Gene 10243 (Tetrahymena)
10243
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 10243.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10243.AA | Ciliate-B2 | 832-909 | 32 | 1.6e-13 | 28.07 | In-house | 70-149 (197) | Show / Hide |
Range on Protein: 832-909 Range on HMM: 70-149/197 Sequence Identity: 32% (26 aa) QIEYNLSYFVMELGETNLQQELY---IKKISFKPQELHDMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQKYKISDLG ||. . ..|| | |.||| ... |. | | |.. | || |... |.| || .|| ... .|. .| | QINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRM-YNILHLDIKPQNILFMQNGNYVYCDFG |
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| Kinase | 10243.AA | CMGC | 745-909 | 18 | 4.3e-13 | 38.43 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 745-909 Range on HMM: 1-249/513 Sequence Identity: 18% (46 aa) FKKIVDLGAGGFAQVYKVIDLKNNQD--------GKKSQELAIKAQNLPTKESVYAA------------TKEFNITKRLS-------------FHKTES- ...| .| | ...||| .| ..|| . .. ||| .| . | | | |.|. ..| . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IIKLKYGILINNISIQNYDGHQI---EYNLSYFVMELGETNLQQELYIKK--------ISFKPQE------------LHDMM------YSLCRGLY--QL |.||.. . .| ..|.. .| ..| |.|.|. ...| | .. .. . ... . .| | ..||| . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HIDAK--IVHMDISLDNIIKTKDQKY--------------------KISDLG | .. |.| |. || ... .. || | | H-SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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| Kinase | 10243.AA | S_TKc | 745-1058 | 14 | 1.6e-10 | -22.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 745-1058 Range on HMM: 1-231/231 Sequence Identity: 14% (49 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDGKKSQELAIKAQNLPTKESVYAATKEFNITKRLSFHKTESIIKLKYGILINNISIQNYDGHQIEYNLSYFVMEL .... .| |.|..|||... | .. ||| . . .| .| |. . . |.||.. . . |.|||. YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD---------------DHLYMVMEY GET---NLQQELYIKKIS-----FKPQELHDMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQKYKISDLGGGLVQRNQFSQIVSKHLQCKQQYLSP- .. .| . . .. | . . .|| .|..| .| .|.| |. .|| .. ||.| | . ... |..| CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPE LIKNQLETQNLIEKNWNYQENIFEIKKDFTLLK-QNDCYALGFIFYMVVT----FNFKNLNNEYQSHDQLEQTRQEMISVLNKYKDSNNQQQEDVLQLYP .. | | ...| |.| .. | |.... . . . VL---------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG---------------------S DYLIEQIQRLLDYK-----DITEVFS----VMLLSSF . ... |...|.. . |.. ... | PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 10243.AA | Pkinase | 745-909 | 23 | 4e-09 | 33.33 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 745-909 Range on HMM: 1-157/293 Sequence Identity: 23% (43 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDGKKSQELAIKAQNLPTKES--VYAATK--EFNITKRLSFHKTESIIKLKYGILINNISIQNYDGHQIEYNLSYF .... .|.|.|..||| .. .... . |.| ......| ..... | | |||. |. |..| |.. . . |. YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPN--IVRL-YDWFED-------------KDHIYM VMELGET-----NLQQELYIK---KISF--KPQELHDMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQKY----KISDLG |||. | | ||. . .| ..|. ..|| ..|||. .| .|.| |. ..|| .. ||.| | VMEYCEGGLYVMDLF--DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Kinase | 10243.AA | Ciliate-A1 | 839-909 | 28 | 5.6e-08 | 23.17 | In-house | 77-146 (301) | Show / Hide |
Range on Protein: 839-909 Range on HMM: 77-146/301 Sequence Identity: 28% (20 aa) YFVMELGETNLQQELYIKKISFKPQELHDMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQKYKISDLG ...|| . ...... . | | .. | . |. .| | |.| |. .||. | |.|| ||| FIIMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIH-DHNILHRDLKPQNILIHFDDKWKICDLG |
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| Kinase | 10243.AA | Ciliate-E2-Unclassified | 745-909 | 23 | 9.5e-08 | 22.98 | In-house | 1-192 (352) | Show / Hide |
Range on Protein: 745-909 Range on HMM: 1-192/352 Sequence Identity: 23% (47 aa) FKKIVDLGAGGFAQVYKVIDLKNNQD-----GKKSQELAIKAQNLPTKESVYAATKEFNITKRLSFHKTESIIKLKYGILINNISIQNYDGHQIE--YNL .|.| .| |||..|||... |..| ||.|. . | .. | . .. ..|. | .. | . | . ||.|. .. . . .. .. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQ---ILLNHPHPFIVKMFYCFQDKQN SYFVMELGE-TNLQQELYIKK----------------ISFKPQELH-----DMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQ---KYKISDLG |.|||. | .|.| . ..| | |. .... .. || .|| .|.| || ..||. .... . ||.|.| IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG |
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| Kinase | 10243.AA | STE20 | 745-807 | 23 | 7.2e-07 | 21.45 | In-house | 1-64 (288) | Show / Hide |
Range on Protein: 745-807 Range on HMM: 1-64/288 Sequence Identity: 23% (16 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDGKKSQELAIKAQNLPTK----ESVYAATKEFNITKRLSFHK .... .| |.. .|||... .... . |. ||| || .. .... || .| |.. |. YELLEKIGQGSYGKVYKAYHKPTGEYCN--QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HP |
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| Kinase | 10243.AA | STE | 745-780 | 26 | 9e-06 | 16.55 | In-house | 1-45 (359) | Show / Hide |
Range on Protein: 745-780 Range on HMM: 1-45/359 Sequence Identity: 26% (12 aa) FKKIVDLGAGGFAQVYKVIDL------KNNQD---GKKSQELAIK ...| .| |.| .||| .. |... |.. . ||| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIK |
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| Kinase | 10243.AA | PLK | 745-780 | 33 | 1.3e-05 | 14.34 | In-house | 1-30 (258) | Show / Hide |
Range on Protein: 745-780 Range on HMM: 1-30/258 Sequence Identity: 33% (12 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDGKKSQELAIK ... || |||| .|...|... .|..||| YERGHFLGKGGFAKCYEMTDIHT------KQVYAIK |
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| Kinase | 10243.AA | SAK | 836-909 | 32 | 1.9e-05 | 14.21 | In-house | 72-145 (254) | Show / Hide |
Range on Protein: 836-909 Range on HMM: 72-145/254 Sequence Identity: 32% (25 aa) NLSYFVMELGETNLQQELYIKKI--SFKPQELHDMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQKYKISDLG | | |.|. . | . |.|.. | .| ..| . |. || |.| |..| ||. |.| . || | | NYVYLVLEMCH-NGEMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHG-IMHRDLTLSNILLTRDMHCKIADFG |
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| Kinase | 10243.AA | TTBKL | 745-770 | 42 | 5e-05 | 13.0 | In-house | 1-26 (288) | Show / Hide |
Range on Protein: 745-770 Range on HMM: 1-26/288 Sequence Identity: 42% (11 aa) FKKIVDLGAGGFAQVYKVIDLKNNQD .. . .| |||.|||.|.|.|. .| WMIVKMIGEGGFGQVYHVWDMKDKKD |
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| Kinase | 10243.AA | WEE | 839-909 | 20 | 0.000839 | 8.72 | In-house | 81-177 (297) | Show / Hide |
Range on Protein: 839-909 Range on HMM: 81-177/297 Sequence Identity: 20% (20 aa) YFVMELGET-N-----LQQELYIKKISFKPQELHDMMYSLCRGLYQLHIDAKIVHMDISLDNIIKTKDQ--------------------KYKISDLG | .||. . . ..|. . .. .. ... . .|.|| .| .||||| .|| .|.. ..|| |.| YIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFG |
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| Kinase | 10243.AA | WEE | 745-773 | 31 | 0.002049 | 7.4 | In-house | 1-26 (297) | Show / Hide |
Range on Protein: 745-773 Range on HMM: 1-26/297 Sequence Identity: 31% (9 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDGKK |. . .| | |..|||.. ...||.. FQEVQKIGEGSFGEVYKCR---CRIDGCI |
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| Kinase | 10243.AA | Ciliate-A1 | 745-769 | 20 | 0.003267 | 6.71 | In-house | 1-25 (301) | Show / Hide |
Range on Protein: 745-769 Range on HMM: 1-25/301 Sequence Identity: 20% (5 aa) FKKIVDLGAGGFAQVYKVIDLKNNQ . .. |.| .| ...|. |.. YHVVQLIDKGSFGVVMRAYDIQNQK |
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| Kinase | 10243.AA | SAK | 745-770 | 34 | 0.01937 | 3.81 | In-house | 1-26 (254) | Show / Hide |
Range on Protein: 745-770 Range on HMM: 1-26/254 Sequence Identity: 34% (9 aa) FKKIVDLGAGGFAQVYKVIDLKNNQD .. || |||| ||. .. |. YQVQHLLGKGGFACVYRAKCIHTHQE |
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| Kinase | 10243.AA | CMGC | 1857-1965 | 21 | 1.3e-08 | 23.44 | In-house | 1-144 (513) | Show / Hide |
Range on Protein: 1857-1965 Range on HMM: 1-144/513 Sequence Identity: 21% (31 aa) FKKIVDLGAGGFAQVYKVIDLKNN-------QDCQESQEELAIKAQNLPTKDDVYAA------------TKEFNIAKRLS-------------FHQTEN- ...| .| | ...||| .| ..| .. |..|. ||| .| .. | | | |.|. ... .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IIKLRYGILINNISIQNYDGH----QKEYNLSYLIMELGETNLQGF |.||.. . .| ..|.. | ..| ||..|. ...| .. IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQY |
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| Kinase | 10243.AA | STE20 | 1857-1920 | 25 | 4e-06 | 18.74 | In-house | 1-64 (288) | Show / Hide |
Range on Protein: 1857-1920 Range on HMM: 1-64/288 Sequence Identity: 25% (17 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDCQESQEELAIKAQNLPTK----DDVYAATKEFNIAKRLSFHQ .... .| |.. .|||... .... | .. ||| || .. |... || .| |.. |. YELLEKIGQGSYGKVYKAYHKPTGEYCN---QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HP |
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| Kinase | 10243.AA | STE | 1857-1893 | 28 | 1.1e-05 | 16.13 | In-house | 1-45 (359) | Show / Hide |
Range on Protein: 1857-1893 Range on HMM: 1-45/359 Sequence Identity: 28% (13 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDCQESQEE---------LAIK ...| .| |.| .||| .. || . . ...|. ||| WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIK |
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| Kinase | 10243.AA | TTBKL | 1857-1883 | 44 | 1.2e-05 | 15.15 | In-house | 1-27 (288) | Show / Hide |
Range on Protein: 1857-1883 Range on HMM: 1-27/288 Sequence Identity: 44% (12 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDC .. . .| |||.|||.|.|.|. .|| WMIVKMIGEGGFGQVYHVWDMKDKKDC |
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| Kinase | 10243.AA | PLK | 1857-1881 | 36 | 1.5e-05 | 14.14 | In-house | 1-25 (258) | Show / Hide |
Range on Protein: 1857-1881 Range on HMM: 1-25/258 Sequence Identity: 36% (9 aa) FKKIVDLGAGGFAQVYKVIDLKNNQ ... || |||| .|...|....| YERGHFLGKGGFAKCYEMTDIHTKQ |
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| Kinase | 10243.AA | Ciliate-E2-Unclassified | 1857-1912 | 15 | 2.5e-05 | 14.49 | In-house | 1-96 (352) | Show / Hide |
Range on Protein: 1857-1912 Range on HMM: 1-96/352 Sequence Identity: 15% (15 aa) FKKIVDLGAGGFAQVYKVIDLKNN---------------------QDCQESQEELAIKAQN--------------------LPTKDDVYAATKEFNI .|.| .| |||..|||... |.. .| ....|..... .. . ..|. ....|| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI |
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| Kinase | 10243.AA | Pkinase | 1857-1929 | 20 | 5.6e-05 | 18.68 | Pfam | 1-67 (293) | Show / Hide |
Range on Protein: 1857-1929 Range on HMM: 1-67/293 Sequence Identity: 20% (16 aa) FKKIVDLGAGGFAQVYKVIDLKNNQDCQESQEELAIKAQNLPTKDD--VYAATK--EFNIAKRLSFHQTENIIKLRY .... .|.|.|..||| .. .... . |.| ....... ..... | | |||. .||..|.. YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYD |
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| Kinase | 10243.AA | Ciliate-E2-Unclassified | 1962-1998 | 37 | 0.000118 | 12.09 | In-house | 153-192 (352) | Show / Hide |
Range on Protein: 1962-1998 Range on HMM: 153-192/352 Sequence Identity: 37% (15 aa) LQGFYQLHNVAKIVHMDISLDNIIKTKDQ---KYKISDLG |||. .|| .|.| || ..||. .... . ||.|.| LQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG |
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| Kinase | 10243.AA | WEE | 1968-1998 | 25 | 0.000163 | 11.14 | In-house | 127-177 (297) | Show / Hide |
Range on Protein: 1968-1998 Range on HMM: 127-177/297 Sequence Identity: 25% (13 aa) LHNVAKIVHMDISLDNIIKTKDQ--------------------KYKISDLG .|. .||||| .|| .|.. ..|| |.| IHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFG |
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| Kinase | 10243.AA | Ciliate-B2 | 1974-1998 | 36 | 0.000241 | 6.01 | In-house | 125-149 (197) | Show / Hide |
Range on Protein: 1974-1998 Range on HMM: 125-149/197 Sequence Identity: 36% (9 aa) IVHMDISLDNIIKTKDQKYKISDLG |.| || .|| ... .|. .| | ILHLDIKPQNILFMQNGNYVYCDFG |
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| Kinase | 10243.AA | WEE | 1857-1876 | 35 | 0.001902 | 7.51 | In-house | 1-20 (297) | Show / Hide |
Range on Protein: 1857-1876 Range on HMM: 1-20/297 Sequence Identity: 35% (7 aa) FKKIVDLGAGGFAQVYKVID |. . .| | |..|||... FQEVQKIGEGSFGEVYKCRC |
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| Kinase | 10243.AA | Ciliate-A1 | 1974-1998 | 48 | 0.002878 | 6.9 | In-house | 122-146 (301) | Show / Hide |
Range on Protein: 1974-1998 Range on HMM: 122-146/301 Sequence Identity: 48% (12 aa) IVHMDISLDNIIKTKDQKYKISDLG |.| |. .||. | |.|| ||| ILHRDLKPQNILIHFDDKWKICDLG |
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| Kinase | 10243.AA | Ciliate-A1 | 1857-1881 | 20 | 0.003267 | 6.71 | In-house | 1-25 (301) | Show / Hide |
Range on Protein: 1857-1881 Range on HMM: 1-25/301 Sequence Identity: 20% (5 aa) FKKIVDLGAGGFAQVYKVIDLKNNQ . .. |.| .| ...|. |.. YHVVQLIDKGSFGVVMRAYDIQNQK |
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| Kinase | 10243.AA | SAK | 1974-1998 | 48 | 0.003921 | 6.21 | In-house | 121-145 (254) | Show / Hide |
Range on Protein: 1974-1998 Range on HMM: 121-145/254 Sequence Identity: 48% (12 aa) IVHMDISLDNIIKTKDQKYKISDLG |.| |..| ||. |.| . || | | IMHRDLTLSNILLTRDMHCKIADFG |
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| Kinase | 10243.AA | SAK | 1857-1882 | 34 | 0.01937 | 3.81 | In-house | 1-26 (254) | Show / Hide |
Range on Protein: 1857-1882 Range on HMM: 1-26/254 Sequence Identity: 34% (9 aa) FKKIVDLGAGGFAQVYKVIDLKNNQD .. || |||| ||. .. |. YQVQHLLGKGGFACVYRAKCIHTHQE |
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| Kinase | 10243.AA | Ciliate-E2-Unclassified | 2061-2117 | 16 | 0.212556 | 0.64 | In-house | 252-326 (352) | Show / Hide |
Range on Protein: 2061-2117 Range on HMM: 252-326/352 Sequence Identity: 16% (12 aa) DCYALGFIFYMVVTFNFKNLKNNKQSHAQLE-----------QTRQEMIQVLNKYK-------DSNNQQQEDVLQ |...|| |.| .. .. ||. .| ||. . .. . . ... | . .....| .. DIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN |
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