Gene 11644 (Tetrahymena)

11644

Species: Tetrahymena
Alias: TTHERM_00006360, PreTt11644, 11644, 940, 1.m00692
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
11644.AA Protein None 459 None Fasta, JSON
11644.kin_dom Protein Kinase Domain None 419 None Fasta, JSON
11644.NA RNA None 1380 None Fasta, JSON

Protein domain

Protein domains of 11644.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11644.AA Ciliate-A7 28-126 31 1.5e-23 82.48 In-house 48-166 (360) Show / Hide 
Range on Protein: 28-126
Range on HMM: 48-166/360
Sequence Identity: 31% (37 aa)

HSPKCKRLQKEHSILVKMNHPNIVK-CD-------IQFYQNEERCCIRLEQADCDFLEYLTHFFQN-RTKAF----------FRTQVSLLRNIASAIDYL
|...|. |..| ..| ||.||.|..          . |..... ||| .||| || . |..   .. . .              .  ...| ||.|..||
HCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYL

HQ-KNYVHNDIKLENCLLF
|. ||..|||||.|| ..|
HNEKNIAHNDIKPENIFIF
Kinase 11644.AA Ciliate-A7 360-451 28 5.6e-16 54.54 In-house 257-360 (360) Show / Hide 
Range on Protein: 360-451
Range on HMM: 257-360/360
Sequence Identity: 28% (30 aa)

DIFCYGILCFSSIFGVYPFQKE-PSKQDPI-YNLIVEDRLNEFWNLFESRIKDMLAQGL------------QLEQLNLLKDLLQRLLQYNPQNRPNSQQI
|.|  |.  | ..|.. ||..|  .. ||. |.......  .||  . . |..|.                | .   ..||||  .|..||  |....||
DVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFW--QWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQI

LNHPYF
| || |
LQHPWF
Kinase 11644.AA Ciliate-E2a 425-451 48 1.8e-15 42.06 In-house 249-275 (275) Show / Hide 
Range on Protein: 425-451
Range on HMM: 249-275/275
Sequence Identity: 48% (13 aa)

KDLLQRLLQYNPQNRPNSQQILNHPYF
|||....|...|..|.. ||.||||.|
KDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 11644.AA Ciliate-E2-Unclassified 360-451 25 9.2e-15 47.65 In-house 252-352 (352) Show / Hide 
Range on Protein: 360-451
Range on HMM: 252-352/352
Sequence Identity: 25% (27 aa)

DIFCYGILCFSSIFGVYPFQKEPSKQDP--------------IYNLIVEDRLNEFWNLFESRIKDMLAQGLQLEQLNLLKDLLQRLLQYNPQNRPNSQQI
||.. |....  .|| |||. . ..|.               .|. | .  .. ..  . .       .... |. ....||||..|..|| .|.. .||
DIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-----IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI

LNHPYF
||||.|
LNHPWF
Kinase 11644.AA Ciliate-C1 424-451 42 7.8e-13 29.1 In-house 301-328 (328) Show / Hide 
Range on Protein: 424-451
Range on HMM: 301-328/328
Sequence Identity: 42% (12 aa)

LKDLLQRLLQYNPQNRPNSQQILNHPYF
..||....| ||||.|.  |.|..||  
FMDLINQMLAYNPQKRITLQEIKCHPWY
Kinase 11644.AA Ciliate-E2 357-451 22 8.2e-13 40.29 In-house 275-365 (365) Show / Hide 
Range on Protein: 357-451
Range on HMM: 275-365/365
Sequence Identity: 22% (23 aa)

KANDIFCYGILCFSSIFGVYPFQKEPSKQDPIYNLIVEDRLNEFWNLFESRIKDMLAQGLQL---EQLNLL-KDLLQR----LLQYNPQNRPN-SQQILN
.. ||.. |.. .  .|| .||          .. | .  .. . . .... ...  | .     ... .  |||...    .||..|..|..  .||||
YKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKD-TQCI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN

HPYF
||.|
HPWF
Kinase 11644.AA CMGC 426-451 53 9.5e-13 37.3 In-house 488-513 (513) Show / Hide 
Range on Protein: 426-451
Range on HMM: 488-513/513
Sequence Identity: 53% (14 aa)

DLLQRLLQYNPQNRPNSQQILNHPYF
|||...|||.|..|.  .|.|.||||
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase 11644.AA Ciliate-E2 33-226 15 1.6e-12 39.3 In-house 78-203 (365) Show / Hide 
Range on Protein: 33-226
Range on HMM: 78-203/365
Sequence Identity: 15% (33 aa)

KRLQKEHSILVKMNHPNIVKCDIQFY-QNEERCCIRLEQADC-DFLEYLTHFFQNRTKAFF-------RTQVSLLRNIAS---------------AIDYL
|.. .| .|| ..|||||.|.   |. .... . . .| ..  | ..|. .. ..|.. .        .    . . |..               |. ||
KKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYL

HQKN-YVHNDIKLENCLLFVQADKTSIYQQSKSKTNTFDSKPQINTEDQMSRSTTQSETYSELTNKQQSGGDISSSCSLSDQSARRKDSTNSDGSKKQSK
|.||  .| |||.|| |.                                                                                  
HSKNNIIHRDIKPENILF----------------------------------------------------------------------------------

KTSSKKGRLILKLADFEFS
          .|..|| .|
----------IKIIDFGLS
Kinase 11644.AA AGC 360-451 20 1.6e-12 27.22 In-house 285-395 (395) Show / Hide 
Range on Protein: 360-451
Range on HMM: 285-395/395
Sequence Identity: 20% (23 aa)

DIFC--YGILCFSSIFGVYPFQKEPSK--------QDPIYNLIVEDRLNEFWNLFESRIKDMLAQGLQLEQLNL---LKDLLQRLLQYNPQNRPN-----
|. .  .|.| .  ..|  ||. ..          .. ....| ..|.  .|..   . .|        |. ..   .|||...||. .| .|.      
DWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDP----QFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGND

-----SQQILNHPYF
      ..| |||.|
FGDKGAEEIKNHPWF
Kinase 11644.AA CAMK 425-451 44 1.4e-11 32.87 In-house 399-425 (425) Show / Hide 
Range on Protein: 425-451
Range on HMM: 399-425/425
Sequence Identity: 44% (12 aa)

KDLLQRLLQYNPQNRPNSQQILNHPYF
|||....||..|..|.. .|.|||| .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 11644.AA AGC 13-125 21 2e-11 24.28 In-house 63-188 (395) Show / Hide 
Range on Protein: 13-125
Range on HMM: 63-188/395
Sequence Identity: 21% (31 aa)

NNQSKSSSVETGNYCHSPKCKRLQKEHSILVKMN----------HPNIVKCDIQFYQNEER--CCIRLE-----------QADCDFLEYLTH-----FFQ
. |        | |        ...|  ||.|.|          ||.|||     .|....   .. .|             .|... .| .      | 
D-Q--------G-Y--------VWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFD

NRTKAFFRTQ---VSLLRNIASAIDYLHQ-KNYVHND-IKLENCLL
  .  |.  .   . .   |..|..|||. ....| | .|.|| ||
EERARFYAAEMQKI-CG-CIVLALEYLHSHMGIIHRDYLKPENILL
S_TKc 11644.AA S_TKc 3-451 11 1.4e-10 -21.74 SMART 15-231 (231) Show / Hide 
Range on Protein: 3-451
Range on HMM: 15-231/231
Sequence Identity: 11% (53 aa)

VFKKRQLH--------SLNNQSKSSSVETGNYCHSPKCKRLQKEHSILVKMNHPNIVKCDIQFYQNEERCCIRLEQADC---DFLEYLTHF--------F
|.| |  .         ..                   .....| .|| | .||||||.   |.   .. .. .| .|    | ..|. .         |
VYKCRHKKTGRIVAIKIIK-------------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QNRTKAFFRTQVSLLRNIASAIDYLHQKNYVHNDIKLENCLLFVQADKTSIYQQSKSKTNTFDSKPQINTEDQMSRSTTQSETYSELTNKQQSGGDISSS
   . .|.      .. |..|..|.|... .| |.| || ||                                                          
PE-HARFY------MYQICCALEYCHSHGIIHRDLKPENILLDE--------------------------------------------------------

CSLSDQSARRKDSTNSDGSKKQSKKTSSKKGRLILKLADFEFSCVDEQCQTIDYLKSWKLRNRKYMSPEMLDICYLLETTSQTTHEIEKEGQIPNNALSL
                                  .|..|| ....                                                       
---------------------------------HIKICDFGLARQL------------------------------------------------------

SSILNSNFKRACSLYCDEPQKSVTSVNGEEEISDSQMTISTDVTVGSNLTNNEQQQIITSQ----EKMQNLVKNISMKANDIFCYGILCFSSIFGVYPFQ
                                                       .. |      | .       . .. |.   |.. .  . |  ||.
-----------------------------------------------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP

KEPSKQDPIYNLIVEDRLNEFWNLFESRIKDMLAQGLQLEQLNLLKDLLQRLLQYNPQNRPNSQQILN-------HPYF
     .. ....|.                              .||.....||..|..||   ..|.       ||.|
----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11644.AA Pkinase 357-451 20 8.1e-10 35.79 Pfam 191-293 (293) Show / Hide 
Range on Protein: 357-451
Range on HMM: 191-293/293
Sequence Identity: 20% (22 aa)

KANDIFCYGILCFSSIFGVYPFQ-K----EPSKQDPIYNLIVEDRLNEFWNLFES--------RIKDMLAQGLQLEQLNLLKDLLQRLLQYNPQNRPNSQ
.. |.. .|....  ..|  ||. .    .   |. ....| . .| . |    |        . .   .. .  ..   .||.. ..|...|. ||. .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

QILNHPYF
|||.||.|
QILQHPWF
Kinase 11644.AA CAMKL 424-451 46 1.3e-09 26.71 In-house 270-297 (297) Show / Hide 
Range on Protein: 424-451
Range on HMM: 270-297/297
Sequence Identity: 46% (13 aa)

LKDLLQRLLQYNPQNRPNSQQILNHPYF
..||....|| ||  ||. .||.||| .
CRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 11644.AA CAMKL 34-125 26 2.2e-09 25.97 In-house 58-160 (297) Show / Hide 
Range on Protein: 34-125
Range on HMM: 58-160/297
Sequence Identity: 26% (29 aa)

RLQKEHSILVKMN---HPNIVKCDIQFYQNEER------CCIRLEQADCD---FLEYLTHFFQNR-------TKAFFRTQVSLLRNIASAIDYLHQKNYV
|...| .|. ..|   ||||.|   . ....|       ... .| ..      ..|.      |       .. .||        | ||..|.|... |
RIRREIQIMKMLNIGKHPNIIKL-YEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQ-------IVSAVNYCHSHGIV

HNDIKLENCLL
| |||.|| ||
HRDIKPENILL
Kinase 11644.AA Ciliate-C1 103-125 52 2.6e-09 19.74 In-house 140-162 (328) Show / Hide 
Range on Protein: 103-125
Range on HMM: 140-162/328
Sequence Identity: 52% (12 aa)

SAIDYLHQKNYVHNDIKLENCLL
..|.|.|| |. | |.|.|| ||
NVIQYIHQNNICHRDLKPENILL
Kinase 11644.AA Ciliate-E2-Unclassified 5-255 15 9.4e-09 26.52 In-house 49-239 (352) Show / Hide 
Range on Protein: 5-255
Range on HMM: 49-239/352
Sequence Identity: 15% (45 aa)

KKRQLHSLNNQSKSSSVETGNYCHSPKCKRLQKEHSILVKMNHPNIVKCDIQFYQNEERCCIRLEQA-DCDFLEYLTHFFQ------------NRTKAFF
...... .||..| ....  .       ... ..  ||. ..||.|||.  .| |... ..| .|.. . | ..|.... .            ...| | 
IMNEMKEMNNKKK-YHQR-KY-------NKIMQQ--ILLNHPHPFIVKMFYCF-QDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFT

RTQVS------LLRNIASAIDYLHQKN-YVHNDIKLENCLLFVQADKTSIYQQSKSKTNTFDSKPQINTEDQMSRSTTQSETYSELTNKQQSGGDISSSC
  |..      ... | ....|||.||  .| |||.|| .|| .  |                                                     
EQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPEN-ILFDNNGK-----------------------------------------------------

SLSDQSARRKDSTNSDGSKKQSKKTSSKKGRLILKLADFEFSC-----------------------VDEQCQTIDYL-KSWKLRNRKYMSPEMLD
                              .. .|..|| .|                         . .|.|. |. .        | .||.|.
------------------------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ--------YTAPEVLQ
Kinase 11644.AA RSK 425-451 31 1.1e-08 28.28 In-house 247-278 (278) Show / Hide 
Range on Protein: 425-451
Range on HMM: 247-278/278
Sequence Identity: 31% (10 aa)

KDLLQRLLQYNPQNRPN-----SQQILNHPYF
|||....|. .|..|..      ..|..||.|
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 11644.AA Ciliate-E2a 96-223 11 6e-08 19.5 In-house 105-153 (275) Show / Hide 
Range on Protein: 96-223
Range on HMM: 105-153/275
Sequence Identity: 11% (15 aa)

SLLRNIAS-AIDYLHQKNYVHNDIKLENCLLFVQADKTSIYQQSKSKTNTFDSKPQINTEDQMSRSTTQSETYSELTNKQQSGGDISSSCSLSDQSARRK
...... . .. |.||.|..| |.|.|| |.                                                                     
DIMQQLLWQGLHYMHQRNIMHRDLKPENILFKN-------------------------------------------------------------------

DSTNSDGSKKQSKKTSSKKGR--LILKLADF
                ||..   . .|..||
---------------CSKNSIQNSDIKIIDF
Kinase 11644.AA Ciliate-C1 360-401 35 6.3e-08 16.09 In-house 243-284 (328) Show / Hide 
Range on Protein: 360-401
Range on HMM: 243-284/328
Sequence Identity: 35% (15 aa)

DIFCYGILCFSSIFGVYPFQKEPSKQDPIYNLIVEDRLNEFW
|||  |.  |. . |  ||.|  .  || | ...|.|   .|
DIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYW
Kinase 11644.AA Pkinase 28-223 12 1.2e-07 28.08 Pfam 38-156 (293) Show / Hide 
Range on Protein: 28-223
Range on HMM: 38-156/293
Sequence Identity: 12% (26 aa)

HSPKCKRLQK--EHSILVKMNHPNIVKCDIQFYQNEERCCIRLEQADC-----DFLEYLTHFFQNRTKA--FFRTQVSLLRNIASAIDYLHQKNYVHNDI
.| |.... .  | .|. ..||||||.. . ..... .... .| ...     |  .|..   .....     ..  . .. |.....|.|... .| |.
KSWKDQTHRRLSEIQIMKRLNHPNIVRL-YDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDL

KLENCLLF--VQADKTSIYQQSKSKTNTFDSKPQINTEDQMSRSTTQSETYSELTNKQQSGGDISSSCSLSDQSARRKDSTNSDGSKKQSKKTSSKKGRL
|.||.|.    . |                                                                                      
KPENILIDNNGHIDA-------------------------------------------------------------------------------------

ILKLADF
..|..||
CVKICDF
Kinase 11644.AA CAMK 31-125 20 1.3e-07 19.86 In-house 74-212 (425) Show / Hide 
Range on Protein: 31-125
Range on HMM: 74-212/425
Sequence Identity: 20% (30 aa)

KCKRLQKEHSILVK-------MNHPNIVKCDIQFYQN-------------------EERCCIRL---EQADC-----DFLEYLTHF--------------
..|....| .|. |       ..||||.|. ...|..                   ...... .   | ..      | ..|..                
DRKNVRREIEIMKKLQGIGNKLDHPNIIKL-YEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVE

---F-QNRTKAFFRTQVSLLRNIASAIDYLHQKNYVHNDIKLENCLL
   |    .. .||        |.||..|.|..| || |.|.|| ||
RGRFTEREARRYFRQ-------ICSAVHYCHSHNIVHRDLKPENILL
Kinase 11644.AA RSK 98-125 39 1e-06 20.92 In-house 110-137 (278) Show / Hide 
Range on Protein: 98-125
Range on HMM: 110-137/278
Sequence Identity: 39% (11 aa)

LRNIASAIDYLHQKNYVHNDIKLENCLL
...|..|...|||.  .| |.|.||.|.
MAEIVLAVEHLHQQGIIHRDLKPENILY
Kinase 11644.AA CMGC 32-223 11 3.5e-05 11.96 In-house 55-248 (513) Show / Hide 
Range on Protein: 32-223
Range on HMM: 55-248/513
Sequence Identity: 11% (31 aa)

CK----------RLQKEHSILVKMN-----------------HPNIVKCDIQFYQNE----------------ERCCIRLEQADCDFLEYLTHFFQN---
.|          | . | .|| ..|                 |.||||.   || ..                .  ..  |  |.| ..|. .  ..   
AKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQG

-RTKAFFRTQ-------------VSLL------RNIASAID--YLHQKN--YVHNDIKLENCLLFVQADK--------TSIYQQSKSKTNTFDSKPQINT
 | . .   .              ...      . |  ...  |.|...   .| |.| || |.  . .         .                     
KRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSE---------------------

EDQMSRSTTQSETYSELTNKQQSGGDISSSCSLSDQSARRKDSTNSDGSKKQSKKTSSKKGRLILKLADF
                                                . . ...    . . .||..||
------------------------------------------------D-W-NPC----QKNGRLKICDF
Kinase 11644.AA Ciliate-A7 219-256 31 0.000232 11.7 In-house 178-225 (360) Show / Hide 
Range on Protein: 219-256
Range on HMM: 178-225/360
Sequence Identity: 31% (15 aa)

KLADFEFSCV--DEQCQ--TI------DYLKSWKLRNRKYMSPEMLDI
||||| |..   ... .  |       |  | || |...|..||....
KLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINC
TyrKc 11644.AA TyrKc 3-298 11 0.000662 -159.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-298
Range on HMM: 1-280/280
Sequence Identity: 11% (45 aa)

VFKKRQLHS-------------------LNNQSKSSSVETGNYCHSPKCKRLQKEHSILVKM--NHPNIVKCDIQFYQNE-------ERCCIRLEQADC-
. ....| .                   |.. .                . . .| .|. |   .|||||.. .     .       |  .| .| ..  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---------------REDFMREARIMCKLGGHHPNIVRL-YGVCTQQGRNFMYIEPLMIVMEYMPHG

---DFLEYLTHFFQNRTKAFFRTQVSLLRNIASAIDYLHQKNYVHNDIKLENCLLFVQADKTSIYQQSKSKTNTFDSKPQINTEDQMSRSTTQSETYSEL
   |.| .  .          .. .|    ||.  .|||.||..| |.   |||.  .                                          
DLKDYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------------------------------

TNKQQSGGDISSSCSLSDQSARRKDSTNSDGSKKQSKKTSSKKGRLILKLADFEFSCVDEQC-----QTIDYLK-----SWKLRNRKYMSPEMLDIC---
                                              . | .||  |   .        .  | |     .  .   . |.|| .. .   
----------------------------------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

----------------------YLLE----TTSQTTHEIEKEG---QIPNN-------------ALSLSSILNS------NFKRACSLY
                      |  .     . |  .|  |.|    .| |                 ..  .       .|.  ... 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF