Gene 14836 (Tetrahymena)
14836
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 14836.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14836.AA | STE | 88-321 | 23 | 3.1e-66 | 226.35 | In-house | 14-359 (359) | Show / Hide |
Range on Protein: 88-321
Range on HMM: 14-359/359
Sequence Identity: 23% (83 aa)
SIYRGMNK------QNAEI---------VALKEYNVIPA-----------------EDLQQIIQEISKESRVQ--DEFVSGLNDYFVSDG-------KLY
. |..||. .. |. .| |. |. . |..|||..||. .. . ... .... .| .|.
TVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELW
LISQYFSEGSVYDLIQNI--------------GPISEENICIIIKQALMG-LKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILS------
.. | . ||. |.|.. ....|. |..|..| | | |.|||.... | ||..||.| |||||| ....||....
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNN
---------QCRNYSY---WQSPETII------DQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTV----------------QEEPQIDS---
| || | .|| | |.. ..|.||||.|.|.|||| |.||.....| .| |.. .. |.. .
IIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS
----------------SFSPQFQEFLKMCLEKNPEERASVGDLLL--SNFI
..|| |..|.. ||.|.|..|... .|| ||
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | 14836.AA | STE20 | 88-321 | 32 | 7.2e-63 | 215.17 | In-house | 14-288 (288) | Show / Hide |
Range on Protein: 88-321 Range on HMM: 14-288/288 Sequence Identity: 32% (90 aa) SIYRGMNKQNAEI----VALKEYNVIPA----EDLQQIIQEISKESRVQDEFVSGLNDYFVSD----GKLYLISQYFSEGSVYDLIQ---NIG------P ..|.. .|.. |. || | |. .. .... |..||| .. . . . . .. | .|... | . ||. |... ..| | KVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHP ISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTE----ILSQCRNYS----YWQSPETIID-----QHFNEKSDIWSI ..|| | | ...| ||.|||.|.. | ||. ||.| .|| |||.|| . .||. .. || || .|| | . ..|.|||| MNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSL GITAIEMAKGEPPYFNLPPKKAQFLTV--QEEPQIDSS-----FSPQFQEFLKMCLEKNPEERASVGDLLLSNFI ||||||||.||||||...| .| |.. |..| ... .||.|..|.. ||.|.||.|... .|| || GITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | 14836.AA | YSK | 89-321 | 36 | 2.1e-61 | 183.49 | In-house | 15-257 (257) | Show / Hide |
Range on Protein: 89-321 Range on HMM: 15-257/257 Sequence Identity: 36% (89 aa) IYRGMNKQNAEIVALKEYNVIPAED-LQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEGSVYDLIQN--IGPISEENICIIIKQALMGLKY .| | ... ..|| | . ||| | ||| | .. . | || | | ||. ||. .|.. |. | ||.. | ||.| VYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDY LHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNYS---YWQSPETIID--QHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTV ||... .| ||. |. |. .| |||||| . ..|. || || | ..| ||||.||||.||||||||| . | .. || . LHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIP QEE-PQIDS-SFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI .. |. |.| | || .||.|.||.| | .|| . || KNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI |
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| Kinase | 14836.AA | S_TKc | 75-321 | 21 | 2.7e-42 | 147.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-321 Range on HMM: 1-231/231 Sequence Identity: 21% (58 aa) DILEKKTTQSMHSSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSE--GSVYDLIQNIGP------ . .| . .. |.. .| .|||.|. . ..|..||. .. . ... | |.|.. ..||.. | . |...|.|.. |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP ISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNY---SYWQSPETIIDQHFNE-KSDIWSIGITAIEMAK ..| .. ...| . .|.|.|... .| .| .||.| . .|.||| ...| . . .. .|| . ... |.|.||.|.. .||. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC GEPPYFNLPPKKAQFLTVQEEPQIDSSFSPQFQEFLKMCLEKNPEERASVGDLLL-------SNFI |.||. .. | . ||.. .|.. ||.|.||.| .. ..| .. GYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 14836.AA | STE-Unique | 143-321 | 20 | 6.9e-42 | 145.47 | In-house | 367-616 (616) | Show / Hide |
Range on Protein: 143-321
Range on HMM: 367-616/616
Sequence Identity: 20% (50 aa)
GKLYLISQYFSEGSVYDLIQNIGP---------ISEENICIIIKQALMGLKYLHKNN--RLHKNIKSSNIMLQSDG-----IVKLCDFSTSKKLTEI---
. .... | . |.. ..|.. |. . |. . ...|.| || ||| .| ..|..||.. .|| ||.||| ........
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE
--------------------------------------LSQCRNYSYWQSPETIIDQ-----HFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKA--QFL
. |... . .||.| . ... |.||||.|.. ..|. | ||. .. . .| . .
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC
TVQEEPQI-------DSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
. .. ....|..|.|. |||.|| |.|. .|| . .
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
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| Kinase | 14836.AA | KHS | 74-321 | 31 | 2.5e-41 | 136.66 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 74-321 Range on HMM: 1-258/258 Sequence Identity: 31% (81 aa) YDILEKKTTQSMHSSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEGSVYDLIQNIGPISEENIC |..| .. .|. ..| |..|.| . | .|.. | ||| . . . ... ||... | ||. |. . ||.|| | YELL-QRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIA IIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNY---SYWQSPETIIDQH---FNEKSDIWSIGITAIEMAKGEPPY . ...| ||.||| . ..|. || ||.|...| ||| || | ..| ... . . || || .. .|. |||..||||||.| || YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM FNLPPKKAQFLTVQEE---PQID--SSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI |.| | .| || . . |.. . .|..| .|.||.| ||| | . || .|. FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV |
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| Kinase | 14836.AA | SLK | 89-321 | 29 | 2.5e-40 | 133.71 | In-house | 15-259 (259) | Show / Hide |
Range on Protein: 89-321 Range on HMM: 15-259/259 Sequence Identity: 29% (72 aa) IYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEGSVYDLIQNIG-PISEENICIIIKQALMGLKYLH .|. .|.. . | | .. |.|. . || | .. . .| . . |.||... . | | .. ... |. |. | .. |. . .|..|| VYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLH KNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNY---SYWQSP-----ETIIDQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLT .|. .|...| ||.. || |.| || | |... . . . || | ||. || . |.||||.||| ||||..|||. .. | . . SNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEMNPMRVLLKI VQEEP---QIDSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI . || . | .| .|..||| ||.|.|. | . .|. ... QKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV |
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| Kinase | 14836.AA | MEKK15 | 155-321 | 35 | 4e-38 | 132.98 | In-house | 86-264 (264) | Show / Hide |
Range on Protein: 155-321 Range on HMM: 86-264/264 Sequence Identity: 35% (64 aa) GSVYDLIQNIGPISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEI-LSQCR--------NYSYWQSPETIIDQHFN ||. .| ||. | | || | | .||| |. .|. || |.|| . ||.|| || |.|. ... . || || | . . GSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYG EKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTVQE---EPQIDSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI |||||||| | ||| . ||. .... | | . ||. || . ..| .||| . .||.. .|| || RKSDIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI |
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| Kinase | 14836.AA | PAKL | 155-275 | 42 | 2.7e-30 | 106.98 | In-house | 82-207 (256) | Show / Hide |
Range on Protein: 155-275 Range on HMM: 82-207/256 Sequence Identity: 42% (54 aa) GSVYDLIQNIG-PISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILS-QCRNYS---YWQSPETIIDQHFNEKSD ||. |... .. |. | .|..|.| || ||| | | ||. || | |..||. || | .| .. | . || || | | | | | GSINDMMESCCKTLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCD IWSIGITAIEMAKGEPPYFNLPPKKA ||| |||||||| |.|| .|| .| IWSLGITAIEMADGFPPHYDMPPMRA |
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| Kinase | 14836.AA | Pkinase | 87-321 | 21 | 5.2e-30 | 107.19 | Pfam | 13-293 (293) | Show / Hide |
Range on Protein: 87-321 Range on HMM: 13-293/293 Sequence Identity: 21% (61 aa) SSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQ----EISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEG----SVYDLIQ--NIGPI--SEENICI .. |....| . .|||.|. .. ... .... ||. |.. ... | |.| .....|.. | | . .|.|. . |.. ||. .. GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF IIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIV----KLCDFSTSKKL-TEILSQCRNY---SYWQSPETII-DQHFNEKSDIWSIGITAIEMAKGEP ...| | ||.|.|... .| .|..||.. ..| . |.||| .|.. . | . . ... .|| | .|. |.|.||.|.. .||. |.| YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP PYFNL---PPKKAQFLTVQEEPQIDSSFS-------------------------PQFQEFLKMCLEKNPEERASVGDLLLSNFI |. . .. | ... . . .|. . ...|.| ||.|.|..| . ..| . .. PFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 14836.AA | PAKA | 232-321 | 44 | 5.9e-30 | 102.35 | In-house | 168-260 (260) | Show / Hide |
Range on Protein: 232-321 Range on HMM: 168-260/260 Sequence Identity: 44% (41 aa) YWQSPETIIDQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTVQE-EPQIDS--SFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI || .|| | . .|| ||||.|| ||||. ||||| | || .| .| .. | | . ..|..|..||. ||......|||. .|| |. YWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL |
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| Kinase | 14836.AA | MST | 232-321 | 44 | 2.4e-29 | 90.35 | In-house | 162-254 (254) | Show / Hide |
Range on Protein: 232-321 Range on HMM: 162-254/254 Sequence Identity: 44% (41 aa) YWQSPETIIDQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTVQEEPQI---DSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI || .|| | . . | |||| |||||||| |.|||... | | |. | |. . .|..| |.. || ||||.|.. .|| || YWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI |
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| Kinase | 14836.AA | MST | 88-214 | 33 | 7.3e-18 | 53.29 | In-house | 14-141 (254) | Show / Hide |
Range on Protein: 88-214 Range on HMM: 14-141/254 Sequence Identity: 33% (44 aa) SIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFV--SDGKLYLISQYFSEGSVYDLIQNIG-PISEENICIIIKQALMGLK | |. .||. .||| | .| ||||.|| ||| . . ... .. . . . . .. | ||| |.. .. . .|. | | ...| ||. SVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACILYDTLQGLQ YLHKNNRLHKNIKSSNIMLQSDGIVKLCDF |||.| . | ||. || | .| || || YLHDNKKIHRDIKAGNILLNHEGECKLADF |
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| Kinase | 14836.AA | PAKA | 138-214 | 34 | 3.5e-17 | 56.93 | In-house | 67-147 (260) | Show / Hide |
Range on Protein: 138-214 Range on HMM: 67-147/260 Sequence Identity: 34% (28 aa) YFVSDGKLYLISQYFSEGSVYDLIQNIG-----PISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDF | | | .|... | . |. |.|.. ...|. | .... | ||...|...| | ||| || | .|| ||. || YLV-DDELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDF |
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| Kinase | 14836.AA | TyrKc | 75-320 | 18 | 1.2e-12 | -18.25 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-320 Range on HMM: 1-280/280 Sequence Identity: 18% (53 aa) DILEKKTTQSMHSSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRV--QDEFVSGLNDYFVSD-------GKLYLISQYFSEGSVYDLIQNIG |.|| .|.|. | . || | . .. ...|.. ... . . . | . ... . |... | . |. | ... . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR P-ISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLT---------EILSQ----CRNY-S--YWQSPETIIDQHFNEKS | .. . . . |. | |||..| | . |... ....|| .|| |.... . .. .... | .||.| . |..|| PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DIWSIGITAIEMA-KGEPPYFN-----LPPKKAQFLTVQE--EPQIDS-------SFSPQFQEFLKMCLEKNPEERASVGDLLLSNF |.|| |.. |. |..|| . .... . . | || .. .. . |.| . .||.| . .. . | DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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| Kinase | 14836.AA | PAKL | 290-321 | 50 | 1.3e-08 | 28.47 | In-house | 225-256 (256) | Show / Hide |
Range on Protein: 290-321 Range on HMM: 225-256/256 Sequence Identity: 50% (16 aa) FSPQFQEFLKMCLEKNPEERASVGDLLLSNFI .|| | || |. | ||.|.|. ||| || WSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI |
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| Kinase | 14836.AA | Pkinase_Tyr | 233-272 | 38 | 0.000223 | 15.45 | Pfam | 180-221 (270) | Show / Hide |
Range on Protein: 233-272 Range on HMM: 180-221/270 Sequence Identity: 38% (16 aa) WQSPETIIDQHFNEKSDIWSIGITAIEMAK-GEPP-YFNLPP | .|| | . |..|||.|| |.. |. || | | .... WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSN |
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| Kinase | 14836.AA | Pkinase_Tyr | 181-214 | 32 | 0.102101 | 6.44 | Pfam | 122-155 (270) | Show / Hide |
Range on Protein: 181-214 Range on HMM: 122-155/270 Sequence Identity: 32% (11 aa) MGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDF .|. ||. .| | . |... ....|| ||| KGMEYLESKNCIHRDLAARNCLVTENNVVKICDF |
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