Gene 18946 (Tetrahymena)

18946

Species: Tetrahymena
Alias: TTHERM_00242080, 20.m00410, 18946, PreTt18946, 1017, 3706.m01523
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
18946.AA Protein None 637 None Fasta, JSON
18946.NA RNA None 1914 None Fasta, JSON
18946.kin_dom Protein Kinase Domain None 243 None Fasta, JSON

Protein domain

Protein domains of 18946.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 18946.AA S_TKc 24-270 26 8.3e-49 169.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-270
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

YNLQEQIGQGAFSEVYTVFNQNKKRFEVLKKLILKESVDEYIQEYKILKSIKHEFVIQFYDCLLLDDDLCFLMEYAEQ--GTLQQFIDNPYL--LNKKID
| . ..||.|||..|| . . . .|   .|..      .  ..| .|||. .|......||.    |.|.. |||...  |.| ..|..     |.....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

ANFILEICEGIFEGIQYLQIKKIIHRDLKPENILISDFKAKIADLGLSKFLLSKYANTNVGNMLYAAPEKNNADKGGYGL-KSDIYSAGLILCQVILRLA
   .  ..  |.....|.  ..||||||||||||...   ||.| ||...|     .| .|   | |||       |||  |.|..| | ||   . .  
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYP

----VKQISQINFFDNQDSFKNIPQELKKLISLLISKNPEERPSCDFVIQ-----QINAFK
    .... ..            ..|.| .|. .  |.||.||..  . |      .  . 
PFPQMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18946.AA Ciliate-E2 24-260 21 5.1e-45 152.46 In-house 1-357 (365) Show / Hide 
Range on Protein: 24-260
Range on HMM: 1-357/365
Sequence Identity: 21% (78 aa)

YNLQEQIGQGAFS-----EVYTVFN-------------------QNKKRFEVLKK----LILKESVDEYI----------QEYKILKSIKHEFVIQFYDC
|.....||||.|.     .|. | .                   ...| ...  .    .. .....  .          .| .||....| ..|..|.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LL--LDDDLCFLMEYAEQGTLQQFIDNPYLLN-------KKIDANFILEICEGIFE---------------GIQYLQIKK-IIHRDLKPENILISDFKAK
     |. . . |||...|.|...| | ..         |... . |..| . |..               ...||  |. |||||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADLGLSKFLLSK---------------------------------YANTNVGNMLYAAP----EKN---NADKGGYGLKSDIYSAGLILCQVILR----
|.|.||||..  .                                  .|| .|.  | ||     |.   . .. ||. |.||.|.| || . .      
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

LAVKQISQINFFDNQD------------SFKNIPQELKKLISL----LISKNPEERPS-CD
.  ..  .|.|. ..             |.|...|| | ||.     .. |.||.|..  .
QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE
Kinase 18946.AA TKL 30-266 17 3.5e-41 143.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 30-266
Range on HMM: 1-364/364
Sequence Identity: 17% (65 aa)

IGQGAFSEVYTVFNQNKK-------RFEVLKKLILKESV------------------------------DEYIQEYKILKSIKHEFVIQFYDCLLLDDD-
||.|.|.|||    ..           .|  | . ....                              .. ..| .......|. ..||. . .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCFLMEYAEQGT-LQQFIDNPYLLNKKIDANFILEICEGIFEGIQYLQI--------KKIIHRDLKPENILIS-DFK-----------
            ||. |||.. |. | ...            . .. .. .|  |..||          ..|||||||..|||.  ...           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AKIADLGLSKFLLSKY---------------------ANTNVGNMLYAAPEKNNAD--------------KGGYGLKSDIYSAGLILCQVILR-LAV
   .||.|.|||.|.  .                       .| .|.  . |||  . .              .. |  |.|.|| |..|. .. | .  
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

KQISQ----------INFFDNQDSF------------------KNIPQELKKLISLLISKNPEERPSCDFVIQQI
...            . |  . | .                  ...|...|||.    . .||.|||.. .....
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 18946.AA Pkinase 24-210 28 2.4e-40 143.75 Pfam 1-202 (293) Show / Hide 
Range on Protein: 24-210
Range on HMM: 1-202/293
Sequence Identity: 28% (59 aa)

YNLQEQIGQGAFSEVYTVFNQNKKRFEVLKKLILKESVDEYIQ------EYKILKSIKHEFVIQFYDCLLLDDDLCFLMEYAEQG----TLQQFIDNPYL
| . ..||.|.|..||   ...  .  ..|.. ...  ..  |      | .|.|...|......||.   .|.... |||.| |     |  .|     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

LNKKI--DANFILEICEGIFEGIQYLQIKKIIHRDLKPENILIS-DFKA----KIADLGLSK---FLLSKYANTNVGNMLYAAPEKNNADKGGYGLKSDI
 ....  . . .  ..  |..|..|.  ..|||||||||||||. .       ||.| ||.|      .  ..| .|   |.|||  . .  .|| |.|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDM

YSAGLIL
.|.|.||
WSCGCIL
Kinase 18946.AA STE 24-258 20 6.3e-39 135.1 In-house 1-347 (359) Show / Hide 
Range on Protein: 24-258
Range on HMM: 1-347/359
Sequence Identity: 20% (73 aa)

YNLQEQIGQGAFSEVYTVFNQNKKRFE--------------VLKKLIL--------------------KESVDEYIQEYKILKSIK--HEFVIQFYDCLL
. ..|.||.||| .||.  | .. ...              .  | .                     .| ......| ||.|  .  |......|.| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LD-------DDLCFLMEYAEQGTLQQFIDNPYLLNK----------KIDANFILEICEGIFEG-IQYLQIKKIIHRDLKPENILISDFKAKIADLGLSKF
 .       |.|.  ||| . |.| ..|.. |  .|          ... . |  ||  | .|  .||  ..|||||.|| |||.    .|..| |... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LLS------------------KYANTNVGNMLYAAPEKNNAD----KGGYGLKSDIYSAGLIL-------CQVILRLAVKQISQINFF------------
| .                  .  || ||   . |||  . .    ..||. |.||.| |. .                . . .|.|             
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--------DNQDS--------------FKNIPQELKKLISLLISKNPEERPS
         .  |               ..  .|.|  |..   |.|..||.
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase 18946.AA Ciliate-E2-Unclassified 24-210 23 5.7e-38 129.3 In-house 1-260 (352) Show / Hide 
Range on Protein: 24-210
Range on HMM: 1-260/352
Sequence Identity: 23% (62 aa)

YNLQEQIGQGAFSEVYTVFNQNKK---------RFEVLKKLILKESVDEYIQEYKILKSIK-------------------HEFVIQFYDCLLLDDDLCFL
|....|||||.|..|| . . ..|          . . |... ...  |...| |.....|                   |.|.. ...|   .. ... 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYAEQGTLQQFIDN------------PYLLNKK-IDANFIL-----EICEGIFEGIQYLQIKK-IIHRDLKPENILISDF----KAKIADLGLSKFLL-
|||.|.|.|.|.| .              ....| .. . ..      ..  | .|..||  |. |||||.||||||...     . ||.|.|.||..  
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------SKYANTNVGNMLYA----APEKNNADKGGYGLK----SDIYSAGLIL
                .. ..|..|.  |     |||    .. .|. .    .||.| | ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE--VLQGQNYDHSKAYKCDIWSLGVIL
Kinase 18946.AA NEK 24-188 28 1.5e-36 126.38 In-house 1-194 (286) Show / Hide 
Range on Protein: 24-188
Range on HMM: 1-194/286
Sequence Identity: 28% (56 aa)

YNLQEQIGQGAFSEVYTVFNQNKKRFEV-----LKKLILKES----VDEYI-QEYKILKSIKHEFVIQFYDCLLLDD--DLCFLMEYAE-QGTLQQFIDN
| ....||||.|..|| |  .. .. .|     .||  ...      .. . .| .|||..||. .. .||. . ..   ||  |||.|  |.|.|.| .
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

PYLLNKK-----IDANFILEICEGIFEGIQYLQIK-----KIIHRDLKPENILIS-DFK----AKIADLGLSKFLLSK--YANT-NVGNMLYAAPE
  . ..|     .. . |....  .  ...|.  .     ||.|||.|| || .. . .    .|| |.|.|| | ..  .|.|  ||   |..||
--IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPE
Kinase 18946.AA CAMK 29-210 17 9e-36 112.23 In-house 1-324 (425) Show / Hide 
Range on Protein: 29-210
Range on HMM: 1-324/425
Sequence Identity: 17% (56 aa)

QIGQGAFSEVYTVFNQNKKR-----------FEVLKKLILKE-------------------------------SVDEYIQEYKILKS-------IKHEFV
..|.|.|..|. ... | ..            .|  | | |.                               . ..  .|..|.|.       ..|. .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQFYDCLLL-------------------DDDLCFLM---EYAEQG----TLQQFID-NPY---------LLNKK--IDANFILEICEGIFEGIQYLQIKK
|..|.                       |..... |   ||.. |     | ..|  ...         .. ..  ..      .   | ....|.  ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPENILISD------------------FKAKIADLGLSKFLLS-------------------------KYANTNVGNMLYAA-PEKNNAD----
|.||||||||||..|                  .. ||.| |..... .                         .  .| .|   |.| ||  |      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KGGYGLKSDIYSAGLIL
        | .|| |.|. |.| ||
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 18946.AA ULK 24-210 26 1.4e-35 123.71 In-house 1-242 (324) Show / Hide 
Range on Protein: 24-210
Range on HMM: 1-242/324
Sequence Identity: 26% (64 aa)

YNLQEQIGQGAFS-EVYTVFNQNKK--RFEV------LKKLILKESVDE-------YIQEYKILKSIK---HEF--VIQFYDCLLLDDD--LCFLMEYAE
|.| ...|.|.|   ||  .|....     |      .||.. |.. .|        ..| .|.| .|   |..  ....||..  ...  ... ||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGTLQQFID-NPYL----LNKKIDANFILEICEGIFEGIQYLQIKKIIHRDLKPENILISDFK-------------AKIADLGLSKFLLS-----KYANT
.|.|.|.|  | .|     .|..  . .....  | .| ..|. ..|||||.||.||||.. .             .|||| |..|.. .         |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

NV------GNMLYAAPE--KNNADKGGYG-LKSDIYSAGLIL
 |      |  || ||.  ...  .  |.  |.||.| | |.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 18946.AA ULK 24-210 26 1.5e-35 121.58 In-house 1-246 (329) Show / Hide 
Range on Protein: 24-210
Range on HMM: 1-246/329
Sequence Identity: 26% (65 aa)

YNLQEQIGQGAFSEVYTVFNQNKK---RFEVLKKLILKESVDE-------------YIQEYKILKSIK----HEF----VIQFYDCLLLDDD--LCFLME
|.| ...|.|.|  ||  .|...|      |  | |.|.. ..              ..| ||.| .|    |..    ....||..  ...  . . ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAEQGTLQQFID-NPYL-----LNKKIDANFILEICEGIFEGIQYLQIKKIIHRDLKPENILISDFK-------------AKIADLGLSKFLLSK-----
| ..|.|.|.|  | .|      .|..  . .....  | .| ..|. ..|||||.||.||||.. .             .|||| |..|.. .      
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

YANTNV------GNMLYAAPE--KNNADKGGYG-LKSDIYSAGLIL
 . | |      |  || ||.  ...  .  |.  |.||.| | |.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 18946.AA CAMKL 24-210 23 1.3e-32 101.23 In-house 1-226 (297) Show / Hide 
Range on Protein: 24-210
Range on HMM: 1-226/297
Sequence Identity: 23% (54 aa)

YNLQEQIGQGAFSEVYTVFNQNKKRFEVLKKLIL--KESVDEYIQ----------------EYKILKSIK---HEFVIQFYDCLLLDDD------LCFLM
|.. ...|.|.|..|    ..   . .|  | |   | . |....                |..|.|...   |. .|..|...  ..       ..  |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAEQGT--LQQFID-NPYLLNKKIDANFILEICEGIFEGIQYLQIKKIIHRDLKPENILIS-DF--KAKIADLGLSKFLL------SKYANTNVGNMLY
||.. |   |...|. ...   .... .    .   | ....|.  ..|.|||.||||||.. .   ..||.| |.| .         .  .|  |   |
EYCSGGEMDLFDYIVKHGHRR-GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPEKNNA-DKGGYGLKSDIYSAGLIL
.|||  .   |  .| | || |.| ||
MAPEIFQGNNKPYDGPKVDIWSCGVIL
Kinase 18946.AA Ciliate-A1 24-269 27 6.9e-29 95.44 In-house 1-301 (301) Show / Hide 
Range on Protein: 24-269
Range on HMM: 1-301/301
Sequence Identity: 27% (83 aa)

YNLQEQIGQGAFSEVYTVFN-QNKKRFEVLKKLILK--ESVDEYIQEYKILKSIKHEFVIQFYDCLLLDDD--LC--FLMEYAEQGTLQQFIDNPYLLNK
|     |. | |. |  ... ||.|..  .| .| .  |   . ||||...| | |  ||  |. |   ..  .|  . ||| . | |.... .    |.
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQ----ND

KIDANFILEICEGIFEGIQYLQIKKIIHRDLKPENILIS-DFKAKIADLGLSKFLLSKY------------------ANT--NVGNMLYAAPEK------
 .    | |||  |.||.  .  . |.||||||.||||  | | ||.|||.|| |. .                    .|    || .| .||       
YMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYR

-NNADKGGYGLKSDIYSAGLILCQVIL-------RLAVKQISQINFFDNQ-------------DSFKNIP----QELKKLISLLISKNPEERPSCDFVIQ
     ..  . .||.|| |.|.|              . .|   |. . |               |  ..     ||  ||  .....|. | | ...|.
DQMFIENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCID

QINAF
.   |
CLYIF
Kinase 18946.AA TyrKc 24-266 20 1.7e-15 27.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-266
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YNLQEQIGQGAFSEVYTVFNQNKKRFEVLKKLILKESVDEYIQEYKILKSI--KHEFVIQFYDCLLLD-------DDLCFLMEYAEQGTLQQFI-DNPYL
  | ...| ||| |||          .|  | . .... . ..| .|....  .|. ....| . . .       . |. .|||.. | |.... ..   
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LNKKIDANFILEICEGIFEGIQYLQIKKIIHRDLKPENILISDFK-AKIADLGLSKFLLSK--------YANTN---VGNML----YAAPEKNNADKGGY
    .     |..|  | .| .||  |..|||||   |.|... . .||.| |||... ..        |  .     |...      |||    ..| .
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE--CINYGKF

GLKSDIYSAGLIL-----------CQ-----VILRLAVKQISQINFFDNQDS-----FKNIPQELKKLISLLISKNPEERPSCDFVIQQI
  |||..| |  .                  .  . ..... | .  .  ..     |   |.|. ....     .||.||.   .....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 18946.AA Pkinase_Tyr 65-170 27 5e-09 31.19 Pfam 51-161 (270) Show / Hide 
Range on Protein: 65-170
Range on HMM: 51-161/270
Sequence Identity: 27% (30 aa)

IQEYKILKSI-KHEFVIQFYDCLL-LDDD--LCFLMEYAEQGTLQQFIDNPYLLNKKIDANFILEICEGIFEGIQYLQIKKIIHRDLKPENILIS-DFKA
..| ||.|.. .|. ....| . .  ..   ..  |||.. | |  .  ..   .....   .|..|  | .| .||  |..|||||   |.|.. ....
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVV

KIADLGLSKFL
||.| ||.. .
KICDFGLARDI
Kinase 18946.AA NEK 239-268 40 3e-06 18.49 In-house 257-286 (286) Show / Hide 
Range on Protein: 239-268
Range on HMM: 257-286/286
Sequence Identity: 40% (12 aa)

QELKKLISLLISKNPEERPSCDFVIQQINA
|.|..|||... |.||.||||. ....   
QDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 18946.AA CAMKL 232-260 24 0.002171 6.51 In-house 262-289 (297) Show / Hide 
Range on Protein: 232-260
Range on HMM: 262-289/297
Sequence Identity: 24% (7 aa)

DSFKNIPQELKKLISLLISKNPEERPSCD
. .. .. ... ||. .  .|||.||...
PIWYHVS-DCRDLIRKMLQVNPEKRPTIH
Kinase 18946.AA CAMK 220-260 18 0.002827 5.61 In-house 357-417 (425) Show / Hide 
Range on Protein: 220-260
Range on HMM: 357-417/425
Sequence Identity: 18% (11 aa)

KQISQINFFDNQDSFKNIP--------------------QELKKLISLLISKNPEERPSCD
..| . ..    . |..|.                    || | ||. .  ..||.|....
EKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE
Kinase 18946.AA Pkinase 228-266 24 0.023962 9.38 Pfam 255-293 (293) Show / Hide 
Range on Protein: 228-266
Range on HMM: 255-293/293
Sequence Identity: 24% (10 aa)

FDNQDSFKNIPQELKKLISLLISKNPEERPSCDFVIQQ--I
| ..   .|...|.|..|. .. |.|..||... . |   .
F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18946.AA Pkinase_Tyr 24-39 43 0.119383 6.21 Pfam 1-16 (270) Show / Hide 
Range on Protein: 24-39
Range on HMM: 1-16/270
Sequence Identity: 43% (7 aa)

YNLQEQIGQGAFSEVY
  . ...|.||| |||
ITFGKKLGEGAFGEVY