Gene 22799 (Tetrahymena)
22799
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 22799.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22799.AA | Ciliate-C7 | 78-240 | 81 | 9.3e-123 | 395.2 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 81% (133 aa) FRFLGQGAQGLVLLAKDPKTKIRYAIKGVQIRDTQGKLDEDLNNGVKKEIEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLNQILERNQNKRLN |||||||.||||||||| ||..||||||||.|| ||..|.|.||.|..||.|||.|.||||||.|..|||||||.||||.||| ||||||.||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNLVNKSGYAINQYM ||||||||.||||||||||||||.|||||||||||||.|||||.|||||||| .||.|.||||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 22799.AA | Pkinase | 75-225 | 29 | 1.1e-27 | 98.98 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-159/293 Sequence Identity: 29% (49 aa) YSDFRFLGQGAQGLVLLAKDPKTKIRYAIKGVQIRDTQGKLDED---LNNGVKKEIEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLNQI | | .|.|. | | .... .| ...|.| . |.. . |. | ||.|.|.. ..|..| |.| || . |.|. |.| | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY LERNQNKRL--NEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNA----VVSDFGLA ... ..... | ...|. |..||.|.||.... ||| .||||| .|. ..||||| ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 22799.AA | CAMK | 80-225 | 20 | 4.1e-24 | 73.99 | In-house | 1-243 (425) | Show / Hide |
Range on Protein: 80-225 Range on HMM: 1-243/425 Sequence Identity: 20% (49 aa) FLGQGAQGLVLLAKDPKTK------------IRYAIKGVQIRDTQGKL----------------------DEDLNNGVKKEIEILKKCR------DSPYV ||.|. | | |... .|. ..||| . . ..| .. |..||||.||.. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLIDQFEG-------------------QQFSYLVL---TECQGT------LNQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKNC ..|.. .| ... |.|. |.| .. | |. .. .|..| | .| |.... |.||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYH-----------------GNAVVSDFGLA ||| .|||.|.. .| ..|||.| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 22799.AA | Ciliate-E1 | 81-267 | 20 | 1.1e-23 | 74.19 | In-house | 1-198 (202) | Show / Hide |
Range on Protein: 81-267 Range on HMM: 1-198/202 Sequence Identity: 20% (41 aa) LGQGAQGLVLLAKDPKTK-IRYAIKGVQIRDTQGKLDEDLNNGVKKEIEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLNQILE--------- .|.| ...|. || ... . .|.| ..... . . ... .. |....|.| . |.. .||... .| ........|. .|.. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEI--KEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ --RNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNLVNKSGYAINQYMGNFLCQAPECY-DPSVSSIGKVYHDE ..... ... .. . .. .|| ..|..| . |.|..||||. || | .|||....| |.. . ... . ||.| .| . . | . .. QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKIN YQ |. YK |
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| Kinase | 22799.AA | CAMKL | 75-225 | 26 | 9.2e-23 | 69.34 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-176/297 Sequence Identity: 26% (47 aa) YSDFRFLGQGAQGLVLLAKD-PKTKIRYAIKGVQIR----DTQGKLD------EDLNNGVKKEIEILKKCR--DSPYVVSLIDQFEGQQF------SYLV | . ||.|. | | ||.. |....||| . .. |.. | |. ...||.|.|. . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LNQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHG--NAVVSDFGLA . |.| | . .... ..| . | | .| | ...|.||.. |.| .|||.|..| |. ..|||.. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 22799.AA | ULK | 75-225 | 25 | 3.4e-22 | 74.33 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-189/329 Sequence Identity: 25% (49 aa) YSDFRFLGQGAQGLVLLAKDPKTK----IRYAIKGVQIR-DTQGKLD---EDLNNGVKKEIEILKKCRD---SPY----VVSLIDQFEGQQF--SYLVLT |. . ||.|. | | ... ||| . .|.| ... | . . . . . .|.||.|.|| . ... .| |.| || ... |... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECQG-TLNQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGLA |.| .| |....|.. |||.| ||.. .|..|. ..|..|. |.| .||||. . ..|||.| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 22799.AA | ULK | 75-225 | 26 | 3.2e-21 | 72.08 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-185/324 Sequence Identity: 26% (49 aa) YSDFRFLGQGAQG-LVLLAKDPKT---KIRYAIKGVQIR-DTQGKLD---EDLNNGVKKEIEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVLTECQ |. . ||.|. | | ... || . .|.| ... . |.. . . . |.||.|.|| .|. .| |.| || . . |... |. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN G-TLNQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGLA | .| |....|.. |||.| ||.. .|..|. ..|..|. |.| .|||| . ..|||.| GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 22799.AA | Ciliate-E2-Unclassified | 75-225 | 25 | 1e-20 | 68.57 | In-house | 1-194 (352) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-194/352 Sequence Identity: 25% (50 aa) YSDFRFLGQGAQGLVLLAKDPKTKIRY----AIKGVQIRD--TQGKLDEDLNNGVKKEIEILK---------------KCRDSPYVVSLIDQFEGQQFSY | . .|||..| | .... |.| | .| .||.. . . | ...| .||....| . ..|..| ....|. .| | YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMN-EMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY LVLTEC-QGTLNQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKN-CLVNDLKMDNILIDYHG---NAVVSDFGLA .|. | .|.| |... ..|.|.. | |. .|. | ||| |.|.|| .. |.| .|||.| | . ..|||.. IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS |
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| Kinase | 22799.AA | Ciliate-E2 | 75-249 | 17 | 2.9e-19 | 62.75 | In-house | 1-252 (365) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-252/365 Sequence Identity: 17% (46 aa) YSDFRFLGQGAQGLVLLAKDPKTKIRYA--------------------IKGVQIRDTQGKLDEDLNNGVKKEIEI---------LKKCRDSPYVVSLIDQ | . .|||..| | ..|. |.. ..| |. . | ... . . .||.. ... ..|... ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFSYLVLTECQG-TLNQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKN-CLVNDLKMDNILIDYHGN |. .. |||. ||| .| .... | . |...| .... |.| .| |.|||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDFGLADNLVNKSGYAI-----NQYMGNF---------------------LCQAPE ..||||. .. ... . . . || . .| |. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPG |
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| Kinase | 22799.AA | S_TKc | 75-338 | 21 | 5.6e-18 | 66.97 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-338
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)
YSDFRFLGQGAQGLVLLAKDPKTKIRYAIKGVQIRDTQGKLDEDLNNGVKKEIEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLNQILERNQ
| | .|.|| | | .... ||. ..||| . . ...||.|||| . |..| |.| |. .. |.|. | | .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNLVNKSGYAINQYMGNFLCQAPECYDPSVSS----------
.. ..| | .|. |...| |.||.. . ||| .|||.| . ..||||| | . . | ||| . .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC
------IGKV-YHDEYQKLGVTVKQEPSNRGIDFNLVSNKHKPLNYDDEFQNFVYHKQLKYIIEGLTNFVPRDRMPIKEALI-----ILKGII
|. .. ..|.. .. ...| .|... .. |..|. . ||| . .
ILYEMLCGYPPFP-QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 22799.AA | STE | 75-230 | 21 | 1.7e-17 | 58.44 | In-house | 1-199 (359) | Show / Hide |
Range on Protein: 75-230 Range on HMM: 1-199/359 Sequence Identity: 21% (44 aa) YSDFRFLGQGAQGLVLLAKDPK---------------TKIRYAIKGVQIRDTQGKLDE------------DLNNGVKKEIEILKKCRD-SPYVVSLIDQF . . ...|.|| | | .|.. | |. ..||| . ... . | | . . ..|||.|.|||.. .|..| .. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY EGQ-------QFSYLVLTECQ-GTLNQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLA . . .... . |.| .|.. ...| .|..| .... .| .| |||.||.. |.| .|||. . .|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC DNLVN .|.. GQLTD |
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| Kinase | 22799.AA | Ciliate-A2 | 159-225 | 32 | 2.2e-12 | 39.58 | In-house | 80-150 (272) | Show / Hide |
Range on Protein: 159-225 Range on HMM: 80-150/272 Sequence Identity: 32% (23 aa) C-QGTLNQILE--RNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGN-AVVSDFGLA | .. |.. . || | ... ....|. | ... |.|.|| . ||. ||||| ... .. ||||| CPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLA |
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| Kinase | 22799.AA | Ciliate-A2 | 82-133 | 29 | 2.2e-07 | 22.0 | In-house | 1-55 (272) | Show / Hide |
Range on Protein: 82-133 Range on HMM: 1-55/272 Sequence Identity: 29% (16 aa) GQGAQGLVLLAKDP--KTKIRYAIKGVQIRDTQGK-LDEDLNNGVKKEIEILKKC |||. |.|..... . |||| . | |. .. .. . |.|...||.| GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNC |
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| Kinase | 22799.AA | TyrKc | 75-334 | 18 | 3e-07 | -105.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-334 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) YSDFRFLGQGAQGLVLLAKDPKTKIRYAIKGVQIRDTQGKLDEDLNNGVKKEIEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLNQ . . || || | | ... | |.| .. .|..|..| . | .| |. |. .....| . | |.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD ILERNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNLVNK--SGYAINQYMGNF--LCQ--------APECYDP | ....| |. .... .||.| |.||||| || |.|.. . . .|||||. .. .. .| . |. . |||| . YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY SVSSI-----------------GKVYHDE-YQ--KLGVTVKQEPSNRGIDFNLVS----NKHKPLNYDDEFQNFVYHKQLKYIIEGLTNFVPRDRMPIKE .. .. |. . . | . | . ... . | .. . |.. .. | || .| GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------F--VCCPDEMYQIMKQCWHEDPEDRPTFSE ALIIL .. IHECF |
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