Gene 12856 (Tetrahymena)
12856
Sequence
Protein domains of 12856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12856.AA | CAMKK | 3-11 | 44 | 0.147859 | 0.2 | In-house | 1-9 (396) | Show / Hide |
Range on Protein: 3-11 Range on HMM: 1-9/396 Sequence Identity: 44% (4 aa) YELLEKLGS |||....|. YELMKEIGQ |
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| S_TKc | 12856.AA | S_TKc | 2103-2400 | 19 | 3.8e-29 | 104.07 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2103-2400
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)
YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQMDLPKSIYDRCVLHDIFNEITCLELFRFDQCVTDLYDYGLAENDYKIIMKRYPM---SLKQWRQQQKS
|. |. .| ||. . .. . . .|||||... .| .|| .|. . |||. ... ..| . .|.. .....
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
--DQFTENLPTYLNIYRDALKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVSKGTQFIQSPEMQTLAIQ
.| . . . . ..|.. .||. .|| |.| .||||| . ..|||... . || . .||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----
SKKEGDKYDRRKKVGTTR-SSDVWSLGCLLYEILTNEFLFYNQNETAFLFRVTSNTEQILTQENLDRVQNNMYAIDFLKYILVRDQQIRPNIDNVIK---
| .. ..|.||.||.||| |. . .|. . . .|.. |.||.. .|..| . || . . .
--------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW
-RFEHIYA
| .
DIKCHPWF
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| Kinase | 12856.AA | STE | 2103-2387 | 17 | 7.7e-29 | 99.03 | In-house | 1-347 (359) | Show / Hide |
Range on Protein: 2103-2387 Range on HMM: 1-347/359 Sequence Identity: 17% (66 aa) YTDLQFMASGQFGSIFEAKTNL-----SDPQI---------VAIKQMDLPK-------------SIYDRCVLHDIFNEITCLELFRF-DQCVTDLYDYGL ...... .| ||. . |. . . .. .|||||.| . .. . . .| .|| . .. . . |.. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF AE-------NDYKIIMKRYP-MSLKQWRQQQKSDQFTEN----------LPTYLNIYRDALKA-VQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQS | .. |.| . || . .. .. ... | . | |. ||. ..|||. .|| |||..|||| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------- IKVVLGDFGVCKMFRN---------------EEDEYCLVSKGTQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQN | | |||||. . . .. . ||. .||. . |. . . | ....|.|||||.. | .| . . . . --VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMH ETAFLFRVTSNT-------------EQILTQE-NLDRV--------------QNNMYAIDFLKYILVRDQQIRPN . .|. . |. ... . . .|. . . .||.. |..| . ||. PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT |
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| Kinase | 12856.AA | Ciliate-E2 | 2217-2393 | 18 | 3.3e-20 | 66.03 | In-house | 170-361 (365) | Show / Hide |
Range on Protein: 2217-2393
Range on HMM: 170-361/365
Sequence Identity: 18% (43 aa)
LKAVQLLHSNS-VIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEED--------EYCLVSK-----------------------GTQ
..|.. |||. .|| ||| .|||. . . ||| .| . .... . .. | ||
ILALEYLHSKNNIIHRDIKPENILF-----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTP
FIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNETAFLFRVTSNTEQILTQENLDRVQNNMY---------------
..||. ...||.. |. | . ..|.||||..||| |.... | .|. | ..| ....
GYMAPEI----LNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKK
----AIDFLKY----ILVRDQQIRPN-IDNVIK
..|..| .|..|.. |.. .. ...
WSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
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| Kinase | 12856.AA | Pkinase | 2217-2395 | 20 | 8.4e-20 | 71.09 | Pfam | 118-293 (293) | Show / Hide |
Range on Protein: 2217-2395 Range on HMM: 118-293/293 Sequence Identity: 20% (41 aa) LKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVSKGTQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRS |.... .||...|| |.| .|||.| |. ... .| ..|||..| |.. .. . . || . .|| |. . . ... LRGLEYCHSMGIIHRDLKPENILID--NNGHIDA------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IR-----------GGQYYGPK SDVWSLGCLLYEILTNEFLFYNQ-----NETAFLFRVTSNTEQILTQENLDRVQNN---------------MYAIDFLKYILVRDQQIRPNIDNVIKR-- .|.||.||.||| |. ...|... .. .... . .. ...... . ..||.|..| .| . ||... . . VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW F | F |
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| Kinase | 12856.AA | Ciliate-E2-Unclassified | 2217-2393 | 19 | 5.5e-17 | 55.48 | In-house | 153-348 (352) | Show / Hide |
Range on Protein: 2217-2393 Range on HMM: 153-348/352 Sequence Identity: 19% (43 aa) LKAVQLLHSNS-VIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVS-KGTQFIQSPEMQTLA--IQSK--------KEGDK |.. . ||.. .||.||| .|||.| .| .. . ||| .| . .... . .|.... .|.| . .. . .| . LQGLEYLHHKNNIIHRDIKPENILFDNNGK---------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQN YDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNETA-----------FLFRVTSNTEQILTQENLDR-------------VQNNMYAIDFLK----Y || .| ..|.||||..|||.|.... || .|.. . ....| |. ... . . |.||.. YDHSKA----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA-------YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK ILVRDQQIRPNIDNVIK .|. .. |.... ... MLKKNPNKRITFEQILN |
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| Kinase | 12856.AA | AGC | 2219-2342 | 20 | 6.1e-14 | 30.95 | In-house | 165-323 (395) | Show / Hide |
Range on Protein: 2219-2342
Range on HMM: 165-323/395
Sequence Identity: 20% (39 aa)
AVQLLHS-NSVIHYD-IKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEE-------------------------------------------
|.. ||| . .|| | .| .||||| . | ||| ||...|..
ALEYLHSHMGIIHRDYLKPENILLDED------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQED
------DEYCLVSKG--TQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWS--LGCLLYEILTNEFLFYNQN------------ET
.. . | | .||. ... | || ||||.|| || ||..| |.
DTTRKKRDRTWTFCGPCTPEYMAPEIL--------------------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEM
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| Kinase | 12856.AA | CMGC | 2103-2264 | 14 | 1.9e-12 | 36.27 | In-house | 232-480 (513) | Show / Hide |
Range on Protein: 2103-2264 Range on HMM: 232-480/513 Sequence Identity: 14% (37 aa) YTDLQFMASGQFGSIFEAKTNLSD-------------PQIVAIKQMDLPKSIYDRCV---LHDIFN-----EITCLELFR----------------FDQC |. .. .| .| .... .... .||||| . .|. . . . | |. || .|. .. . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VTDLYDYGLAEN-----------------DYKIIMKRYPMSLKQWRQQQKSD-------QFTENL----------PTYLNIY------RDALKAVQ--LL . |||. .| . ... ...|.| .... | ..| .. .. . |... . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSNS--VIHYDIKADNILLDFPNK----------SENGNPNDQSIKVVLGDFG ||. .|| |.| |||.. .. . . ||.... .. ..||| HSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPCQKNGRLKICDFG |
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| Kinase | 12856.AA | TKL | 2200-2341 | 19 | 6.7e-12 | 39.15 | In-house | 127-294 (364) | Show / Hide |
Range on Protein: 2200-2341
Range on HMM: 127-294/364
Sequence Identity: 19% (34 aa)
DQFTENLPTYLNIYRDALKAVQLLHSNS--------VIHYDIKADNILLDFPNKSENGN---PNDQSIKVVLGDFGVCKMFRNEEDEYCL----------
.... .. ... .|. .... |||. .|| |.| .|||.| .. . | . ... ..||| .... .... .
HYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEH
--------VSKGTQFIQSPEM-QTLAIQSKKEG-DKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNE
|| .||. . ..| | |. . |. . ..||.| | .|.|||| . .|....
QNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE--FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
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| Kinase | 12856.AA | Ciliate-E1 | 2109-2305 | 19 | 1.2e-11 | 34.61 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 2109-2305
Range on HMM: 1-202/202
Sequence Identity: 19% (41 aa)
MASGQFGSIFEAKTNLSDPQIVAIKQMDLPKSIYDRCVLHDIFNEITCLELFRFDQCVTDLYDYGLAENDYKI--IMKRYPMSLKQWRQ---------QQ
..| |. .|.|| . .. ... .... . . .|. ..|. .|. ... |.. ... ...|| .. | . |. . .|||. | |.
IGNGSFSIVFKAK-QQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC
KSDQFTENLPTYLNIYRDALKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVSKGTQFIQSPEMQT----
...|. . ..| ....... ||.. .|| ||| .||| . .. . |||..| . |.....| .. |. ..|| .
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC------------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ
--LAI-QSKKEGDKY
. ... | |
EHNKNQKINYKSDIY
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| Kinase | 12856.AA | CAMKK | 2214-2341 | 23 | 1.7e-11 | 32.28 | In-house | 183-331 (396) | Show / Hide |
Range on Protein: 2214-2341 Range on HMM: 183-331/396 Sequence Identity: 23% (37 aa) RDALKAVQLLH-SNS-------------------VIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLV----------SKGT || .|... || .. .|| ||| .|||.| |.|. .|.. ||||...| .... || RDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILID-----EEGC----GEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGT QFIQSPEMQTL-AIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNE . ||... ... | | | . . . |.|.||. || ..... |...|. PAFMAPELCSKENQKENYNGYK-YRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNL |
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| Kinase | 12856.AA | TyrKc | 2103-2395 | 17 | 4.9e-10 | -60.44 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2103-2395
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)
YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQMDLPKSIYDRCVLHDIFNEITCLELF--RFDQCVTDLYDYGLAE-------NDYKIIMKRYPM-SLKQ
| .. .|.|| ..... . . ||.| . . . |. .|. . . . . | || . . . . |.| | .||.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVR-LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
WRQQQKSDQFTENLPTYLNIYRDALKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNE------EDEYCL----VSK-
. . . .... |.. .. . . |||. .|| |. | |.|.. .. | .||| .. .. .| | .|
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT
-GTQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNET--AFLFRVTSNTEQILTQENLDR--------VQNNMYA
.|| . . | ||||| | ...||.|. | . ..| . .| . . ||
MLPIRWMAPECINYGKFTTK----------------SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ
IDFLKYILVRDQQIRPNIDNVIKRF
| .| ||. .....|
--IMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 12856.AA | STE20 | 2103-2154 | 27 | 1.3e-07 | 24.17 | In-house | 1-55 (288) | Show / Hide |
Range on Protein: 2103-2154 Range on HMM: 1-55/288 Sequence Identity: 27% (16 aa) YTDLQFMASGQFGSIFEAKTNLSDPQI----VAIKQMDLPKS---IYDRCVLHDIFNEI |..|. .| .|... | .. . .. ||||.|.| | . ..||..|| YELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQ---DEWEDIQKEI |
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| Kinase | 12856.AA | STE11-Unclassified | 2223-2242 | 65 | 1.9e-07 | 22.49 | In-house | 123-142 (308) | Show / Hide |
Range on Protein: 2223-2242 Range on HMM: 123-142/308 Sequence Identity: 65% (13 aa) LHSNSVIHYDIKADNILLDF |||...|| |||..|||.|| LHSHGIIHRDIKGANILIDF |
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| Kinase | 12856.AA | STE20 | 2212-2241 | 60 | 2e-06 | 20.08 | In-house | 122-151 (288) | Show / Hide |
Range on Protein: 2212-2241 Range on HMM: 122-151/288 Sequence Identity: 60% (18 aa) IYRDALKAVQLLHSNSVIHYDIKADNILLD | |..|.. . |||| .|| |||||||||. ICREVLQGLDYLHSNHIIHRDIKADNILLT |
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| Kinase | 12856.AA | CMGC | 2318-2341 | 31 | 4e-06 | 14.96 | In-house | 317-348 (513) | Show / Hide |
Range on Protein: 2318-2341 Range on HMM: 317-348/513 Sequence Identity: 31% (10 aa) DVWSLGCLLYEILTN--------EFLFYNQNE |.||.|| ..|..|. . || ..| DMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSE |
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| Kinase | 12856.AA | STE11-Unclassified | 2312-2328 | 58 | 2.8e-05 | 14.71 | In-house | 214-230 (308) | Show / Hide |
Range on Protein: 2312-2328 Range on HMM: 214-230/308 Sequence Identity: 58% (10 aa) GTTRSSDVWSLGCLLYE |..|.||.|||||. .| GHCRKSDIWSLGCTVIE |
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| Kinase | 12856.AA | Ciliate-E2-Unclassified | 2103-2135 | 24 | 0.002922 | 7.19 | In-house | 295-326 (352) | Show / Hide |
Range on Protein: 2103-2135 Range on HMM: 295-326/352 Sequence Identity: 24% (8 aa) YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQM |. .. .|.||...... . . |. |.|.| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYM |
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| Kinase | 12856.AA | Pkinase | 2103-2139 | 24 | 0.003486 | 12.34 | Pfam | 1-36 (293) | Show / Hide |
Range on Protein: 2103-2139 Range on HMM: 1-36/293 Sequence Identity: 24% (9 aa) YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQMDLPK |. .. || ||. .... . ....|||.|...... YHIGRKIGSGSFGCVYKCH-HKGTGKIVAVKIIKKRH |
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| Kinase | 12856.AA | Ciliate-E2 | 2103-2135 | 18 | 0.147876 | 1.09 | In-house | 1-55 (365) | Show / Hide |
Range on Protein: 2103-2135 Range on HMM: 1-55/365 Sequence Identity: 18% (10 aa) YTDLQFMASGQFGSIFEAKTNLSDP----------------------QIVAIKQM | .. .|.|||....| . . .|.|.|.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIM |
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