Gene 5174 (Tetrahymena)
5174
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 5174.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 5174.AA | Ciliate-C7 | 48-210 | 78 | 2.7e-119 | 383.94 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 48-210 Range on HMM: 1-164/164 Sequence Identity: 78% (128 aa) FRFLGQGAQGLVLLAKDFKNQMRYAIKGVQVRDLQGNLYDEVYNKVKQEIDILKQCRGSPYVVSLLDSFEGKQFMYLVLNECQ-GTLTEIIESKLNKRLN |||||||.||||||||| |..|||||||||||| |||......|.|.|||.|||||..|||||.||..|||.||.|||||||| |||..|||.. ||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTVKSGYSHNQYM |||||||||||..||||||||||.|||||||||||||||||||.||||||.|| ||.|..|||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 5174.AA | Pkinase | 45-213 | 28 | 7.7e-28 | 99.52 | Pfam | 1-171 (293) | Show / Hide |
Range on Protein: 45-213
Range on HMM: 1-171/293
Sequence Identity: 28% (52 aa)
YSDFRFLGQGAQGLVLLAKDFKNQMRYAIKGVQVRDLQGNLYDEVYNKVK-QEIDILKQCRGSPYVVSLLDSFEGKQFMYLVLNECQGTLTEIIESK---
| | .|.|. | | .... ... ..|.| . .| .. .. ..... .|| |.| . ..|..| |.|.|| |. .|.|. |.|.|. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYI
---LNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----VVSDFGLADKLTVKSGYSHNQYMGNF
.... | ...|.. | .||.|.||.... ||| .||||| ||. ..||||| .. | .|. | |
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTF
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| Kinase | 5174.AA | AGC | 48-195 | 24 | 2.2e-26 | 63.86 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 48-195 Range on HMM: 1-202/395 Sequence Identity: 24% (49 aa) FRFL---GQGAQGLVLLAKDF------KNQMRYAIKGVQ----VRDLQGNLYDEVYNK--------VKQEIDILKQCRG---------SPYVVS-LLDSF |.|| |.|. | | |... .. ||.| .. . ... | . ... |..| .||..|.. .|..|. | || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGKQF--MYLVLNECQ----------G-TLTEIIESK-LNKRLNEISAIKYAKD-------ITEGLYYIHS-KNCLVND-LKMDNILIDYNGNAVVSDFG . |. |.|. .. | | .. . ..|..| | || |. .| |.|| .. | || .|||.| .|. .||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LA |. LC |
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| S_TKc | 5174.AA | S_TKc | 45-304 | 22 | 2.2e-25 | 91.56 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 45-304
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)
YSDFRFLGQGAQGLVLLAKDFKNQMRYAIKGVQVRDLQGNLYDEVYNKVKQEIDILKQCRGSPYVVSLLDSFEGKQFMYLVLNECQG---TLTEIIESKL
| | .|.|| | | .... | . ..||| . .....||.|||. . |..| |.|.|. ...|.|. | | .| ..|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTVKSGYSHNQYMGNFIYQAPECYDPTDK-----------
.. ..| | .|.. | ..| |.||.. . ||| .|||.| . ..||||| .| . . | | ||| . .|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI
----IIGKVYYDEYQKLGIQVKQEPSNRGIDFNLVFNKHKPLNYDGEFQNFVYKKNLQELIDGLTQFVPRKRLPIKEALI---------VL
. |. .. | . | . . ..|... |. |.||. . ||| .
LYEMLCGYPPFP--QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 5174.AA | CAMK | 50-219 | 18 | 3.6e-25 | 77.43 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 50-219 Range on HMM: 1-290/425 Sequence Identity: 18% (54 aa) FLGQGAQGLVLLAKD-FKNQ-----------MRYAIKGVQVRDLQGNL----------------------YDEVYNKVKQEIDILKQCRG------SPYV ||.|. | | |... .. ..||| . . |... .. .|..||.|.|...| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLLDSFEG-------------------KQFMYLVL---NECQGT------LTEIIESKLN------------KRLNEISAIKYAKDITEGLYYIHSKNC ..|.. .| ...||.|. |.| . |.| . . .|..| | .| . | ... |.||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYN-----------------GNAVVSDFGLADKLTVKSGYS----------------------HNQYMGNFIYQA-PE ||| .|||.|.| .| ..|||.| |.. .... . . | | | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | 5174.AA | CAMKL | 45-195 | 25 | 7.8e-25 | 76.05 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 45-195 Range on HMM: 1-176/297 Sequence Identity: 25% (45 aa) YSDFRFLGQGAQGLVLLAKD-FKNQMRYAIKGVQVRDLQGNLYDE----------VYNKVKQEIDILKQCR--GSPYVVSLLDSFEGKQF------MYLV | . ||.|. | | ||.. .. ..||| . . .. . . . . ....|| |.|. . . | ...|.. .| ... .||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LNECQGT---LTEIIESKLNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAVVSDFGLA . |.| | . |... ..| . | | .| . | ....|.||.. |.| .|||.|.|| |. ..|||.. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 5174.AA | Ciliate-E2 | 45-219 | 21 | 3.9e-23 | 76.25 | In-house | 1-257 (365) | Show / Hide |
Range on Protein: 45-219 Range on HMM: 1-257/365 Sequence Identity: 21% (57 aa) YSDFRFLGQGAQGLVLLAKDFKNQMRYAIKGVQVRD---------LQGNLYDEVYNK------VKQEIDILKQCR---------------GSPYVVSLLD | . .|||..| | ..|. |.| ..||| . . ....| ..| .||||.|... . .|... . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE SFE--GKQFMYLVLNECQG-TLTEIIESK----------LNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLVNDLKMDNILIDYNG .|. .. .|||. ||| .| ..|... |...| .... | |.. .| |.|||| .. |.| .|||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- NAVVSDFGLADKLTVK----------------------SGYS--------HNQYMGNFIYQAPE ..||||. |.. . .||. .|.. |. |.||| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE |
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| Kinase | 5174.AA | Ciliate-E2-Unclassified | 45-222 | 21 | 1.8e-22 | 74.77 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 45-222 Range on HMM: 1-239/352 Sequence Identity: 21% (53 aa) YSDFRFLGQGAQGLVLLAKDFKNQ----MRYAIKGVQVRDLQGNLYDEVYNKVKQEIDILK---------------QCRGSPYVVSLLDSFEGKQFMYLV | . .|||..| | .... |.. | |..| .. ..| . | .. ..|. ..| . .|..| ... |. || .|.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LNEC-QGTLTEIIESKLN---------------KRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAVVSDFGLADKLTV . | .|.| ..|... . |.. | |. .|.. | .|| |.|.|| .. |.| .|||.| || . ..|||.. |. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KSGYSHNQY---------------MGNFIYQ----APECYD ... .. .|. .|. |||... NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 5174.AA | Ciliate-E1 | 51-236 | 18 | 3.1e-22 | 69.45 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 51-236 Range on HMM: 1-202/202 Sequence Identity: 18% (38 aa) LGQGAQGLVLLAKDFKNQMRYAIKGVQVRDLQGNLYDEVYNKVKQEID-ILKQCRGSPYVVSLLDSFEGKQ--FMYLVLNECQGTLTEIIE--------- .|.| ...|. || .|. . .. .. ...| .. ......|.. |.| .. |.. ..| .. .| ........|. .|.. .. IGNGSFSIVFKAKQQNNNYNQVAQKIIN--CCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ --SKLNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTVKSGYSHNQYMGNFIYQAPECYD-----PTDKIIGKV .. .. ... .. .... .|| ..|..| . |.|..||||. .|| | .|||....| .. .. .. |. ||.| . .. . . QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY YYDEY .| | KSDIY |
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| Kinase | 5174.AA | STE | 45-219 | 20 | 9.3e-22 | 73.68 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 45-219 Range on HMM: 1-232/359 Sequence Identity: 20% (49 aa) YSDFRFLGQGAQGLVLLAKDFK---------------NQMRYAIKGVQVRDLQ-----------GNLYDEVYNKVKQEIDILKQCRG-SPYVVSLLDSFE . . ...|.|| | | .|.. | .. ..||| . ... . | .| .....||.|.|.|. .|..| ..... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------QFMYLVLNECQ-GTLTEIIES--KLNKRLN----------EISAIKYAKDITEG-LYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLAD . . .... . |.|..||.. . .|.|| | ......| .| |||.||.. |.| .|||. . .|||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG KLTV---------------KSGYSHNQYMGNFIYQAPE .|| .. | | . ||| QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 5174.AA | STE20 | 45-199 | 27 | 5.1e-20 | 70.08 | In-house | 1-168 (288) | Show / Hide |
Range on Protein: 45-199 Range on HMM: 1-168/288 Sequence Identity: 27% (47 aa) YSDFRFLGQGAQGLVLLAKDFKNQMR----YAIKGVQVRDL---QGNLYDEVYNKVKQEIDILKQCRGSPYVVSLLDSFEGK----QFMYLVLNECQG-T | ... .|||. | | .| . ... .||| . ... | . . ...||.|.|||. .|..|. ..|. . . ..| |.| . YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS LTEIIES--KLNK-----RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLT ||.|.. |..| ..|| ... .|| |.||... |.| ||||.. .|.. .|||.. .|| LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLT |
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| Kinase | 5174.AA | ULK | 45-195 | 24 | 1.9e-19 | 64.65 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 45-195 Range on HMM: 1-189/329 Sequence Identity: 24% (46 aa) YSDFRFLGQGAQGLVLLAKDFKNQMRYAIKGVQVRDLQGNLYDEVYNK---------VKQEIDILKQCR---GSPY----VVSLLDSFEGKQF--MYLVL |. . ||.|. | | ... |.. .|. . | . .. . .. .| .|.||.|.|. .... .| |.| || ... |... YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM NECQG-TLTEIIESK--------LNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAV------------VSDFGLA |.| .| ..|. . .|||.| ||.. |.| .|. ..|..|. |.| .||||. . ..|||.| EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 5174.AA | TyrKc | 45-304 | 16 | 2e-06 | -118.59 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 45-304 Range on HMM: 1-280/280 Sequence Identity: 16% (53 aa) YSDFRFLGQGAQGLVLLAKDFKNQMRYAIKGVQVRDLQGNLYDEVYNKVKQEIDILKQC-RGSPYVVSLL-DSFEG-------KQFMYLVLNECQGTLTE . . || || | | ... . |.| .. .|. |... | .| |. .. .. | .. . | | . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD IIESKLNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTVK------SGYSHNQY--MGN--FIYQ--APECYDP . .. .| |. .... .| .| |.||||| || |.|.. |. . .|||||. ... . . | . . |. . . |||| YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-- TDKI-------------------IGKVYYDE-------------YQKLGIQVKQEPS----NRGIDFNLVFNKHKPLNYDGEFQNFVYKKNLQELIDGLT ... |. | . | | | .| |. | . . ... NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------F--VCCPDEMYQIMKQCW QFVPRKRLPIKEALIVL .. | .| .| . HEDPEDRPTFSEIHECF |
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