Gene 10505 (Tetrahymena)

10505

Species: Tetrahymena
Alias: 244, 3810.m02065, PreTt10505, TTHERM_00571750, 76.m00207, 10505
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
10505.AA Protein None 292 None Fasta, JSON
10505.kin_dom Protein Kinase Domain None 250 None Fasta, JSON
10505.NA RNA None 879 None Fasta, JSON

Protein domain

Protein domains of 10505.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10505.AA Ciliate-E2 29-276 20 5.8e-30 100.04 In-house 1-361 (365) Show / Hide 
Range on Protein: 29-276
Range on HMM: 1-361/365
Sequence Identity: 20% (78 aa)

IDMSRLIGESYTSKVYLAYLISNPTQV----------------------YACKIIDKKDVISFDNLKRLVQKWK-------------KFNHLNIIQVFDC
..  ..||.   ..||..  .... |.                      || ||. |...... . ... .. .             . || |||. ..|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YM--TDHNIYLITEFCQQGYLFCAQQQMNWNY------------QQIISISNQIIQGS---------------LFLSQQQ-IIDQVLTPENILFQNGTPK
.   .|.||||..|.||.| ||   .... .             ..|. |. ||.||                 .| ..  ||   . ||||||    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

I-DISF----------------QLNSMELLQKSYVPQRYK-----------------FSSPQIYEEDE---------YSNKSNVWSIGIILYYQFQGRDP
| |  .                . . |.  .. .. ..|                  . .|.|..  .         |. |. .||.|.|||.   |. |
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEEQFINLIQRLQAIHKTKTIQFSQN----------------KPVSDEIKNLINS----MLQYQESERAT-MEDIQN
|           | ..| . |.|...                | .|.| |.||.     |||.....| | .|.| |
F-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 10505.AA CAMK 34-113 18 4.2e-18 54.25 In-house 1-152 (425) Show / Hide 
Range on Protein: 34-113
Range on HMM: 1-152/425
Sequence Identity: 18% (28 aa)

LIGESYTSKVYLAYLISNPT-----------QVYACKIIDKKDVI----------------------------SFDNLKRLVQKWKK-------FNHLNI
 .|.   .||.|.. ....            | .|.|||||| .                             . .|..| ..  ||        .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQVFDCYMTDHN-------------------IYLIT---EFCQQG----YLF
|. .. | ..|.                   .|...   |.|. |    .||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLF
Kinase 10505.AA ULK 29-110 28 5.8e-18 60.38 In-house 1-102 (324) Show / Hide 
Range on Protein: 29-110
Range on HMM: 1-102/324
Sequence Identity: 28% (29 aa)

IDMSRLIGESYTS-KVYLAYLISNPT--QVYACKIIDKKDVISF----------DNLKRLVQKWKKFN------HLNIIQVFDCYMTD--HNIYLITEFC
. ... .|.     ||| .. . . |  |..|||.||||  . .          ..||. .| .||..      | .|.. .|...|.   |||.|.|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

QQG
..|
NGG
Kinase 10505.AA ULK 189-279 30 4.8e-17 57.08 In-house 215-324 (324) Show / Hide 
Range on Protein: 189-279
Range on HMM: 215-324/324
Sequence Identity: 30% (34 aa)

SPQIYEED----EYSNK-SNVWSIGIILYYQFQGRDP----FEEQFINLIQRL-------QAIHKTKTIQFS---QNKPVSDEIKNLINSMLQYQESERA
.||| ..     .|... . .||.|.|.|.   |. |    |..|... ||.|       | . |.. |||    .....|.|.|.||  ||||.|..| 
APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRI

TMEDI-QNKFT
. |.| .... 
SWEEIFNHPWF
Kinase 10505.AA ULK 189-279 27 6.8e-16 52.05 In-house 219-329 (329) Show / Hide 
Range on Protein: 189-279
Range on HMM: 219-329/329
Sequence Identity: 27% (30 aa)

SPQIYEED----EYSNK-SNVWSIGIILYYQFQGRDP----FEEQFINLIQRLQAIHKTKT-------IQFS---QNKPVSDEIKNLINSMLQYQESERA
.||| ..     .|... . .||.|.|.|.   |. |    |..|... ||.|  . ..         .||     ....|.|.|.||  ||||.|..| 
APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRI

TMEDI-QNKFT
. |.. .... 
SWEELFNHPWF
Kinase 10505.AA ULK 29-110 26 1.5e-15 50.81 In-house 1-105 (329) Show / Hide 
Range on Protein: 29-110
Range on HMM: 1-105/329
Sequence Identity: 26% (28 aa)

IDMSRLIGE-SYTSKVYLAY-LISNPT---QVYACKIIDKKDVISFDN----------LKRLVQKWKKFN--------HLNIIQVFDCYMTD--HNIYLI
. ... .|. |.  ||| ..  ... .   ...|||.|||.  . . |          ||. .. .|| .        | ||.. .|...|.   |||.|
YCLNHCLGKGSFG-KVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

TEFCQQG
.|.|..|
MEYCNGG
Kinase 10505.AA Ciliate-E2-Unclassified 29-276 20 2.3e-14 46.24 In-house 1-348 (352) Show / Hide 
Range on Protein: 29-276
Range on HMM: 1-348/352
Sequence Identity: 20% (70 aa)

IDMSRLIGESYTSKVYLAYLISNPTQVYACKIIDKKDVIS-------FDNLKRLVQKWKKFN-------------------HLNIIQVFDCYMTDHNIYL
  . . ||.   .|||... ...  |.|| |.. |. ...         ....  . ... .                   |..|.  |.|  .. |||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITEFCQQGYLFCAQQQ------------MNWNYQQII-----------SISNQIIQGSLFLSQQQ-IIDQVLTPENILFQNGTP--KIDISFQLNSM---
..|.|..| |.   ..            .| ....|.            .  ||.||  .| ... ||   ..||||||.|.    .| |.   .|.   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------------ELLQKSYVPQRYK--FSSPQIYEEDEYSNK----SNVWSIGIILYYQFQGRDPFE--EQFINL-----------IQRLQAIH
                  ....      .|.    .| .... .|...    . .|| |.|||.   |. ||.   . ..            .. |. . 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KTKTIQFSQNKP------VSDEIKNLIN----SMLQYQESERATMEDIQN
| | |||.  ..      .|.| |..||    .||... ..| |.|.| |
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 10505.AA Ciliate-E2c 187-277 26 5.8e-14 45.42 In-house 184-307 (310) Show / Hide 
Range on Protein: 187-277
Range on HMM: 184-307/310
Sequence Identity: 26% (33 aa)

FSSPQIYEE-DEYSNKSNVWSIGIILYYQFQGRDPFE---------------EQFINLIQRLQAIHK---------------TKTIQFSQN--KPVSDEI
...||| |   .|  || .|| |. |||    . |.|                ...|. . |  . .               |. |.|..|  . .| |.
YMAPQILEGKNYYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEV

KNLINSMLQYQESERATMEDIQNK
| ||. |||. |. |   ..| |.
KQLIHKMLQVDEEKRIDWDEIFNH
Kinase 10505.AA S_TKc 29-279 21 1.5e-13 21.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-279
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

IDMSRLIGESYTSKVYLAYLISNPTQVYACKIIDKKDVISFDNLKRLVQKWKKFNHLNIIQVFDCYMTDHNIYLITEFCQQ--GYLFCAQQQMN------
 .. |.||.   .|||... ..   ...|.|||.       ....| .|  || .| ||.. .|.. . ...|...|.| .  | ||   ....      
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-WNYQQIISISNQIIQGSLFLSQQQII--DQVLTPENILFQNGTPKI---DISFQLNSMELLQKSYVPQRYKFSSPQIYEEDEYSN-KSNVWSIGIILYY
  .  .. ..  ||...  .. ...||  |  | |||||. . . ||    .. ||        . .     . .| .     |.  |. .||.|.||| 
PFPE-HARFYMYQICCALEYCHSHGIIHRD--LKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

QFQGRDPFEEQFINLIQRLQAIHKTKTIQFSQNKPVSDEIKNLINSMLQYQESERATMEDIQN--------KFT
 . |. ||. |   .....                 |.| |..|. .||.  ..| |  .. .         . 
MLCGYPPFP-QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10505.AA CAMK-Unique 29-113 22 1.1e-11 34.65 In-house 1-123 (363) Show / Hide 
Range on Protein: 29-113
Range on HMM: 1-123/363
Sequence Identity: 22% (28 aa)

IDMSRLIGESYTSKVYLAYLISNPTQVYACKIIDKKDV--ISFDN------------------LKRLVQKWKKFNHLNIIQVFDC----YMTDH------
..| |.||.   ..|| .  .....  .|||.. |...  .. .                   ||| .| ||. .| |||...|     . ..       
YKMHRIIGHGNFGHVYECMDRETGKK-WACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------NIYLITEFCQQGYLF
         ..|...|.|| | ||
IIKTPRALPYMYIVMEYCQGGDLF
Kinase 10505.AA CAMKL 30-113 29 1.7e-11 32.76 In-house 2-111 (297) Show / Hide 
Range on Protein: 30-113
Range on HMM: 2-111/297
Sequence Identity: 29% (32 aa)

DMSRLIGESYTSKVYLAYLISNPTQVYACKIIDKK----DVISFDN-----------LKRLVQKWKKFN---HLNIIQVFDCYMTDHN------IYLITE
.. . .|.   .|| ||  |... . .| ||||||    | .. .|           ..| .|  |..|   | |||. .... |. .      |||..|
RIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVME

FCQQGY--LF
 |. |   ||
YCSGGEMDLF
Kinase 10505.AA CAMKL 187-276 27 2.6e-11 32.22 In-house 199-293 (297) Show / Hide 
Range on Protein: 187-276
Range on HMM: 199-293/297
Sequence Identity: 27% (27 aa)

FSSPQIYEE--DEYS-NKSNVWSIGIILYYQFQGRDPFEEQFIN-----LIQRLQAIHKTKTIQFSQNKPVSDEIKNLINSMLQYQESERATMEDIQN
. .| |..   ..|   |  .||.|.|||    |. ||... .|      | .|  . ..   ..   . || . ..|| .|||   ..|.|...| |
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 10505.AA SNRK 187-280 33 6e-11 31.8 In-house 165-254 (254) Show / Hide 
Range on Protein: 187-280
Range on HMM: 165-254/254
Sequence Identity: 33% (32 aa)

FSSPQIYEEDEYSNKS-NVWSIGIILYYQFQGRDPFEEQFINLIQRLQAIHKTKTIQFSQNKPVSDEIKNLINSMLQYQESERATMEDIQNKFTD
.| | |   |.|     ..||.|.|||    |. ||.|   |    |  |   |   ..  . |||| ..||.|||. .   ||..|.|...   
YSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQE--ANDSETLTMIMDCK---YTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase 10505.AA CAMK 187-276 20 2.2e-10 28.91 In-house 285-421 (425) Show / Hide 
Range on Protein: 187-276
Range on HMM: 285-421/425
Sequence Identity: 20% (28 aa)

FSS-PQIYE--------------EDEYSNKSNVWSIGIILYYQFQGRDPFEEQ-----------------FINLIQRLQ---AIHKTKTIQ---------
. . | . .              .. |. |. .||.|.|||    |. ||..                      |.. .     .. ..|          
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD

-----FSQNKPVSDEIKNLINSMLQYQESERATMEDIQN
     | ..  ||.| |.||..|||.  ..|.| |.. |
DISDEF-HH-FVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase 10505.AA Pkinase 197-278 23 3.9e-08 29.83 Pfam 188-293 (293) Show / Hide 
Range on Protein: 197-278
Range on HMM: 188-293/293
Sequence Identity: 23% (25 aa)

EYSNKSNVWSIGIILYYQFQGRDPFEEQ--FINLIQRLQAIHKTKTIQFSQNKPVS---------------------DEIKNLINSMLQYQESERATMED
.|. |. .||.|.|||. . || || ..   .| .  .| | ...  ... . | .                     .| | .|...|..  ..| | |.
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

IQNK--F
| .   |
ILQHPWF
Kinase 10505.AA Ciliate-E2c 29-164 30 4.1e-08 24.61 In-house 1-155 (310) Show / Hide 
Range on Protein: 29-164
Range on HMM: 1-155/310
Sequence Identity: 30% (47 aa)

IDMSRLIGESYTSKVYLAYLIS---------NPTQVYACKIIDKKDV----ISFDNLK----RLVQKWKKFNHLNIIQVFDCYMTDHNIYLITEFCQQGY
||     |     |||.||. .         .  |..| |..  |      |.. . |    | ..  |. || .||.  |   ||..||||.|.| .| 
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LFCAQQQM-NWNYQQIISISNQIIQGSLFLSQQ-QIIDQVLTPENILFQNGTPKI
|        . | .|..   .|||..   | ..  |.   . |||||  ||..||
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKI
Kinase 10505.AA TyrKc 29-278 17 1.4e-07 -100.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-278
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

IDMSRLIGESYTSKVYLAYLISNPTQVYACKIIDKKDVISFDNLKRLVQKWKKF--NHLNIIQVFDCYMTD-------HNIYLITEFCQQGYL--FCAQQ
| . . .||    .||.. ..   .|| | | . .        . |  .  .|.  .| ||.. . . ...       . .....|..  | |  .    
ITLGKKLGEGAFGEVYKGTWK---IQV-AVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

QMNWNYQQIISISNQIIQGSLFLSQQQIIDQVLTPENILFQNGT-PKI-D--ISFQLNSM-------ELLQKSY-VPQR----YKFSSPQIYEEDEYSNK
. . . .. .|.. || .|  .|.....|   |   |.|  ..   || |   |  . .        .   |.     .    ..  .|    . ... |
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SNVWSIGIILYYQF-QGRDPFEE---QFINLIQRLQAIHKTKTIQFSQNKP------VSDEIKNLINSMLQYQESERATMEDIQNKF
| ||| |. ..  |  |  | ..   |... .. .. . . .     .|         .||. ... .  ... ..| |...|  .|
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 10505.AA Pkinase 41-113 29 1e-06 24.31 Pfam 13-92 (293) Show / Hide 
Range on Protein: 41-113
Range on HMM: 13-92/293
Sequence Identity: 29% (24 aa)

SKVYLAYLISNPTQVYACKIIDKKDVIS-FDNLKRL---VQKWKKFNHLNIIQVFDCYMTDHNIYLITEFCQQG----YLF
..||... ....  ..|.|||.|..  | .|  .|.   .|  |..|| ||.. .|..... .||...|.|. |     ||
GCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF
Kinase 10505.AA TSSK 204-276 28 1e-06 17.87 In-house 212-285 (289) Show / Hide 
Range on Protein: 204-276
Range on HMM: 212-285/289
Sequence Identity: 28% (22 aa)

VWSIGIILYYQFQGRDPFEE---QFINLIQRLQAIHKTKTIQFSQ--NKPVSDEIKNLINSMLQYQESERATMEDIQN
||| |.|||    |. || .   .   .... |.    . ..|    .. .|.| |.|| .||| . ..|.....|..
VWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQE----HKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICH
Kinase 10505.AA CAMK-Unique 189-279 13 6e-06 15.41 In-house 243-363 (363) Show / Hide 
Range on Protein: 189-279
Range on HMM: 243-363/363
Sequence Identity: 13% (16 aa)

SP--------------QIYEEDEYSNKS----NVWSIGIILYYQFQGRDPFEEQFIN--------LIQRLQAIHKTKTIQFSQNKP---VSDEIKNLINS
.|              .. ... |. ..      ||.| |.|| . |. ||......         | .   ...  .   ...     .|.| |...  
APEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKC

MLQYQESERATMEDI-QNKFT
 ...  . | . . . .. . 
CMTVDPDHRWSAKELLEHQWI
Kinase 10505.AA TSSK 79-110 32 1.1e-05 14.63 In-house 69-102 (289) Show / Hide 
Range on Protein: 79-110
Range on HMM: 69-102/289
Sequence Identity: 32% (11 aa)

WKK-FNHLNIIQVFDCYMTDH-NIYLITEFCQQG
..|  .| ||||..  . | .  ||.. |....|
MRKTLKHPNIIQFYEMFETCQGKIYMVMEYAEHG
Kinase 10505.AA SNRK 30-113 27 0.000484 8.82 In-house 2-86 (254) Show / Hide 
Range on Protein: 30-113
Range on HMM: 2-86/254
Sequence Identity: 27% (24 aa)

DMSRLIGESYTSKVYLAYLISNPTQVYACKIIDKK--DVISFDNLKRLVQKWKKFNHLNIIQVFDCYMTDHNIYLITEFCQQGYLF
|. . .|.     | ||  .    .| | |.|||   | .|   | . |.  |   | ||. ...   |   .||| |    . ..
DLEKTLGRGHFAVVKLARHVFTGEKV-AVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMY
Kinase 10505.AA TSSK 29-65 29 0.012946 4.38 In-house 1-52 (289) Show / Hide 
Range on Protein: 29-65
Range on HMM: 1-52/289
Sequence Identity: 29% (16 aa)

IDMSRLIGE-SYTSKVYLAYLISNPTQ----------------VYACKIIDKKD
..... ||. || .|||.||  ..                   | |.||||.|.
YNVGKKIGHGSY-AKVYCAYSKKHKCKHNPRLRDDLRIKRHTHV-AIKIIDRKK