Gene 17457 (Tetrahymena)

17457

Species: Tetrahymena
Alias: 3818.m00642, 201, 108.m00109, 17457, PreTt17457, TTHERM_00695610
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
17457.AA Protein None 346 None Fasta, JSON
17457.kin_dom Protein Kinase Domain None 169 None Fasta, JSON
17457.NA RNA None 1041 None Fasta, JSON

Protein domain

Protein domains of 17457.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17457.AA TKL 122-233 21 9.6e-17 56.83 In-house 132-284 (364) Show / Hide 
Range on Protein: 122-233
Range on HMM: 132-284/364
Sequence Identity: 21% (34 aa)

NTIIKLAYEIFLGICNIHNEN--------VIIFDLKPENILIDYCGQ--------------AVVSDFGLSKQLQQDLS-------------------TAS
. ....|..| .|..  |..|        .|  |||..|||.|  ..              . ..|||||. ..|. .                   | .
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

QSNGNYLYRAPEGIDQNRQLFEEQV--QGFVFEPNRLSKKADLFSFALILYRMLT
   |.. . ||| .... . ..| |   . ...    |.|.| .||...|. .||
TQCGTPRWMAPEVLRGQMN-YTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILT
Kinase 17457.AA Ciliate-E3 121-199 33 1.5e-16 48.41 In-house 102-184 (202) Show / Hide 
Range on Protein: 121-199
Range on HMM: 102-184/202
Sequence Identity: 33% (28 aa)

ENTIIKLAYEIFLGICNIHNENVIIFDLKPENILIDYCG-QAVV--SDFGLSKQLQQDL-STASQSNGNYLYRAPEGIDQNRQ
.|.|.... .|  |.  ||  |.|  |.||.|||.|    | ..  .|||.||||....  |  | .| . . |.  .... |
QNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQ
Kinase 17457.AA MLK 139-233 30 3.4e-16 52.78 In-house 141-231 (291) Show / Hide 
Range on Protein: 139-233
Range on HMM: 141-231/291
Sequence Identity: 30% (32 aa)

HNEN---VIIFDLKPENILID------YCGQAVVSDFGLSKQLQQDLSTASQSNGNYLYRAPEGIDQNRQLFEEQVQGFVFEPNRLSKKADLFSFALILY
|..    .| .|||. |||||        |.....|||.|. ..|  ..     |.| ..||| | |             |. .. |.|.| .|....|.
HSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQ-------------FRCEKYSEKCDVWSWGVVLW

RMLT
 |||
EMLT
Kinase 17457.AA Ciliate-E2-Unclassified 121-235 24 5e-16 52.11 In-house 137-267 (352) Show / Hide 
Range on Protein: 121-235
Range on HMM: 137-267/352
Sequence Identity: 24% (36 aa)

ENTII-----KLAYEIFLGICNIHNEN-VIIFDLKPENILIDYCG---QAVVSDFGLSKQLQQD---------------LSTASQSNGNYLYR----APE
|. ..     .....| .|.. .| .| .|  |.||||||.|  |   .  ..|||.||..||.                  ...  |.. |     |||
EQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE

GIDQ-NRQ--LFEEQVQGFVFEPNRLSKKADLFSFALILYRMLTDQ
 ... |     .               .|.| .|.  ||| ||. .
VLQGQNYDHSKA---------------YKCDIWSLGVILYEMLFGY
Kinase 17457.AA Ciliate-C7 121-184 43 5.6e-16 48.17 In-house 101-164 (164) Show / Hide 
Range on Protein: 121-184
Range on HMM: 101-164/164
Sequence Identity: 43% (28 aa)

ENTIIKLAYEIFLGICNIHNENVIIFDLKPENILIDYCGQAVVSDFGLSKQLQQDLSTASQSNG
| . || | .|  |.  ||  | .  ||| .|||||| | |||.||||  .| |    .  . .
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Kinase 17457.AA AGC 125-186 31 7.7e-16 35.97 In-house 158-228 (395) Show / Hide 
Range on Protein: 125-186
Range on HMM: 158-228/395
Sequence Identity: 31% (23 aa)

IKLAYEIFLGICNIHN-ENVIIFD-LKPENILIDYCGQAVVSDFGLSKQLQQDL----------STASQSNGNY
| .. .| |..  .|.  ..|  | |||||||.|  |    .||||.|.. .|           .... .|..|
I-CG-CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHW-HNKKY
Pkinase 17457.AA Pkinase 121-292 24 1.2e-14 52.84 Pfam 107-293 (293) Show / Hide 
Range on Protein: 121-292
Range on HMM: 107-293/293
Sequence Identity: 24% (50 aa)

ENTIIKLAYEIFLGICNIHNENVIIFDLKPENILIDYCGQA----VVSDFGLSKQL-QQDLSTASQSNGNYLYRAPEGIDQNRQLFEEQVQGFVFEPNRL
|..... .|.|. |.  .|....|  ||||||||||  |.      ..||||.||.     | ..   | . |.||| |                . .  
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---------------GGQYY

SKKADLFSFALILYRMLTDQKTLFERC-------AYQKYNIDIS---LLDRQLKYK-------------------DEFKLIIQGLTKLDPKKRLEHIKVL
..|.| .|. .||| ||.  ...|  .        .|... . .     |.. ..                    .|.| .| .. ..|||||.  .. .
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQI

LTLEQM
|  . .
LQHPWF
Kinase 17457.AA CAMKK 138-199 29 6.1e-14 40.2 In-house 211-288 (396) Show / Hide 
Range on Protein: 138-199
Range on HMM: 211-288/396
Sequence Identity: 29% (23 aa)

IHNENVIIF-DLKPENILIDYCG---QAVVSDFGLSKQLQQDLSTASQ-----------SNGNYLYRAPEGIDQ-NRQ
|  .. ||. |.||.||||| .|   .....||| |... .. .| |.            .| . ..||| ..  | .
IDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQK
Kinase 17457.AA CAMKK-Unclassified 138-199 28 1.3e-13 40.41 In-house 214-282 (392) Show / Hide 
Range on Protein: 138-199
Range on HMM: 214-282/392
Sequence Identity: 28% (20 aa)

IHNENVIIF-DLKPENILIDYCGQ-----AVVSDFGLSKQLQQDLST-ASQSNGNYLYRAPEGIDQNRQ
|  .. ||. |.||.||||| ...     ....|||.|. .  .  .  .. .| | ..|||... . .
IDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENF
Kinase 17457.AA Ciliate-A3 124-290 35 3.1e-13 40.78 In-house 79-237 (237) Show / Hide 
Range on Protein: 124-290
Range on HMM: 79-237/237
Sequence Identity: 35% (62 aa)

IIKLAYEIFLGICNIHNENVIIFDLKPENILIDYCGQ---AVVSDFGLSKQLQQDLSTASQSNGNYLYRAPEGIDQNRQLFEEQVQGFVFEPNRLSKKAD
.| .| .|  |.  . . |.   |||||||||   |.   | .||.|| |  | ||    .   ||.  |||       .   . .| |..      | |
VIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEKIIAKISDYGLTKEVQCDLKSIVRTP-NYM--APE-------ILSAKKKGSVYD-----DKID

LFSFALILYRMLT-------DQKTLFERCAYQKYNIDISLLDRQLKYKDEFKLIIQGLTKLDPKKRLEHIKVLLTLE
 .|| ||||.| |       ||| .|..  .  ||  |  |  | ...|  ||.|. | | ||||| .  ..   | 
VWSFGLILYEMFTCKQIFKGDQKQIFNQLIH--YNNKIDQLLFQERFQDVSKLVIRCLQK-DPKKRPDFKQIQTELI
Kinase 17457.AA TKL-Unique 124-233 23 5.2e-13 42.4 In-house 112-223 (290) Show / Hide 
Range on Protein: 124-233
Range on HMM: 112-223/290
Sequence Identity: 23% (30 aa)

IIKLAYEIFLGICNIHNEN--VIIFDLKPENILIDYC-----GQAVVSDFGLSKQLQQDLSTASQSN---------GNYLYRAPEGIDQNRQLFEEQVQG
..|.|  | .| ...|...  .| .|||. |.|.|        .. ..|||||| . ... . .  .         |.....||| . .|          
RVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF---------

FVFEPNRLSKKADLFSFALILYRMLT
     .  |.|.| .||. .|. ..|
-----CQYSEKSDVYSFGIVLWEIAT
S_TKc 17457.AA S_TKc 72-294 18 3.3e-10 -27.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 72-294
Range on HMM: 1-231/231
Sequence Identity: 18% (50 aa)

WIKG----------VKQGYFLD-------------MMIEIQCMHSNAMKDNLIVSKHKQR-----------------LMYFNNFQIR------NIENTII
. ..          |....  .             .. |||....    .|..  .   .                 |. .   . |        | .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

KLAYEIFLGICNIHNENVIIFDLKPENILIDYCGQAVVSDFGLSKQLQQDLSTASQSNGNYLYRAPEGIDQNRQLFEEQVQGFVFEPNRLSK-KADLFSF
...|.|....  .|. ..|  ||||||||.|   .  ..||||..||       .   |   |.||| .                     .| |.|  |.
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-------------------GYGKCKCDWWSC

ALILYRMLTDQKTLFERCAYQKYNIDISLLDRQLKYKDEFKLIIQGLTKLDPKKRLEHIKVLL----TLEQMYL
  ||| ||.  ...|.         .  .... .   .|.| .|... . ||.||.   ..|          ..
GCILYEMLC-GYPPFP--------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF