Gene 24183 (Tetrahymena)
24183
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 24183.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24183.AA | Ciliate-C7 | 22-177 | 56 | 7.3e-79 | 252.55 | In-house | 14-142 (164) | Show / Hide |
Range on Protein: 22-177 Range on HMM: 14-142/164 Sequence Identity: 56% (88 aa) LAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIHLLMHKLNGISRQKIGT |||...|| ||||||. ..|...|.|| |..||||||..|.|||.|||| .|||..||...|.|||.||.| || LAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG---------------------------GT LSDIIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAV |..||...||.||||.||||| ||||.|||.||||.|.|||||||||||||||||| LNQIIERNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV |
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| Kinase | 24183.AA | Ciliate-E2-Unclassified | 120-178 | 25 | 1.8e-10 | 32.58 | In-house | 106-187 (352) | Show / Hide |
Range on Protein: 120-178 Range on HMM: 106-187/352 Sequence Identity: 25% (21 aa) GTLSDIIKNTQN---------------QRLNELSAI-----KYTKDIAEGLYFIHSKK-CLVNDLKMDNILIDYNGN--AVK |.|...||. . ... | |. .|.. | .|| ..|.|. .. |.| .|||.| ||. .| GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIK |
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| Kinase | 24183.AA | STE-Unique | 120-177 | 31 | 6.2e-10 | 30.88 | In-house | 379-450 (616) | Show / Hide |
Range on Protein: 120-177 Range on HMM: 379-450/616 Sequence Identity: 31% (23 aa) GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKK--CLVNDLKMDNILIDYNG-----NAV |||..|||.. | . | .|.||. |.||| ..||.. . ||| .||... | ... GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVK |
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| Kinase | 24183.AA | Ciliate-E2 | 120-178 | 22 | 1.4e-08 | 25.59 | In-house | 119-196 (365) | Show / Hide |
Range on Protein: 120-178 Range on HMM: 119-196/365 Sequence Identity: 22% (19 aa) GTLSDIIKNT----------QNQRLNELSAIKYTKDIAE---------------GLYFIHSKK-CLVNDLKMDNILIDYNGNAVK |.| |.||| . ....| .....| |.. .| ..|||. .. |.| .|||. .| GDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IK |
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| Kinase | 24183.AA | urchA | 145-170 | 61 | 1.4e-08 | 23.92 | In-house | 116-141 (208) | Show / Hide |
Range on Protein: 145-170 Range on HMM: 116-141/208 Sequence Identity: 61% (16 aa) DIAEGLYFIHSKKCLVNDLKMDNILI |||||| .|.| |.|||| ||.|. DIAEGLKVMHEKGFLCNDLKEDNCLV |
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| S_TKc | 24183.AA | S_TKc | 11-303 | 17 | 2.8e-08 | -55.42 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 11-303
Range on HMM: 1-231/231
Sequence Identity: 17% (56 aa)
HEMVKELKD-----XXLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIH
|..... ....|.|....||| |. ....|||.| . . |.. .|. .. |....|. | |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDG-------------
LLMHKLNGISRQKIGTLSDIIKNTQNQR----LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVK--------------GNVIFQAPE
|.| |.||. . .. ..| | .|.. |...| ..||.. . ||| .|||.| .| | . |||
------------DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQLTTFCGTPWYMAPE
CYDPSKFDIYSQEYMNLGVPVQQNPSQRVFYRQNLINIQKIYYINL-KSEACSLGYLLYTMISGFQANLVFSKHQPLQYNADFQNLAYEKQLRYIIDGLT
. |. |.| .|| |..| |... |... .... .|...
VL----------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-SPEAKDFIRKCL
KFIPRERLKVKEALI---------VL
.. |..|. . ||| .
QKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 24183.AA | ULK | 120-173 | 30 | 5.4e-08 | 24.1 | In-house | 105-166 (329) | Show / Hide |
Range on Protein: 120-173 Range on HMM: 105-166/329 Sequence Identity: 30% (19 aa) GTLSDIIKNTQN--------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN |.|...||. .. .||.| ||.. |.|..|. ..|.... |.| .||||. . GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG |
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| Kinase | 24183.AA | Pkinase | 120-178 | 33 | 7.1e-08 | 28.92 | Pfam | 85-152 (293) | Show / Hide |
Range on Protein: 120-178 Range on HMM: 85-152/293 Sequence Identity: 33% (23 aa) G----TLSDIIKNTQNQRL--NELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNA---VK | |.|.|. .. .. | ...| . |..||...||.... ||| .||||| ||. || GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK |
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| Kinase | 24183.AA | CAMK | 22-89 | 14 | 3.5e-07 | 18.42 | In-house | 12-140 (425) | Show / Hide |
Range on Protein: 22-89
Range on HMM: 12-140/425
Sequence Identity: 14% (19 aa)
LAKEKSTN------------KRYAIKGIPIKDSKDNV----------------------DQVILGQVQQEIQMLNQCKG------SPYVANLLHKIEG--
|...|.|. ...||| |. | ||.. ... . .|..||.......| | . .|.. .|
LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPH
-----------------NDYIFLVL--TE
......|. .|
YFKNTNDYETSKQVFTKDKHMYMVMEIME
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| Kinase | 24183.AA | STE | 120-178 | 29 | 8.6e-07 | 20.14 | In-house | 122-187 (359) | Show / Hide |
Range on Protein: 120-178 Range on HMM: 122-187/359 Sequence Identity: 29% (21 aa) GTLSDIIK---NTQN---------QRLNELSAIKYTKDIAEG-LYFIHSKKCLVNDLKMDNILIDYNGNAVK |.|.|||| ... .|..| ......| .| ||..||.. |.| .|||. || GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VK |
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| Kinase | 24183.AA | ULK | 120-173 | 31 | 2e-06 | 19.26 | In-house | 102-162 (324) | Show / Hide |
Range on Protein: 120-173 Range on HMM: 102-162/324 Sequence Identity: 31% (19 aa) GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN |.|...||. .. .||.| ||.. |.|..|. ..|.... |.| .|||| . GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNG |
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| Kinase | 24183.AA | CAMKL | 120-178 | 32 | 2e-06 | 16.73 | In-house | 106-169 (297) | Show / Hide |
Range on Protein: 120-178 Range on HMM: 106-169/297 Sequence Identity: 32% (21 aa) GT--LSDIIKNTQN--QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGN-AVK | | | |.. . .|. | | .| . | ......||.. |.| .|||.|.||| .| GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIK |
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| Kinase | 24183.AA | ULK | 28-87 | 21 | 9e-06 | 16.57 | In-house | 26-96 (324) | Show / Hide |
Range on Protein: 28-87 Range on HMM: 26-96/324 Sequence Identity: 21% (15 aa) T-NKRYAIKGIP---IKDSKDNVD-QVILGQVQQEIQMLNQCK--GSPY--VANLLHKIEGN--DYIFLVL | |. .|.| |. ....| . . |... . ..||| . . | .|. . |.. | ..|.... TQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM |
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| Kinase | 24183.AA | ULK | 24-87 | 16 | 2.3e-05 | 14.81 | In-house | 20-99 (329) | Show / Hide |
Range on Protein: 24-87 Range on HMM: 20-99/329 Sequence Identity: 16% (13 aa) KEKST---NKRYAIKGIPIK-DSKDNVD---QVILGQVQQEIQMLNQCK---GSPY----VANLLHKIEGN--DYIFLVL ..|. |. .|.| |... ...| . |... ....||. . . | .... . |.. | ..|.... NKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM |
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| Kinase | 24183.AA | STE | 25-74 | 16 | 2.5e-05 | 14.92 | In-house | 35-96 (359) | Show / Hide |
Range on Protein: 25-74 Range on HMM: 35-96/359 Sequence Identity: 16% (10 aa) EKSTNKRYAIKGIPIKDSK-----------DNVDQVILGQVQQEIQMLNQCKG-SPYVANLL ...|....||| ....... .|... .. |...||.....|. .|.. . . NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY |
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| Kinase | 24183.AA | CAMK | 125-178 | 21 | 0.000685 | 7.63 | In-house | 155-236 (425) | Show / Hide |
Range on Protein: 125-178 Range on HMM: 155-236/425 Sequence Identity: 21% (18 aa) IIKNTQN------------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNG----------------NAVK |...... |..| | .| . |.... ..||.. ||| .|||.|.|. | .| IVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK |
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| Kinase | 24183.AA | Pkinase | 22-87 | 27 | 0.002812 | 12.67 | Pfam | 17-79 (293) | Show / Hide |
Range on Protein: 22-87 Range on HMM: 17-79/293 Sequence Identity: 27% (19 aa) LAKEKSTNKRYAIKGIPIKDSKDNVDQVI--LGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVL ....|.|.|..|.| |. .. |...|| | .|||... . ..|.. |.. | .|.| .|. KCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVM |
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| Kinase | 24183.AA | CAMKL | 22-87 | 21 | 0.002884 | 6.11 | In-house | 17-100 (297) | Show / Hide |
Range on Protein: 22-87 Range on HMM: 17-100/297 Sequence Identity: 21% (18 aa) LAKE-KSTNKRYAIKGIP--IKDSKDNVDQVILG-------QVQQEIQMLNQCK--GSPYVANLLHKIEGNDY------IFLVL ||. . |....||| | . ...... .| ...||| . . . . | . |.. || .. |.||. LATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM |
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| Kinase | 24183.AA | STE-Unique | 22-74 | 20 | 0.016936 | 4.01 | In-house | 16-67 (616) | Show / Hide |
Range on Protein: 22-74 Range on HMM: 16-67/616 Sequence Identity: 20% (11 aa) LAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLL ... |....|.||| |..| || . . ||. . .. ........ NCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY |
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