Identity: 21% (49 aa)

IHCDLKLANIFCEKHESDD---------DGVQIRRVKIGDLGLIQKIDAEKKTA---------------------YLEETCGTFGFKA-PEAKKG-----
.|.|||. || . ....|.         |  .   .|| | |. .|.|  ..                        ... ||| .. | ||  .|     
VHRDLKPENILLDDNNDDSDPVEHDEIFD-WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------AHITQQSDMWSLGIILYFMTVAYMPHH-----------------MKGY-KYGQGPVPFREFD------------WKKRSPE--------LR
           .....||||.|.|||.| . |.|                    . . |  .|   | ..             |.. | |         .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFVQKMLSLDPSQRPTAREALQHPFL
|...|||  ||..|.|. ..|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 24136.AA Ciliate-E2 17-159 24 3.2e-31 104.41 In-house 183-365 (365) Show / Hide
Range on Protein: 17-159
Range on HMM: 183-365/365
Sequence Identity: 24% (50 aa)

IHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKK--------TAYLEET----------------------CGTFGFKAPEAKKGAH----
|| |.|. ||.               .|| |.|| .|.| . .          |..                        ||| |..|||  .|      
IHRDIKPENILF--------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

-----ITQQSDMWSLGIILYFMTVAYMPHHMKGYK-YGQGPVPFREF--------------DWKKRSPELRDFVQK----MLSLDPSQRPT-AREALQHP
      . ..|.||||.|||.|   . |     ..   |... |...              .||| |.|  |. .|    ||  ||..|.| . ..|.||
QKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

FL
..
WF

Pkinase 24136.AA Pkinase 15-159 28 5.7e-31 110.6 Pfam 128-293 (293) Show / Hide
Range on Protein: 15-159
Range on HMM: 128-293/293
Sequence Identity: 28% (50 aa)

SFIHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKKTAYLEETCGTFGFKAPEAKK-GAHITQQSDMWSLGIILYFMTVAYMPHHMK----
..||.|||..||.. ..   |.     .|||.| ||  ..| . .   .   ||| .. |||  . | .... .||||.|.||| |   . |   .    
GIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHD

-------GYKYGQGPVPFREFDWKKRS-----------------PELRDFVQKMLSLDPSQRPTAREALQHPFL
        .. ...|..| .. |  .|                 .|..||. ..| .||..||||...||||..
NHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 24136.AA CAMKL 17-159 25 1.4e-25 78.49 In-house 149-297 (297) Show / Hide
Range on Protein: 17-159
Range on HMM: 149-297/297
Sequence Identity: 25% (41 aa)

IHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDA--EKKTAYLEETCGTFGFKAPEAKKG--A-HITQQSDMWSLGIILYFMTVAYMPHH----
.| |.|. ||   .. .         .|| | |.  ...    ..   |.. ||.  . |||  .|    .. .. |.||.|.|||.| . |.|      
VHRDIKPENILLDENGNN-------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTY

------MKGYKYGQGPVPFREF-DWKKRSPELRDFVQKMLSLDPSQRPTAREALQHPFL
       . |.| .  .   ..  |.. | ..||. .|||  .|..|||. . ..||..
NKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 24136.AA STE 17-159 22 6.9e-19 63.42 In-house 174-359 (359) Show / Hide
Range on Protein: 17-159
Range on HMM: 174-359/359
Sequence Identity: 22% (46 aa)

IHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKKTAYLEE----------------TCGTFGFKAPEAKKG------AHITQQSDMWSLGI
|| |.| |||.               ||. | |.  ... .     . .                 .||  . |||  ..       . . ..|.||||.
IHRDIKPANILL--------------VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGC

ILYFMTVAYMPH---H------MKGYKYGQGP---------VPFREF-DW-----------------KKRSPELRDFVQKMLSLDPSQRPTAREALQ--H
 .  |     |.   |      |.  .|. ..          |   . |                  .| |||..||..| |  ||..|||| . |.  |
TIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEH

PFL
||.
PFI

Kinase 24136.AA ULK 17-159 21 1.5e-16 55.27 In-house 148-324 (324) Show / Hide
Range on Protein: 17-159
Range on HMM: 148-324/324
Sequence Identity: 21% (39 aa)

IHCDLKLANIFCEKH----ESDDDGVQIR-----RVKIGDLGLIQKIDA-EKKTAYLEETC------GTFGFKAPEAKK----GAHIT-QQSDMWSLGII
||.|.|..||   ..    .|       .     ..||.| |. ...|  ..    . ...      ||  . ||.  .    . . .   .|.||||.|
IHRDIKPQNILIHNGQPKTDSK------KVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCI

LYFMTVAYMP---HHMKGYK----------------YGQGPVPFREF-DWKKRSPELRDFVQKMLSLDPSQRPTAREALQHPFL
.| |   . |        ..                  . |..|.   . .|.|||..|. ..||  |...| .  | ..||..
FYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 24136.AA ULK 17-159 22 3.5e-16 53.05 In-house 152-329 (329) Show / Hide
Range on Protein: 17-159
Range on HMM: 152-329/329
Sequence Identity: 22% (42 aa)

IHCDLKLANIFCEKH----ESDDDGVQIR-----RVKIGDLGLIQKIDAE-----KKTAYL-EET--CGTFGFKAPEAKK----GAHIT-QQSDMWSLGI
||.|.|..||   ..    .|       .     ..||.| |. ...| .       .... | .  |||  . ||.  .    . . .   .|.||||.
IHRDIKPQNILIHNGQPKTDSK------KVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE-KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

ILYFMTVAYMP---HHMKGY-----KY-GQGPVP-----FREFDWKK------RSPELRDFVQKMLSLDPSQRPTAREALQHPFL
|.| | . . |     .. |     |   ..|..      . ....|      .|||..|. ..||  |...| .  | ..||..
IFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 24136.AA Ciliate-E2a 124-159 45 2.2e-14 38.76 In-house 239-275 (275) Show / Hide
Range on Protein: 124-159
Range on HMM: 239-275/275
Sequence Identity: 45% (17 aa)

D-WKKRSPELRDFVQKMLSLDPSQRPTAREALQHPFL
. |.| | |  |...|||  ||..|.|| .||.||. 
ECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 24136.AA Ciliate-E2-Unclassified 16-99 25 7.9e-14 44.37 In-house 165-263 (352) Show / Hide
Range on Protein: 16-99
Range on HMM: 165-263/352
Sequence Identity: 25% (27 aa)

FIHCDLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKK-------------TAYLEETCGTFGFK----APEAKKGAHITQQ----SDMWSLGI
.|| |.|. ||.  .  .        ..|| |.|.. |..   .                .  .||| ...    |||  .| .  ..    .|.||||.
IIHRDIKPENILFDNNGK------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGV

ILYFM
|||.|
ILYEM

Kinase 24136.AA Ciliate-E2-Unclassified 115-159 35 1.4e-13 43.46 In-house 300-352 (352) Show / Hide
Range on Protein: 115-159
Range on HMM: 300-352/352
Sequence Identity: 35% (19 aa)

QGPVPFREFDW----KKRSPELRDFVQ----KMLSLDPSQRPTAREALQHPFL
|... |..|.|    |. |||  ||..    |||  .|..|.|. ..|.||..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 24136.AA CAMK-Unique 17-105 26 8.9e-12 34.95 In-house 179-292 (363) Show / Hide
Range on Protein: 17-105
Range on HMM: 179-292/363
Sequence Identity: 26% (30 aa)

IHCDLKLANIFCEKHESD-------DDGVQIRRVKIGDLGLIQKIDAEKKTAYLEETCGTFGFKAP--------------EAKKGAHITQQS----DMWS
.| |||| ||   . . |       .      ..|. | ||  ...  |. . . ..|||  ..||              |  ..  . ||.    | ||
VHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWS

LGIILYFMTVAYMP
|| |.|.| . ..|
LGVIMYYMLCGCPP

Kinase 24136.AA PLK 129-159 51 1.3e-11 34.18 In-house 228-258 (258) Show / Hide
Range on Protein: 129-159
Range on HMM: 228-258/258
Sequence Identity: 51% (16 aa)

SPELRDFVQKMLSLDPSQRPTAREALQHPFL
|.|..|..||||. .|..|||. . |||||.
SDEAKDLIQKMLNWNPDERPTIDQILQHPFF

Kinase 24136.AA Ciliate-E2a 17-99 32 2.9e-11 29.43 In-house 124-209 (275) Show / Hide
Range on Protein: 17-99
Range on HMM: 124-209/275
Sequence Identity: 32% (30 aa)

IHCDLKLANIFCE--KHESDDDGVQIRRVKIGDLGLIQKI--DAEKKTAYLEETCGTFGFKAPEAKKGAHI------TQQSDMWSLGIILYFM
.| |||. ||. .  . .|.    |   .|| | || ..|  |   .  |.   ||| |. |||  .  ..      ... ||||.|.|.|..
MHRDLKPENILFKNCSKNSI----QNSDIKIIDFGLATFIDKD---EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYIL

Kinase 24136.AA CAMK-Unique 129-159 38 9.4e-10 28.17 In-house 333-363 (363) Show / Hide
Range on Protein: 129-159
Range on HMM: 333-363/363
Sequence Identity: 38% (12 aa)

SPELRDFVQKMLSLDPSQRPTAREALQHPFL
|.|. |||.. . .||..| .| |.|.|...
SQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

S_TKc 24136.AA S_TKc 1-159 19 9.6e-10 -33.99 SMART 19-231 (231) Show / Hide
Range on Protein: 1-159
Range on HMM: 19-231/231
Sequence Identity: 19% (49 aa)

MDRQ----------------------------------------------IDS------QFVSQMDS-----------------------------FIHC
 ..                                               .|       ..  .. .                             .||.
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR

DLKLANIFCEKHESDDDGVQIRRVKIGDLGLIQKIDAEKKTAYLEETCGTFGFKAPEAKKGAHITQ-QSDMWSLGIILYFMTVAYMPHHMKGYKYGQGPV
||| .||.. .           ..||.| ||  ..            |||  . |||     . .   .|.||.|.||| | . | | .           
DLKPENILLDE-----------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----------Q

PFREFDWKKRSPELRDFVQKMLSLDPSQRPTAREALQ-------HPFL
... |.  . |||..||..|.|  ||..|||| ||||       ||..
MQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 24136.AA PLK 17-97 37 7e-06 15.27 In-house 122-193 (258) Show / Hide
Range on Protein: 17-97
Range on HMM: 122-193/258
Sequence Identity: 37% (33 aa)

IHCDLKLANIFC-EKHESDDDGVQIRRVKIGDLGLIQKIDAE---KKTAYLEETCGTFGFKAPEA---KKGAHITQQSDMWSLGIILY
|| ||||.|.|  ....          ||||| ||  ... .   |||      |||  . |||    .|  |   ..|.||||.|.|
IHRDLKLGNLFLNDNMH----------VKIGDFGLATRLEYDGERKKTM-----CGTPNYIAPEVLDGNKQGH-SYEVDCWSLGCIMY