Gene 22155 (Tetrahymena)
22155
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 22155.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22155.AA | Ciliate-C7 | 78-240 | 78 | 7.1e-118 | 379.34 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 78% (128 aa) FRYLGQGSSGLVLLAKDSKTNMRYAIKGVQVRDPHGNFDQDIYIQVKREIEILKTCRDSPYVISLLDQFEGQQFSYLVLTECQ-GTLTQIIERNKNKRLN ||.||||. ||||||||.|||||||||||||||..||.||||..||..||.||| |.|||||..||.|||||||.||||.||| |||.||||||.||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNAVLCDFGTADNQINISGYSINQYM |||||||| ||||||||||||.|..|||| |||||||.||||.|||| |||... |.|.||||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Kinase | 22155.AA | CAMK | 80-249 | 18 | 5.8e-29 | 89.89 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 80-249 Range on HMM: 1-290/425 Sequence Identity: 18% (54 aa) YLGQGSSGLVLLAKDSKTN------------MRYAIKGVQ-----------------VRDPHGNF-----DQDIYIQVKREIEILKTCR------DSPYV ||.|| | | |... .|. ..||| . ... . .. .|.|||||.|... | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI ISLLDQFEG-------------------QQFSYLVL---TECQGT------LTQIIERNKN------------KRLNEISAIKYASDIAQGLYYIHSKSC |.|.. .| ... |.|. |.| . |.|. .. .|..| | .| |.... |.||. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LLNDLKADNILIDYH-----------------GNAVLCDFGTADNQINISGYS----------------------INQYMGNILYQA-PE ||| .|||.|.. .| ..||| | . ... . . | | | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Pkinase | 22155.AA | Pkinase | 75-223 | 30 | 6.9e-28 | 99.68 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 75-223 Range on HMM: 1-157/293 Sequence Identity: 30% (49 aa) YSDFRYLGQGSSGLVLLAKDSKTNMRYAIKGVQVRDPHGNFDQD---IYIQVKREIEILKTCRDSPYVISLLDQFEGQQFSYLVLTECQG-----TLTQI | | .|.||.| | .... .|. ..|.| . .|. . ..|| . .||.|.| . ..|... |.| || . |.|. |.| | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY IERNKNKRL--NEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNA----VLCDFG |.. ..... | ...|. |..||.|.||.... ||| .||||| .|. .|||| ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Kinase | 22155.AA | CAMKL | 75-223 | 28 | 8.1e-26 | 79.24 | In-house | 1-174 (297) | Show / Hide |
Range on Protein: 75-223 Range on HMM: 1-174/297 Sequence Identity: 28% (50 aa) YSDFRYLGQGSSGLVLLAKD-SKTNMRYAIKGVQVR----DPHGNFD------QDIYIQVKREIEILKTCR--DSPYVISLLDQFEGQQF------SYLV | . ||.|| | | ||.. . |. ..||| . . ||. . .. ..|||.|.| . | .|.|.. .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LTQIIERNKNKR--LNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHG--NAVLCDFG . |.| | . |......| . | | .| | ...|.||. |.|..|||.|..| |. ..||| MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG |
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| S_TKc | 22155.AA | S_TKc | 75-338 | 22 | 2.1e-25 | 91.65 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-338 Range on HMM: 1-231/231 Sequence Identity: 22% (66 aa) YSDFRYLGQGSSGLVLLAKDSKTNMRYAIKGVQVRDPHGNFDQDIYIQVKREIEILKTCRDSPYVISLLDQFEGQQFSYLVLTECQG---TLTQIIERNK | | .|.|. | | .... ||. ..||| . ....|||.||| . |... |.| |. .. |.|. | | .| ..|.... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG NKR----LNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNAVLCDFGTADNQINISGYSINQYMGNILYQAPESLDPAEPFIGKVYHDEYL .. ..| | .|. |...| |.||. . ||| .|||.| . .|||| | . . | | ||| | | RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------------GYG K-----------LGVSVRQEPSQRGIDFNLISNKHKPLNYDAEFKNFVYHKQLKYIIDGLTNFVPKNRMTIKEALI-----ILKGII | | . .| . . ... .| . ...| .|... .. |..|.|. ||| . . KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 22155.AA | Ciliate-E2-Unclassified | 75-249 | 21 | 1.6e-24 | 81.96 | In-house | 1-236 (352) | Show / Hide |
Range on Protein: 75-249
Range on HMM: 1-236/352
Sequence Identity: 21% (50 aa)
YSDFRYLGQGSSGLVLLAKDSKTN----MRYAIKGVQVRDPHGNFDQDIYIQVKREIEILK---------------TCRDSPYVISLLDQFEGQQFSYLV
| . .|||. | | .....|.. | |..| .. . .. . .... . |....| ..|... ....|. .| |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
LTEC-QGTLTQIIERNKN---------------KRLNEISAI-----KYASDIAQGLYYIHSKS-CLLNDLKADNILIDYHG---NAVLCDFGTAD----
. | .|.| |.|. .|. |.. | |. .|. | ||| |.|.| .. |.| .|||.| | . ..||| .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
---------NQINISGYSINQYM-GNILYQ----APE
....| . . . . |.. |. |||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE
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| Kinase | 22155.AA | Ciliate-E1 | 81-251 | 21 | 7.9e-23 | 71.38 | In-house | 1-182 (202) | Show / Hide |
Range on Protein: 81-251 Range on HMM: 1-182/202 Sequence Identity: 21% (40 aa) LGQGSSGLVLLAKDSKTN-MRYAIKGVQVRDPHGNFDQDIYIQVKREIE-ILKTCRDSPYVISLLDQFEGQQ--FSYLVLTECQGTLTQIIE-------- .|.||...|. || ..| .|.| ..... |..|. . ....|. |.| . |.| ..|... .| ........|. .|.. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---RNKNKRLNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNAVLCDFGTADNQINISGYSINQYMGNILYQAPESL ..... ... .. . .. .|| ..|.. . |.| .||||. || |.||||......| . ..... |. || . QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQY |
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| Kinase | 22155.AA | STE | 75-249 | 19 | 2.5e-22 | 75.75 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-232/359 Sequence Identity: 19% (47 aa) YSDFRYLGQGSSGLVLLAKDSK---------------TNMRYAIKGVQVRD--------PHGNFD-----QDIYIQVKREIEILKTCRD-SPYVISLLDQ . . . .|.|..| | .|.. | |. ..||| . ... . . . ... |...||.|.| |.. .|... .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC FEGQ-------QFSYLVLTECQ-GTLTQIIER--NKNKRLN----------EISAIKYASDIAQG-LYYIHSKSCLLNDLKADNILIDYHGNAVLCDFGT .. . .... . |.|..||.. ..|.|| | .... .| .| |||.||. |.|..|||. . |||||. YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGV ADNQINI---------------SGYSINQYMGNILYQAPE . . ... .. | | . ||| CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 22155.AA | Ciliate-E2 | 75-249 | 20 | 3.7e-22 | 72.84 | In-house | 1-257 (365) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-257/365 Sequence Identity: 20% (53 aa) YSDFRYLGQGSSGLVLLAKDSKTNMRYAIK-------------GVQ-VRDPHGNFDQDIYIQVKREIEILKTCR---------------DSPYVISLLDQ | . .|||. | | ..|. |.. ..||| .|. .. .. .|.|.|| |... . ..|..| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFSYLVLTECQG-TLTQIIERNKNKR---------LNEISAIKYASDIAQ---------------GLYYIHSKS-CLLNDLKADNILIDYHGNA |. .. |||. ||| .| ..|. || || ..| .... |.| .| |.||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I VLCDFGTADNQI---------NISGYSINQY----------------------MGNILYQAPE ..|||.. .. .... .. |. |.||| KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE |
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| Kinase | 22155.AA | ULK | 75-223 | 25 | 1.3e-21 | 72.3 | In-house | 1-187 (329) | Show / Hide |
Range on Protein: 75-223 Range on HMM: 1-187/329 Sequence Identity: 25% (49 aa) YSDFRYLGQGSSGLVLLAKDSKT----NMRYAIKGVQ----VRDPH---GNFDQDIYIQVKREIEILKTCRD---SPY----VISLLDQFEGQQF--SYL |. . ||.|| | | ... || | .|.| .. .... | | . ..|.||.|.|. . ... .. |.| || ... |. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI VLTECQG-TLTQIIERNKN--------KRLNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNAV------------LCDFG .. |.| .| |.|..||. |||.| ||.. .|..|. ..|.. . |.| .||||. . ..||| IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG |
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| Kinase | 22155.AA | ULK | 75-223 | 26 | 2.5e-21 | 72.47 | In-house | 1-183 (324) | Show / Hide |
Range on Protein: 75-223 Range on HMM: 1-183/324 Sequence Identity: 26% (50 aa) YSDFRYLGQGSSG-LVLLAKDSKT---NMRYAIKGVQ--------VRDPHGNFDQDIYIQVKREIEILKTCR--DSPY--VISLLDQFEGQ--QFSYLVL |. . ||.|| | | ... || | .|.| .. ... | | . . |.||.|.|. .|. .. |.| || . . |... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM TECQG-TLTQIIERNKN-------KRLNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNAV------------LCDFG |.| .| |.|..||. |||.| ||.. .|..|. ..|.. . |.| .|||| . ..||| EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG |
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| Kinase | 22155.AA | Ciliate-A2 | 159-249 | 30 | 6.5e-12 | 37.91 | In-house | 80-177 (272) | Show / Hide |
Range on Protein: 159-249 Range on HMM: 80-177/272 Sequence Identity: 30% (30 aa) C-QGTLTQIIE--RNKNKRLNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGN-AVLCDFGTA---DNQINISGYSINQYMGNILYQAPE | .. | . |. | | ... ....| | ... |.|.| | ||. ||||| ... .||||| | ...|| . ..... | ..| || CPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPE |
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| Kinase | 22155.AA | Ciliate-A2 | 82-133 | 30 | 2.2e-10 | 32.51 | In-house | 1-55 (272) | Show / Hide |
Range on Protein: 82-133 Range on HMM: 1-55/272 Sequence Identity: 30% (17 aa) GQGSSGLVLLAKD--SKTNMRYAIKGVQVRDPHGN-FDQDIYIQVKREIEILKTC |||..|.|..... . | |||| . . |... .| . |.|...|| | GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNC |
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| Kinase | 22155.AA | TyrKc | 75-334 | 15 | 5.2e-07 | -109.31 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-334
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)
YSDFRYLGQGSSGLVLLAKDSKTNMRYAIKGVQVRDPHGNFDQDIYIQVKREIEILKTC-RDSPYVISLLDQFEGQQ------FSYLVLTE--CQGTLTQ
. . || | | | ... . . |.| .. ||..|.. . | .. |. |. .....| . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
IIERNKNKRLNEISAIKYASDIAQGLYYIHSKSCLLNDLKADNILIDYHGNAVLCDFGTADNQINI-------SGYSIN---QYM--GNILYQAPESL--
. ....| |. .... .||.| |.||| | || | |.|.. . . .||| . . . . |. . | |||..
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
---------------------DPAEPFIG-----KVYHDEYLKLGVSVRQEPSQRGIDFNLISNKHKPLNYDAEFKNFVYHKQLKYIIDGLTNFVPKNRM
. ..| | . . . .. | .. . . .| | .. . |. .. |..|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS-----------F--VCCPDEMYQIMKQCWHEDPEDRP
TIKEALIIL
| .| ..
TFSEIHECF
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