Gene 10000 (Tetrahymena)

10000

Species: Tetrahymena
Alias: 5.m00351, 10000, 141, TTHERM_00075560, PreTt10000, 3828.m01263
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
10000.AA Protein None 630 None Fasta, JSON
10000.kin_dom Protein Kinase Domain None 287 None Fasta, JSON
10000.NA RNA None 1893 None Fasta, JSON

Protein domain

Protein domains of 10000.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10000.AA CDPK 93-380 41 1.8e-126 389.78 In-house 1-271 (271) Show / Hide 
Range on Protein: 93-380
Range on HMM: 1-271/271
Sequence Identity: 41% (125 aa)

YNISDTVLGKGTFGTVKEASLI-SNPSKRFAVKCISKEAGGDTKNFDWLYREVSIFRQLDHPNIAKLYECYQDDKHFYLVME--NCDGGQLLQLVLEQKR
| |.. |||||.||.|. . .  ..  .|.|.| |.|    | .  . . .|. | .||||||| |.|| |||.|..|.|||   | ||.|.. . |...
YKIKK-VLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH

FSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRDQS------ELKMIDFGLSKQYNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNNMQ
|.|..|...| | |||| | |. .||||||||||.||. . .      ..|.||.|.||.....   |                           .. | 
FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKI--------------------------EDKKMS

TIVGTVQYIAPEVLTQNYDKRCDIWSLGVILYCILYGEFPFTGRNDTEIFEQIRKGNFEFRDEV--TISKQAKDLITKMICVDPNKRIDMSSALKHPWF
...||. ||||||| ..|.. |||||.||||| .| |. || |.|| ||.|...||...| ..    ||..||||| ||.|.||.||.  . ||.||||
QRCGTPYYIAPEVLQKKYNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 10000.AA CAMK1 93-380 37 2.5e-122 357.44 In-house 1-276 (276) Show / Hide 
Range on Protein: 93-380
Range on HMM: 1-276/276
Sequence Identity: 37% (117 aa)

YNISDTVLGKGTFGTVKEASLISNP--SKRFAVKCIS-KE-AGGDT--KNFDWLYREVSIFR---QLDHPNIAKLYECYQDDKHFYLVMENCDGGQLLQL
|.. . ..|.|.|..|...  ....   | .|.|||. |.   ...  |  . |..|..| .   ..||||| |.|| |..|.||||||| . || |.  
YEFGK-EIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

VLEQKRFSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRD--QSELK--MIDFGLSKQYNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKS
..| . ..|. |. .| | ||||.|.|..||||||||||| |.     .|..|   .||||||..... .                              
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN------------------------------

NNMQTIVGTVQYIAPEVLTQ----NYDKRCDIWSLGVILYCILYGEFPFTGRN-DTEIFEQIRKGNFEFRDE--VTISKQ-AKDLITKMICVDPNKRIDM
 .|.| .||  |.|||||..     ||| ||.|| |||.| .| |  || . | | |.||.| |. .||       ||.| |||.|..|..|||.||.. 
-LMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTC

SSALKHPWF
. .|.|||.
EQCLNHPWI
Kinase 10000.AA CAMK 99-380 26 1e-110 358.07 In-house 1-425 (425) Show / Hide 
Range on Protein: 99-380
Range on HMM: 1-425/425
Sequence Identity: 26% (117 aa)

VLGKGTFGTVKEASLISNPS-----------KRFAVKCISKEAGGD-------------------------TKNFDWLYREVSIFRQ-------LDHPNI
.||.|.||.||..  ....            ...|.| |.|.   |                          |. . ..||..| ..       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AKLYECYQD-------------------DKHFYLVM---ENCDGG----QLLQLVLEQ---------------KRFSEQMASQVMSQMLSAVKYLHELGI
 |||| |.|                   |||.|.||   | |.||     |.. . |.               .||.|. |.... |..|||.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENFLFTRDQ----------------SELKMIDFGLSKQYNS-----------------QLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNN
||||||||| |.. .                   .| ||||.......                 |                          . . .   
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW-------------------------TTPTEGQK

MQTIVGTVQYIA-PEVLTQN---------------YDKRCDIWSLGVILYCILYGEFPFTGR-------------NDTEIFEQIRKGNFEFRDEV-----
|.| .||  |.| |||| ..               |.. ||.||.|||||  | |..|| |              || |.||.|.||...| ..      
MKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPIS

-----------------TISKQAKDLITKMICVDPNKRIDMSSALKHPWF
                 ..|...|||| || .|||.||.  . .|.|||.
CNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 10000.AA Ciliate-E2a 93-380 36 2.2e-110 326.14 In-house 1-275 (275) Show / Hide 
Range on Protein: 93-380
Range on HMM: 1-275/275
Sequence Identity: 36% (112 aa)

YNISDTVLGKGTFGTVKEASLISNPSKRFAVKCISKEAGGDTKNFDWLYREVSIFRQLDHPNIAKLYECYQDDKHFYLVMENCDGGQLLQLVLEQK-RFS
| . . ..|||.|| |. | .. .. |.||.| ..| .  ..|.   ...|..| |||||||| |||| |.|....||||| |.||.|..   ..|  |.
YKFIK-KIGKGNFGSVYLAQHKQTG-KQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFE

E-QMASQVMSQMLS-AVKYLHELGIVHRDLKPENFLFT---RDQ---SELKMIDFGLSKQY--NSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNN
| | ....| |.|. .. |.| ..|.||||||||.||.    .    |..|.|||||....  .                                 ...
EIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD---------------------------------EKK

-MQTIVGTVQYIA------PEVLTQN-YDKRCDIWSLGVILYCILYGEFPFTGRNDTEIFEQIRKGNFEFRDEV---TISKQAKDLITKMICVDPNKRID
 | ...||  |.|      .|||... ||. ||.||.|||.|. |.|. || |.. .||..|..| .. | . .    .||..|||. ||  .||.|||.
YMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRIT

MSSALKHPWF
   ||.||||
AQQALNHPWF
Kinase 10000.AA AGC 94-380 24 1e-105 273.75 In-house 1-395 (395) Show / Hide 
Range on Protein: 94-380
Range on HMM: 1-395/395
Sequence Identity: 24% (101 aa)

NISDTVLGKGTFGTVKEASLISNP-----SKRFAVKCISKEA---GGDTKNFDWLYRE------------VSIFRQLD----------HPNIAK-LYECY
    .|.|||.||.|  .   ...      | .|.|...|.      . .  .  ..|              |. ...          ||.| | |. ..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDKH--FYLVMEN---------CDGG-QLLQLVL---EQKRFSEQMASQVMSQ-------MLSAVKYLHE-LGIVHRD-LKPENFLFTRDQSELKMIDF
||..|   |.|||          | ||  |..       ..||.|..|   ...       ...|. |||. .||.||| ||||| |...|   .|  ||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-GHIKLTDF

GLSKQ----------------YNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNN--------------MQTIVG--TVQYIAPEVLTQNYDKRCD
||.|.                ...  .  . |  .  ...       . . ... ..||               .|..|  | .|.|||.|   |.| ||
GLCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS--NMD----T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---YGKACD

IWS--LGVILYCILYGEFPFTGRNDT----------EIFEQIRKGNFEFRDE--------------VTISKQAKDLITKMICVDPNKRID----------
.||  ||...|  |.|  ||.| |.           |.|..|..|.... ..              . .|..|||||.|..|.||.||.           
WWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKG

MSSALKHPWF
 .   .||||
AEEIKNHPWF
Kinase 10000.AA Ciliate-E2 94-380 28 1.8e-100 340.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 94-380
Range on HMM: 1-365/365
Sequence Identity: 28% (110 aa)

NISDTVLGKGTFGTVKEASLISNPS----------------------KRFAVKCISKEAGGDTKNFDWLYREVS----------IFRQLDHPNIAKLYEC
 .   ..|.|.||.|.... ....                       | .|.|...|     .|. . ..||.           | .||.|||| |.|||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--DDKHFYLVMENCDGGQLLQLVLEQ-----------KRFSEQMASQVMSQMLS---------------AVKYLHELG-IVHRDLKPENFLFTRDQSE
.|  ||...||||| |.|| |...  ..           |.|.|. ....| | |.               |..|||. . |.|||.|||| ||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

LKMIDFGLSKQYNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNNM-------QTIVGTVQYIAPEVLT-QN---------YDKRCDIWSLGVILY
.| |||||||.|. . ... . ....... . .  ... .....     .       .||.||  | |||.|  ..         ||. |||||||||||
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD-----QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

CILYGEFPFTGRNDTEIFEQIRKGNFEFR----------------DEVTISKQAKDLITK----MICVDPNKRID-MSSALKHPWF
. |.|..||        ..|| .....|.                .   .|...|||| |    |...||.|||. .. .|.||||
EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 10000.AA S_TKc 94-380 32 9e-100 338.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 94-380
Range on HMM: 1-231/231
Sequence Identity: 32% (98 aa)

NISDTVLGKGTFGTVKEASLISNPSKRFAVKCISKEAGGDTKNFDWLYREVSIFRQLDHPNIAKLYECYQDDKHFYLVMENCDG--GQLLQLVLEQKR--
     ..|||.||.|. .  ..   ...|.|.|.          . ..||..| .. .|||| |||...|| .|.|.||| |||  | |...  ...|  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRDQSELKMIDFGLSKQYNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNNMQTI
    |.| .|  .| |...|..|.|..||.|||||||| |...   ..| .||||..|.                                       |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------------------------------------TTF

VGTVQYIAPEVLTQNYDK-RCDIWSLGVILYCILYGEFPFTGRNDTEIFEQIRKGNFEFRDEVTISKQAKDLITKMICVDPNKRIDMSSALK-------H
.||  |.|||||   |.| .||.||.|.|||  |.|. ||   .. ..|..|.            |..|||.| |. ..||.||.    ||.       |
CGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PWF
|||
PWF
Kinase 10000.AA CAMKL 93-380 30 2e-92 295.23 In-house 1-297 (297) Show / Hide 
Range on Protein: 93-380
Range on HMM: 1-297/297
Sequence Identity: 30% (101 aa)

YNISDTVLGKGTFGTVKEASLISNPSKRFAVKCISKEAGG-DTKNFDW-----------LYREVSIFRQLD---HPNIAKLYECYQDDKH------FYLV
|.| . .||||.||.|| |  |... .. |.| | |.    |... .            ..||..| ..|.   |||| ||||......|      .|||
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MENCDGGQ--LLQLVLEQ----KRFSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRDQS-ELKMIDFGLSKQYNSQLEMIKYQLNENYKLEQS
|| |.||   |.. . ..    .|..|  | .   |..|||.|.|..||||||.|||| |.. ...  .| ||||.| .|  .                 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-----------------

RLSIYTPQSNYSSKSNNMQTIVGTVQYIAPEVLTQ--N-YD-KRCDIWSLGVILYCILYGEFPFTGRNDT-------EIFEQIRKGNFEFRDEVTISKQA
             . . . |  |.  | |||..      || .  ||||.||||| ...|..|| . ..        . ...|..| ....  . .| ..
----------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DC

KDLITKMICVDPNKRIDMSSALKHPWF
.||| ||  |.|.||. .   ..|||.
RDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 10000.AA RSK 95-380 30 2.2e-84 286.68 In-house 1-278 (278) Show / Hide 
Range on Protein: 95-380
Range on HMM: 1-278/278
Sequence Identity: 30% (94 aa)

ISDT-VLGKGTFGTVKEASLISNPSKRFAVKCISKEAGGDT-KNFDWLYREVSIFRQLD-HPNIAKLYECYQDDKHFYLVMENCDGGQLLQLVLEQKR--
...   .|.| . ....    ..  . .|.| ..|     . |      .|..|      ||.| .|.. .|.....||.|| | || |.   ...|.  
LKVLGQGGYGKVFLCRKCT-HHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-FSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTR--DQSELKMIDFGLSKQYNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNNMQTIV
 |||  |...|..  .||..||..||.|||||||| |..   .. ..| .|||..||                                 .... ..| .
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF------------------------------RCDHNQWTMTFC

GTVQYIAPEVLT----QN-YDKRCDIWSLGVILYCILYGEFPFTG---RNDTEIFEQIRKGNFEFRDE--VTISKQAKDLITKMICVDPNKRID-----M
.|..|.|||.|.    |. .|| ||.|||||..|  | |  ||.|    |  ||...|.||.| .. .   ..|. |||||.|| ..||.||.      .
YTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDA

SSALKHPWF
.  ..||||
EEIKQHPWF
Kinase 10000.AA Pkinase 94-380 29 5e-82 283.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 94-380
Range on HMM: 1-293/293
Sequence Identity: 29% (97 aa)

NISDTVLGKGTFGTVKEASLISNPSKRFAVKCISKEAGGDTKNFDWLYR--EVSIFRQLDHPNIAKLYECYQDDKHFYLVMENCDGG----QLLQLVL--
     ..|.|.||.|...  ....  ..|||.|.|. . . .    . |  |..| . |.|||| .||....|..| |.||| |.||     |  ..   
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

EQKRF--SEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRDQSEL----KMIDFGLSKQYNSQLEMIKYQLNENYKLEQSRLSIYTPQSNYSSKS
....|  ||. .  .| |.|....|.|. ||.||||||||.|.  .. ..    | .||||.||..                             | ..|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----------------------------Y-NNS

NNMQTIVGTVQYIAPEVLT--QNYDKRCDIWSLGVILYCILYGEFPFTGR------NDTEIFEQIRKGNFEFRDEVTIS-------------------KQ
  |.|..||  |.||||.   | |....|.||.|.|||. | |..|| |.      .. .....|... ..|  . ..|                   . 
--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

AKDLITKMICVDPNKRIDMSSALKHPWF
.||.|....|.||.||.    .|.||||
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 10000.AA ULK 94-380 29 2.1e-81 276.77 In-house 1-324 (324) Show / Hide 
Range on Protein: 94-380
Range on HMM: 1-324/324
Sequence Identity: 29% (102 aa)

NISDTVLGKGTFG-TVKEAS-LISNP-SKRFAVKCISKEAGGDTKNF-------DWLYREVSIFRQLD---HPN--IAKLYECYQDD--KHFYLVMENCD
 . . .||||.|| .| ..   ..|   . .|.|.|.|    . ||        . | .|..| ..|.   |||  | |||......  ...|..|| |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGQLLQLVL---------EQKRFSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRDQSE-----------LKMIDFGLSKQYN---SQLEMIKY
|| | |.           |.||.||| | |.. | ... |.||. .|.|||.||.| | . .|             ||  |||..|. .    .  |...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QLNENYKLEQSRLSIYTPQSNYSSKSNNMQTIVGTVQYIAPEVLTQN-----YD-KRCDIWSLGVILYCILYGEFPFTGRNDTEIFEQ------------
..||  |                        |.||  | ||..| ..     |. . |||||||.|.| .|||. || ..  .. ...            
CVNE--K-----------------------RIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQ

--IRKGNFEFR---DEVTISKQAKDLITKMICVDPNKRIDMSSALKHPWF
  |.. ...|.   ... ||.. |||| .|...|...||.    ..||||
IYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 10000.AA CAMK-Unique 94-252 26 8.1e-49 159.18 In-house 1-233 (363) Show / Hide 
Range on Protein: 94-252
Range on HMM: 1-233/363
Sequence Identity: 26% (62 aa)

NISDTVLGKGTFGTVKEASLISNPSKRFAVKCISKEAGGDTKNFD-----------------WLYREVSIFRQLDHPNIAKLYEC----YQDDK------
 .   ..|.|.|| |.|.  .... | .|.| . |.. |  |.                    | ||..| . .||||| |||.     ..|.|      
YKMHRIIGHGNFGHVYECMDRETG-KKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------HFYLVMENCDGGQLLQLVLE--------------------QKRFSE--QMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRD------
         ..|.||| |.|| |......                    | .|||    ....| . ||||.|.|...|||||||.|| ..         
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

---------QSELKMIDFGLSKQYN-SQLE-MIK
         .. .| .||||...|| .. . |..
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQ
Kinase 10000.AA CAMK-Unique 276-380 34 2e-40 131.05 In-house 225-363 (363) Show / Hide 
Range on Protein: 276-380
Range on HMM: 225-363/363
Sequence Identity: 34% (48 aa)

SSKSNN-MQTIVGTVQYIAP--------------EVLT-QNYDKRC----DIWSLGVILYCILYGEFPFTGRNDT--------EIFEQIRKGNF-EFRDE
..|..  |||..||  |.||              ||.  | ||  |    ||||||||.|  | |. ||.. ..         |||| |.||.. .|. .
HNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWK

V---T--ISKQAKDLITKMICVDPNKRIDMSSALKHPWF
.   .  ||..|||....   |||..|.  . .|.|.|.
MWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 10000.AA TyrKc 94-380 20 1.7e-15 28.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 94-380
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

NISDTVLGKGTFGTVKEASLISNPSKRFAVKCISKEAGGDTKNFDWLYREVSIFRQL--DHPNIAKLYECYQDD-------KHFYLVMENCDGGQLLQLV
   . .|| | ||.| .. ..       |||.. ..|         ..|| .| ..|  .|||| .|| .  ..       .  ..||| ...| |..  
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

LEQKR-FSEQMASQVMSQMLSAVKYLHELGIVHRDLKPENFLFTRDQSELKMIDFGLSKQYNSQ-LEMIKYQLNENYKLEQSRLSIYTPQSNYSSKSNNM
 . .. .. .   . . |  .   |||. ...||||   | | ....   |  |||||.   .   .                          |..   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG------------------------ESKDYYRK

----QTI-VGTVQYIAPEVLTQN-YDKRCDIWSLGVILYCIL-YGEFPFTG-----RNDTEIFEQIRKGNFEFRDEV-------TISKQAKDLITKMICV
    ..  .  .   |||..  . .    |.|| || .. |. ||. |  |      ...|..|....|.   . .        . ..   .....    
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

DPNKRIDMSSALKHPWF
||..|  .|    |  |
DPEDRPTFSEI--HECF
Kinase 10000.AA Pkinase_Tyr 99-219 29 2.4e-15 52.58 Pfam 6-137 (270) Show / Hide 
Range on Protein: 99-219
Range on HMM: 6-137/270
Sequence Identity: 29% (39 aa)

VLGKGTFGTVKEASLI---SNPSKRFAVKCISKEAGGDTKN--FDWLYREVSIFRQL-DHPNIAKLYECYQ-DDKH--FYLVMENCDGGQLLQLVLE---
.||.| ||.|... .    .|.    |||.. || | . ..   . . ||..| .|| .|||| .|| .   ....   |.||| . .| ||    .   
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRE

-QKRFSEQMASQVMSQMLSAVKYLHELGIVHRDL
 ..... ..  |   |  ..  ||.. ...||||
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 10000.AA Pkinase_Tyr 306-340 36 0.118574 6.22 Pfam 196-233 (270) Show / Hide 
Range on Protein: 306-340
Range on HMM: 196-233/270
Sequence Identity: 36% (14 aa)

DIWSLGVILYCILY-GEFP-FTGRNDTEIFEQI-RKGN
|.|| || .. |.  || | . |  ..|..|.| ..|.
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY