Gene 20431 (Tetrahymena)

20431

Species: Tetrahymena
Alias: 3682.m00022, 141.m00088, 650, 20431, PreTt20431, TTHERM_00823610
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
20431.AA Protein None 589 None Fasta, JSON
20431.kin_dom Protein Kinase Domain None 217 None Fasta, JSON
20431.NA RNA None 1770 None Fasta, JSON

Protein domain

Protein domains of 20431.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RAB 20431.AA RAB 70-189 16 0.000182 -86.91 SMART 1-172 (172) Show / Hide 
Range on Protein: 70-189
Range on HMM: 1-172/172
Sequence Identity: 16% (30 aa)

QKLIV-----------FRRLKKSTPEFFQMNYKA------YLKDIEV-------------------------------VLLCVDLAKAQTLQSFSDSFFE
 |.|.            .| .. .   |. .||.        | |||                               ..|. |. . ..        ||
FKIILIGDSGVGKSCLLHRFTDDK---FSEQYKHTIGVDFKTKTIEVDGKRVKLQIWDTAGQERFRSITSSYYRGAHGCILVYDITNRES--------FE

KI---IEYVRQHGNR---SFRVIIVGLKSDKQC-RNKTEEDALVK---KCKELQLPFV-KASSLEETNIQ----QVLNEIMNY
..   .. .|.| |     . ...|| |.|    |  ..|.|       .... .||   .|... ||..    ... .|.. 
NVKNWLKEIRMHANPPPENVVIMLVGNKCDLEHQRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR
Kinase 20431.AA Ciliate-E1 380-486 25 4.6e-15 45.85 In-house 76-202 (202) Show / Hide 
Range on Protein: 380-486
Range on HMM: 76-202/202
Sequence Identity: 25% (32 aa)

MPLCKYSLKHLLK--------NCFN----QITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEKQTEAFNMLGTTAK
. .|..|||  |.        ....    | |.. |..   |.|. |. ..  .| |.|.|||||| ....  . .|.. ||.. ..|..  .  | | .
FECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHY

YAHPAAII--------NHELSPRFDIY
|. |  .         | . .   |||
YYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 20431.AA LZK 396-505 36 7.5e-14 43.01 In-house 82-190 (241) Show / Hide 
Range on Protein: 396-505
Range on HMM: 82-190/241
Sequence Identity: 36% (40 aa)

NQITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEKQTEAFNMLGTTAKYAHPAAIINHELSPRFDIYSFGVILLEL
..||  | . || || . ..     || | |||  |||  .|| . ..|   |.  .|.        || |  | |  | |   | . ||.||||.| |.
RTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMA-PEVIRNEPCSEKVDIWSFGVVLWEM

FTGKQPWGQV
 |.  |.  |
LTCEIPYKDV
S_TKc 20431.AA S_TKc 294-561 16 1.5e-13 21.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 294-561
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

VKTRMQLDKGNFGVVYRIDLEG--ETCALKICKIEMNDETAMNRFQIIFSEAENMQRFMLNRNMRIMPLKGISFQVDMQRQNVLIGYWMPLCKY---SLK
 .   .. || ||.||.    .  . .|.|| |            . | .| . ...    .   |  |...            .   | .|     .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK----HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLF

HLLKNCFNQ-----ITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEKQTEAFNMLGTTAKYAHPAAIINHELSP-R
...|..  .     ..     ..  ||.. ||   . .| | ||||.|||||.   | ..|  .....        . .  |  |  |  .     .. .
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCK

FDIYSFGVILLELFTGKQPWGQVKRDELKDIYTQILTQPEVMNPLRYHKENYPNDMKYIEGKCQPIQDIIYMCCV--------------------SIFI
 |..|.|.|| |...|. |.      ... .. .|.                           ..  |.|  |..                      ..
CDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 20431.AA Ciliate-E2-Unclassified 409-521 24 2.6e-12 39.02 In-house 151-302 (352) Show / Hide 
Range on Protein: 409-521
Range on HMM: 151-302/352
Sequence Identity: 24% (37 aa)

QIIECLEVFYKEK-IQHMDLKPQNILLDQND---DIIVSDLSMSKVFEE---------------KQTEAFNMLGTTA-K--YAHPAAIINHELSPR----
||...||   ... | | |.||.|||.|.|     | ..|.. ||  ..               || ..  . ||   .  |. |  . ... . .    
QILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYK

FDIYSFGVILLELFTGKQPWGQVKRDE-------------LKDIYTQILTQP
 ||.|.|||| |. .|. | .. ....              | .| .|. ..
CDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKN
Kinase 20431.AA Ciliate-E2b 409-508 27 9.3e-12 32.17 In-house 110-216 (272) Show / Hide 
Range on Protein: 409-508
Range on HMM: 110-216/272
Sequence Identity: 27% (30 aa)

QIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEKQT---EAFNMLGTTAKYAHPAAII-----NHELSPRFDIYSFGVILLELFTGKQ
.|. |||   . .| . |.|| ||..|..  .   |.  .|....|.      | . | |  |  |  |      .   .   ||.|.|..| |.  |. 
SICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIG-TPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYV

PWGQVKRD
||.  ..|
PWAEDVQD
Kinase 20431.AA TKL 424-502 18 1.8e-11 37.58 In-house 163-289 (364) Show / Hide 
Range on Protein: 424-502
Range on HMM: 163-289/364
Sequence Identity: 18% (24 aa)

HMDLKPQNILLDQNDD--------------IIVSDLSMSKVFEE------------------KQTEAFNMLGTTAKYAHPAAIINH--------------
| |||..|||.|.|                . ..|.  |.....                  .. .. .. . |  .  | .. ..              
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

--ELSPRFDIYSFGVILLELFTGKQPW
  | |.. |.||||..| |..|...|.
GFEYSEKCDVYSFGIVLWEILTRCRPY
Kinase 20431.AA Ciliate-B2 383-489 30 2.7e-11 22.71 In-house 83-197 (197) Show / Hide 
Range on Protein: 383-489
Range on HMM: 83-197/197
Sequence Identity: 30% (36 aa)

CKYSLKHLLK------NCFNQITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEKQTEAFNMLGTTAKYAHPAAIIN
|..|||  |.       |||.  .   ..   | |. |  |    | | |.||||||. ||.. . .|  .| . .  .    .  | | ||| |  ...
CECSLKQELQKIQKQQKCFNNQKL---YQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK--DNQQIKIKGFTKKYASPEQMEC

H-------ELSPRFDIYSFG
        ..  . |||| |
DHNQTFVTNIDFQSDIYSMG
Kinase 20431.AA Ciliate-C5 386-499 31 3.3e-11 32.9 In-house 78-195 (260) Show / Hide 
Range on Protein: 386-499
Range on HMM: 78-195/260
Sequence Identity: 31% (38 aa)

SLKHLLKNCFNQ---ITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLD-QNDDIIVSDLSMSKVFEEKQTEAFNMLGTTAKYAHPAAI-INHELS
.|| .... |.|   . ..  | . .|.    |   .... | |.||.||| | |    ...|   || |..    .... | | ||| |  .  |    
NLKDIMQSFFDQKKTLPLNQIIGFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKD-GSKTYDLKGFTRKYAAPEITDDNGFFN

PRFDIYSFGVILLELFTGK
 ..|||  |.|||||  ||
IKYDIYGLGIILLELTLGK
Kinase 20431.AA Ciliate-E2 380-521 19 4.1e-11 34.38 In-house 113-304 (365) Show / Hide 
Range on Protein: 380-521
Range on HMM: 113-304/365
Sequence Identity: 19% (40 aa)

MPLCKY-SLKHLLKNC---FNQI-------TIDLKIKWSLQIIE---------------CLEVFYKEK-IQHMDLKPQNILLDQNDDIIVSDLSMSK---
| .|.. .|....||.   .|..       |.   .. . ||..               .||   ... | | |.||.|||.     | ..|. .||   
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD

VFEEKQTEAFNMLG----------------------------TTAKYAHPAAIINHE---------LSPRFDIYSFGVILLELFTGKQPWGQVKRDELKD
 .....|. ... .                             |. |  |  . . .          .   ||.|.|||| |. .|| |.          
DDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------

IYTQILTQP
 . ||. ..
-QQQIKQCK
Kinase 20431.AA C8 380-492 25 1.4e-10 33.04 In-house 99-226 (226) Show / Hide 
Range on Protein: 380-492
Range on HMM: 99-226/226
Sequence Identity: 25% (33 aa)

MPLCKYSLKHLLKNCFNQITI---DLKIKWSLQIIECLEVFYKEKIQHMDLKPQNIL--LDQNDD--IIVSDLSMSKVFEEKQT--EAFNM--LGTTAKY
| ||.  ||.| . . |.      . | .  .|.|....     .|.| |.||.|.|  ||||    |  .|. ..   .. .   .  .|  .|| | |
MELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWA-Y

AHPAAIIN-----HELSPRFDIYSFGVIL
  |  .        . . . |..| |..|
FAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 20431.AA Pkinase 380-518 24 1.9e-10 38.03 Pfam 79-231 (293) Show / Hide 
Range on Protein: 380-518
Range on HMM: 79-231/293
Sequence Identity: 24% (38 aa)

MPLCKY-----SLKHLLK----NCFNQITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLDQNDDI----IVSDLSMSKVFEEKQTEAFNMLGTTA
|..|       .|.....    .||   . .  ... .||.. ||  ....| | ||||.|||.|.|..|     ..|   .|.|..   . .. .  | 
MEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

KYAHPAAII-NHELSPRFDIYSFGVILLELFTGKQPWGQV----KRDELKDIYTQIL
 |. |  |  . . .|. |..|.|.|| |...|. |. .     . .. . .. .|.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIM
Kinase 20431.AA Ciliate-A1 408-495 27 6.3e-10 29.92 In-house 108-221 (301) Show / Hide 
Range on Protein: 408-495
Range on HMM: 108-221/301
Sequence Identity: 27% (32 aa)

LQIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEKQ------------------TEAFNMLGTTAKYAHPAA---------IINHELS
.|||| .    .  | | ||||||||.   | . . || |||. | .|                   .    .|.   |  |           .|   ..
YQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLY-YMSPEQYQMHYRDQMFIENKIY

PRFDIYSFGVILLEL
 . |.|| |.|...|
KQSDMYSLGCIICFL
Kinase 20431.AA TyrKc 294-560 18 1.8e-08 -85.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 294-560
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

VKTRMQLDKGNFGVVYRIDLEGETCALKICKIEMNDETAMNRFQIIFSEAENMQRF-MLNRNMRIMPLKGISFQVD---MQRQNVLIGYWMPLCKY-SLK
..   .|  |.||.||.  .  ...| | .| .          . . .||. | ..    ..  |  | |.  |     |  . ..|   | .... .||
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNFMYIEPLMIV--MEYMPHGDLK

HLLKNCFNQITIDLKIKWSLQIIECLEVFYKEKIQHMDLKPQNILLDQNDDIIVSDLSMSKVFEEK-----QTEAFNM----LGT---TAKYAHPAAIIN
. |... .... . ......|| .  |   . .. | ||   |.|.. |  . .||  .|.  ...      ..   .     |      .   | .|  
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

HELSPRFDIYSFGVILLELFT-GKQPWGQ-----VKRDELKDIYTQI--LTQPEV---MNPLRYHKENYPNDMKYIEGKCQPIQDIIYMCCVS-------
.. ..  |..|||| . |.|| |.||.       .. .|.     |   . ||.    |               .  .  . . .|. .|.         
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------F-VCCPDEMYQIMKQCWHEDPEDRPT

------IF
      .|
FSEIHECF
Kinase 20431.AA Ciliate-A1 294-325 31 0.008641 5.25 In-house 1-35 (301) Show / Hide 
Range on Protein: 294-325
Range on HMM: 1-35/301
Sequence Identity: 31% (11 aa)

VKTRMQLDKGNFGVVYR-IDLEGET--CALKICKI
      .||| |||| | .|....    ..|| ..
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIIC
Kinase 20431.AA TKL 300-322 24 0.016969 4.82 In-house 1-33 (364) Show / Hide 
Range on Protein: 300-322
Range on HMM: 1-33/364
Sequence Identity: 24% (8 aa)

LDKGNFGVVYRIDLEG----------ETCALKI
. .| ||.||.  . |          .. | |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK