Gene 24609 (Tetrahymena)
24609
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 24609.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24609.AA | Ciliate-C7 | 13-175 | 81 | 1.1e-123 | 398.2 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 13-175 Range on HMM: 1-164/164 Sequence Identity: 81% (133 aa) FRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN ||||||| |||||||||.||||| |||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYM ||||||||.||||||||||||.|.|||||||||||||.|||||.||||||||..||.|..|||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 24609.AA | Pkinase | 10-184 | 28 | 2e-27 | 98.08 | Pfam | 1-181 (293) | Show / Hide |
Range on Protein: 10-184 Range on HMM: 1-181/293 Sequence Identity: 28% (54 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER | | .|.| | | .... .|. .||.| . .|. . |. . .. .|..|.|.. ..|..| |.| || . |.|. |.| | .... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLADNL-INKSGYAMNQYMGNFLYQAPE ..... | ...|. |..||.|.||.... ||| .||||| .|. ..||||| . . ... |. . | | ||| WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE |
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| Kinase | 24609.AA | CAMK | 15-184 | 18 | 1.3e-24 | 75.65 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 15-184 Range on HMM: 1-290/425 Sequence Identity: 18% (55 aa) FLGQGVQGLVLLAKDSKTN------------MRVAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV ||.| | | |... .|. .|||| . .| ... . . .|..|.||.||.. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC ..|.. .| ... |.|. |.| . | |. .. .|..| | .| |.... |.||. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLINKS----------------------GYAMNQYMGNFLYQA-PE ||| .|||.|.. .| ..|||.| .. .. | |. . | | | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | 24609.AA | Ciliate-E1 | 16-185 | 21 | 5e-24 | 75.32 | In-house | 1-181 (202) | Show / Hide |
Range on Protein: 16-185 Range on HMM: 1-181/202 Sequence Identity: 21% (39 aa) LGQGVQGLVLLAKDSKTN-MRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE--------- .|.| ...|. || ..| ||.| ..... . ...... |.. .|.| . |.. .||... .| ........|. .|.. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ --RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPEC ..... ... .. . .. .|| ..|.. . |.|..||||. || | .|||....|.|.. . ... |. ||. QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ |
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| Kinase | 24609.AA | CAMKL | 10-186 | 26 | 5.4e-24 | 73.32 | In-house | 1-205 (297) | Show / Hide |
Range on Protein: 10-186 Range on HMM: 1-205/297 Sequence Identity: 26% (55 aa) YSDFRFLGQGVQGLVLLAKD-SKTNMRVAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV | . ||.| | | ||.. . |. .|||| . . ||. . |. |...|..|.|. . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLADNLI---NKSGYAMNQYMGNFLY . |.| | . .... ..| . | | .| | ...|.||. |.| .|||.|..| |. ..|||.. . ...| .. | | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY QAPECF .||| | MAPEIF |
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| Kinase | 24609.AA | Ciliate-E2-Unclassified | 10-187 | 20 | 4.9e-23 | 76.77 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 10-187 Range on HMM: 1-239/352 Sequence Identity: 20% (49 aa) YSDFRFLGQGVQGLVLLAKDSKTN-------MRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFS | . .||| .| | .....|.. | .... | . . .. .. ..|....| . ..|..| ....|. .| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EI---MNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI YLVLTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADN |.|. | .|.| |... ..|.|.. | |. .|. | ||| |.|.| .. |.| .|||.| | . ..|||.. . YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK LINKSGYA--------------MNQYMGNFLYQ----APECFD ... ... |.. .|. |. |||... YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| S_TKc | 24609.AA | S_TKc | 10-273 | 21 | 2.2e-22 | 81.6 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-273
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)
YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
| | .|.| | | .... ||. .|||| . .....|..|||| . |..| |.| |. .. |.|. | | .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPECFDPADP-----------
.. ..| | .|. |...| |.||. . ||| .|||.| . ..||||| | . . | | ||| . . ..
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI
----FIGKV-YHDEYQKLGFSVRQQPSNRGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFVPKNRMPIKEALI-----ILKGII
. |. .. ..|.. .. ...| .|... .. |..|. . ||| . .
LYEMLCGYPPFP-QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 24609.AA | Ciliate-E2 | 10-186 | 18 | 1e-21 | 71.29 | In-house | 1-259 (365) | Show / Hide |
Range on Protein: 10-186 Range on HMM: 1-259/365 Sequence Identity: 18% (50 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRVAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ | . .||| .| | ..|. |.. ..||| .|. .. .. . .||| |... . ..|... ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN |. .. |||. ||| .| .... | . |...| .... |.| .| |.||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDFGLADNLINK---------SGYAMNQY----------------------MGNFLYQAPECF ..||||. .. .. .. |. |. |.||| . IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL |
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| Kinase | 24609.AA | ULK | 10-184 | 24 | 2.6e-20 | 67.7 | In-house | 1-221 (329) | Show / Hide |
Range on Protein: 10-184 Range on HMM: 1-221/329 Sequence Identity: 24% (55 aa) YSDFRFLGQGVQGLVLLAKDSKT----NMRVAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL |. . ||.| | | ... || | ||.| .. .... | . . . .|.|..|.|| . ... .| |.| || ... |. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLADNLINK-- .. |.| .| |....|.. |||.| ||.. .|..|. ..|.. . |.| .||||. . ..|||.| . | IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM SGYAMNQYM------GNFLYQAPE . | . | || ||. EQQMMMTCVNEKRLCGTPLYMAPQ |
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| Kinase | 24609.AA | ULK | 10-160 | 25 | 6.3e-20 | 67.44 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 10-160 Range on HMM: 1-185/324 Sequence Identity: 25% (49 aa) YSDFRFLGQGVQG-LVLLAKDSKT---NMRVAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL |. . ||.| | | ... || | ||.| .. ... | . . . |.|..|.|| .|. .| |.| || . . |... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA |.| .| |....|.. |||.| ||.. .|..|. ..|.. . |.| .|||| . ..|||.| EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 24609.AA | STE | 10-184 | 18 | 4.1e-19 | 64.24 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 10-184 Range on HMM: 1-232/359 Sequence Identity: 18% (45 aa) YSDFRFLGQGVQGLVLLAKDSK---------------TNMRVAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF . . ...|.| | | .|.. | |. ..||| . ... . . | . .....|..|.|||.. .|..| .. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLA . . .... . |.|..|.. ...| .|..| .... .| .| |||.||. |.| .|||. . .|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC DNLIN---------------KSGYAMNQYMGNFLYQAPE .|.. .. | | . ||| GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 24609.AA | SAK | 10-163 | 30 | 3.6e-17 | 54.76 | In-house | 1-150 (254) | Show / Hide |
Range on Protein: 10-163 Range on HMM: 1-150/254 Sequence Identity: 30% (47 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNK | ||.| | || .| . |||| . . |. . .||..|||| . . | .. | || . . |||| |. | . . ... . YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKT---GMVQRVRNEVEIHCQLKH-PSILELYNYFEDNNYVYLVLEMCHNGEMHRYM-KHRMR RLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNL | | .. ..| |. |.|| . || . |||. . . ||||| | PFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQL |
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| Kinase | 24609.AA | TyrKc | 10-269 | 17 | 2.1e-07 | -102.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-269
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)
YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLTQ
. . || | | | ... . . ||.| .. .| .|..| . | .| |. |. .....| . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINK------SGYAMNQY--MGNFL----YQAPECF--
| ....| |. .... .||.| |.||| | || |.|.. . . .|||||. .. .. . | . . |... ||||.
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
---------------------DPADPFIG-----KVYHDEYQKLGFS-VRQQPSN----RGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFV
. . | | . . .... . || | | .. . |. ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQCWHED
PKNRMPIKEALIIL
|..| .| ..
PEDRPTFSEIHECF
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