Gene 25184 (Tetrahymena)
25184
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 25184.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 25184.AA | Ciliate-C7 | 45-185 | 66 | 5.6e-93 | 298.42 | In-house | 1-142 (164) | Show / Hide |
Range on Protein: 45-185 Range on HMM: 1-142/164 Sequence Identity: 66% (95 aa) FKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQFIYLVLTECL-GSLSELIKQTQNGVLN |..||.| ||||||||....|.|||||||.|.||.| .|......||||||.|.|||.|||| ... |.||||||||||.||. |.|...|...|| || FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNAV ||.|||||||||.|| .|||.||||||.|||||||||||||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV |
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| Kinase | 25184.AA | AGC | 42-183 | 22 | 6.9e-23 | 54.61 | In-house | 1-193 (395) | Show / Hide |
Range on Protein: 42-183 Range on HMM: 1-193/395 Sequence Identity: 22% (44 aa) YDQFKYLGKGGQGLVLLAKQK------QSNRRYAIKGVK----VKDKKGILDENTLKE--------VQQEINTLNQCKG---------SPYVAN-FIGQI .. | .|||. | | |.. | .... ||.| .| ...|| |.|. | |..| | | .|.. .|.. . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGQQF--IYLVLTECL---------GS-LSELIKQT--QNGVLNEITAIKYAKD-------IAEGLDFIHS-RNCVVND-IKMDNILIDYNGN . .. .|.|. . | . |..| ..|...| .| || |. .|...|| .. . | .| .|||.| .|. QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH |
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| Kinase | 25184.AA | CAMK | 47-186 | 17 | 2.9e-20 | 61.34 | In-house | 1-236 (425) | Show / Hide |
Range on Protein: 47-186 Range on HMM: 1-236/425 Sequence Identity: 17% (41 aa) YLGKGGQGLVLLAKQKQSN------------RRYAIKGVKVKDKKGIL----------------------DENTLKEVQQEINTLNQCKG------SPYV ||.|. | | |...|... ...||| .. | |. .....|.|..||. .....| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI ANFIGQIEG-------------------QQFIYLVL--TECLGSL------SELIKQTQN-------------GVLNEITAIKYAKDIAEGLDFIHSRNC ... .| ....|.|. .| . |.. . | ..| | .| . |.......||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VVNDIKMDNILIDYNG----------------NAVK | |.| .|||.|.|. | .| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK |
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| Pkinase | 25184.AA | Pkinase | 42-186 | 26 | 7.4e-20 | 71.29 | Pfam | 1-152 (293) | Show / Hide |
Range on Protein: 42-186 Range on HMM: 1-152/293 Sequence Identity: 26% (41 aa) YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQFIYLVLTECLG-----SLSELIKQ | . .|.|. | | ... | .....|.| .|....| |.. .. .|| .. . ..|.. ... | . ||.|. | | .|...|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST TQNGVL--NEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNA---VK ..|.. | ....|.. |..||...||.... |.| .||||| ||. || WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK |
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| Kinase | 25184.AA | Ciliate-E2 | 42-186 | 20 | 1.3e-19 | 63.97 | In-house | 1-196 (365) | Show / Hide |
Range on Protein: 42-186 Range on HMM: 1-196/365 Sequence Identity: 20% (42 aa) YDQFKYLGKGGQGLVLLAKQKQSNRRYAIK-------------GVKVKD-KKGILDENTLKEVQQEINTLNQCK---------------GSPYVANFIGQ |. | .|.|..| | ..|... ....||| .||.| . |. .| .... |||. ... . .|.. ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IE--GQQFIYLVLTECLG-SLSELIKQT----------QNGVLNEITAIKYAKDIAE---------------GLDFIHSRN-CVVNDIKMDNILIDYNGN . .. ||||. | | .| ..||. . . ..| .... | |.. .| ..||.| .. ||| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVK .| -IK |
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| Kinase | 25184.AA | Ciliate-E2-Unclassified | 42-186 | 23 | 8.3e-18 | 58.36 | In-house | 1-187 (352) | Show / Hide |
Range on Protein: 42-186 Range on HMM: 1-187/352 Sequence Identity: 23% (45 aa) YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKG-ILDENTLKEVQQEINTLNQCK------------------GSPYVANFIGQIEGQQFIYLV | | .|.||.| | ....|. . ||.| |.. .. . .| | .|....|. | .|.. ... . . .| ||.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTECLG-SLSELIKQTQN---------------GVLNEITAI-----KYAKDIAEGLDFIHSRN-CVVNDIKMDNILIDYNGN--AVK . | | .|.. ||. . . | |. .|.. | .||...|. | .. ||| .|||.| ||. .| MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIK |
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| Kinase | 25184.AA | Ciliate-E1 | 48-189 | 22 | 2.5e-17 | 53.32 | In-house | 1-153 (202) | Show / Hide |
Range on Protein: 48-189 Range on HMM: 1-153/202 Sequence Identity: 22% (35 aa) LGKGGQGLVLLAKQKQSN-RRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQ--FIYLVLTECLGSLSELIK--------- .|.|....|. |||...| . .|.| ..... . ..|.. ....|.. . . |. |. ..| .|. .| ........| || . .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ --QTQNGVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNAVKGNF |.... ... .. .... .|| .|. | |||..||||. .|| |. | QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDF |
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| Kinase | 25184.AA | STE | 42-186 | 17 | 4e-17 | 57.1 | In-house | 1-187 (359) | Show / Hide |
Range on Protein: 42-186
Range on HMM: 1-187/359
Sequence Identity: 17% (34 aa)
YDQFKYLGKGGQGLVLLAKQK------QSNRR---------YAIKGVKVKDKK-----------GILDENTLKEVQQEINTLNQCKG-SPYVANFIGQIE
.. . .|||. | | .|. . .... .||| ....... . ... ......||.....|. .|.. ...| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
GQ-------QFIYLVLTECL-GSLSELIK------QTQN------GVLNEITAIKYAKDIAEG-LDFIHSRNCVVNDIKMDNILIDYNGNAVK
. ..... . |||...|| ...| ....| ......| .| |...|| . . ||| .|||. ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VK
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| Kinase | 25184.AA | CAMKL | 42-186 | 29 | 9.1e-17 | 49.89 | In-house | 1-169 (297) | Show / Hide |
Range on Protein: 42-186 Range on HMM: 1-169/297 Sequence Identity: 29% (51 aa) YDQFKYLGKGGQGLVLLAKQ-KQSNRRYAIKGVKVKDKKGIL-DENTLKE-----------VQQEINTLNQCK--GSPYVANFIGQIEGQQF------IY |. | ||||. | | ||. . ....|| |. |||.| |....| ...||. . . . . | . . || ... || YRIGKTLGKGSFGKVKLATHIRTTGEKVAI---KIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY LVLTECLGS---LSELIKQTQN--GVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGN-AVK ||. | | | . |.. . | . | | .| . | ......||.. | ||| .|||.|.||| .| LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIK |
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| Kinase | 25184.AA | STE20 | 42-184 | 24 | 2.6e-14 | 49.0 | In-house | 1-156 (288) | Show / Hide |
Range on Protein: 42-184 Range on HMM: 1-156/288 Sequence Identity: 24% (39 aa) YDQFKYLGKGGQGLVLLAKQKQSNRR----YAIKGVKVKDK---KGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQ----QFIYLVLTECLG-S |. .. .|.|. | | .| |.... .||| ...... . . ....|.||. ..||| .|.. ...| . ...| | | | YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS LSELIKQ--TQNG-----VLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNA |....|. . .. ..|| ... .|||..||.... ||| ||||.. .|.. LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEV |
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| Kinase | 25184.AA | S_TKc | 42-347 | 14 | 3.2e-12 | 2.33 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-347
Range on HMM: 1-231/231
Sequence Identity: 14% (51 aa)
YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQFIYLVLTECLG---SLSELIKQTQ
|. . .|||. | | ... | ..|..||| .| . ...||. | . . |.. .... .. ...|.|. | | .| ..||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NGV----LNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNAVK--------------GNFDCQAPECFTQFDIYSKKYKEQGVDV------
. ..| .| .|.. |...|...||.. . |.| .|||.| .| | . ||| . .| .|.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQLTTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCI
------KQKPSPRLSINTFLQNTMNISRVLFIRNSFNTQLMDQLNSNQERGIISFEFQLDSKFIEVIDDGAAQDIIKSFNSDIEFIQVMKQKLQKFNQPK
. | | ... ... .
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------------
QNEVISKQKQEIQNLEDEINDLLLKDQQINQQ-----QIIQ--------PFI
.| |.. | | . . .. | |..
---------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | 25184.AA | Ciliate-A2 | 126-183 | 27 | 5.7e-10 | 31.09 | In-house | 80-140 (272) | Show / Hide |
Range on Protein: 126-183 Range on HMM: 80-140/272 Sequence Identity: 27% (17 aa) C-LGSLSELIK--QTQNGVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGN | .||.. |. | | . ... ....|. | .... .|..| |. |.. ||||| ... CPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQ |
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| Kinase | 25184.AA | Ciliate-A2 | 49-101 | 26 | 2.3e-08 | 25.42 | In-house | 1-56 (272) | Show / Hide |
Range on Protein: 49-101 Range on HMM: 1-56/272 Sequence Identity: 26% (15 aa) GKGGQGLVLLAKQK--QSNRRYAIKGVKVKDKKGI-LDENTLKEVQQEINTLNQCK |.|. |.|.... . . | |||| ... |... ... |.| . |. | |. GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCN |
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| Kinase | 25184.AA | TyrKc | 42-301 | 14 | 5.3e-07 | -109.39 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 42-301
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)
YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQC-KGSPYVANFIGQIEGQ-------QFIYLVLTEC-LGSLSE
| || | | | ... | . |.| .| ... .|.. . . . | . ...| . | . ...|. . .|.| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
LIKQTQNGVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNG-----------------------NAVKGNF--DCQ--------APECFTQ
.. ... |. . .... .||.| ...||.||. |. |.|.. |. . .. ||||. .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N
FDIYSKKYKEQGVDV-------------KQKPSPR-----LSINTFLQNTMNISRVLFIRN----SFNTQLMDQLNSNQERGIISFEFQLDSKFIEVIDD
. ... | || |.| | .| ... .. | | | | |.
YGKFTTK-----SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------F--VCCP
GAAQDIIKSFNSD-----IEFIQVMKQKL
. .|.|. | .. ....
DEMYQIMKQCWHEDPEDRPTFSEI-HECF
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| Kinase | 25184.AA | Pkinase_Tyr | 126-167 | 20 | 0.000379 | 14.67 | Pfam | 90-133 (270) | Show / Hide |
Range on Protein: 126-167 Range on HMM: 90-133/270 Sequence Identity: 20% (9 aa) CLGSLSELIKQT--QNGVLNEITAIKYAKDIAEGLDFIHSRNCV ..|.| . .. ... |. . .... .||.|... .|.||. PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI |
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