Gene 19406 (Tetrahymena)

19406

Species: Tetrahymena
Alias: 19406, 26, PreTt19406, TTHERM_01948320, 844.m00002
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
19406.AA Protein None 318 None Fasta, JSON
19406.kin_dom Protein Kinase Domain None 151 None Fasta, JSON
19406.NA RNA None 957 None Fasta, JSON

Protein domain

Protein domains of 19406.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19406.AA Ciliate-C7 113-275 63 1.8e-106 342.27 In-house 1-164 (164) Show / Hide 
Range on Protein: 113-275
Range on HMM: 1-164/164
Sequence Identity: 63% (104 aa)

FKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQ-GTLSELIKKSPNEKLN
|...|||.||||.|||. .||.|.||||..|.|.||.|.|....|.|||||.|..||.| |||.||...||..||||||.||| |||...|....|..||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYE
|.||||||||||.||..|||..|. ||||||||||||||||||.|.|||| ||. |.| .||| 
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 19406.AA Pkinase 110-260 26 2.3e-22 80.13 Pfam 1-159 (293) Show / Hide 
Range on Protein: 110-260
Range on HMM: 1-159/293
Sequence Identity: 26% (44 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQE---TFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQG-----TLSEL
.   . ||.|  | |..... .|....|.| . ...   .  |.   .     .|| .. .. .. ..| |.   | |  ||.|.  |.|      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IKKSPNEKL--NELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNA----VVSDLGLA
|. . . ..   |  ...|.. |..|| ..||...|  ||| .||||| ||.      ..| |||
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 19406.AA AGC 110-260 23 1.9e-21 50.8 In-house 1-202 (395) Show / Hide 
Range on Protein: 110-260
Range on HMM: 1-202/395
Sequence Identity: 23% (48 aa)

FSDFKYIGQGKQGLVFLAKEL------STNRRFAIKGLHVKD--------SQGKIFQE-TFDQ----AQQEINMLEKCKG---------STYVVN-LLKK
|   | ||.|  | |.|...       .|.. .|.| |  |.         . ..  | . .|     ..| |.||||..         . ..|. |   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS

IEGKEF--IYLVLSECQ----------G-TLSELIKKS-PNEKLNELSAIKYAKD-------IAEGLLHIHS-QKCISND-LKMDNILIDYNGNAVVSDL
 . |.   .|.|.  ..          |  |   ...   . ...|  |  ||         |. .| ..|| .. |  | || .|||.| .|.   .| 
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GLA
||.
GLC
Kinase 19406.AA Ciliate-E2-Unclassified 110-260 21 1.7e-19 64.29 In-house 1-194 (352) Show / Hide 
Range on Protein: 110-260
Range on HMM: 1-194/352
Sequence Identity: 21% (41 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQG-KIFQETFDQAQQEINMLEKCK------------------GSTYVVNLLKKIEGKEFIYLV
.   | |||| .| |..... ...  .|.| .... ..  |. ..   .  .|.. ... |                   . ..|...   . |. ||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LSEC-QGTLSELIKKSPN---------------EKLNELSAI-----KYAKDIAEGLLHIHSQK-CISNDLKMDNILIDYNG---NAVVSDLGLA
.  | .|.|.. |||...               ... |  |.     .|.. | .|| ..|... .|  |.| .|||.| ||   .  ..|.|..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS
Kinase 19406.AA CAMK 115-260 16 2.6e-18 54.93 In-house 1-243 (425) Show / Hide 
Range on Protein: 115-260
Range on HMM: 1-243/425
Sequence Identity: 16% (41 aa)

YIGQGKQGLVFLAKELSTN------------RRFAIKGLHVKDSQGKI----------------------FQETFDQAQQEINMLEKCKG------STYV
 .|.|  | |.|... .|.            ...||| .  |  ..|                        ... .. ..||... |..|         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLLKKIEG-------------------KEFIYLVL---SECQGT-----LSELIKKSPN-------------EKLNELSAIKYAKDIAEGLLHIHSQKC
..|.  .|                    ....|.|.     |.|      | . |.. ..              ...|  | .| . |.... ..||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

ISNDLKMDNILIDYN-----------------GNAVVSDLGLA
.  ||| .|||.|.|                 .|  ..| |.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
Kinase 19406.AA Ciliate-E1 116-298 17 2.8e-18 56.4 In-house 1-202 (202) Show / Hide 
Range on Protein: 116-298
Range on HMM: 1-202/202
Sequence Identity: 17% (36 aa)

IGQGKQGLVFLAKELSTN-RRFAIKGLHVKDSQGKIFQETFDQAQQEIN-MLEKCKGSTYVVNLLKKIEGKE--FIYLVLSECQGTLSELIK--------
||.| ...|| ||  ..| .  |.|   .   .... |..|.. ..|.. ...  |.  |...... |. ..  ...... .|. .| . ..        
IGNGSFSIVFKAKQQNNNYNQVAQK---IINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW

---KSPNEKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLAD--SLTKTSGYGMNQYETCYSKLQNVM------IQRNFKI
   .. . .....  .. .... .||  .|... |  |.|..||||. .|| | .|.|...   . ... .  ..| ..|.  . ..      .. .   
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN

IQMNIK
.. .| 
YKSDIY
Kinase 19406.AA STE 110-268 18 5.3e-18 60.24 In-house 1-217 (359) Show / Hide 
Range on Protein: 110-268
Range on HMM: 1-217/359
Sequence Identity: 18% (41 aa)

FSDFKYIGQGKQGLVFLAKEL------STNRR---------FAIKGLHVKDSQ-----------GKIFQETFDQAQQEINMLEKCKG-STYVVNLLKKIE
. . . ||.|  | |..|.        .|..          .||| .......            ....| ..| ..||... ||.  . ..|. .   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GK-------EFIYLVLSECQ-GTLSELIK-K-SPNEKLN----------ELSAIKYAKDIAEG-LLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLAD
 .       . .....  .  |.|...|| | .... ||          |   ......| .| | ..||.. |  |.| .|||.     .  .| |.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SLTK---------------TSG
.||.               |..
QLTDSMANIQSNNIIDCIETMQ
Kinase 19406.AA STE20 110-266 24 7.3e-18 62.11 In-house 1-174 (288) Show / Hide 
Range on Protein: 110-266
Range on HMM: 1-174/288
Sequence Identity: 24% (44 aa)

FSDFKYIGQGKQGLVFLAKELSTNRR----FAIKGLHVKDS---QGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGK----EFIYLVLSECQG-T
. ... ||||  | |..| . .|..      ||| . ...    |     . ..  |.||... .|| . ..|. .     .    . ...|   |.| .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS

LSELIK---KSPNE----KLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTK----T
|....|   |  .     ..||       ... .|| ..||...|  |.| ||||.. .|..  .| |.. .|||    |
LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDT
Kinase 19406.AA CAMKL 114-260 26 2.8e-17 51.54 In-house 5-176 (297) Show / Hide 
Range on Protein: 114-260
Range on HMM: 5-176/297
Sequence Identity: 26% (46 aa)

KYIGQGKQGLVFLAKE-LSTNRRFAIKGLHVK----DSQGKIF------QETFDQAQQEINMLEKCK--GSTYVVNLLKKIEGKEF------IYLVLSEC
| .|.|  | | ||.  . |... ||| .. |    | . |        .      ..||. ... .  .   .. |.  || .|.      ||||.  |
KTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYC

QGT---LSELIKKSPNEK--LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNG--NAVVSDLGLA
.|    | . |.| .. .  . |  | .| . | ... ..||.. .  |.| .|||.|.||  |. ..| |..
SGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 19406.AA Ciliate-E2 110-303 18 2e-15 49.41 In-house 1-250 (365) Show / Hide 
Range on Protein: 110-303
Range on HMM: 1-250/365
Sequence Identity: 18% (48 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFA--------------------IKGLHVKDSQGKIFQETFDQAQQEIN----------MLEKCKGSTYVVNLLK
.   | |||| .| |...|  .....||                    |. . ..  .......  ..  .|||          .||. . . .....  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

KIE--GKEFIYLVLSECQG-TLSELIK---KSPNEKLN------ELSAIKYAKDIAE---------------GLLHIHSQK-CISNDLKMDNILIDYNGN
  .   .. ||||.  ||| .| ..||   |. |....      |  .... | |..               .| ..||.. .|  |.| .|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVSDLGLAD------------SLTKTSGYGMNQYETCYSKLQNVMIQRNFKIIQMNIKSQDQT
  ..|.||.             .. |   .  |. ........       ..|.|. ....  |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-------QIIQQNMFNTICGT
Kinase 19406.AA IRE 182-259 27 2.7e-15 49.1 In-house 63-170 (292) Show / Hide 
Range on Protein: 182-259
Range on HMM: 63-170/292
Sequence Identity: 27% (30 aa)

EGKEFIYLVLSECQGTLSELIKK--------------SPNEKLN--------ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDY--------NGN
|...|.|| |. |||.|.... .                |...|        ..  .. .|....|| | |||. . .|||  ||||..        |. 
EDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNR

AVVSDLGL
.. ||.||
FMISDFGL
Kinase 19406.AA S_TKc 110-318 20 6.8e-13 12.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 110-318
Range on HMM: 1-231/231
Sequence Identity: 20% (54 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQG---TLSELIKKSP
.   . ||.|  | |..... .|.|..||| ..             .....||..|.|  .  ..|.|.  ..  ...|.|.  | |   .| ..||| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NEK----LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYETC------------YSK----------
 ..    ..|  | .|.. |...| ..||.. |  ||| .|||.|   .  ..| |||  |          .  |            |.|          
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVLGYGKCKCDWWSCGC

-----------LQNVMIQRNFKIIQMNIKSQDQTQAQNQLLRQLLI-----------LV----------I
            .   .|. ||.|         ..   ...|..|            |           .
ILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 19406.AA TyrKc 110-297 15 3.1e-05 -138.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 110-297
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFDQAQQEINMLEKC-KGSTYVVNLLKKIEGK-------EFIYLVL-SECQGTLSE
 .  | .| |  | |....     .  |.| |.         .| |    .|.... |  .    .|.|.  .  .       | ...|.   . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIKKSPNEKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSL--------------------TK---------------
 ..|. .. |.    .... .||.|  ..||..||  ||   |.|.. |. . .|| ||.  .                    .|               
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

--------------------------------------------TSGYGMNQYET--------CYSKLQNVMIQ---R------NFKIIQMNI
                                             .|| | | .         | ... ..| |   .      .|. |   .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF