Gene 9595 (Tetrahymena)
9595
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 9595.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9595.AA | Ciliate-C7 | 78-240 | 78 | 9.40000000001e-121 | 388.69 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 78% (129 aa) FRFLGQGAQGLVLLAKDSKTQMRYAIKGVQVRDIQGNLYDDVQNKVKQEIDILEQCRGSPYVVSLLDSFEGKQFIYLVLNECQ-GTLTEIIDMNQNKRLN |||||||.|||||||||.||.||||||||||||.|||...|..|.|.|||.||.||..|||||.||..|||.||||||||||| |||..||. ||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAIVSDFGLADKLTDKSGYSANQYV |||||||||||..||||||||||.|||||||||||||||||.|.||||||.||.||.|. |||. EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Kinase | 9595.AA | AGC | 78-225 | 24 | 2.2e-30 | 74.47 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 78-225 Range on HMM: 1-202/395 Sequence Identity: 24% (50 aa) FRFL---GQGAQGLVLLAKDS------KTQMRYAIKGVQ----VRDIQGNLYDDVQNK--------VKQEIDILEQCRG---------SPYVVS-LLDSF |.|| |.|. | | |... |. ||.| .. . ... | . ... |..| .|||.|.. .|..|. | || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGKQF--IYLVLNECQ---------GT-LTEIIDMN--QNKRLNEISAIKYAKD-------ITEGLYYIHS-KNCLVND-LKMDNILIDYNGNAIVSDFG . |. .|.|. .. | . .. .. ...|..| | || |. .| |.|| .. | || .|||.| .|. .||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LA |. LC |
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| Pkinase | 9595.AA | Pkinase | 75-233 | 29 | 6.4e-29 | 103.35 | Pfam | 1-167 (293) | Show / Hide |
Range on Protein: 75-233 Range on HMM: 1-167/293 Sequence Identity: 29% (51 aa) YSDFRFLGQGAQGLVLLAKDSKTQMRYAIKGVQVRDIQGNLYDDVQNKVK-QEIDILEQCRGSPYVVSLLDSFEGKQFIYLVLNECQGTLTEIIDMN--- | | .|.|. | | .... .|. ..|.| . .|.. . |.... .|| |. . ..|..| |.|.|| |. ||.|. |.|.|. .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHE---KSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYI ---QNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----IVSDFGLADKL-TDKSG ..... | ...|.. | .||.|.||.... ||| .||||| ||. ..||||| .. . ... STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS |
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| Kinase | 9595.AA | CAMKL | 75-225 | 26 | 6.2e-26 | 79.63 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-176/297 Sequence Identity: 26% (47 aa) YSDFRFLGQGAQGLVLLAKD-SKTQMRYAIKGVQVRDIQ------------GNLYDDVQNKVKQEIDILEQCR--GSPYVVSLLDSFEGKQF------IY | . ||.|. | | ||.. . |. ..||| . . |. . .... ....|| |... . . | ...|.. .| ... || YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH--ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY LVLNECQGT---LTEIIDMNQNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAIVSDFGLA ||. |.| | . |. . ..| . | | .| . | ....|.||.. |.| .|||.|.|| |. ..|||.. LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 9595.AA | CAMK | 80-225 | 18 | 1.4e-24 | 75.48 | In-house | 1-243 (425) | Show / Hide |
Range on Protein: 80-225 Range on HMM: 1-243/425 Sequence Identity: 18% (45 aa) FLGQGAQGLVLLAKDSKTQ------------MRYAIKGVQVRDIQGNL----------------------YDDVQNKVKQEIDILEQCRG------SPYV ||.|. | | |... .|. ..||| . . .... . . .|..||.|. ...| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLLDSFEG-------------------KQFIYLVL---NECQGT------LTEIIDMNQN------------KRLNEISAIKYAKDITEGLYYIHSKNC ..|.. .| ....|.|. |.| . |.. .. .|..| | .| . | ... |.||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYN-----------------GNAIVSDFGLA ||| .|||.|.| .| ..|||.| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 9595.AA | Ciliate-E2-Unclassified | 75-225 | 24 | 2.2e-23 | 78.0 | In-house | 1-194 (352) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-194/352 Sequence Identity: 24% (48 aa) YSDFRFLGQGAQGLVLLAKDSKTQMRYAIKGVQVRDIQG-NLYDDVQNKVKQEIDILEQCR------------------GSPYVVSLLDSFEGKQFIYLV | . .|||..| | .....|.. ||.| . |. ... .. ..|...... .|..| ... |. || ||.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LNEC-QGTLTEIID---------------MNQNKRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAIVSDFGLA . | .|.| ..| |.|.|.. | |. .|.. | .|| |.|.|| .. |.| .|||.| || . ..|||.. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS |
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| Kinase | 9595.AA | Ciliate-E2 | 75-231 | 24 | 7e-22 | 71.87 | In-house | 1-209 (365) | Show / Hide |
Range on Protein: 75-231 Range on HMM: 1-209/365 Sequence Identity: 24% (52 aa) YSDFRFLGQGAQGLVLLAKDSKTQMRYAIK-------------GVQVRDIQGNLYDDVQ-NKVKQEIDILEQCR---------------GSPYVVSLLDS | . .|||..| | ..|. |.| ..||| .|.. . . . | . .||||.|. . . .|... . .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GKQFIYLVLNECQG-TLTEIIDMN----------QNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLVNDLKMDNILIDYNGN |. .. ||||. ||| .| ..| | . |...| .... | |.. .| |.|||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AIVSDFGLADKLTDK ..||||. |..|. IKIIDFGLSKKYDDD |
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| Kinase | 9595.AA | Ciliate-E1 | 81-235 | 17 | 8.8e-22 | 67.95 | In-house | 1-166 (202) | Show / Hide |
Range on Protein: 81-235 Range on HMM: 1-166/202 Sequence Identity: 17% (30 aa) LGQGAQGLVLLAKDSKTQ-MRYAIKGVQVRDIQGNLYDDVQNKVKQEID-ILEQCRGSPYVVSLLDSFEGKQ--FIYLVLNECQGTLTEIID-------- .|.| ...|. || ... .|.| ....... . ......|.. |.. .. |.. ..| .. .| ........|. .|.. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNH---FQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---MNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAIVSDFGLADKLTDKSGYS ..... ... .. .... .|| ..|..| . |.|..||||. .|| . .|||....| .. .. QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQ |
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| Kinase | 9595.AA | STE | 75-230 | 21 | 1.9e-21 | 72.57 | In-house | 1-199 (359) | Show / Hide |
Range on Protein: 75-230 Range on HMM: 1-199/359 Sequence Identity: 21% (43 aa) YSDFRFLGQGAQGLVLLAKDSK---------------TQMRYAIKGVQVRDIQ-----------GNLYDDVQNKVKQEIDILEQCRG-SPYVVSLLDSFE . . ...|.|| | | .|.. | |. ..||| . ... . | .. ......||.|. .|. .|..| ..... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------QFIYLVLNECQ-GTLTEIID------MNQN------KRLNEISAIKYAKDITEG-LYYIHSKNCLVNDLKMDNILIDYNGNAIVSDFGLAD . . ..... . |.|..||. ...| .|..| ......| .| |||.||.. |.| .|||. . .|||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG KLTD .||| QLTD |
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| Kinase | 9595.AA | STE20 | 75-230 | 27 | 2e-20 | 71.58 | In-house | 1-169 (288) | Show / Hide |
Range on Protein: 75-230 Range on HMM: 1-169/288 Sequence Identity: 27% (48 aa) YSDFRFLGQGAQGLVLLAKDSKTQMR----YAIKGVQVRDI---QGNLYDDVQNKVKQEIDILEQCRGSPYVVSLLDSFEGK----QFIYLVLNECQG-T | ... .|||. | | .| . .|. .||| . ... | | .. ...||.|. ||. .|..|. ..|. . . ...| |.| . YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS LTEIID--MNQNK-----RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAIVSDFGLADKLTD ||.|.. |. .| ..|| ... .|| |.||... |.| ||||.. .|.. .|||.. .||. LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTK |
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| Kinase | 9595.AA | ULK | 75-225 | 24 | 6.6e-20 | 66.25 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-189/329 Sequence Identity: 24% (47 aa) YSDFRFLGQGAQGLVLLAKDSKT----QMRYAIKGVQVRDIQGNLYDDV----QNKVKQEIDILEQCR---GSPY----VVSLLDSFEGKQF--IYLVLN |. . ||.|. | | ... || . .|.| .. .. ..... . .|.||.|. . .... .| |.| || ... ||... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECQG-TLTEIIDMNQN--------KRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAI------------VSDFGLA |.| .| ..| |.. |||.| ||.. |.| .|. ..|..|. |.| .||||. . ..|||.| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 9595.AA | S_TKc | 75-376 | 19 | 1.4e-15 | 51.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-376
Range on HMM: 1-231/231
Sequence Identity: 19% (64 aa)
YSDFRFLGQGAQGLVLLAKDSKTQMRYAIKGVQVRDIQGNLYDDVQNKVKQEIDILEQCRGSPYVVSLLDSFEGKQFIYLVLNECQG---TLTEIIDMNQ
| | .|.|| | | .... ||. ..||| . .....||.||.. . |..| |.|.|. ...|.|. | | .| ..|. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAIVSDFGLADKLTDKSGYSANQYVQINIFTHINNKKFDQFNQKILSWETLF
.. ..| | .|.. | ..| |.||.. . ||| .|||.| . ..||||| .|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------
IKRQNAMTQLTKSQSEACSLGIKQNQKSNGLIQ--------LIQNKQIGY----------IIYSLIQGID-FNLVFNKHKPLNYDSEFQNFVYRKQLKQL
. .. .. . |. |.| .. | | ... |.. . ...|..
----------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-SPEAKDF
IDELTQFIPRNRLPIKEALI---VLKGIICF
|. . |. |..|. . ||| . | |
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 9595.AA | TyrKc | 75-370 | 15 | 6e-06 | -127.02 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-370
Range on HMM: 1-280/280
Sequence Identity: 15% (51 aa)
YSDFRFLGQGAQGLVLLAKDSKTQMRYAIKGVQVRDIQGNLYDDVQNKVKQEIDILEQC-RGSPYVVSLLDSFEGK-------QFIYLVLNECQ-GTLTE
. . || || | | ... . . |.| .. . .|. |. . | .| |. . . ...|. . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
IIDMNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAIVSDFGLADKLTDK-------SGYSANQ--YVQ--INIFTHINNKKFD
. ...| |. .... .| .| |.||||| || |.|.. |. . .|||||. ...|. . |.. . . |
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----------
QFNQKILSWETLFIKRQNAMTQLTKSQS----------EACSLGIKQNQKS----NGLIQLIQNKQIGYIIYSLIQ----GIDFNLVFNKHKPLNYDSEF
. ...|.. .. ..| | ...| . ...|.. . || |
----RWMAPECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------F
QNFVYRKQLKQLIDELTQFIPRNRLPIKEALIVL
. . |.. . .. | .| .| .
--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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