Gene 6993 (Tetrahymena)

6993

Species: Tetrahymena
Alias: PreTt06993, 1216, 1479.m00002, TTHERM_02370050, 6993
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
6993.AA Protein None 655 None Fasta, JSON
6993.kin_dom Protein Kinase Domain None 151 None Fasta, JSON
6993.NA RNA None 1965 None Fasta, JSON

Protein domain

Protein domains of 6993.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6993.AA Ciliate-C7 113-275 64 3.6e-107 344.53 In-house 1-164 (164) Show / Hide 
Range on Protein: 113-275
Range on HMM: 1-164/164
Sequence Identity: 64% (106 aa)

FKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQ-GTLSELIEKSPNKKLN
|...|||.||||.|||. .||.|.||||..|.|.||.|.|....|.|||||.|..||.| |||.||...||..||||||.||| |||...||...||.||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYL
|.||||||||||.||..|||..|. ||||||||||||||||||.|.|||| ||. |.| .||| 
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 6993.AA Pkinase 110-260 26 3.2e-23 83.19 Pfam 1-159 (293) Show / Hide 
Range on Protein: 110-260
Range on HMM: 1-159/293
Sequence Identity: 26% (44 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQE---TFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQG-----TLSEL
.   . ||.|  | |..... .|....|.| . ...   .  |.   .     .|| .. .. .. ..| |.   | |  ||.|.  |.|      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IEKSPNKKL--NELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNA----VVSDLGLA
|. . ....   |  ...|.. |..|| ..||...|  ||| .||||| ||.      ..| |||
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 6993.AA Ciliate-E1 116-298 19 1.1e-21 67.61 In-house 1-202 (202) Show / Hide 
Range on Protein: 116-298
Range on HMM: 1-202/202
Sequence Identity: 19% (40 aa)

IGQGKQGLVFLAKELSTN-RRFAIKGLHVKDSQGKIFQETFDQAQQEIN-MLEKCKGSTYVVNLLKKIEGKE--FIYLVLSECQGTLSELIE--------
||.| ...|| ||  ..| .  |.|   .   .... |..|.. ..|.. ...  |.  |...... |. ..  ...... .|. .| . ..        
IGNGSFSIVFKAKQQNNNYNQVAQK---IINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW

---KSPNKKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYLGNWLFQAPECY--------DPNKFQ
   .. .......  .. .... .||  .|... |  |.|..||||. .|| | .|.|... | . . . ...      .. ||.|        ...|  
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN

DYADEY
   | |
YKSDIY
Kinase 6993.AA AGC 110-260 23 1.2e-21 51.33 In-house 1-202 (395) Show / Hide 
Range on Protein: 110-260
Range on HMM: 1-202/395
Sequence Identity: 23% (48 aa)

FSDFKYIGQGKQGLVFLAKEL------STNRRFAIKGLHVKD--------SQGKIFQE-TFDQ----AQQEINMLEKCKG---------STYVVN-LLKK
|   | ||.|  | |.|...       .|.. .|.| |  |.         . ..  | . .|     ..| |.||||..         . ..|. |   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS

IEGKEF--IYLVLSECQ----------G-TLSELIEKS-PNKKLNELSAIKYAKD-------IAEGLLHIHS-QKCISND-LKMDNILIDYNGNAVVSDL
 . |.   .|.|.  ..          |  |   . .   .....|  |  ||         |. .| ..|| .. |  | || .|||.| .|.   .| 
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GLA
||.
GLC
Kinase 6993.AA Ciliate-E2-Unclassified 110-287 19 1.5e-21 71.58 In-house 1-239 (352) Show / Hide 
Range on Protein: 110-287
Range on HMM: 1-239/352
Sequence Identity: 19% (46 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQG-KIFQETFDQAQQEINMLEKCK------------------GSTYVVNLLKKIEGKEFIYLV
.   | |||| .| |..... ...  .|.| .... ..  |. ..   .  .|.. ... |                   . ..|...   . |. ||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LSEC-QGTLSELIEKSPN---------------KKLNELSAI-----KYAKDIAEGLLHIHSQK-CISNDLKMDNILIDYNG---NAVVSDLGLADSLTK
.  | .|.|.. |.|...               |.. |  |.     .|.. | .|| ..|... .|  |.| .|||.| ||   .  ..|.|..  . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

TSGYG--------------MNQYLGNWLFQ----APECYD
 ...               |..  |.  ..    |||...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 6993.AA CAMK 115-284 15 9.1e-21 62.99 In-house 1-290 (425) Show / Hide 
Range on Protein: 115-284
Range on HMM: 1-290/425
Sequence Identity: 15% (46 aa)

YIGQGKQGLVFLAKELSTN------------RRFAIKGLHVKDSQGKI----------------------FQETFDQAQQEINMLEKCKG------STYV
 .|.|  | |.|... .|.            ...||| .  |  ..|                        ... .. ..||... |..|         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLLKKIEG-------------------KEFIYLVL---SECQGT-----LSELIEKSPN-------------KKLNELSAIKYAKDIAEGLLHIHSQKC
..|.  .|                    ....|.|.     |.|      | . | . ..             ....|  | .| . |.... ..||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

ISNDLKMDNILIDYN-----------------GNAVVSDLGLADSLTKTSGYG----------------------MNQYLGNWLFQA-PE
.  ||| .|||.|.|                 .|  ..| |.|  ... ...                       |. . |   . | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
Kinase 6993.AA STE 110-284 19 3.3e-19 64.57 In-house 1-232 (359) Show / Hide 
Range on Protein: 110-284
Range on HMM: 1-232/359
Sequence Identity: 19% (46 aa)

FSDFKYIGQGKQGLVFLAKEL------STNRR---------FAIKGLHVKDSQ-----------GKIFQETFDQAQQEINMLEKCKG-STYVVNLLKKIE
. . . ||.|  | |..|.        .|..          .||| .......            ....| ..| ..||... ||.  . ..|. .   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GK-------EFIYLVLSECQ-GTLSELIE-K-SPNKKLN----------ELSAIKYAKDIAEG-LLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLAD
 .       . .....  .  |.|...|. | ...| ||          |   ......| .| | ..||.. |  |.| .|||.     .  .| |.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SLTK---------------TSGYGMNQYLGNWLFQAPE
.||.               |..   |   |   . |||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 6993.AA Ciliate-E2 110-284 18 5.3e-19 61.85 In-house 1-257 (365) Show / Hide 
Range on Protein: 110-284
Range on HMM: 1-257/365
Sequence Identity: 18% (49 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFA--------------------IKGLHVKDSQGKIFQETFDQAQQEIN----------MLEKCKGSTYVVNLLK
.   | |||| .| |...|  .....||                    |. . ..  .......  ..  .|||          .||. . . .....  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

KIE--GKEFIYLVLSECQG-TLSELIEKSPNK---------KLNELSAIKYAKDIAE---------------GLLHIHSQK-CISNDLKMDNILIDYNGN
  .   .. ||||.  ||| .| ..|.... |         ...|  .... | |..               .| ..||.. .|  |.| .|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVSDLGLADSLT----------------------KTSGY--------GMNQYLGNWLFQAPE
  ..|.||.  ..                      .|.||          |...|.  ..|||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE
Kinase 6993.AA STE20 110-266 23 1e-17 61.54 In-house 1-174 (288) Show / Hide 
Range on Protein: 110-266
Range on HMM: 1-174/288
Sequence Identity: 23% (43 aa)

FSDFKYIGQGKQGLVFLAKELSTNRR----FAIKGLHVKDS---QGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGK----EFIYLVLSECQG-T
. ... ||||  | |..| . .|..      ||| . ...    |     . ..  |.||... .|| . ..|. .     .    . ...|   |.| .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS

LSELIE---KSPNK----KLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTK----T
|.....   |  ..    ..||       ... .|| ..||...|  |.| ||||.. .|..  .| |.. .|||    |
LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDT
Kinase 6993.AA CAMKL 114-260 26 1.5e-17 52.44 In-house 5-176 (297) Show / Hide 
Range on Protein: 114-260
Range on HMM: 5-176/297
Sequence Identity: 26% (46 aa)

KYIGQGKQGLVFLAKE-LSTNRRFAIKGLHVK----DSQGKIF------QETFDQAQQEINMLEKCK--GSTYVVNLLKKIEGKEF------IYLVLSEC
| .|.|  | | ||.  . |... ||| .. |    | . |        .      ..||. ... .  .   .. |.  || .|.      ||||.  |
KTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYC

QGT---LSELIEKSPNKK--LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNG--NAVVSDLGLA
.|    | . |.| ....  . |  | .| . | ... ..||.. .  |.| .|||.|.||  |. ..| |..
SGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 6993.AA IRE 182-259 29 2.8e-17 56.06 In-house 63-170 (292) Show / Hide 
Range on Protein: 182-259
Range on HMM: 63-170/292
Sequence Identity: 29% (32 aa)

EGKEFIYLVLSECQGTLSELIEK--------------SPNKKLN--------ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDY--------NGN
|...|.|| |. |||.|....|.                ||..|        ..  .. .|....|| | |||. . .|||  ||||..        |. 
EDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNR

AVVSDLGL
.. ||.||
FMISDFGL
Kinase 6993.AA S_TKc 110-426 17 3.2e-16 61.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 110-426
Range on HMM: 1-231/231
Sequence Identity: 17% (58 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQG---TLSELIEKSP
.   . ||.|  | |..... .|.|..||| ..             .....||..|.|  .  ..|.|.  ..  ...|.|.  | |   .| ..|.| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKK----LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYLGNWLFQAPECYDPNKFQDYADEYQKLG
 ..    ..|  | .|.. |...| ..||.. |  ||| .|||.|   .  ..| |||  |        . . |   . |||                  
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------------

LNISTKPTI-KSECFSLG------NQQSQLFAYKYLSTLIDYYINIQILRQLDIQFDKMFNKYQGYLIYLMVQDFKSTLMFKKHLPLNYSNEFEQFTYKN
     . .  |.   |.|           .|         ...  .....                                                  
-----GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG------------------------------------------------SP

QLKFIINGLTQFKPEDRLSIKDVLI-----ILKGII
..| .|... |. ||.|... ..|       .   .
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6993.AA TyrKc 110-422 17 2e-06 -118.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 110-422
Range on HMM: 1-280/280
Sequence Identity: 17% (62 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKC-KGSTYVVNLLKKIEGK-------EFIYLVL-SECQGTLSE
 .  | .| |  | |....     .  |.| |.         .| |    .|.... |  .    .|.|.  .  .       | ...|.   . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIEKSPNKKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKT------SGYGMNQY--LGN------WLFQAPECY
 . |. .| |.    .... .||.|  ..||..||  ||   |.|.. |. . .|| ||.  ..        . | . .    |.      |.  |||| 
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM--APECI

DPNKFQDYADEYQKLGLNISTKPTIKS----------ECFSLGNQQSQLFAY--KYLSTLIDYYINIQILRQLDI----QFDKMFNKYQGYLIYLMVQDF
. .||                  |.||          | |..| |     .   .  . .| |  .   ..| .                          
NYGKF------------------TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------

KSTLMFKKHLPLNYSNEFEQFTYKNQLKFIINGLTQFKPEDRLSIKDVLIIL
                 |   .    .  |.    ...|||| . ...  ..
-----------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
TMF_DNA_bd 6993.AA TMF_DNA_bd 483-533 36 0.000935 16.45 Pfam 24-75 (75) Show / Hide 
Range on Protein: 483-533
Range on HMM: 24-75/75
Sequence Identity: 36% (19 aa)

LSKQQQGQDAIISQLRQSNIQLEQQIKSLK-DIQKQLENELKALRNQKVQLE
||||.. . ..| .||. | .||.||..|| . . .|| |.  |.. . . |
LSKQELKHNNTIKKLRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE