Gene 11112 (Tetrahymena)

11112

Species: Tetrahymena
Alias: 3.m01952, PreTt11112, 3824.m02873, 183, 11112, TTHERM_00046330
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
11112.AA Protein None 794 None Fasta, JSON
11112.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
11112.NA RNA None 2385 None Fasta, JSON

Protein domain

Protein domains of 11112.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11112.AA NEK 4-261 48 1.4e-150 506.6 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-286/286
Sequence Identity: 48% (138 aa)

YIKIELVGKGNFGLAVLVQSKINRKY-----YIMKIIDILRLDQRQRQDAL-NEVKFLKELGHPFIIAYRESFVDKD-RYLCIVMDYCE-EGDLYNQ---
| .|. .|.|.|| . .|..|.. |      |..| |.. .......|.|. |||. ||.| || |..|..||....  .|||||.||| .||||..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IIEQKKTGQGFTEQQILEWFVQICFGLKFIHDR-----RILHRDLKTQNIFLTKSKQ----IKIGDFGIAKVLQNTCEMAKT-AIGTPYYLSPEICQQKP
| .||. |. | | ||..||.|.| .||..|||     .|||||.|.|||||||.      .|||||||.|||..|..||.|  .|||||.|||.||.||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNQKTDIWSLGCILYELCTL--RHAFDAK--HQQGLVLKILKG-NYPSIPNC--YSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
||.| |||||||.|||.|||  .|.|.|.   . .|..|| || .|| ||    ||..|..||  |||. | .|||...|||. |.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 11112.AA NEK1 4-261 49 1.2e-138 466.9 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-276/276
Sequence Identity: 49% (137 aa)

YIKIELVGKGNFGLAVLVQSKINRKYYIMKIIDILRLDQRQRQDALNEVKFLKELGHPFIIAYRESFVDKDR-YLCIVMDYCEEGDLYNQIIEQKKTGQG
|..|  .|.|.|| |.||..|  .. | .| | . .  .  |....|||. |. . || |..|.|||.   .  | |||.||. |||.  | .||  |. 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLT--KSK---------------QIKIGDFGIAKVLQNTCEMAKTAIGTPYYLSPEICQQKPYNQ
| | ||. ||.||| .|..||||.|||||.|.||||||  |.                 .|.||||||..|..| | |.| ||||||||||||| ||||.
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KTDIWSLGCILYELCTLRHAFDAKHQQGLVLKILKGNYPSIPNCYSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
|.|||||||.||||||| |.|.|.  . |||||..| || ||. ||  |. |.  |..| |  ||||  |||. |.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 11112.AA NEK8 4-261 40 2.6e-120 345.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-278/278
Sequence Identity: 40% (113 aa)

YIKIELVGKGNFGLAVLVQSKINR--KYYIMKIIDILRLDQRQRQDALNEVKFLKELGHPFIIAYRESFVDKDRYLCIVMDYCEEGDLYNQIIEQKK---
|..|  ||.| || ..|   |     .  | | |.  |.. ..||.|.||.  |. | || ||.| ..| . |  | |.| |.. | ||  | .|.    
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME-DNTLMIEMEYADGGTLYQMIQHQQNKLF

---T---------GQGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKS-KQIKIGDFGIAKVLQNTCEMA--KTAIGTPYYLSPEICQQKPY
   .            | ||.||  |.|.| .. ..|.  ||||||||||||.|..   .|||||||.|..     |.  || .|||||.|||.|. |||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

NQKTDIWSLGCILYELCTLRHAFDAKHQQGLVLKILKG-NYPSIPNCYSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
||| |.|.|||.|||.|.|. ||.|  .  ||.||  . .|  |.  ||. .  |. . || .|..|||.  |.    .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 11112.AA NEK4 4-261 47 3.2e-118 399.05 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-257/257
Sequence Identity: 47% (124 aa)

YIKIELVGKGNFGLAVLVQSKINRKYYIMKIIDILRLDQRQRQDALNEVKFLKELGHPFIIAYRESFVDKDR-YLCIVMDYCEEGDLYNQIIEQKKTGQG
|  .  |||| .|   ||.... .| |.|| .. .. ..|.|..|. |.. |  | || |. | ||.   .  .|.||| .|| ||||..  .||  .| 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQK--NQF

FTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSKQIKIGDFGIAKVLQNTCEMAKTAIGTPYYLSPEICQQKPYNQKTDIWSLGCILYELCTL
  |.|..||||||  .| ..|...|||||||||||||||   ||||||||..||.| |.|||| ||||||.|||.   .||. | ||||||| .||. ||
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

RHAFDAKHQQGLVLKILKGNYPSIPNCYSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
.||||||    |. .|..|  | .|  ||..| .|. .||.. | ||||.  |. . ..
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 11112.AA S_TKc 4-261 30 3.8e-91 310.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YIKIELVGKGNFGLAVLVQSKINRKYYIMKIIDILRLDQRQRQDALNEVKFLKELGHPFIIAYRESFVDKDRYLCIVMDYCEE--GDLYNQIIEQKK--T
| .....||| ||   ... |   ... .|||.         .....|.. ||. .||.|. . ..|.|   .|..||.||.   |||.  | ....  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

GQGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSKQIKIGDFGIAKVLQNTCEMAKTAIGTPYYLSPEICQQKPYNQ-KTDIWSLGCILYE
...|.| ..  .. ||| .|...|...|.||||| .||.|..  .|||.|||.|..|       .| .|||.|..||..   .|.  | |.||.||||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCTLRHAFDAKHQQGLVLKILKGNYPSIPNCYSPQLSDLIGEMLQRHPAKRPSVKKILE-------KQFL
... .  |.   |. ...|...          ||.. |.|  .||. |.|||.. ..|.        ...
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11112.AA NEK-Unclassified 4-261 36 1.7e-75 249.33 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-258/258
Sequence Identity: 36% (97 aa)

YIKIELVGKGNFGLAVLVQSKINRKYYIMKIIDILRLDQRQRQDALNEVKFLKELGHPFIIAYRESFVDKDRYLCIVMDYCEEGDLYNQIIEQKKTGQ--
| ||  .|.|  |   ||  .| ..  . .|    |  ...||   | .  |  | || |. | .|| .  . |    |||. |.|   |  ||. .   
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISK--RKKKKKRQ---NKIIILSQLRHPHIVTYHDSFFENAK-LFYTQDYCDGGNLDRRI--QKHRKKNE

GFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSKQIKIGDFGIAKVLQNTCEMAKTAIGTPYYLSPEICQQKPYNQKTDIWSLGCILYELCT
 | |  |  |..|.   . .|| |.|.|||||.||||||..  . .|||||....  | . |.| .||. ..|||.||..||| . |.||||||.||.||
PFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCT

LRHAFDAKHQQGLVLKILKGNY-------PSIPNCYSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
   .||..    .  || ..         | .   ||  |...|  ||.| . .|||   |.|  . 
CEPFFDTHNMGEVYMKIKQDDNRLEEALEP-VSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 11112.AA Pkinase 4-261 28 1.6e-73 255.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YIKIELVGKGNFGLAVLVQSKINRKYYIMKIIDILRLDQRQRQDALN--EVKFLKELGHPFIIAYRESFVDKDRYLCIVMDYCEEG----DLYNQIIE--
| ... .|.|.||   . . | ..| . .|||.  . .  ..| ...  |.. .|.|.||.|. ....| | ......||.||| |    ||.  .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF-DYISTW

QKKTGQGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSKQI----KIGDFGIAKVL-QNTCEMAKTAIGTPYYLSPEICQ-QKPYNQKTDI
....   |.|...  .. ||. ||...|...|.||||| .||.. .  .|    ||.|||.||..     . ..|  |||.|..||... ...| .| |.
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGCILYELCTLRHAFDAK------HQQGLVLKILKGNYPSI-PNCYS-------------------PQLSDLIGEMLQRHPAKRPSVKKILEKQFL
||.||||||... |  |. .       |. .. .|... ...  |. .|                   . . |.|  .|.. |.|||. . ||.  ..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 11112.AA NEK11 4-261 40 2e-73 250.24 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-259/259
Sequence Identity: 40% (106 aa)

YIKIELVGKGNFGLAVLVQSKINRK---YYIMKIIDILRLDQRQRQDALNEVKFLKELGHPFIIAYRESFVDKDRYLCIVMDYCEEGDLYNQIIEQKKTG
|.    .| | ||   ||  |  ..     ..| | .  |       |  | . |  | || |. .  ||...| . ||. .|||  || ..| | |. |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNF-CIITEYCEGRDLDYRIQEYKQAG

QGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSKQIKIGDFGIAKVLQNTCEMAKTAIGTPYYLSPEICQQKPYNQKTDIWSLGCILYELC
. | | ||.|||.|.  |  ..|.||||||||| .|||| |   .||||||....|   |..| |  ||| |.|||  . . |  | ||||| |||||.|
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

TLRHAFDAKHQQGLVLKILKGNYPSIPNCYSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
 . |||       .||.|  |. ||.|. |   |  ..  || . |. |||   ||   ..
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase 11112.AA CAMK 9-261 21 6e-70 224.35 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

LVGKGNFGLAVLVQSKINR------------KYYIMKIIDILRLD--------------------------QRQRQDALNEVKFLKELG-------HPFI
  |.|.||   |.. | .             . . .||||  .|.                          .. |.  ..|.. .| |        || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAYRESFVDK------------------DRYLCIVM---DYCEEG----DLYNQIIEQKKTG-----------QGFTEQQILEWFVQICFGLKFIHDRRI
|   | . |.                  |.....||   .||. |    ||.. |.|... |             |||..   .| ||| .....|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKTQNIFLTKSK-----------------QIKIGDFGIAKVLQNTC-----------------------EMAKTAIGTPYYLS-PEICQQ------
 |||||  || |....                 .||| ||| |....                          .. ||  |||.| . ||. ..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYNQKTDIWSLGCILYELCTLRHAFDAK-------------HQQGLVLKILKGNYPSIPNCYSP-----------------------QLSD
        ..|..|.|.||.|.||| . . .  |...             ... |  ||.||.|  .|   ||                       .  |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIGEMLQRHPAKRPSVKKILEKQFL
||  |||. | ||.... .|. ...
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 11112.AA STE 4-261 22 6.1e-64 218.75 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-359/359
Sequence Identity: 22% (84 aa)

YIKIELVGKGNFGLAVLVQSK----IN-----------RKYYIMKIIDILRLDQ---------------RQRQDALNEVKFLKELG--HPFIIAYRESFV
. .|| .|||.||  ..   .    |.            ... .|.... . ..                ..|. |.|.|..|..   ||.|. |  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DKDR------YLCIVMDYCEEGDLYNQIIEQKKTGQGFT----------EQQILEWFVQICFG-LKFIHDRRILHRDLKTQNIFLTKSKQIKIGDFGIAK
....      .|.|.| |.. | |   | . ...|....          |.||    .||. | |...|. .| |||.| .||.|     .|. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLQN---------------TCE-MAKTAIGTPYYLSPEICQQ------KPYNQKTDIWSLGCILYELCTLRHAF---DAK---HQQG----------LVL
 |..               |.  . .| .||| . .||. ||      |.|. | ||||||| . |..| .. .          .            .. 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

KILKGNYPSIPNC-------------------YSPQLSDLIGEMLQRHPAKRPSVKKILE--KQFL
.|..|. |..|.                    .|| . | |   ||. | |||.... |.    |.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 11112.AA Ciliate-E2 4-261 23 2e-63 216.58 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YIKIELVGKGNFGLAVLVQSKINRKYY------------------IMKIIDILRLDQRQRQDALNEVKFLKELG----------------HPFIIAYRES
|..|.. |.||||   ... . ..| .                   .||. . .. ..| .  ..| . ..|.                 ||.|| . |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FVD-KDRYLCIVMDYCEEGDLYNQIIEQ-KKTGQG------FTEQQILEWFVQICF---------------GLKFIHDRR-ILHRDLKTQNIFLTKSKQI
| . .| .. .||.||. |||.  |... || ..       |||..|.. . ||.                .|...| .  |.|||.| .||..     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGIAK------------VLQN-------------------TCEMAKTAIGTPYYLSPEICQQKP---------YNQKTDIWSLGCILYELCTLRHA
|| |||..|            ....                     .|..| .|||.|..||| . |.         |. | ||||||.||||... .. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FDAKHQQGLVLKILKGNYPSIP------------------NCYSPQLSDLIGE----MLQRHPAKRPS-VKKILEKQFL
|         ... | .  ..|                  .  |..  |||      |||. | ||..  ..||. ...
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 11112.AA ULK 4-261 28 3.1e-62 213.07 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-329/329
Sequence Identity: 28% (93 aa)

YIKIELVGKGNFGLAVLVQS--KINR----KYYIMKIIDILRLDQRQRQDA--------LNEVKFLKELG--------HPFIIAYRESFVDKD-RYLCIV
|....  ||| ||  .  .   |..     .... |.||.  ..| . ..          ||.| .|.|         || |. . . | ...  .. |.
YCLNHCLGKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MDYCEEGDLYNQIIEQKK------TGQGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSK------------QIKIGDFGIAKVLQNT---
|.||. ||| . | ..||      ... ..||.... | ||. |.|..|...| |||.| ||| ... .            ..||.||| ||...|    
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

CEMAKTAI------GTPYYLSPEICQ----QKPYN-QKTDIWSLGCILYELCTLRHAFDAKHQQGLVLKILKGNYPSIPNCY------------------
 .|..|.       |||.| .|.| |    ||||.  |.||||||||.||. . .  | |   . ..|.|.. ..   |...                  
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

-SPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
 ||.. |||  |||. . .| |   ...  ..
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 11112.AA Pkinase_Tyr 41-159 29 2.8e-20 69.31 Pfam 41-164 (270) Show / Hide 
Range on Protein: 41-159
Range on HMM: 41-164/270
Sequence Identity: 29% (37 aa)

DQRQ--RQDALNEVKFLKEL-GHPFIIAYRESFVDKDRY--LCIVMDYCEEGDLYNQIIEQKKTGQGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQ
...|  |.| ..|.| .|.|  || |. .    .|...   ..||| |.. |||..   ...  .| .| ...|.. .||. |. . ..... |||| . 
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAAR

NIFLTKSKQIKIGDFGIAKVLQNT
|. .|.....||.||| |. ..|.
NCLVTENNVVKICDFGLARDIYND
Kinase 11112.AA TyrKc 4-261 18 3.7e-17 54.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YIKIELVGKGNFG---LAVLVQSKINRKYYIMKIID----ILRLDQRQRQDALNEVKFLKEL--GHPFIIAYRESFVDK------DRYLCIVMDYCEEGD
  ...  | |.||   ....              |.     |. |   |.| ..| . ...|   || |..     ...      .  |.||| |.. ||
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LYNQIIEQKKTGQGFTEQQILEWFVQICFGLKFIHDRRILHRDLKTQNIFLTKSKQIKIGDFGIAKVLQNT------CEMAKTA--IGTP-----YYLSP
| . . . ...   .. .. |.. .||. |  ..|.... |||| . |. ... ...||.||| .. . .        .. ...   |.        ..|
LKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EICQQKPYNQKTDIWSLGCILYELCTLRHAFDA------KHQQGLVLKILKGNYPSIPNC--------YSPQLSDLIGEMLQRHPAKRPSVKKILEKQFL
|  . . .. |.|.|| |  ..|..|.            .  | .. .. .|... .|           .. . ... .  .. |..||. . |  ....
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 11112.AA Pkinase_Tyr 183-202 35 0.059268 7.24 Pfam 191-210 (270) Show / Hide 
Range on Protein: 183-202
Range on HMM: 191-210/270
Sequence Identity: 35% (7 aa)

YNQKTDIWSLGCILYELCTL
.. |.|.|| |  ..|..|.
FTTKSDVWSFGVLMWEIFTY