Gene 13752 (Tetrahymena)
13752
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 13752.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13752.AA | Ciliate-E2 | 6-271 | 22 | 4.8e-57 | 194.35 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 6-271 Range on HMM: 1-365/365 Sequence Identity: 22% (86 aa) TSKRKLIAEGYSGKIYLT-HINSDNGKKMK--------------AIIKKFNLKCQKHYQ-----IEKDIFQEIN-----------------PHILFPQVY . |.| .| |..|. ... .. . .| . ||....|..|..| |..|..||| |.|. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FT--DDQQYEICMEYCKGGTLFDLLIKC-----------GRFEEELAFRYFKQILE---------------ALRHLKKHS-ICHRDIKLENILILRDDRR | ||. . . ||||.||.|||..... ..| |. . ...||||. ||..|.. |.|||||.||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ YLKIVDLSFCAKILK----------AETKQDRR-----------------CFHDNVGTEGYQCPEMLLDQPYSG--------YEADMFSLGVLLFEMIHG .||.|. .. |. . .. ... . |. .|| ||..||.| ..|.. |..|..||||.|.||. | -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG KPPFFCASKKSCEFYTLFCDNRKQYWELFESL--------------APNKSPELIQLLEQ----LLEFNPDKRIA-MGKVFKQQWF |||| . . .. ..... . |.| ..|. . .|. .|.||| . .... .|| KPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | 13752.AA | CAMK | 67-271 | 23 | 4e-53 | 169.17 | In-house | 125-425 (425) | Show / Hide |
Range on Protein: 67-271
Range on HMM: 125-425/425
Sequence Identity: 23% (72 aa)
VYFTDDQQYEICM---EYCKGG----TLFDLLIKC---------------GRFEEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRR-----
|. |.|... . | ||| || ||| ... |||.|. | |||.||..|.... .| |.|||.|.||||. ...
VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVE
---------Y-LKIVDLSFCAKILKAETKQ------------------DRRCFHDNVGTEGYQC-PEMLLD-------------QPYSGYEADMFSLGVL
. .||.| | .|. . | . ... .|| .| . ||.|. .|| |...|| |.||.
HDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
LFEMIHGKPPFFCASKKSCE--------FYTLFCDNRKQYWE-LFESLAP-------------------NKSPELIQLLEQLLEFNPDKRIAMGKVFKQQ
|. | |.||| . .. . | || .| .. . . | . |.| ..|. ..|. .|.||. . . .
LYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHP
WF
|.
WM
|
|||||||||
| Kinase | 13752.AA | Ciliate-E2-Unclassified | 7-271 | 23 | 4.2e-49 | 168.47 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 7-271 Range on HMM: 2-352/352 Sequence Identity: 23% (84 aa) SKRKLIAEGYSGKIYLTHINSDNGKK--MKAIIKKFNLK-CQKHYQ----IEKDIFQEIN--------------------PHILFPQVYFTDDQQYEICM . | | .| ||.|. .... .. || ..|. . | .|. .. |... .... |.|. .|.|.| | | KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EYCKGGTLFDLLIKC-----------------GRFEEELAF-----RYFKQILEAL-RHLKKHSICHRDIKLENILILRDDR-RYLKIVDLSFCAKILKA |||.||.|.. . |. .|.|. | .||.|||..| .|. |.|||||.||||. . . |.|| |.... |. . EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN ETKQDRRC-----------FHDNVGTEGYQ----CPEMLLDQPYSG---YEADMFSLGVLLFEMIHGKPPFFCASKKS---------C-----EFYTLFC . .. . .....|| .|. ||.| | |.. |..|..||||.|.||. |..||.. .... . ..| .. NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK DNRKQ-YWELFESLAPNKSPELIQLLE----QLLEFNPDKRIAMGKVFKQQWF .. | .. . . . ||| . ... ..|. ||.||| . .... .|| QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | 13752.AA | S_TKc | 6-271 | 26 | 8.8e-49 | 169.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 6-271 Range on HMM: 1-231/231 Sequence Identity: 26% (74 aa) TSKRKLIAEGYSGKIYLTHINSDNGKKMKAIIKKFNLKCQKHYQIEKDIFQEINPHILFPQVYFTDDQQYEICMEYCKG--GTLFDLLIKCGR------F . ..| .| || |. . .. . . ||. . .| . | .| .. |.| .| | . . ..|||| | |.|||.. |.|| | YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF EEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRRYLKIVDLSFCAKILKAETKQDRRCFHDNVGTEGYQCPEMLLDQPYSGYEADMFSLGVL | | .|..||..|| .. .| |.|||.| ||||. . .|| | ..... . .|| | ||.| .|.. ..|. |.|.. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI LFEMIHGKPPFFCASKKSCEFYTLFCDNRKQYWELFESLAPNKSPELIQLLEQLLEFNPDKRIAMGKVFK-------QQWF |.||. |.||| . ...| . |||........|...|.||. .... .|| LYEMLCGYPPFP-------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 13752.AA | CAMKL | 79-271 | 30 | 9.6e-48 | 150.36 | In-house | 100-297 (297) | Show / Hide |
Range on Protein: 79-271 Range on HMM: 100-297/297 Sequence Identity: 30% (62 aa) MEYCKGGT--LFDLLIKC----GRFEEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRRYLKIVDLSFCAKILKAETKQDRRCFHDNVGTEG |||| || ||| ..| ||..|. | |||.||..|. .. .| |.|||||.||||. .... .||.| |.... . ... . .. |. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-IFGPGQKLKTFCGSPP YQCPEMLLD--QPYSGYEADMFSLGVLLFEMIHGKPPFFCAS----KKSCEFYTLFCDNRKQYWE-LFESLAPNKSPELIQLLEQLLEFNPDKRIAMGKV |..||.... .|| |...|. |.||.|. |. |. || ... .|.. | . ... |.. . .. | ....|. ..|. ||.||. . . YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHV----S-DCRDLIRKMLQVNPEKRPTIHQI FKQQWF . |. MNHPWM |
|||||||||
| Kinase | 13752.AA | Pkinase | 68-271 | 25 | 3.5e-44 | 157.32 | Pfam | 68-293 (293) | Show / Hide |
Range on Protein: 68-271
Range on HMM: 68-293/293
Sequence Identity: 25% (59 aa)
YFTDDQQYEICMEYCKGG----TLFDLLI--KCGRF--EEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRR--YLKIVDLSFCAKILKAET
.|.|.. . ..|||| || |||.. . |.| .|. . .|..|||..| .. ...|.|||.|.||||| ... .|| | .....
WFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----
KQDRRCFHDNVGTEGYQCPEMLLDQPYSGYEADMFSLGVLLFEMIHGKPPFFCA------SKKSCEFYTLFCDNRKQYWEL-------------FESLAP
. ... .|| .| || .....| |...||.|.|..|.||. |.||| . ... . . .. .... ..... .. . .
Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-H
NKSPELIQLLEQLLEFNPDKRIAMGKVFKQQWF
| |.|...... .|...| ||. ... ||
NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
|
|||||||||
| Kinase | 13752.AA | Ciliate-E9 | 77-271 | 28 | 3.1e-37 | 116.38 | In-house | 87-298 (298) | Show / Hide |
Range on Protein: 77-271 Range on HMM: 87-298/298 Sequence Identity: 28% (61 aa) ICMEYCKGGTLFDLL-IKCGRFEEELAFRYFKQILEALRHLKKHS-ICHRDIKLENILILRDDRRYLKIVDLSFCAKILKAETKQD---RRCFHDNVGTE | ||| | ||||. . |.|..| ||||.... .. . |||||.|.||.|| | .||.|. . |. |. .|.|| IVMEYANNGCLFDLISMHTEKFNENVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLI--DKNYNMKICDFGMSAQCRNDKTQVIGNLQCQPKENHGTN GYQCP----EMLLDQPYSGYEADMFSLGVLLFEMIHGKPPFFCASKKSC-------EFYT---LFCDNRKQYWELFESLAPNKSPELIQLLEQLLEFNPD | | . . |.| |.||.|..|| |. . ||| . | .. ||. ..|..| . . | | .. . |. | QYNPPNNQQQQYQGIKYNGQKFDIFSAGCILFMMVMNQYPFFHTNCYNDTTIDKIWQYYRIFFFCMDNCQNFWDQFIYNYRPEEQEFIDMMNWMLQQDPQ KRIAMGKVFKQQWF .|| . | NRISIQEIRMHPWM |
|||||||||
| Kinase | 13752.AA | ULK | 6-271 | 23 | 1.3e-35 | 121.83 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 6-271
Range on HMM: 1-329/329
Sequence Identity: 23% (82 aa)
TSKRKLIAEGYSGKIYLTHINSDNG---KKMKAIIKKFNLKCQKHY------------QIEKDIFQEI---------NPHIL-FPQVYFTDD-QQYEICM
.... . .| || | .| ... ... |. . |... . . | .| ... .|.| . .. |.. . | |
YCLNHCLGKGSFGKVYKG-RNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM
EYCKGGTLFDLLIKCGR----------FEEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRRY----------LKIVDLSFCAKILKA-ETK
||| ||.|.... | .. ..|. | .|||||.....| || | |||||..|||| .. . ||| | |. .. . . .
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ
QDRRCFHDNV------GTEGYQCPEMLLDQ----PYSGYEADMFSLGVLLFEMIHGKPPFFCASKKSCEFYTLFCDNRKQYWELFESLAPN---------
|. .. | || | .|. | .| ||. |..|..|||....||. |||||.. . ...||. ..| |
QM---MMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYA------------W-FNDQYLQIIQKLINNPPPWPQQIK
--------------KSPELIQLLEQLLEFNPDKRIAMGKVFKQQWF
|||...|. ..|......|| .|. ||
KQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
|
|||||||||
| Kinase | 13752.AA | CAMK-Unique | 68-271 | 20 | 1.1e-34 | 111.74 | In-house | 84-363 (363) | Show / Hide |
Range on Protein: 68-271 Range on HMM: 84-363/363 Sequence Identity: 20% (58 aa) Y----FTDDQ---------------QYEICMEYCKGGTLFDLLIK--------------------CGRFEE--ELAFRYFKQILEALRHLKKHSICHRDI . | |.. . | |||| ||.|||...| |.|.| .. ... ..|.|. .. . .| |||. WNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDL KLENILILRD--D------------RRYLKIVDLSFCAKILKAETKQDRRCFHDNVGTEGYQCP--------------EMLLDQPYSGYEA---DMFSLG |||||.. | . .|. | |... .... . . .||. | | |.. |.|.. | ||| KLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHY---NHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLG VLLFEMIHGKPPFFCASKKS------CEFYTLFCDNRK-QYWELFESLAPNKSPELIQLLEQLLEFNPDKRIAMGKVFKQQWF |....|. |.||| |..... | . .| . . . ... .|.|.......... ||.|. . ||. VIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
|||||||||
| Kinase | 13752.AA | ULK | 6-271 | 24 | 5.1e-34 | 118.12 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 6-271
Range on HMM: 1-324/324
Sequence Identity: 24% (81 aa)
TSKRKLIAEGYSG-KIYLTH-INSDN-GKKMKA-IIKKFNLKCQKH----------YQIEKDIFQEI----NPH---ILFPQVYFTDD-QQYEICMEYCK
.... . .| | | | ..... ... .. .| |.... .|. . | | ... .|. . . .. |.. . | ||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN
GGTLFDLLIKC---------GRFEEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRRY----------LKIVDLSFCAKILKAETKQDRRCF
||.|.... | .|..|. | .||||......| || | |||||..|||| .. . ||| | | ||.. ..... |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF-AKHVDNNNMEQQMC-
HDNV------GTEGYQCPEMLLDQ----PYSGYEADMFSLGVLLFEMIHGKPPFFCASKKS-C----EF------YTLFCDNRKQYWELFESLAPNK---
. | || | .|. | .| ||. |..|..|||....||. ||.|||. . . . . |. . . . ..|
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ--------QIYIKNQPIQFPKPPK
----SPELIQLLEQLLEFNPDKRIAMGKVFKQQWF
|||...|. ..|......|| .|. ||
DPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
|
|||||||||
| Kinase | 13752.AA | Ciliate-C1 | 168-271 | 38 | 1.2e-27 | 68.4 | In-house | 221-328 (328) | Show / Hide |
Range on Protein: 168-271 Range on HMM: 221-328/328 Sequence Identity: 38% (43 aa) VGTEGYQCPEMLLDQPYSGYEADMFSLGVLLFEMIHGKPPFFC-ASKKSCEFYTLFCDNR-KQYWELFESLAPNK------SPELIQLLEQLLEFNPDKR .||||| || . |.| | | |..|| || |.|| |||. |. . .| .||.|| |||. .. |. | |.. |. |.|..|| || MGTEGYMAPELHEKQRYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSD-PYYRFFCENRYHQYWQC---HQKNYGQHNFFSNEFMDLINQMLAYNPQKR IAMGKVFKQQWF | . | ITLQEIKCHPWY |
|||||||||
| Kinase | 13752.AA | Ciliate-C1 | 73-133 | 44 | 4.7e-26 | 64.19 | In-house | 98-162 (328) | Show / Hide |
Range on Protein: 73-133 Range on HMM: 98-162/328 Sequence Identity: 44% (29 aa) QQYE---ICMEYCKGGTLFDLLIKCGR-FEEELAFRYFKQILEALRHLKKHSICHRDIKLENILI |.|. | .||| .| ||| . . |. |.|||| ||.| .. . .|||||.|.||||. QTYCFMCIVFEYCSNGELFDYIAHKGPLFNEELARYYFHQLINVIQYIHQNNICHRDLKPENILL |
|||||||||
| Kinase | 13752.AA | MARK | 79-145 | 45 | 7.7e-21 | 65.01 | In-house | 81-149 (262) | Show / Hide |
Range on Protein: 79-145 Range on HMM: 81-149/262 Sequence Identity: 45% (32 aa) MEYCKGGTLFDLLIKC--GRFEEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRR--YLKIVD |||. || |.| ... || .||.| |.|.||..|. . ...|.|||||.||||| |... || | MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI--DENGNHNIKIID |
|||||||||
| Kinase | 13752.AA | MARK | 169-208 | 47 | 2.8e-13 | 39.91 | In-house | 167-206 (262) | Show / Hide |
Range on Protein: 169-208 Range on HMM: 167-206/262 Sequence Identity: 47% (19 aa) GTEGYQCPEMLLDQPYSGYEADMFSLGVLLFEMIHGKPPF || | .||..| .|| |...|. ||||.|. |..|. || GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPF |
|||||||||
| Kinase | 13752.AA | TyrKc | 6-271 | 15 | 5e-08 | -92.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 6-271 Range on HMM: 1-280/280 Sequence Identity: 15% (47 aa) TSKRKLIAEGYSGKIYLTHINSDNGKKMKAIIKKFNLKCQKHYQIEKDIFQEINPHILFPQV------------YFTDD-------QQYEICMEYCKGGT .. | . || |..|. . . .. .|. . . ..|. .|.. . .. . |.. ... | |||...| ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA------REDFMREAR---IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD LFDLLIKCGR-FEEELAFRYFKQILEALRHLKKHSICHRDIKLENILILRDDRRYLKIVDLSFCAKILKA-----ETKQDRRCF--HDN-VGTEGYQCPE | | | |... . . . || . ..| .. . |||. |.|. .. || | . .| ... | . . . || LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE MLLDQPYSGYEADMFSLGVLLFEMI-HGKPPFFC---ASKKSCEFYTLFCDNRKQYWELFES-----LAPNKSPELIQLLEQLLEFNPDKRIAMGKVFKQ . . .. . | .| ||...|. |..| ..| . . . . . . .. . ..|. |. .| ...|..| . . CINYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQ-EVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--H QWF . | ECF |
|||||||||
| Kinase | 13752.AA | MARK | 241-271 | 32 | 2.4e-05 | 13.64 | In-house | 232-262 (262) | Show / Hide |
Range on Protein: 241-271 Range on HMM: 232-262/262 Sequence Identity: 32% (10 aa) SPELIQLLEQLLEFNPDKRIAMGKVFKQQWF |.|. .|. .|| .||..|. . . | |. SKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
|||||||||