Gene 22110 (Tetrahymena)
22110
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 22110.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22110.AA | Ciliate-A7 | 236-378 | 22 | 1e-18 | 64.66 | In-house | 179-356 (360) | Show / Hide |
Range on Protein: 236-378
Range on HMM: 179-356/360
Sequence Identity: 22% (40 aa)
LGDFGLSCYYQDQDSLS-------FEGYKKIFDNRNLLFQAPEVHYFTQE-----------------ETQQQFDLKKADIYALGMTFFVLIFGQYPKKYP
|.|||... ||.| . . | .| ...|.. ..||| .. . |. ||.||.|..|.|..||...|.| | .
LADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCE
QPQMRDPI-YRYIIKHDVENFYL--KIKGFRKDFEKEVG--------GYENAIKLVTLLMKMMHQDPQKRIPLNEVIS
||. | .... ..|. .|. . |.||. . ... ... || ||....| .|. .....
ACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQ
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| Kinase | 22110.AA | S_TKc | 86-385 | 14 | 1.3e-10 | -21.26 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 86-385
Range on HMM: 1-231/231
Sequence Identity: 14% (47 aa)
INIRQQLEKGSGSEIWEGRNSS--RDCIFKMVKKNSNTSTYTQLVNEYEILKKKIPNSHPNIVKIYDLYHNIEHPNEPEQPVAA--------LSMKKTNN
| ... ||. .. . .|. . | . |..| .. .| .|||| ||||||.|| ... .| . . ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
-----CSVISSSNTQDIACGVQELKNNN--------SNDFCDGEQIQSESYQNQKTVNLQSNQKNLDEQLHFVLGDFGLSCYYQDQDSLSFEGYKKIFDN
. .. |.|... . ... .| ..| | ..||||.. .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------------HIKICDFGLARQL-----------------
RNLL----FQAPEVHYFTQEETQQQFDLKKADIYALGMTFFVLIFGQYPKKYPQPQMRDPIYRYIIKHDVENFYLKIKGFRKDFEKEVGGYENAIKLVTL
. . . |||| ... .|.|....| ... .. |. | . ... | . .
TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------SPEAKDF
LMKMMHQDPQKRIPLNEVIS----TVNEIAF
..|... ||.||. |. . |
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 22110.AA | Ciliate-E2 | 236-371 | 19 | 1.1e-08 | 25.98 | In-house | 197-353 (365) | Show / Hide |
Range on Protein: 236-371
Range on HMM: 197-353/365
Sequence Identity: 19% (35 aa)
LGDFGLSCYYQDQ----------DSLSFEG--------YK--KIFDNR------NLLFQAPEVHYFTQEET--QQQFDLKKADIYALGMTFFVLIFGQYP
. ||||| .|.|. . | . | .|..| .. ..|||.. .... .|. .|.||..||.... ..||..|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
KKYPQPQMRDPIYRYIIKHDVENFYLKIKGFRKDFEKEVGGYENAIKLV---------------TLLMK----MMHQDPQKRI
. .|| || .. . . . .. |. | |. ||.|||
F-----------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
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| Kinase | 22110.AA | Ciliate-E2-Unclassified | 228-307 | 20 | 1.9e-08 | 25.43 | In-house | 177-269 (352) | Show / Hide |
Range on Protein: 228-307 Range on HMM: 177-269/352 Sequence Identity: 20% (20 aa) LDEQL---HFVLGDFGLSCYYQDQDS--------LSFEGYKKIFDNR-NLLFQ----APEVHYFTQEETQQQFDLKKADIYALGMTFFVLIFGQYP .|.. . . |||.| .||... ... .... .. .. .. |||| . ... .|.||..||. .. ..||.|| FDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLFGYYP |
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| Kinase | 22110.AA | CAMK | 91-152 | 17 | 1e-06 | 16.76 | In-house | 1-107 (425) | Show / Hide |
Range on Protein: 91-152 Range on HMM: 1-107/425 Sequence Identity: 17% (19 aa) QLEKGSGSEIWEGRNS-SRD-------------CIFKMVKKNSNTS---------------------------TYTQLVNEYEILKK--KIPN--SHPNI .| .|| .. .... . . |...|. .. . .. .|.||.|| .| | .|||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKIYDLY .|.|. | IKLYEVY |
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| Kinase | 22110.AA | CAMKK | 267-307 | 30 | 1e-06 | 16.74 | In-house | 276-325 (396) | Show / Hide |
Range on Protein: 267-307 Range on HMM: 276-325/396 Sequence Identity: 30% (16 aa) FQAPEVHYFTQEETQQQ-----------FDLKKADIYALGMTFFVLIFGQYP |.|||. .. |. .. .. |.||| ||| |.. ..||. | FMAPEL--CSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCP |
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| Kinase | 22110.AA | CAMK1 | 116-152 | 42 | 2e-06 | 14.84 | In-house | 38-77 (276) | Show / Hide |
Range on Protein: 116-152 Range on HMM: 38-77/276 Sequence Identity: 42% (18 aa) KKNSNTSTY---TQLVNEYEILKK--KIPNSHPNIVKIYDLY ||. ... ..| || ||.|| || .||||.|.|. | KKFMKKKDMQKQEALENEIEIMKKVSKI--DHPNIIKFYEWY |
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| Kinase | 22110.AA | HAL | 269-313 | 32 | 2e-06 | 17.39 | In-house | 218-267 (363) | Show / Hide |
Range on Protein: 269-313 Range on HMM: 218-267/363 Sequence Identity: 32% (16 aa) APEVHYFTQ-----EETQQQFDLKKADIYALGMTFFVLIFGQYPKKYPQP |||| ||.. |. || .| .|....| .. .| ...| |.| . APEVMYFDEKKHYDEKFQQEYDPRCVDCWSCGIIYCCMIMKRFPWKIPCK |
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| Kinase | 22110.AA | ULK | 281-307 | 37 | 3e-06 | 18.33 | In-house | 225-251 (324) | Show / Hide |
Range on Protein: 281-307 Range on HMM: 225-251/324 Sequence Identity: 37% (10 aa) QQQFDLKKADIYALGMTFFVLIFGQYP |.... .|.||. ||. |. ...|.|| QKPYYDYKCDIWSLGCIFYEMLYGKYP |
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| Kinase | 22110.AA | ULK | 281-329 | 19 | 3e-06 | 17.92 | In-house | 229-288 (329) | Show / Hide |
Range on Protein: 281-329 Range on HMM: 229-288/329 Sequence Identity: 19% (12 aa) QQQFDLKKADIYALGMTFFVLIFGQYP---KKYPQPQ---MRDPIYRY------IIKHDVE |.... .|.||. ||. |. ...|..| . . . ... | . | |. . QKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQ |
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| Kinase | 22110.AA | Ciliate-E2-Unclassified | 86-153 | 10 | 4e-06 | 17.2 | In-house | 1-89 (352) | Show / Hide |
Range on Protein: 86-153 Range on HMM: 1-89/352 Sequence Identity: 10% (10 aa) INIRQQLEKGSGSEIWEGRNSSRDCIF----KMVKKNSNTSTYTQLVNEYEILKKKIPNS-------------------HPNIVKIYDLYH .| .|. .|. ..... .... . . | |.... . . . .. .....|. |. ||........|. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC |
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| Kinase | 22110.AA | Ciliate-D1 | 290-308 | 36 | 6e-06 | 20.77 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 290-308 Range on HMM: 1-19/19 Sequence Identity: 36% (7 aa) DIYALGMTFFVLIFGQYPK ||...|.... ..|||.| DIWSFGCILYEMLFGQPPF |
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| Kinase | 22110.AA | ULK | 86-152 | 27 | 6.3e-05 | 13.24 | In-house | 1-87 (329) | Show / Hide |
Range on Protein: 86-152 Range on HMM: 1-87/329 Sequence Identity: 27% (24 aa) INIRQQLEKGSGSEIWEGR---NS---SRDCIFKMVKKNSNTSTYTQ---------LVNEYEILKKKI-----PNSHPNIVKIYDLY ......| ||| .|| . ... ||. |.. . . | || .|.|| .|.|||||| || . YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF |
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| Kinase | 22110.AA | Ciliate-E2 | 86-152 | 15 | 0.000512 | 9.66 | In-house | 1-101 (365) | Show / Hide |
Range on Protein: 86-152 Range on HMM: 1-101/365 Sequence Identity: 15% (16 aa) INIRQQLEKGSGSEIWEGRNSSRDCIFKMV---------------------KKNSNTSTYTQLVNEYEILK------KKIPN--------SHPNIVKIYD ... ... .|. . ...... . .. | .. .|. . . |. .| |.. ||| | .||||.|.|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE LY . CF |
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| Kinase | 22110.AA | ULK | 113-152 | 33 | 0.072025 | 2.49 | In-house | 34-84 (324) | Show / Hide |
Range on Protein: 113-152 Range on HMM: 34-84/324 Sequence Identity: 33% (17 aa) KMVK---KNSNTSTYT------QLVNEYEILKKKIPNSHPN--IVKIYDLY ||. | . . .. .| || .|.|| .||| ||| || . KMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWF |
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