Gene 16697 (Tetrahymena)
16697
Sequence
Protein domains of 16697.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 16697.AA | Ciliate-C8 | 2-149 | 48 | 2.8e-55 | 189.97 | In-house | 101-238 (238) | Show / Hide |
Range on Protein: 2-149 Range on HMM: 101-238/238 Sequence Identity: 48% (79 aa) NLKQLFDFLKSTQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFEFLQNLSIQKIFENQGDLGFASAVTKSKSHYI ||||.||... .|.. |...||||||||....|.||..|||||||||||||||..|.|..|||||. | . .| .|.||||...|.||||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH SKK--RTDAY-----------FAPEVEKGQSRIQVFKQNQSLNFQFNFNVQKSDLFSLGLVL ||| ||.| |||||||.||||| . .| .. ||..|.|||| SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQ--------SDIFSKK---SDSYSVGLVL |
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| Kinase | 16697.AA | C8 | 1-121 | 53 | 1.7e-49 | 169.96 | In-house | 104-216 (226) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 104-216/226 Sequence Identity: 53% (71 aa) ENLKQLFDFLKSTQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFEFLQNLSIQKIFENQGDLGFASAVTKSKSHY .|||||.|... .|.. |||.||||||||..|.|..|.||||||||||||||||..|.|||.|||| |.||||.|.|.|||. QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNKSHI ISKK----RTDAYFAPEVEKG------QSRIQ .||| |.||||||.||. |.||| QSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQ |
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| Kinase | 16697.AA | C2 | 2-162 | 32 | 4.4e-26 | 86.17 | In-house | 104-245 (245) | Show / Hide |
Range on Protein: 2-162
Range on HMM: 104-245/245
Sequence Identity: 32% (56 aa)
NLKQLFDFLKSTQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-KKFEFLQNLSIQKIFENQGDLGFASAVTKSKSHY
|||| |. .. . |....|.|.||||. . | || ..| |||||| |||. .| ||||| .. |.
NLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K------------------------
ISKKRTDAYFAPEVEKGQSRIQV--FKQNQSLNFQ-FNFNVQK------SDLFS-LGLVLLELDNLKVLNENW
.| || ... .||| . || |. .. | . |.. ||||| .|.||||||| . . .
-----CDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
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| Kinase | 16697.AA | Ciliate-E2a | 4-51 | 40 | 2e-12 | 32.89 | In-house | 84-134 (275) | Show / Hide |
Range on Protein: 4-51 Range on HMM: 84-134/275 Sequence Identity: 40% (21 aa) KQLFDFLKSTQ-LPSK--EIKEIIAIQML-EGLNNLHVKNIMHRDIKPHNFL ..|.| .| . . .. ||..|. |.| .||...| .||||||.|| |.| GELYDKIKQCKRFFEEIQEICDIMQ-QLLWQGLHYMHQRNIMHRDLKPENIL |
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| Kinase | 16697.AA | CMGC | 6-65 | 19 | 2.2e-12 | 36.1 | In-house | 141-246 (513) | Show / Hide |
Range on Protein: 6-65 Range on HMM: 141-246/513 Sequence Identity: 19% (21 aa) LFDFLKSTQ----------LPSKE------------IKEII-----AIQMLEGLN--NLHVKN--IMHRDIKPHNFLVCPSQTY---------------- |....|..| |. . || .. . |.|.||. .| .. |.|||.|| | |... .. LYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQK GFTIKLC ...|.| NGRLKIC |
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| Kinase | 16697.AA | CDK-DD1 | 27-54 | 57 | 4.6e-12 | 32.92 | In-house | 106-133 (379) | Show / Hide |
Range on Protein: 27-54 Range on HMM: 106-133/379 Sequence Identity: 57% (16 aa) QMLEGLNNLHVKNIMHRDIKPHNFLVCP | |||.| .|. |||||||| | |. . QLLEGINECHNQGIMHRDIKPANLLINN |
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| Kinase | 16697.AA | CK1-Unclassified | 24-52 | 58 | 1.7e-11 | 30.19 | In-house | 109-137 (244) | Show / Hide |
Range on Protein: 24-52 Range on HMM: 109-137/244 Sequence Identity: 58% (17 aa) IAIQMLEGLNNLHVKNIMHRDIKPHNFLV || ||.. . .|| ||. |||||| |||. IADQMIQRIEYLHNKNFIHRDIKPDNFLM |
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| Kinase | 16697.AA | Ciliate-E1 | 3-108 | 23 | 3e-11 | 33.31 | In-house | 93-202 (202) | Show / Hide |
Range on Protein: 3-108 Range on HMM: 93-202/202 Sequence Identity: 23% (27 aa) LKQLFDFLKSTQLPSKEI-KEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFT-IKLCKKFEFLQNLSIQKIFENQGDLGFASAVTKS----- | .... ....| .. |. |..|...||. || .||.||||||.| |.. . | .. . ..| ||.| ..| . ... ... . L-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISK---FLKNNQNQQCQYKGYTHYYYPPEQYNCPEQE -KSHYISKKRTDAY . .. .. .| | HNKNQKINYKSDIY |
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| Kinase | 16697.AA | RCK | 6-65 | 31 | 3.8e-11 | 31.32 | In-house | 86-156 (298) | Show / Hide |
Range on Protein: 6-65 Range on HMM: 86-156/298 Sequence Identity: 31% (23 aa) LFDFLKS----TQ-LPSKE--IKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTY-----GFTIKLC |. ..|. .. ||... || |. | | ||. .| ....|||.|| | ....|| | ..||.. LYQMMKDFKERRKYLPENQRSIKNIM-YQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIA |
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| Kinase | 16697.AA | Ciliate-B2 | 27-61 | 37 | 4.3e-11 | 22.24 | In-house | 112-146 (197) | Show / Hide |
Range on Protein: 27-61 Range on HMM: 112-146/197 Sequence Identity: 37% (13 aa) QMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFT |...|| ....||.| |||| | |. . | .. QLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYC |
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| Kinase | 16697.AA | Pkinase | 6-65 | 30 | 7.6e-10 | 35.9 | Pfam | 91-154 (293) | Show / Hide |
Range on Protein: 6-65 Range on HMM: 91-154/293 Sequence Identity: 30% (20 aa) LFDFLK---STQL--PSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC |||... .. . . .|.| .. |.|.||. .| ..|.|||.|| |.|. . . ..|.| LFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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| Kinase | 16697.AA | S_TKc | 1-215 | 12 | 2.3e-05 | -98.2 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-215 Range on HMM: 19-231/231 Sequence Identity: 12% (37 aa) ENLK----------------------------------------------------QLFDFLKSTQ-------LPSKEIKEIIAIQMLEGLNNLHVKNIM . | |||..|. . .| ... ... |....|. .| ..|. RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGII HRDIKPHNFLVCPSQTYGFTIKLC-----KKFEFLQNLSIQKIFENQGDLGFASAVTKSKSHYISKKRTDAYFAPEVEKGQSRIQVFKQNQSLNFQFNFN |||.|| | |.. .||.| ... . | | |||| .. HRDLKPENILLDE------HIKICDFGLARQL-------------------------------TTFCGTPWYMAPEVL-------------------GYG VQKSDLFSLGLVLLELDNLKVLNENWIDYFTKGEIYQGKSIASNYQIDRNSNIYKIAQICLKPNYLERTTSGDLLS--------ELI |.| |.| .| |. . . . . .... . . . ||. . .| | ..| . . KCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 16697.AA | C8 | 132-149 | 55 | 0.0003 | 10.78 | In-house | 209-226 (226) | Show / Hide |
Range on Protein: 132-149 Range on HMM: 209-226/226 Sequence Identity: 55% (10 aa) QFNFNVQKSDLFSLGLVL |. .. .|||||.|||| QYKQYRIQSDLFSVGLVL |
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| Kinase | 16697.AA | Ciliate-B2 | 139-146 | 50 | 0.009183 | 2.21 | In-house | 190-197 (197) | Show / Hide |
Range on Protein: 139-146 Range on HMM: 190-197/197 Sequence Identity: 50% (4 aa) KSDLFSLG .|| .|.| QSDIYSMG |
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| Kinase | 16697.AA | Ciliate-E1 | 143-190 | 22 | 0.268856 | 0.56 | In-house | 153-202 (202) | Show / Hide |
Range on Protein: 143-190 Range on HMM: 153-202/202 Sequence Identity: 22% (11 aa) FSLGLVLLELDNLKVLNENWIDYFTKGEIYQGKSI--ASNYQIDRNSNIY |.....| . .| . .. ..|. | |. . |..|. .|.|| FGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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