Gene 17295 (Tetrahymena)
17295
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 17295.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 17295.AA | STE | 351-590 | 20 | 1.3e-36 | 126.88 | In-house | 13-359 (359) | Show / Hide |
Range on Protein: 351-590
Range on HMM: 13-359/359
Sequence Identity: 20% (72 aa)
GSTCSALHQH---------------TGHLYAVKTYKKDQYD-------------GFIRDQITEQKWIDASQKCS----NLCRCYCIYQQE-------NGL
|... |.. . || ..|.| .... . .. .. .| |. .||. | ..|. | .| . |
GTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDEL
DVVYEHISGESIQKIIQ-SFNTFQ-------------EKLITIFARQIFKG-IDFLHSYGLVHGNLKASNILIDNDAIIKITDLNIFKKSIQVMDYLKS-
.. |...| |. .||. . ... |..| ...||| || ..||| . .| .|..|||. .|..| . .. .. |. . .
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-QS
--------TSS------------APETLLY------NELTTKSDIWSAGIVILEMMAGNPWVLKTGDL--MTRDQVIKALKE---------NKKFQIPIK
|.. ||| .. .. .||.|||| |..|.|| |.| . .. | . . .. . .. ..| .
NNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDH
IK-------------------KDFQDFLNSILQIDPAKRLSAAELLK--HKFL
.. ..|.||.| ||.|| || .| .||| |.|.
LSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | 17295.AA | Ciliate-E2 | 364-590 | 18 | 1.1e-32 | 109.5 | In-house | 49-365 (365) | Show / Hide |
Range on Protein: 364-590
Range on HMM: 49-365/365
Sequence Identity: 18% (62 aa)
LYAVKTYKKDQYDGFIRDQITEQKWID------------ASQKCSNLCRCYCIYQ--QENGLDVVYEHISGESIQKIIQSFNTFQ-----------EKLI
.||.|..||.| .| | . . |. . .. |....| .| ..| . | | ..| . ...|....... || |
IYAMKIMKKNQIE-QIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI
TIFARQIFK---------------GIDFLHSYG-LVHGNLKASNILIDNDAIIKITDLNIFKKSIQVMD--------YLKSTSS----------------
. .||.. .. .||| . .| ..| .|||. |||.|. . || . .. ... .
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQ
-------------APETLLYNE---------LTTKSDIWSAGIVILEMMAG-NPWVLKTGDLMTRDQVIKALKENKK----FQ----------------I
||| | . . ..|.||||.|... ||. | |. ....|. |. .
NMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKS
PIKIKKDFQDFLNS----ILQIDPAKRLS-AAELLKHKFL
. |. .. .|... .|| || ||.. . ..|.|...
WKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 17295.AA | Ciliate-E2-Unclassified | 414-590 | 20 | 7.8e-31 | 104.2 | In-house | 99-352 (352) | Show / Hide |
Range on Protein: 414-590 Range on HMM: 99-352/352 Sequence Identity: 20% (51 aa) VYEHISGESIQKIIQSFNT-----------------FQEKLIT-----IFARQIFKGIDFLHSYG-LVHGNLKASNILIDNDA---IIKITDLNIFKKSI |.| . | . ...|..... |.|. . ...|| .|...||. . .| ..| .|||.||. |||.|. |.||.. VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ QV---------------MDYLKSTS------S---APETLLYNELT----TKSDIWSAGIVILEMMAGNPWVLKTGDLM------------TRDQVIKAL | . ..... . ||| | .. |.|||| |... ||. |.. . . .| |... QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI KENKKFQIP-------IKIKKDFQDFLN----SILQIDPAKRLSAAELLKHKFL |... .. . .. . .||.| ..|. .| ||... ..|.| .. KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| S_TKc | 17295.AA | S_TKc | 344-590 | 22 | 2.9e-28 | 101.16 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 344-590 Range on HMM: 1-231/231 Sequence Identity: 22% (62 aa) GDLLDP-----NGSTCSALHQHTGHLYAVKTYKKDQYDGFIRDQITEQKWIDASQKCSNLCRCYCIYQQENGLDVVYEHISG--ESIQKIIQSFNT---- ..|.. |. . . | .||...|.| | .. . | . .. |....| ..| . | .| |...| . ..|.. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FQEKLITIFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAIIKITDLNIFKKSIQVMDYLKSTSS--APETLLYNELTT-KSDIWSAGIVILEMMAG | | . ...||.......|| | .| || .|||.|. |||.| . .. . . | ||| | .. |.|.|| |... ||..| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG NP-WVLKTGDLMTRDQVIKALKENKKFQIPIKIKKDFQDFLNSILQIDPAKRLSAAELLK-------HKFL | . . ....| .. ... ||.. .|| ||.||..| |.|. | .. YPPFP-------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 17295.AA | STE-Unique | 416-590 | 20 | 1e-26 | 91.55 | In-house | 374-616 (616) | Show / Hide |
Range on Protein: 416-590
Range on HMM: 374-616/616
Sequence Identity: 20% (50 aa)
EHISGESIQKIIQSFNT---------FQEKLITIFARQIFKGIDFLHSYG--LVHGNLKASNILIDNDA-----IIKITDLNIFKKSIQV----------
| .. . | ||.. . |.| .. ...|| .| ..||| . .|..||..||....| .|| | . .... .
EYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKN
-------------------------------MDYLKSTSS--APETLLYN-----ELTTKSDIWSAGIVILEMMAGNPWVLKTGDL----MTRDQVIKAL
|.|. | .||... . . ||.|||| |.....| | | . . . ... . .
SNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQP
KENKKFQIPIKIKKDFQDFLNSILQIDPAKRLSAAELLKHKFL
.. || | ....|.|. . | .| .| ||..||.| .|
PQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
|
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| Kinase | 17295.AA | Pkinase | 499-590 | 22 | 1.5e-19 | 70.16 | Pfam | 179-293 (293) | Show / Hide |
Range on Protein: 499-590 Range on HMM: 179-293/293 Sequence Identity: 22% (26 aa) APETLL-YNELTTKSDIWSAGIVILEMMAGNPWVLKTG----DLMTRDQVIKALKE-NKKFQIPIKIK-------------------KDFQDFLNSILQI ||| .. ... ..|.|.||.|... ||. |.| . .. .|.|. .. .|..| .. ....||....|. APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DPAKRLSAAELLKHKFL ||.||..|...|.|... DPKKRPTAEQILQHPWF |
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| Kinase | 17295.AA | GCN2 | 509-590 | 32 | 1e-15 | 51.12 | In-house | 430-511 (511) | Show / Hide |
Range on Protein: 509-590 Range on HMM: 430-511/511 Sequence Identity: 32% (30 aa) TTKSDIWSA-GIVILEMMAGNPWV-LKTGDLMTRDQVIKALKENKKFQIPIKIK-------KDFQDFLNSILQIDPAKRLSAAELLKHKFL ..| |..| ||...|| . |. | | |..|.|. ....| ||.||.... |..||.||.|| .||.|.|| NQKVDMYSLGGIIFFEMW----YPPFCTQ--MERVQILKQLR---SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL |
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| Kinase | 17295.AA | CAMK | 499-590 | 17 | 5.7e-15 | 43.97 | In-house | 288-425 (425) | Show / Hide |
Range on Protein: 499-590
Range on HMM: 288-425/425
Sequence Identity: 17% (24 aa)
APETLLY--------------NELTTKSDIWSAGIVILEMMAG-NPWVLKTGDLMT-------RDQVIKALKENKKFQ-IPIKIKK--------------
||| |.. . |.|.||.|.. | | |. .... |. .. . |.. .| ....
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDIS
---------DFQDFLNSILQIDPAKRLSAAELLKHKFL
. .|.....|| || ||..... |.|...
DEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 17295.AA | CAMK | 356-479 | 15 | 2.3e-14 | 42.0 | In-house | 13-239 (425) | Show / Hide |
Range on Protein: 356-479
Range on HMM: 13-239/425
Sequence Identity: 15% (35 aa)
ALHQHTG------------HLYAVKTYKK------------------------------DQYDGFIRDQITEQKWIDASQK---CSNLCRCYCIYQ----
. | .|. . .|.| ..| .. ..| | | . . . |....| .|.
CIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHY
----QENG------------LDVVY---EHISGE----SIQKIIQSF---------------NTFQEKLITIFARQIFKGIDFLHSYGLVHGNLKASNIL
.. . . | |..|| . |.. |.|. . ||| .....|| . || || |||
FKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENIL
IDND-----------------AIIKITD
.|.. . |||.|
LDDNNDDSDPVEHDEIFDWNNNNIKIID
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| Kinase | 17295.AA | STE11-Unclassified | 404-479 | 36 | 2.9e-14 | 47.0 | In-house | 75-150 (308) | Show / Hide |
Range on Protein: 404-479 Range on HMM: 75-150/308 Sequence Identity: 36% (28 aa) IYQQENGLDVVYEHISGESIQKIIQSFNTFQEKLITIFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAIIKITD | ..|...... | ..| || .. . | |..|.....|| .|...||| | .| .|. ||||| | |.|.|| IHKHEDCINIFMEYMPGGSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTD |
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| Kinase | 17295.AA | STE11-Unclassified | 499-590 | 30 | 8.1e-14 | 45.41 | In-house | 203-308 (308) | Show / Hide |
Range on Protein: 499-590 Range on HMM: 203-308/308 Sequence Identity: 30% (34 aa) APETLLY--NELTT-KSDIWSAGIVILEMMAGN-PWVLKTGDLMT---RDQVIKALKENKKFQIPIKIK-----------KDFQDFLNSILQIDPAKRLS |||.. .. .. |||||| | ...|| .| || .. . . . |. ..| ||| . . .|||. .|||| ||.. APEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWS----NCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPT AAELLKHKFL | .||.|.|. ANQLLQHPFI |
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| Kinase | 17295.AA | Pkinase | 351-479 | 26 | 2.4e-13 | 48.26 | Pfam | 13-155 (293) | Show / Hide |
Range on Protein: 351-479 Range on HMM: 13-155/293 Sequence Identity: 26% (38 aa) GSTCSALHQHTGHLYAVKTYKKDQYDGFIRDQIT---EQKWIDASQKCSNLCRCYCIYQQENGLDVVYEHISGE----SIQKIIQ--SFNTF--QEKLIT |. . . |. ||...|||. ||. . . . . | . .. | .|.|.... .. . .| |. | . .|. . ..| .|. . GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK IFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAII----KITD ...||..|....|| | .| || .||||||. | ||.| FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD |
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| Kinase | 17295.AA | CMGC | 420-479 | 17 | 6.6e-13 | 37.82 | In-house | 138-247 (513) | Show / Hide |
Range on Protein: 420-479
Range on HMM: 138-247/513
Sequence Identity: 17% (19 aa)
GESIQKIIQSFN---------TFQEKL------------ITIFA------RQIFKGID--FLHSYG--LVHGNLKASNILIDND----------------
. . ..|.. . . | | | .||..|.. ..|| . .| || .||||...
DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNP
----AIIKITD
..|| |
CQKNGRLKICD
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| Kinase | 17295.AA | STE20 | 561-590 | 50 | 9.5e-12 | 39.5 | In-house | 259-288 (288) | Show / Hide |
Range on Protein: 561-590 Range on HMM: 259-288/288 Sequence Identity: 50% (15 aa) KDFQDFLNSILQIDPAKRLSAAELLKHKFL ..|.||... ||.||.|| .| .||||.|. PEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | 17295.AA | CMGC | 558-590 | 27 | 1.3e-11 | 33.49 | In-house | 467-513 (513) | Show / Hide |
Range on Protein: 558-590 Range on HMM: 467-513/513 Sequence Identity: 27% (13 aa) KIK--------------KDFQDFLNSILQIDPAKRLSAAELLKHKFL |.| ... |.|. .||.||.||..|.. |.| .. KFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| TyrKc | 17295.AA | TyrKc | 333-590 | 20 | 2.5e-11 | -39.53 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 333-590 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) IQLNDP------AYIRKGDLLDPNGSTCSALHQHTGHLYAVKTYKKDQYDGFIRDQITEQKWIDAS-QKCSNLCRCYCIYQQE-------NGLDVVYEHI |.|.. ..|| . |||. |.| ..| . | . . |. |.| . |. | .| |. ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM SGESIQKIIQSFNT-FQEKLITIFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAIIKITDLNIFKKSIQVM-------DYLKS----TSS-------- .. . .. ... .. | |. || .| ..||| ...| | | |.|.... ..||.| . | || .. . PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM APETLLYNELTTKSDIWSAGIVILEMM--AGNPW--VLKTGDLMTRDQVIKALKENKKFQIPIK--------IKKDFQDFLNSILQIDPAKRLSAAELLK |||.. |.. |||||.|| |... |.. . |. . . |. ..||. .|. . .| .. . . . ||..| . .|. APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-- HKFL |... HECF |
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| Kinase | 17295.AA | STE20 | 413-479 | 28 | 2.5e-11 | 37.97 | In-house | 85-160 (288) | Show / Hide |
Range on Protein: 413-479 Range on HMM: 85-160/288 Sequence Identity: 28% (22 aa) VVYEHISGESIQKIIQSFN---------TFQEKLITIFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAIIKITD .| |. .| |.. |.. .. ...|. | |.. .| |.||| . .| .|| |||.. |. .|..| IVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLAD |
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| Kinase | 17295.AA | STE11 | 546-590 | 27 | 1.4e-10 | 34.72 | In-house | 253-303 (303) | Show / Hide |
Range on Protein: 546-590 Range on HMM: 253-303/303 Sequence Identity: 27% (14 aa) ALKENKKFQIPIKIK------KDFQDFLNSILQIDPAKRLSAAELLKHKFL . ... .|| .. . .|||. ...|| || .|..||.|.|. GMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI |
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| Kinase | 17295.AA | STE11 | 407-479 | 29 | 3.8e-10 | 33.16 | In-house | 84-160 (303) | Show / Hide |
Range on Protein: 407-479 Range on HMM: 84-160/303 Sequence Identity: 29% (23 aa) QENGLDVVYEHISGESIQKIIQ-SFNT--FQEKLITIFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAI-IKITD |.... . |...| |. ... . . |.|..| .. .|| .|. .||| | .| .|. |||.| | . .|..| QNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLAD |
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| Kinase | 17295.AA | Pkinase_Tyr | 441-525 | 30 | 1.7e-09 | 32.76 | Pfam | 116-208 (270) | Show / Hide |
Range on Protein: 441-525 Range on HMM: 116-208/270 Sequence Identity: 30% (29 aa) FARQIFKGIDFLHSYGLVHGNLKASNILIDNDAIIKITDLNIFKKSIQVMDYL-KSTS--------SAPETLLYNELTTKSDIWSAGIVILEMM ...|| || ..|.| ...| | | |.|.... ..||.| . . || .... ||| . |.. |||||.|| |... |.. MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF |
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| Kinase | 17295.AA | GCN2 | 411-479 | 30 | 8.5e-09 | 26.5 | In-house | 282-351 (511) | Show / Hide |
Range on Protein: 411-479 Range on HMM: 282-351/511 Sequence Identity: 30% (21 aa) LDVVYEHISGESIQKIIQSFNTFQEKL-ITIFARQIFKGIDFLHSYGLVHGNLKASNILIDNDAIIKITD |. . |...| . .| . . .... . .||| | ...|| | .| ||.|||..|.. .||.| LYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGD |
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| Kinase | 17295.AA | STE11 | 499-529 | 38 | 0.000114 | 13.14 | In-house | 203-236 (303) | Show / Hide |
Range on Protein: 499-529 Range on HMM: 203-236/303 Sequence Identity: 38% (13 aa) APETLLYNE---LTTKSDIWSAGIVILEMMAGNP |||.. . ..|.|||| | ...||. |.| APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKP |
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| Kinase | 17295.AA | CMGC | 499-529 | 30 | 0.000504 | 8.09 | In-house | 293-341 (513) | Show / Hide |
Range on Protein: 499-529 Range on HMM: 293-341/513 Sequence Identity: 30% (15 aa) APETLL-YNELT---------TKSDIWSAGIVILEMMAG--------NP ||| || . . | |. |.||.| .. ||. | | APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP |
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| Kinase | 17295.AA | STE20 | 509-529 | 52 | 0.001032 | 9.79 | In-house | 205-225 (288) | Show / Hide |
Range on Protein: 509-529 Range on HMM: 205-225/288 Sequence Identity: 52% (11 aa) TTKSDIWSAGIVILEMMAGNP ..|.|||| || ..|| |.| DYKCDIWSLGITAIEMAEGEP |
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