Gene 12145 (Tetrahymena)
12145
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 12145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12145.AA | STE20 | 675-708 | 47 | 4.1e-14 | 48.23 | In-house | 255-288 (288) | Show / Hide |
Range on Protein: 675-708 Range on HMM: 255-288/288 Sequence Identity: 47% (16 aa) KKYSSNFKDFLCKCLQYNYRSRLSIEELLKHPFV .|.|..|.||. ||||... | . ..||||||. HKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | 12145.AA | STE | 675-708 | 47 | 1.3e-13 | 44.55 | In-house | 324-359 (359) | Show / Hide |
Range on Protein: 675-708 Range on HMM: 324-359/359 Sequence Identity: 47% (17 aa) KKYSSNFKDFLCKCLQYNYRSRLSIEELLK--HPFV .|.|..||||. ||||.... | . ..||| |||. HKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 12145.AA | MEK1 | 466-536 | 36 | 2.7e-12 | 37.81 | In-house | 69-139 (297) | Show / Hide |
Range on Protein: 466-536 Range on HMM: 69-139/297 Sequence Identity: 36% (26 aa) EGCVSIIMEHMNGNSLQDLLENIGNLNERAIQELTMQVISALYTLHNEHHICHGSISPSQILFNKQGFLKL .| .|| ||.| | || .| ..| . |. . ... |. | |...|.| | . || || | .| .|| DGEISICMEYMDGGSLDQVLKKAGRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKL |
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| Kinase | 12145.AA | ULK | 654-708 | 26 | 2.3e-11 | 35.99 | In-house | 265-329 (329) | Show / Hide |
Range on Protein: 654-708 Range on HMM: 265-329/329 Sequence Identity: 26% (17 aa) ENIMQSIRKNGANCLS-INILLKK---------YSSNFKDFLCKCLQYNYRSRLSIEELLKHPFV ..|.|. ..|. .. |. . |...||.. ..|||. . | |.|||..||.. LQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| S_TKc | 12145.AA | S_TKc | 399-708 | 14 | 3.2e-11 | -12.35 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 399-708
Range on HMM: 1-231/231
Sequence Identity: 14% (48 aa)
LLKSNK----NSGAIKKMLHAPTLSIFAVKEQPIATKDIRKILKDWLHFWPTVLNSNEQFIRVYGTCWNVPEGCVSIIMEHMNG--NSLQDLLENIGN--
. .| | .| | | |.|.|. . ..|.. . .. |... . ... ..||...| .| |.... |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LNERAIQELTMQVISALYTLHNEHHICHGSISPSQILFNKQGFLKLS-LGITNRTQNNQSVSSSIFNTVSYNKNEKKSFYDYQSMASIWQKS--ML
..| .. .. |...|| .|. .|.| . |. ||... .|.. |. . . . | . .|
LRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------TTFCGTPWYMAPEVL
ERNGDKSKQGDLLDR-QDEIFKLGLLLLVSAIGNLDLLDDQLYLFFEQVQKQVELSSKNNDNKFCCLLHDEENIMQSIRKNGANCLSINILLKKYSSNFK
.. . .| .| . | |... |... |. .|
-----------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------------------SPEAK
DFLCKCLQYNYRSRLSIEELLK-------HPFV
||..||||.. . |... |.|. ||..
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 12145.AA | CAMK | 675-708 | 28 | 1.1e-10 | 29.87 | In-house | 384-425 (425) | Show / Hide |
Range on Protein: 675-708 Range on HMM: 384-425/425 Sequence Identity: 28% (12 aa) KKYSSN--------FKDFLCKCLQYNYRSRLSIEELLKHPFV .. | . ||...|.||.. |..||. |.||.. DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 12145.AA | YSK | 673-708 | 43 | 1.8e-10 | 27.39 | In-house | 221-257 (257) | Show / Hide |
Range on Protein: 673-708 Range on HMM: 221-257/257 Sequence Identity: 43% (16 aa) LLK-KYSSNFKDFLCKCLQYNYRSRLSIEELLKHPFV | . .|| .||.| || .. . |.| .||||| |. LEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI |
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| Kinase | 12145.AA | STE7 | 672-708 | 42 | 3.6e-10 | 33.58 | In-house | 252-288 (288) | Show / Hide |
Range on Protein: 672-708 Range on HMM: 252-288/288 Sequence Identity: 42% (16 aa) ILLKKYSSNFKDFLCKCLQYNYRSRLSIEELLK-HPFV .| |.| |.|| |||| ... | ....|.| |||. RLP-KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI |
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| Kinase | 12145.AA | STE7-Unclassified | 674-708 | 33 | 4.6e-10 | 31.75 | In-house | 260-301 (301) | Show / Hide |
Range on Protein: 674-708 Range on HMM: 260-301/301 Sequence Identity: 33% (14 aa) LKK------YSSNFKDFLCKCLQYNYRSRLSIEELLK-HPFV |.. .|..|.|| ||.. . | | .| .||. ||.. LPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI |
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| Kinase | 12145.AA | Ciliate-E2 | 657-708 | 24 | 5.5e-10 | 30.46 | In-house | 312-365 (365) | Show / Hide |
Range on Protein: 657-708 Range on HMM: 312-365/365 Sequence Identity: 24% (14 aa) MQSIRKNGANCLSINI-LLKKYSSNFKDFLCK----CLQYNYRSRLS-IEELLKHPFV .|. .. . . ... || | . ||.. | .||.. |.. .|..|.||. WQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 12145.AA | STE7-Unclassified | 466-537 | 31 | 7.3e-10 | 31.04 | In-house | 77-162 (301) | Show / Hide |
Range on Protein: 466-537 Range on HMM: 77-162/301 Sequence Identity: 31% (27 aa) EGC---VSIIMEHMNGNSLQ---DLLENI--------GNLNERAIQELTMQVISALYTLHNEHHICHGSISPSQILFNKQGFLKLS |. . |.|| | . || |.. . | ..|. .. .. ||| .| ||..||| | | |. || |..| |.. ECMDCKIHICMEYMDCGSLDNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKIC |
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| Kinase | 12145.AA | Ciliate-E2-Unclassified | 471-537 | 20 | 1.6e-09 | 29.19 | In-house | 98-189 (352) | Show / Hide |
Range on Protein: 471-537 Range on HMM: 98-189/352 Sequence Identity: 20% (19 aa) IIMEHMNGNSLQDLLENIGN-----------------LNERAIQ-----ELTMQVISALYTLHNEHHICHGSISPSQILFNKQG---FLKLS |.|| ..|..|.. ... .. . |.... .. |....| || ...|.| | |. |||...| .|.. IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII |
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| Kinase | 12145.AA | Pkinase | 678-708 | 35 | 3.3e-09 | 33.66 | Pfam | 263-293 (293) | Show / Hide |
Range on Protein: 678-708 Range on HMM: 263-293/293 Sequence Identity: 35% (11 aa) SSNFKDFLCKCLQYNYRSRLSIEELLKHPFV |...|||...||... .|...|..|.||.. SEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 12145.AA | STE7 | 468-518 | 28 | 1.1e-08 | 28.06 | In-house | 75-134 (288) | Show / Hide |
Range on Protein: 468-518 Range on HMM: 75-134/288 Sequence Identity: 28% (17 aa) CVSIIMEHMNGNSLQDLLENI---------GNLNERAIQELTMQVISALYTLHNEHHICH |..|.||.| | .| ..... | ..|. .. ...||..| ||..|.| | CIWICMEYMDGGCLDKFYKRVKKVYRGIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIH |
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| Kinase | 12145.AA | Ciliate-E2 | 471-537 | 22 | 7e-08 | 23.13 | In-house | 111-198 (365) | Show / Hide |
Range on Protein: 471-537 Range on HMM: 111-198/365 Sequence Identity: 22% (21 aa) IIMEHMNGNSLQDLLENI-----------GNLNERAIQELTMQVIS---------------ALYTLHNEHHICHGSISPSQILFNKQGFLKLS ..|| .|..|.|...| ....|. |.... |... || ||....|.| | |. ||| .|.. LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII |
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| Kinase | 12145.AA | STE | 466-537 | 29 | 1.5e-07 | 22.85 | In-house | 109-189 (359) | Show / Hide |
Range on Protein: 466-537 Range on HMM: 109-189/359 Sequence Identity: 29% (26 aa) EGCVSIIMEHMNGNSLQDLLENI----GNLN----------ERAIQELTMQVISA-LYTLHNEHHICHGSISPSQILFNKQGFLKLS .. . |.||.|.| || |.... ..|| | | . |.. . || ||. | | | | |. ||. ||. DDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLC |
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| Kinase | 12145.AA | Ciliate-E2-Unclassified | 683-708 | 38 | 4.1e-07 | 20.76 | In-house | 327-352 (352) | Show / Hide |
Range on Protein: 683-708 Range on HMM: 327-352/352 Sequence Identity: 38% (10 aa) DFLCKCLQYNYRSRLSIEELLKHPFV |.|.|.|..| .|...|..|.||. DLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 12145.AA | STE20 | 471-537 | 31 | 1e-06 | 20.47 | In-house | 85-159 (288) | Show / Hide |
Range on Protein: 471-537 Range on HMM: 85-159/288 Sequence Identity: 31% (24 aa) IIMEHMNGNSLQDLLE---NIGN------LNERAIQELTMQVISALYTLHNEHHICHGSISPSQILFNKQGFLKLS |.||...| ||.|... ..|. .|| | . .| .| || ..|| | | || ...| ||. IVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLH-SNHIIHRDIKADNILLTEDGEVKLA |
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| Kinase | 12145.AA | Pkinase | 469-518 | 20 | 4e-06 | 22.89 | Pfam | 75-131 (293) | Show / Hide |
Range on Protein: 469-518 Range on HMM: 75-131/293 Sequence Identity: 20% (12 aa) VSIIMEHMNGN----SLQDLLE--NIGNL--NERAIQELTMQVISALYTLHNEHHICH . ..||...| .| |... . |.. |. .. |....|. .|. . |.| IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIH |
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| Kinase | 12145.AA | YSK | 471-516 | 33 | 3.7e-05 | 11.09 | In-house | 74-121 (257) | Show / Hide |
Range on Protein: 471-516 Range on HMM: 74-121/257 Sequence Identity: 33% (16 aa) IIMEHMNGNSLQDLLEN--IGNLNERAIQELTMQVISALYTLHNEHHI ||||. | |. ||. .| . | | .. .| || | | IIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSERKI |
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| Kinase | 12145.AA | CAMK | 471-518 | 20 | 6.7e-05 | 10.94 | In-house | 134-202 (425) | Show / Hide |
Range on Protein: 471-518 Range on HMM: 134-202/425 Sequence Identity: 20% (14 aa) IIM---EHMNGN----SLQDLLENIGN---------------LNERAIQELTMQVISALYTLHNEHHICH ..| |.. | | | . |. ..|| . . |..||. .|. . |.| MVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-IVH |
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| Kinase | 12145.AA | MEK1 | 675-708 | 35 | 0.000115 | 11.29 | In-house | 264-297 (297) | Show / Hide |
Range on Protein: 675-708 Range on HMM: 264-297/297 Sequence Identity: 35% (12 aa) KKYSSNFKDFLCKCLQYNYRSRLSIEELLKHPFV . .|..|.|| |||. | | . .|. |.|. RVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI |
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| Kinase | 12145.AA | ULK | 471-513 | 22 | 0.0006 | 9.77 | In-house | 97-149 (329) | Show / Hide |
Range on Protein: 471-513 Range on HMM: 97-149/329 Sequence Identity: 22% (12 aa) IIMEHMNGNSLQDLLENIGNLNERA----------IQELTMQVISALYTLHNE |||| || |...... ..|.| ... .| .... || . IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH |
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| Kinase | 12145.AA | STE7 | 405-425 | 47 | 0.200653 | 1.41 | In-house | 11-31 (288) | Show / Hide |
Range on Protein: 405-425 Range on HMM: 11-31/288 Sequence Identity: 47% (10 aa) NSGAIKKMLHAPTLSIFAVKE |.| .||.| |. |.|||. NYGVVYKMRHKPSGKIMAVKR |
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