Gene 28253 (Tetrahymena)
28253
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 28253.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 28253.AA | Ciliate-C7 | 78-240 | 66 | 8.20000000001e-106 | 340.13 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 66% (109 aa) FRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECL-GTLSDIIKNTQNQRLN ||||| |. |||.|||...|| ||||||. ..|...|.|| |..||||||..|.|||.|||| .|||..||...|.|||.||. |||..||...||.||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN ELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQQSGYAFDNYK |.||||| ||||.|||.||||.|.|||||||||||||||||||.||| ||||||.|.|....| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Kinase | 28253.AA | AGC | 75-225 | 21 | 8.4e-26 | 62.32 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-202/395 Sequence Identity: 21% (43 aa) YDEFRFLGLGAHGLVVLAKEK------STNKRYAIKGIPIKD---SKD--NVDQVILGQ-------VQQEIQMLNQCKG---------SPYVAN-LLHKI .. . .| |. | | |...| .|.| ||.| . |. |. |.... . |..| ..| .|.. .|.. . | . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGNDY--IFLVLTECL----------G-TLSDIIKNT-QNQRLNELSAIKYTKD-------IAEGLYFIHS-KKCLVND-LKMDNILIDYNGNAVVSDFG . .|. ...|. . | | .... ...|..| | |. |. .| ..|| .. | || .|||.| .|. .||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG FA .. LC |
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| Kinase | 28253.AA | CAMK | 80-249 | 17 | 2.1e-24 | 74.92 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 80-249 Range on HMM: 1-290/425 Sequence Identity: 17% (51 aa) FLGLGAHGLVVLAKEKSTN------------KRYAIKGIPIKDSKDNV----------------------DQVILGQVQQEIQMLNQCKG------SPYV || |. | | |...|.|. ...||| |. | ||.. ... . .|..||.......| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI ANLLHKIEG-------------------NDYIFLVL--TECLGT-------LSDIIKNTQN------------QRLNELSAIKYTKDIAEGLYFIHSKKC .|.. .| ......|. .| .. |...... |..| | .| . |.... ..||.. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYN-----------------GNAVVSDFGFADNLTQQS----------------------GYAFDNYKGNVIFQA-PE ||| .|||.|.| .| ..||||| ... . | . . | . | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Pkinase | 28253.AA | Pkinase | 75-225 | 31 | 4.2e-24 | 86.3 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-159/293 Sequence Identity: 31% (51 aa) YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVI--LGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLG-----TLSDII | | .| |. | | ....|.|.|..|.| |. .. |...|| | .|||... . ..|.. |.. | .|.| .|. | | |.|.| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI KNTQNQRL--NELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNA----VVSDFGFA . .. .. | ...| . |..||...||.... ||| .||||| ||. ..|||.| STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 28253.AA | STE | 75-229 | 20 | 3.2e-22 | 75.36 | In-house | 1-198 (359) | Show / Hide |
Range on Protein: 75-229 Range on HMM: 1-198/359 Sequence Identity: 20% (41 aa) YDEFRFLGLGAHGLVVLAKEK------STNKR---------YAIKGIPIKDSK-----------DNVDQVILGQVQQEIQMLNQCKG-SPYVANLLHKIE .. ...| || | |..|. . .|.. .||| ....... .|... .. |...||.....|. .|.. . . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GN-------DYIFLVLTECL-GTLSDIIK---NTQN---------QRLNELSAIKYTKDIAEG-LYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFAD . |...... . |.|.|||| ... .|..| ......| .| ||..||.. |.| .|||. . .|||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG NLT .|| QLT |
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| Kinase | 28253.AA | Ciliate-E2-Unclassified | 75-252 | 18 | 4.1e-22 | 73.53 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 75-252 Range on HMM: 1-239/352 Sequence Identity: 18% (45 aa) YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKD-NVDQVILGQVQQEIQMLNQCK------------------GSPYVANLLHKIEGNDYIFLV | . .| |..| | ....|.... ||.| . . ... . . . .|.. .|. | .|.. .... . ..|..| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTECLG-TLSDIIKNTQN---------------QRLNELSAI-----KYTKDIAEGLYFIHSKK-CLVNDLKMDNILIDYNG---NAVVSDFGFADNLTQ . | | .|...||. . ... | |. .|.. | .|| ..|.|. .. |.| .|||.| || . ..|||.. .. | MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ QSGYAFDNY---------------KGNVIFQ----APECYD .... .| |. ... |||... NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 28253.AA | Ciliate-E2 | 75-260 | 16 | 2.6e-21 | 69.9 | In-house | 1-281 (365) | Show / Hide |
Range on Protein: 75-260 Range on HMM: 1-281/365 Sequence Identity: 16% (49 aa) YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKD------------SKDNVDQVILGQVQQEIQMLNQCK------------------GSPYVANLLH |. . .| |..| | ..| ....|..||| | . .. .. ... |..| |...... .|.. .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE KIE--GNDYIFLVLTECLG-TLSDIIKNT----------QNQRLNELSAIKYTKDIAE---------------GLYFIHSKK-CLVNDLKMDNILIDYNG . ...|.||. | | .| |.||| . ....| .....| |.. .| ..|||. .. |.| .|||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- NAVVSDFGFADNLTQQSG--------YAFDNYK-----------------------GNVIFQAPECYD--P-----------SKFDIYS ..|||.. ...... . . . | |. ..||| . . | ||.| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS |
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| Kinase | 28253.AA | CAMKL | 75-225 | 27 | 2.9e-21 | 64.46 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-176/297 Sequence Identity: 27% (49 aa) YDEFRFLGLGAHGLVVLAKE-KSTNKRYAIKGIP--IKDSKDNVDQVILG-------QVQQEIQMLNQCK--GSPYVANLLHKIEGNDY------IFLVL |. . || |. | | ||. . |....||| | . ...... .| ...||| . . . . | . |.. || .. |.||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM TECLGT---LSDIIKNTQN--QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNG--NAVVSDFGFA | | | | |.. . .|. | | .| . | ......||.. |.| .|||.|.|| |. ..||||. EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 28253.AA | ULK | 75-225 | 23 | 6.2e-20 | 66.35 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-189/329 Sequence Identity: 23% (45 aa) YDEFRFLGLGAHGLVVLAKEKST----NKRYAIKGIPIK-DSKDNVD---QVILGQVQQEIQMLNQCK---GSPY----VANLLHKIEGN--DYIFLVLT | . || |. | | .. | | |. .|.| |... ...| . |... ....||. . . | .... . |.. | ..|.... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECLG-TLSDIIKNTQN--------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAV------------VSDFGFA | | .|...||. .. .||.| ||.. |.|..|. ..|.... |.| .||||. . ..||||| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 28253.AA | STE20 | 75-230 | 26 | 6.4e-19 | 66.01 | In-house | 1-169 (288) | Show / Hide |
Range on Protein: 75-230 Range on HMM: 1-169/288 Sequence Identity: 26% (45 aa) YDEFRFLGLGAHGLVVLAKEKSTNKR----YAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGN----DYIFLVLTECLG-TLSD |. .. .| |. | | .| .|.|.. .||| ..... .. | . .|.||....||| .|.. . . . | ...| | | .|.| YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNE--QDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTD IIKN--TQNQ-----RLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQ |.|. . .. ..|| .... .|| ..||... |.| ||||.. .|.. .|||.. ||. IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTK |
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| Kinase | 28253.AA | S_TKc | 75-365 | 21 | 1.4e-18 | 68.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-365
Range on HMM: 1-231/231
Sequence Identity: 21% (65 aa)
YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLG---TLSDIIKNTQ
|. | .| || | | ....|.|....||| |. ....|||.| . . |.. .|. .. |....|. | | .| |.||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NQR----LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQQSGYAFDNYKGNVIFQAPECYDPSKFDIYSQEYMNLG
.. ..| | .|.. |...| ..||.. . ||| .|||.| . ..|||.| | . . | . |||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------------
VPVQQNPSQRVFYRQNLINIQKIYYINL-KSEACSLGYLLYTMISGFQANLVFSKHQPLQYNADFQNLAYEKQLRYIIDGLTKFIPRERLKVKEALI---
. |. |.| .|| |..| |... |... .... .|... .. |..|. . |||
------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEW
------VL
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DIKCHPWF
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| Kinase | 28253.AA | STE-Unique | 161-225 | 34 | 2.8e-14 | 46.59 | In-house | 379-457 (616) | Show / Hide |
Range on Protein: 161-225 Range on HMM: 379-457/616 Sequence Identity: 34% (27 aa) GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKK--CLVNDLKMDNILIDYNG-----NAVVSDFGFA |||..|||.. | . | .|.||. |.||| ..||.. . ||| .||... | .....||| | GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHA |
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| Kinase | 28253.AA | STE-Unique | 76-143 | 22 | 4.5e-07 | 20.56 | In-house | 1-67 (616) | Show / Hide |
Range on Protein: 76-143 Range on HMM: 1-67/616 Sequence Identity: 22% (15 aa) DEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLL . ..| |. | |.... |....|.||| |..| || . . ||. . .. ........ NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY |
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| Kinase | 28253.AA | TyrKc | 75-325 | 16 | 1e-06 | -115.28 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-325
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)
YDEFRFLGLGAHGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQC-KGSPYVANLLHKIEGN-------DYIFLVLTEC-LGTLSD
. || || | |.... | |.| . . .|.... . . | . .|. . . ...|. . .| | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
IIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQQ-------SGYAFD---NYK--GNVIFQAPECYDP
....... |. ... .||.| ..|||.| || |.|.. |. . .|||| . ... . | . | . ||||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--
SKFDIYSQ------------EYMNLGVPVQQNPSQRVFYRQNLINIQKIYYINLKSEA--------CSLGYLLYTMISGFQA---------NLVFSKHQP
.. ... | . .| . .. |.. | .|. | | . . |. | . .. .. |.
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI----HEC
L
.
F
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