23775

Species: Tetrahymena
Alias: TTHERM_00660310, 3736.m00019, 23775, 98.m00118, 323, PreTt23775
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
23775.AA Protein None 1181 None Fasta, JSON
23775.kin_dom Protein Kinase Domain None 99 None Fasta, JSON
23775.NA RNA None 3546 None Fasta, JSON

Protein domain

Protein domains of 23775.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23775.AA Ciliate-B2 217-308 34 3.9e-18 39.16 In-house 108-197 (197) Show / Hide
Range on Protein: 217-308
Range on HMM: 108-197/197
Sequence Identity: 34% (34 aa)

KIISNVLECLFIMHIQGIAHLDVKPQNILFVDELNRYTLADFGCSLELNSIDFENYQLATEEIVGFTPQYTDPNILEKE------FFNPFKADIWSVG
..| . .. |  ...  | |||.|||||||  . . | . ||| |    ||  .| |    .| ||| .|  |  .|.           |..||.| |
QMIFQLIDGLIQFRMYNILHLDIKPQNILFMQN-GNYVYCDFGIS----SIKKDNQQI---KIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG

Kinase 23775.AA CAMK 229-311 21 1.7e-15 45.73 In-house 195-324 (425) Show / Hide
Range on Protein: 229-311
Range on HMM: 195-324/425
Sequence Identity: 21% (28 aa)

MHIQGIAHLDVKPQNILFVDEL----------------NRYTLADFGCSLELNSIDFEN------------------YQLATEEIVGFTPQYTD-PNILE
.| ..|.|.| || |||..|                  |   ..||| . .... . ..                  .    .. .| || |   | .|.
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG-TPEYMAAPEVLN

K-------------EFFNPFKADIWSVGVIL
.             .   ..|.|.||.||||
GKGHCNMQNATDEEKPYYGPKCDMWSCGVIL

Kinase 23775.AA Ciliate-E1 204-305 25 2.3e-13 40.27 In-house 100-202 (202) Show / Hide
Range on Protein: 204-305
Range on HMM: 100-202/202
Sequence Identity: 25% (27 aa)

KKNKKPYFIYEINKIISNVLECLFIMHIQGIAHLDVKPQNILFVDELNRYTLADFGCSLELNSIDFENY-QLATEEIVGFTPQYTDPNILEKEFFNPF--
..|.. . . .. .|| . .. | ..|...| |.| ||||||. .. ..| ..|||.|. |.. . ... .    . .  ..||..|.  | .  ..   
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINY

KADIW
| || 
KSDIY

Kinase 23775.AA Ciliate-E2 204-316 24 1.8e-12 39.14 In-house 126-291 (365) Show / Hide
Range on Protein: 204-316
Range on HMM: 126-291/365
Sequence Identity: 24% (42 aa)

KKNKKPYF----------IYEINKIISNVLE---------------CLFIMHIQG-IAHLDVKPQNILFVDELNRYTLADFGCSLELN-----------S
|.|||  .          ..|| .|.  .|.               .|  .| .. | | | ||.||||        ..||| | ...           .
KNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQC

IDFENYQLATEEIVG---------------FTPQYTDPNILEKEFF--------NPFKADIWSVGVILLELLS
  . . .  |.   |                || |  | ||...            .|.||||.|||| |.|.
KWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

Kinase 23775.AA S_TKc 62-395 15 2e-12 5.36 SMART 1-231 (231) Show / Hide
Range on Protein: 62-395
Range on HMM: 1-231/231
Sequence Identity: 15% (54 aa)

YANFEFIAAGGFGLVFKAKKKVNNNKPNKIYEERELAKYIAFKFMLNDLNAKREIAIMKKLFQMSTKLLMARNIQVFRRYEIVTKENGTNQNACRIINSD
|   . |  |.|| |.|...|                .. | | .                                           . ..  .|  . 
YEILRKIGKGAFGKVYKCRHKK-------------TGRIVAIKIIK-----------------------------------------EHIRREIQILKK-

SFFENSPKLVQSASEGTKDKIPYVMVEMSKATF---SVDAAISYRKKNKKP--YFIYEINKIISNVLECLFIMHIQGIAHLDVKPQNILFVDELNRYTLA
    . | .|.           .. . |  .     ..   |  |......  .   .. ...  ... |  .| .|| | |.||.|||. .   .  ..
----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKIC

DFGCSLELNSIDFENYQLATEEIVGFTPQYTDPNILEKEFFNPFKADIWSVGVILLELLS----VGQDFDLVQILKTCKSSQDVEEKIFKKYIFNSNGEM
||| . .|               .  || |  | .|    ....|.|.||.|.|| |.|.         .. ...| ..                     
DFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------

IYCPMLKNFVEIDNQLKMYLQWDENQRWNIIEILI---EIQNSILV
          |  . ..  ||.| ..|. . |.|    .| .   .
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 23775.AA Ciliate-C6 214-269 38 3e-12 39.74 In-house 136-192 (306) Show / Hide
Range on Protein: 214-269
Range on HMM: 136-192/306
Sequence Identity: 38% (22 aa)

EINKIISNVLECLFIMHI-QGIAHLDVKPQNILFVDELNRYTLADFGCSLELNSIDF
|| .. . . . | .... ..||| | ||.|||. |. | | | ||||. .|.  .|
EIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEF

Kinase 23775.AA Ciliate-E2-Unclassified 213-315 28 7.6e-12 37.4 In-house 138-264 (352) Show / Hide
Range on Protein: 213-315
Range on HMM: 138-264/352
Sequence Identity: 28% (36 aa)

YEIN-----KIISNVLECLFIMHIQG-IAHLDVKPQNILFVDELN--RYTLADFGCSL---ELNSIDFENY-----QLATEEIVGF--TPQYT----DPN
...      ...  .|..|  .| .. | | | ||.|||| .. .  .  ..||| |    . | .| .|      ..  ...  |  ||.|      | 
QQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE

ILEKEFFNP---FKADIWSVGVILLELL
.|...  .    .|.||||.|||| |.|
VLQGQNYDHSKAYKCDIWSLGVILYEML

Kinase 23775.AA ULK 229-315 31 9.4e-12 38.04 In-house 142-246 (324) Show / Hide
Range on Protein: 229-315
Range on HMM: 142-246/324
Sequence Identity: 31% (33 aa)

MHIQGIAHLDVKPQNILFVDEL-----------NRYTLADFGCSLELNSIDFENYQLATEE----IVGFTPQYTDPNILE----KEFFNPFKADIWSVGV
.| ..| | | ||||||  .             ... .|||| .  ... ..|  .. |      |.| || |  | ||.    .. .. .|.||||.|.
LHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

ILLELL
|. |.|
IFYEML

Kinase 23775.AA ULK 229-315 30 1.4e-11 36.79 In-house 146-250 (329) Show / Hide
Range on Protein: 229-315
Range on HMM: 146-250/329
Sequence Identity: 30% (32 aa)

MHIQGIAHLDVKPQNILFVDEL-----------NRYTLADFGCSLELNSIDFENYQLATEE----IVGFTPQYTDPNILE----KEFFNPFKADIWSVGV
.| ..| | | ||||||  .             ... .|||| .  ...  .|. .. |      . | || |  | ||.    .. .. .|.||||.|.
LHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

ILLELL
|. |.|
IFYEML

Kinase 23775.AA Pkinase 229-316 30 7.6e-11 39.42 Pfam 124-207 (293) Show / Hide
Range on Protein: 229-316
Range on HMM: 124-207/293
Sequence Identity: 30% (28 aa)

MHIQGIAHLDVKPQNILFVDELNR---YTLADFGCSLELNSIDFENYQLATEEIVGFTPQYTDPNILEKEFFNPFKADIWSVGVILLELLS
.| .|| | |.||.|||.... .      ..|||..  ..     |..  .  ..| || |  | .. .    . |.|.||.|.|| |.|.
CHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS--MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC

Kinase 23775.AA MLCK 229-248 55 2.2e-10 23.06 In-house 113-132 (257) Show / Hide
Range on Protein: 229-248
Range on HMM: 113-132/257
Sequence Identity: 55% (11 aa)

MHIQGIAHLDVKPQNILFVD
|| |.|.|||.||.||....
MHWQNIVHLDLKPENIMCQT

Kinase 23775.AA STE 214-315 25 1.5e-09 30.02 In-house 152-262 (359) Show / Hide
Range on Protein: 214-315
Range on HMM: 152-262/359
Sequence Identity: 25% (31 aa)

EINKIISNVLEC-LFIMHIQGIAHLDVKPQNILFVDELNRYTLADFGCSLELNS-------------IDFENYQLATEEIVGFTPQYTDPNILEKEFFNP
.| .|.  .|.  |   | ..| | |.||.|||.        |.|||..  |..             |  |. |  .  .||    .  | .....  . 
QIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCI--ETMQQKRNTFVGTP--WMAPEVIQQNGQG-

F------KADIWSVGVILLELL
       |.||||.|  ..|..
RDKGYDTKCDIWSLGCTIIEMA

Kinase 23775.AA Ciliate-B2 62-128 27 6.1e-08 14.66 In-house 1-61 (197) Show / Hide
Range on Protein: 62-128
Range on HMM: 1-61/197
Sequence Identity: 27% (19 aa)

YANFEFIAAGGFGLVFKAKKKVNNNKPNKIYEERELAKYIAFK-FMLNDLNAKREIAIMKKLFQMSTK
|   ..|. ||.|....  ||      . | | ..||  | |.    .  ..  || || |.|... .
YYLCKYINKGGCGFICEGYKK------HSIREYQDLAFKIYFNKQDCDKEEIQHEIKIM-KMFEYNIN

Kinase 23775.AA Ciliate-E1 68-87 50 0.000773 8.92 In-house 1-20 (202) Show / Hide
Range on Protein: 68-87
Range on HMM: 1-20/202
Sequence Identity: 50% (10 aa)

IAAGGFGLVFKAKKKVNNNK
|..|.|..|||||.. ||..
IGNGSFSIVFKAKQQNNNYN

Kinase 23775.AA MLCK 300-310 72 0.004052 3.5 In-house 178-188 (257) Show / Hide
Range on Protein: 300-310
Range on HMM: 178-188/257
Sequence Identity: 72% (8 aa)

FKADIWSVGVI
|. |.||||||
FQTDMWSVGVI

Kinase 23775.AA STE 62-122 22 0.00572 6.47 In-house 1-85 (359) Show / Hide
Range on Protein: 62-122
Range on HMM: 1-85/359
Sequence Identity: 22% (19 aa)

YANFEFIAAGGFGLVFKAKKKV---NNNKPNKIYEERELAKYIAFKFML----------------------NDLNAKREIAIMKKL
. . |.|  |.|| |.||...    .. | ...  . |  ...| | |                       .  . ..|| ||||.
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKC

Kinase 23775.AA Pkinase 62-122 22 0.026942 9.2 Pfam 1-57 (293) Show / Hide
Range on Protein: 62-122
Range on HMM: 1-57/293
Sequence Identity: 22% (16 aa)

YANFEFIAAGGFGLVFKAKKKVNNNKPNKIYEERELAKYIAFKFMLNDLNAK---------REIAIMKKL
|   . | .|.|| |.|...| ..                | | .  . . .         .||.|||.|
YHIGRKIGSGSFGCVYKCHHKGTGK-------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL

Kinase 23775.AA CAMK 67-122 20 0.066508 1.11 In-house 1-88 (425) Show / Hide
Range on Protein: 67-122
Range on HMM: 1-88/425
Sequence Identity: 20% (18 aa)

FIAAGGFGLVFKAKKKVNNNKPN-------------KIYEERELA------------KYIAFKFM------LNDLN-AKREIAIMKKL
 .  |.|| |.... | ...| .             ||.. . |             . .  . .       .|.   .|||.|||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKL

Kinase 23775.AA Ciliate-E2 71-122 23 0.259351 0.24 In-house 10-73 (365) Show / Hide
Range on Protein: 71-122
Range on HMM: 10-73/365
Sequence Identity: 23% (15 aa)

GGFGLVFKAKKKVNNNKPNKIYEEREL-----------AKYIAFKFM-LNDLNAK-REIAIMKKL
|.|| |.|.|.. .... ... ..  .           .|..| | |  |..... .|| ||...
GNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREI

Kinase 23775.AA Ciliate-E2-Unclassified 62-92 31 0.279785 0.22 In-house 1-38 (352) Show / Hide
Range on Protein: 62-92
Range on HMM: 1-38/352
Sequence Identity: 31% (12 aa)

YANFEFIAAGGFGLVFKAKKKVNN-------NKPNKIY
|   . |  |||| |.|...| ..       .| ..||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIY

LRR_CC 23775.AA LRR_CC 875-899 26 0.245056 6.54 SMART 1-26 (26) Show / Hide
Range on Protein: 875-899
Range on HMM: 1-26/26
Sequence Identity: 26% (7 aa)

LKNIETLKLCYCQ-INDESISELKQL
 .|...| |..|. | |... .| ..
CPNLRHLNLSHCPNITDHGLQALAKN

LRR_CC 23775.AA LRR_CC 924-949 38 0.344899 5.38 SMART 1-26 (26) Show / Hide
Range on Protein: 924-949
Range on HMM: 1-26/26
Sequence Identity: 38% (10 aa)

MPNVKNLKLNGSQNISFKGLYLLSSN
.|| . | | . .||.  ||. |..|
CPNLRHLNLSHCPNITDHGLQALAKN

LRR_CC 23775.AA LRR_CC 1089-1114 38 0.000146 22.4 SMART 1-26 (26) Show / Hide
Range on Protein: 1089-1114
Range on HMM: 1-26/26
Sequence Identity: 38% (10 aa)

FNQLQHLSLSNCYNLSSKTIQVLLQN
  .|.||.||.|.|..  ..| | .|
CPNLRHLNLSHCPNITDHGLQALAKN

LRR_CC 23775.AA LRR_CC 1146-1171 34 0.000614 20.33 SMART 1-26 (26) Show / Hide
Range on Protein: 1146-1171
Range on HMM: 1-26/26
Sequence Identity: 34% (9 aa)

FPKLEILSVKNCIDISEASLQKLQKK
 |.|. |....|  |.  .|| | |.
CPNLRHLNLSHCPNITDHGLQALAKN