Gene 13938 (Tetrahymena)
13938
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 13938.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13938.AA | Ciliate-A7 | 64-336 | 25 | 4.8e-49 | 169.25 | In-house | 51-360 (360) | Show / Hide |
Range on Protein: 64-336
Range on HMM: 51-360/360
Sequence Identity: 25% (83 aa)
SCKDIENEYNIASRLSHENILSPIE--------YYKQYRGGCAISFPRASCDAFHYFIERSQQ-QKRAA--------YSLEEVRQLLRNVASALNYLHQG
.|... ||||... ..|..|....| ...|..|.| .. | || |.||. ... . . | ..|...| .|.||.|||.
ECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNE
ENIAHNDIKLENILCFISDDQKQVPVFMLTDFAYSYEIHTDHHTDNSQLHDSSFSSSLLSQSTQTSINVYPKWKNRVKMYLSPEMIESIQK---------
||||||||.|||..| . .|. | |.||...... . .|.|.| | | | . | .||.|.| |..||.|. . |
KNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQF----------QSHFESTLR-Q--QIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKN
--------QEVKMGLEKGNDILSLGFALFNIVFLENMIGKYEKEYSSSKKYQQIQKCGAD------FLQTLNQNLI--------NTELE--KKDLLFDLI
... || |. ..| ..|.|.| | ... ... || .... .. ..|.. . . ||. . . |...||.
KKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLL
IGMIQQDPLKRLDACGILNHPWL
..|....| .|. . || |||.
NKMLCPNPSQRYCIKQILQHPWF
|
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| Kinase | 13938.AA | Ciliate-E2 | 66-336 | 21 | 6.8e-17 | 54.5 | In-house | 78-365 (365) | Show / Hide |
Range on Protein: 66-336
Range on HMM: 78-365/365
Sequence Identity: 21% (69 aa)
KDIENEYNIASRLSHENILSPIEYYK-QYRGGCAISFPRASCDAFHYFIERSQQQ-------KRAAYSLEEVRQLLRNVAS---------------ALNY
| | || || ..|.| ||. .|... . . . . . .. ..|. .... . ....|.... . ... ||.|
KKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEY
LHQGENIAHNDIKLENILCFISDDQKQVPVFMLTDFAYSYEIHTD--HHTDNSQLHDSSFSSSLLSQSTQTSINVYPKWKNR------------VKMYLS
||. || | |||.|||| ..|| .| ....| .|. |.. . |.. . .|..
LHSKNNIIHRDIKPENILF-----------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD-------QIIQQNMFNTICGTPGYMA
PEMIE--SIQKQEVKMGLEKGNDILSLGFALFNIVFLENMIGKYEKEYSSSKKYQQIQKCGADFLQTLNQNLINTELEKKDLLF-----------DLIIG
||... ....|. . | . || ||| |. .| . .|||..| || . .|. . .. . |||
PEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKK
----MIQQDPLKRLD-ACGILNHPWL
|.| || ||.. . ||||||.
FGKRMLQKDPEKRITGWEQILNHPWF
|
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| S_TKc | 13938.AA | S_TKc | 41-336 | 16 | 1.6e-13 | 21.35 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 41-336 Range on HMM: 1-231/231 Sequence Identity: 16% (54 aa) SKFVEKL------VIKECLHLRDDE----KCISSCKDIENEYNIASRLSHENILSPIEYYKQYRGGCAISFPRASC---DAFHYFIERSQQQKRAAYSLE ....|. . . | | .... |.|. ..|..| .| .. |.|| .... . . . .. | |.| .| . .| .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- EVRQLLRNVASALNYLHQGENIAHNDIKLENILCFISDDQKQVPVFMLTDFAYSYEIHTDHHTDNSQLHDSSFSSSLLSQSTQTSINVYPKWKNRV--KM ..| ... ...||.|.|. .| | |.| ||||. . ...|| . .. . . HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--------HIKICDFGLARQL-----------------------------------TTFCGTPW YLSPEMIESIQKQEVKMGLEK-GNDILSLGFALFNIVFLENMIGKYEKEYSSSKKYQQIQKCGADFLQTLNQNLINTELEKKDLLFDLIIGMIQQDPLKR |..||.. | | |. |.| |. . . .. ..|.| . . |.| .. | || || YMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKR LDACGILN-------HPWL . | .|. |||. PTA-EALQDEWDIKCHPWF |
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| Kinase | 13938.AA | MAPKAPK | 117-161 | 42 | 4.8e-13 | 36.28 | In-house | 93-136 (292) | Show / Hide |
Range on Protein: 117-161 Range on HMM: 93-136/292 Sequence Identity: 42% (19 aa) QQQKRAAYSLEEVRQLLRNVASALNYLHQGENIAHNDIKLENILC ||. . ... .|..|. . ..||. .||. |||| |.|.||||| QQRGHKHFTEREASQIMKDICSAVDFLHS-MNIAHRDLKPENILC |
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| Kinase | 13938.AA | CAMK | 52-161 | 18 | 1.9e-11 | 32.45 | In-house | 55-212 (425) | Show / Hide |
Range on Protein: 52-161 Range on HMM: 55-212/425 Sequence Identity: 18% (30 aa) CLHLRDDEKCIS--------SCKDIENEYNIASRLS-------HENILSPIEYYK------------QYRGG-------CAISF---PRASC-DAFHYFI |. .|..|| . ..| ...|..| ..|. |.||.. .|.| . . . . . .| . | . CY-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLF ERSQQQKR-------------AAYSLEEVRQLLRNVASALNYLHQGENIAHNDIKLENILC .. ..... .. .|.|.. | ..||..|.|. |.| |.|.||||. DYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILL |
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| Kinase | 13938.AA | MNK | 119-161 | 44 | 1e-09 | 29.63 | In-house | 90-131 (292) | Show / Hide |
Range on Protein: 119-161 Range on HMM: 90-131/292 Sequence Identity: 44% (19 aa) QKRAAYSLEEVRQLLRNVASALNYLHQGENIAHNDIKLENILC |.| .. .| .| ...||||...|. ||| |.| ||||| QQRKHFTEHEASQVIKDIASALDFMHN-KGIAHRDLKPENILC |
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| Kinase | 13938.AA | Pkinase | 62-161 | 21 | 1.1e-09 | 35.28 | Pfam | 37-141 (293) | Show / Hide |
Range on Protein: 62-161 Range on HMM: 37-141/293 Sequence Identity: 21% (24 aa) ISSCKDIEN----EYNIASRLSHENILSPIEYYKQYRGGCAISFPRASCD----AFHYFIERSQQQKRAAY--SLEEVRQLLRNVASALNYLHQGENIAH ..|.||... | | ||.|.||. .... .. . . .. . .. . .|.. ... .. | .|.. .. ....|.|.|. ..| | EKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST---WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIH NDIKLENILC |.|.||||. RDLKPENILI |
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| Kinase | 13938.AA | Ciliate-E2-Unclassified | 117-160 | 30 | 2.2e-09 | 28.73 | In-house | 128-176 (352) | Show / Hide |
Range on Protein: 117-160 Range on HMM: 128-176/352 Sequence Identity: 30% (15 aa) QQQKRAAYSLEEVR-----QLLRNVASALNYLHQGENIAHNDIKLENIL ....| . .... .... . ..|.|||. || | |||.|||| NMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENIL |
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| Kinase | 13938.AA | CAMK | 311-336 | 53 | 2.9e-09 | 25.25 | In-house | 400-425 (425) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 400-425/425 Sequence Identity: 53% (14 aa) DLIIGMIQQDPLKRLDACGILNHPWL ||| .| | || ||. . .|||||. DLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 13938.AA | Ciliate-E2a | 310-336 | 48 | 6e-08 | 19.51 | In-house | 249-275 (275) | Show / Hide |
Range on Protein: 310-336 Range on HMM: 249-275/275 Sequence Identity: 48% (13 aa) FDLIIGMIQQDPLKRLDACGILNHPWL .||. .| . || ||..| .||||| KDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 13938.AA | CAMKL | 311-336 | 50 | 8.8e-08 | 20.75 | In-house | 272-297 (297) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 272-297/297 Sequence Identity: 50% (13 aa) DLIIGMIQQDPLKRLDACGILNHPWL ||| .| | .| || . |.||||. DLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 13938.AA | Ciliate-C1 | 138-160 | 52 | 9e-08 | 15.67 | In-house | 140-161 (328) | Show / Hide |
Range on Protein: 138-160 Range on HMM: 140-161/328 Sequence Identity: 52% (12 aa) SALNYLHQGENIAHNDIKLENIL ... |.|| ||.| |.|.|||| NVIQYIHQ-NNICHRDLKPENIL |
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| Kinase | 13938.AA | Ciliate-E2-Unclassified | 274-336 | 21 | 1.2e-07 | 22.63 | In-house | 270-352 (352) | Show / Hide |
Range on Protein: 274-336 Range on HMM: 270-352/352 Sequence Identity: 21% (18 aa) YSSSKKYQ----------------QIQKCGADFLQTLNQNL----INTELEKKDLLFDLIIGMIQQDPLKRLDACGILNHPWL ... ...| ..|.. . .| ... . | ||.. ||. |.. .| ||... ||||||. FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 13938.AA | Ciliate-C1 | 311-336 | 42 | 2.2e-07 | 14.65 | In-house | 303-328 (328) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 303-328/328 Sequence Identity: 42% (11 aa) DLIIGMIQQDPLKRLDACGILNHPWL ||| .| .| ||... |..|||. DLINQMLAYNPQKRITLQEIKCHPWY |
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| Kinase | 13938.AA | DCAMKL | 311-336 | 53 | 3.3e-07 | 17.88 | In-house | 254-279 (279) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 254-279/279 Sequence Identity: 53% (14 aa) DLIIGMIQQDPLKRLDACGILNHPWL ||| | | || || | |. ||| DLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | 13938.AA | Ciliate-E2a | 127-160 | 40 | 3.4e-07 | 17.26 | In-house | 101-134 (275) | Show / Hide |
Range on Protein: 127-160 Range on HMM: 101-134/275 Sequence Identity: 40% (14 aa) EEVRQLLRNVAS-ALNYLHQGENIAHNDIKLENIL .|....... . .|.|.|| || | |.|.|||| QEICDIMQQLLWQGLHYMHQ-RNIMHRDLKPENIL |
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| Kinase | 13938.AA | DCAMKL | 132-160 | 48 | 5.6e-07 | 17.17 | In-house | 120-147 (279) | Show / Hide |
Range on Protein: 132-160 Range on HMM: 120-147/279 Sequence Identity: 48% (14 aa) LLRNVASALNYLHQGENIAHNDIKLENIL .......||.||| || | |||.|| | MMTCLCKALKYLHE-MNIVHRDIKPENLL |
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| Kinase | 13938.AA | CAMKL | 127-160 | 50 | 1e-06 | 16.96 | In-house | 127-159 (297) | Show / Hide |
Range on Protein: 127-160 Range on HMM: 127-159/297 Sequence Identity: 50% (17 aa) EEVRQLLRNVASALNYLHQGENIAHNDIKLENIL .| |.. | . ||.||.|. .|.| |||.|||| HEARRYFRQIVSAVNYCHS-HGIVHRDIKPENIL |
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| Kinase | 13938.AA | Pkinase | 309-336 | 42 | 2e-06 | 23.81 | Pfam | 266-293 (293) | Show / Hide |
Range on Protein: 309-336 Range on HMM: 266-293/293 Sequence Identity: 42% (12 aa) LFDLIIGMIQQDPLKRLDACGILNHPWL . |.| .....|| ||. | ||.|||. CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 13938.AA | MAPKAPK | 311-336 | 42 | 2e-06 | 15.34 | In-house | 267-292 (292) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 267-292/292 Sequence Identity: 42% (11 aa) DLIIGMIQQDPLKRLDACGILNHPWL ||| . || .|| . ..||||. DLIRKLLRRDPTQRLTIEQVMNHPWI |
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| Kinase | 13938.AA | MNK | 311-336 | 46 | 2.7e-05 | 14.16 | In-house | 267-292 (292) | Show / Hide |
Range on Protein: 311-336 Range on HMM: 267-292/292 Sequence Identity: 46% (12 aa) DLIIGMIQQDPLKRLDACGILNHPWL ||| . .|. || | .||||| DLISNLLVRDAKQRLSAAQVLNHPWV |
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| Kinase | 13938.AA | DCAMKL | 59-92 | 26 | 0.018601 | 2.84 | In-house | 53-86 (279) | Show / Hide |
Range on Protein: 59-92 Range on HMM: 53-86/279 Sequence Identity: 26% (9 aa) EKCISSCKDIENEYNIASRLSHENILSPIEYYKQ .||. .. |.|| | ....| .| . .| . . RKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDT |
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