Gene 15732 (Tetrahymena)

15732

Species: Tetrahymena
Alias: PreTt15732, 15732, 581, TTHERM_00297210, 27.m00392, 3692.m01165
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: TKL
Family: TKL-ciliate4

Sequence

Name Sequence Type Origin Length Description Download
15732.AA Protein None 259 None Fasta, JSON
15732.NA RNA None 783 None Fasta, JSON
15732.kin_dom Protein Kinase Domain None 222 None Fasta, JSON

Protein domain

Protein domains of 15732.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15732.AA TKL 32-255 22 1.4e-65 224.23 In-house 1-364 (364) Show / Hide 
Range on Protein: 32-255
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

IIKGGFSIVHKGKYKG----------CDVAIKKIFNPN-------------------------ITQDVLDEINNEVNMLATLRHPNIILLMGIVSQPQN-
| .|||..|.|||..|           |||.||.   |                          ..   .....|..|.  ||||||...||.. .|.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MCIVTDLVEGGDLFTYLHKQRKDLSGVQKAFIVKQIINAFYYLHSHQ--------IVHRDLKSYNILLDVGFK--------------I
            .|||.....||.|. |||         |.  ....|  . .||||..        |.|||||| |||.|  ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLCDFGLARKYSDLN------------------------QG-------------------------------YDEKVDVFAFGTLLWEIYAQEVPFDGLE
|.|||||.|  |  .                        |.                               |.||.||..|| .||||.. ..|.... 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

P----------NDIMVRVTNDEQLPQK------------QTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
.           ..|... . ...| .             ..  |. ||. .| . .|. ||||..| ...
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 15732.AA TK 27-255 15 4.9e-45 148.44 In-house 1-486 (486) Show / Hide 
Range on Protein: 27-255
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

IHFLLIIKGG-FS---IVHKGKYKG---------------------------CDVAIKKIF--NPNITQDVLD-EIN---------NEVNMLATLR----
|...  .  | |     |.||...|                           ..||.| .   ...  .. .| |..         .|..... ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIILLMGIVSQPQN------------MCIVTDLVEGGD----LFTYLHKQRKD--------------------------------------------
 ||||. | |...|...            ..||. ....||    | .||.| |..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSGVQKAFIVKQIINAFYYLHSH------QIVHRDLKSYNILLDVGFK-----------IKLCDFG---
                               |.  |.  .  || ..  ||||.      ..|||||   |.|.. . .           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARKYSD---------------------------------------------LNQG----------YDEKVDVFAFGTLLWEIYAQE-VPFDGLE
     |||.  .                                             || .          . .| ||..|| |.|||.    .|. |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PN----------DIMVRVTND--------------EQLPQKQTIN--------------SSIYKLIVKCRALNPNLRPSFEKIYQEF
.|          ..| ....                ..|| .                   .| |. .| ...|. ||.|. .....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 15732.AA S_TKc 27-259 28 6.2e-44 153.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-259
Range on HMM: 1-231/231
Sequence Identity: 28% (74 aa)

IHFLLII-KGGFSIVHKGKYKG--CDVAIKKIFNPNITQDVLDEINNEVNMLATLRHPNIILLMGIVSQPQNMCIVTDLVEG--GDLFTYLHKQRKD---
 ..| .| ||.|. |.|.. |.    ||||.|          . | .|...|   .||||. | ..    .....|.....|  ||||.|..|...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSGVQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLARKYSD-------------LNQGYDE-KVDVFAFGTLLWEIYAQEVPF
  ..  . .|...||..|  |.|||.|.|||||  |||||    ||.|||||||.. .             |  ||.  |.|. ..| .|.| .. . ||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPF

DGLEPNDIMVRVTNDEQLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF-----NQLA
.  ... .. ..             ..   .| ||   .|. ||.  .. |.       .  
P--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15732.AA TyrKc 27-255 24 4.8e-40 140.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-255
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

IHFLLII-KGGFSIVHKGKYKGCDVAIKKIFNPNITQDVLDEINNEVNMLATL--RHPNIILLMGIVSQP-------QNMCIVTDLVEGGDLFTYLHKQR
|... ..  | | .|.||..|  .||.|.. .       . .. .| ...  |  .||||. | |...|.       . ..||. ....|||  ||.| |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KDLSGVQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLARKY--------------------SD------------LNQG-YDEKV
..|.  ..  .  || .   ||||....||||   |.|.. .. .| .||||.|.                     ..            .| | . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVFAFGTLLWEIYAQ-EVPFDG-----LEPNDIMVRVTNDEQLPQKQT--------INSSIYKLIVKCRALNPNLRPSFEKIYQEF
||..|| ..|||.   . |  |     ... ... .| . . .|| .           . .|... .| . .|. ||.|. |...|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 15732.AA TKL-Unique 28-170 36 4.8e-38 131.8 In-house 1-165 (290) Show / Hide 
Range on Protein: 28-170
Range on HMM: 1-165/290
Sequence Identity: 36% (60 aa)

HFLLIIKGGFSIVHKGKYKGCDVAIKKIF-NPNITQDVLDEINNEVNMLATLR-HPNIILLMGIVS----QPQNMCIVTDLVEGGDLFTYLH--------
 . .|  ||.. | |||..| .||||... |  .  ....| .|||| . .|. |||| ..||.      .| |||||.. ..|| |  .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KQRKDLSGVQKAFIVKQIINAFYYLHSHQ--IVHRDLKSYNILLDVG-----FKIKLCDFGLAR
 .. ..|.  |.  ....|  . ||||. .  | |||||| |.|.| .     ..||.|||||..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK
Kinase 15732.AA Pkinase 34-173 32 1.8e-37 133.61 Pfam 9-163 (293) Show / Hide 
Range on Protein: 34-173
Range on HMM: 9-163/293
Sequence Identity: 32% (50 aa)

KGGFSIVHKGKYKGCD--VAIKKIFNPNITQDVLDEINN--EVNMLATLRHPNIILLMGIVSQPQNMCIVTDLVEGG----DLFTYLH-KQRKDL--SGV
.|.|. | |.. ||    ||.|.|  ...  ... .  .  |. ... |.||||. | ...  ......|....|||    |||.|.. .... .  |  
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

QKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLD-VGFK---IKLCDFGLARKYS
.  |...||. . .|.||. |.|||||. |||.|  |     .|.||||||....
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD
Kinase 15732.AA LISK 31-171 38 3.3e-37 118.32 In-house 1-154 (296) Show / Hide 
Range on Protein: 31-171
Range on HMM: 1-154/296
Sequence Identity: 38% (59 aa)

LIIKGGFSIVHKGKYK--GCDVAIKKIF---NPNITQDVLDEINNEVNMLATLRHPNIILLMGIVSQ-PQNMCIVTDLVEGGDLFTYLHKQRK---DLSG
 | ||.|. | || ..  | ..|||.|    |  .  . .  .. || |.  ||||||.  ||.  .      ||| ...||||. ||..  |   .|. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

VQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLD----VGFKIKLCDFGLARK
 |.  | . |  .. |||| .|.|||||| |.|..     ...||.||||.||.
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARM
Kinase 15732.AA Dicty4 27-170 35 6.2e-34 110.69 In-house 1-162 (277) Show / Hide 
Range on Protein: 27-170
Range on HMM: 1-162/277
Sequence Identity: 35% (57 aa)

IHFLLII-KGGFSIVHKGKYKGCDVAIKKIFNPNIT--QDVLDEINNEVNMLATLRHPNIILLMGIVS----QPQNMCIVTDLVEGGDLFTYLHK-----
| .  .| ||.|. |.||. .| .||.|| .| |..  .. | |  .||. .. .|||||.|.||       .|  ||||| ..  |.|.. ||.     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QRKDLS--GVQK-AFIVKQIINAFYYLHS--HQIVHRDLKSYNILLDVGFKIKLCDFGLAR
 |.. |.   . .   . . .     .||.    |.|||||| |.| |  ...| |||||..
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ
Kinase 15732.AA LISK-DD1 31-171 35 1.9e-32 114.13 In-house 1-176 (290) Show / Hide 
Range on Protein: 31-171
Range on HMM: 1-176/290
Sequence Identity: 35% (62 aa)

LIIKGGFSIVHKGKYKGCDVAIKKIFN---PNITQDVLDEINNEVNMLAT---LRHPNIILLMGIVSQ-------------PQNMCIVTDLVEGGDLFTY
 | ||.| .| || | | .|||||| .     .  | .  .. |. ||     .|||||.   ||                     ||| ..|||||. |
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

LHK------------QRKDLSGVQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVG----FKIKLCDFGLARK
| .            . ....   .. | . |  |. |||| .|.|||||| |||.|       .||.||||.||.
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARM
Kinase 15732.AA Pkinase_Tyr 37-170 30 3.7e-32 109.52 Pfam 12-159 (270) Show / Hide 
Range on Protein: 37-170
Range on HMM: 12-159/270
Sequence Identity: 30% (45 aa)

FSIVHKGKYK------GCDVAIKKIFNPNITQDV--LDEINNEVNMLATL-RHPNIILLMGIVS-QPQN--MCIVTDLVEGGDLFTYLHKQ---RKDLSG
|  |.||..|      ...||.|.. ... ...   ...  .|.... .| .||||. |.|... | .   ..||. ....||| .||.|.   .. |. 
FGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTM

VQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLAR
 ..  .  || ..  ||.|....||||   |.|.. ....| |||||||
KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 15732.AA MLK 27-170 30 2.5e-30 102.48 In-house 1-181 (291) Show / Hide 
Range on Protein: 27-170
Range on HMM: 1-181/291
Sequence Identity: 30% (56 aa)

IHFLLII-KGGFSIVHKGKYKGCD-----VAIKKIF----NPNITQDVLDEINNEVNMLATLRHPN----IILLMGIVSQPQN-MCIVTDLVEGGDLFTY
| |. .| .|.|  |.||.... |     ||.|...       .|    .... |.. |. |.|||    || ..|. .||..  |||.  .||| |...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHKQRK-------------DLSGVQKAFIVKQIINAFYYLHSHQ---IVHRDLKSYNILLDV------GFKIKLCDFGLAR
|| .|.               .  ... . .|. ..  ||||..   |.|||||| |||.|       . . | ||||..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase 15732.AA RAF 27-169 35 8.9e-30 99.09 In-house 1-147 (275) Show / Hide 
Range on Protein: 27-169
Range on HMM: 1-147/275
Sequence Identity: 35% (52 aa)

IHFL-LIIKGGFSIVHKGKYKGCDVAIKKIFNPNITQ-DVLDEINNEVNMLATLRHPNIILLMGIVSQP--QNMCIVTDLVEGGDLFTYLHKQRK-DLSG
.  .  | .| |  |..|.. | |||.| .    .|. . |..  ||| |.   || ||.| || .. |   .  ||| . .|  |....| |.  ..  
VQIGERIGQGRFGTVYRGHWHG-DVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDM

VQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLA
 ..  | .||. .  |||.  |.|||||| ||.|. | .... ||||.
NWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLF
Kinase 15732.AA LRRK 26-172 25 8.3e-27 91.86 In-house 1-230 (351) Show / Hide 
Range on Protein: 26-172
Range on HMM: 1-230/351
Sequence Identity: 25% (60 aa)

LIHFLLIIKGGFS-IVHKGKYKG---------------------------C-DVAIKKIFNP---------NITQ-----------------------DV
|..  .| .|||  .|...|..|                           | .|||||.  .         | .                         .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LDEINNEVNMLATLRHPNIILLMGIVSQPQNMCIVTDLVEGGDLFTYLHKQRKD--------LSGVQKAFIVKQIINAFYYLHSHQ--IVHRDLKSYNIL
. |  .|| .. .|.||||. |.|.  .|  .|.|....  ||| ..||. ..|        .|   |  |. ||  .  |||||   |.|||||| |||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------VGFKIKLCDFGLAR--KY
|   .            ..|..|||. |  ..
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQC
Kinase 15732.AA Dicty5 40-170 36 2.7e-24 80.5 In-house 15-152 (260) Show / Hide 
Range on Protein: 40-170
Range on HMM: 15-152/260
Sequence Identity: 36% (51 aa)

VHKGKYKGCDVAIKKIFNPN-ITQDVLDEINNEVNMLATLR--HPNIILLMGIVSQPQNM-CIVTDLVEGGDLFTYLHKQRK----DLSGVQKAFIVKQI
| .| ||| |||||     | .  | ..|   || ..      |||.|   |   . ..   .|| ..  | || ||  |||     ..  |.  .   |
VYNGIYKGMDVAIKVYSQENCMCFD-WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDI

INAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLAR
 ..  .|||  |.|||||| |.|.   .|||. |||  |
AQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSR
Kinase 15732.AA TKL-Unique 176-255 26 9.7e-19 62.85 In-house 202-290 (290) Show / Hide 
Range on Protein: 176-255
Range on HMM: 202-290/290
Sequence Identity: 26% (24 aa)

NQGYDEKVDVFAFGTLLWEIYAQEV------PFDGLEPNDIM--VRVTNDEQLPQK-QTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
.  |.||.||..||. ||||.  ..      |..|.... .   |... ... |   . .. .. .|| .|.. .|  ||||. |. . 
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 15732.AA MLK 176-255 32 2.8e-18 60.09 In-house 210-291 (291) Show / Hide 
Range on Protein: 176-255
Range on HMM: 210-291/291
Sequence Identity: 32% (27 aa)

NQGYDEKVDVFAFGTLLWEIYAQEVPFD-GLEPNDIMVRVTNDE-QLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
.. |.||.||. .| .|||. . |||.. ...|  |   |.. .  .|  .|.. .. ||. .|   .|. ||||  | |..
CEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 15732.AA Dicty5 177-259 34 2.5e-16 52.69 In-house 178-260 (260) Show / Hide 
Range on Protein: 177-259
Range on HMM: 178-260/260
Sequence Identity: 34% (29 aa)

QGYDEKVDVFAFGTLLWEIYAQEVPFDGLEPNDIMVRVTNDE--QLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEFNQLA
|.|..|.||..||  |||. ..  |.| .   .| | |   |   .|   .. ..| .|| ||    | .|||| .| . |... 
QPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIP--KDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 15732.AA Pkinase_Tyr 179-255 26 3e-14 48.88 Pfam 191-270 (270) Show / Hide 
Range on Protein: 179-255
Range on HMM: 191-270/270
Sequence Identity: 26% (21 aa)

YDEKVDVFAFGTLLWEIYAQE-VP-FDGLEPNDIMVRV-TNDEQLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
. .| || .|| |.|||.     | . |. ..... ..  . ...|. .     ||.|. .| . .|. ||.|. |....
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 15732.AA LRRK 179-257 25 8.2e-12 38.06 In-house 259-351 (351) Show / Hide 
Range on Protein: 179-257
Range on HMM: 259-351/351
Sequence Identity: 25% (24 aa)

YDEKVDVFAFGTLLWEIYAQE-VPFDGLE-------PNDIMVRVTNDEQLPQKQT-INS-----SIYKLIVKCRALNPNLRPSFEKIYQEFNQ
|.||||...|| .|||..  .  |||...        . |  ....    . .|.  .      .  .||..| . .|. ||.|..| .   |
YTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 15732.AA Dicty4 176-257 32 8.8e-11 32.36 In-house 191-277 (277) Show / Hide 
Range on Protein: 176-257
Range on HMM: 191-277/277
Sequence Identity: 32% (28 aa)

NQGYDEKVDVFAFGTLLWEIYAQEVPFD--GLEPNDIMVRVTN-DEQLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQE--FNQ
.|.|.||.||. || .||||   . |.   . ..  .   | |  . .|  .    |. .||..|   .|. ||||| | |.   . 
HQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 15732.AA Pkinase 176-255 20 2.2e-10 37.77 Pfam 186-293 (293) Show / Hide 
Range on Protein: 176-255
Range on HMM: 186-293/293
Sequence Identity: 20% (22 aa)

NQGYDEKVDVFAFGTLLWEIYAQEVPFDGL----EPNDIMVRVTNDEQ----LPQKQTIN-------------------SSIYKLIVKCRALNPNLRPSF
.|.|. |||....| .|.| .  . ||.|     . .| |... .. .     .  ....                   ..  ..| .| ...|. ||..
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

EKIYQE--F
| | |   |
EQILQHPWF
Kinase 15732.AA RAF 184-255 25 5.1e-10 30.51 In-house 199-275 (275) Show / Hide 
Range on Protein: 184-255
Range on HMM: 199-275/275
Sequence Identity: 25% (20 aa)

DVFAFGTLLWEIYAQEVPFDGLEP-NDIMVRVTNDEQLPQ----KQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
||.|||| . |. |.| |. .  .   |   |   .  ..     ... ... .|.. | . .|. |||| .|  . 
DVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase 15732.AA LISK 231-255 36 7e-06 14.9 In-house 272-296 (296) Show / Hide 
Range on Protein: 231-255
Range on HMM: 272-296/296
Sequence Identity: 36% (9 aa)

YKLIVKCRALNPNLRPSFEKIYQEF
..| ..|  ..|. ||||..| | .
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase 15732.AA LISK 179-195 64 4.4e-05 12.25 In-house 216-232 (296) Show / Hide 
Range on Protein: 179-195
Range on HMM: 216-232/296
Sequence Identity: 64% (11 aa)

YDEKVDVFAFGTLLWEI
|||..||| || .| ||
YDESCDVFSFGIVLCEI
Kinase 15732.AA LISK-DD1 231-255 40 0.005374 6.96 In-house 266-290 (290) Show / Hide 
Range on Protein: 231-255
Range on HMM: 266-290/290
Sequence Identity: 40% (10 aa)

YKLIVKCRALNPNLRPSFEKIYQEF
..| ..|   .|| |||| .| |  
MDLCMWCCKYDPNNRPSFKEIVQTL
Kinase 15732.AA LISK-DD1 175-195 47 0.009712 6.02 In-house 204-224 (290) Show / Hide 
Range on Protein: 175-195
Range on HMM: 204-224/290
Sequence Identity: 47% (10 aa)

LNQGYDEKVDVFAFGTLLWEI
| . ||. .||| || .| |.
LGMSYDWSCDVFSFGMVLLEL