Gene 17306 (Tetrahymena)

17306

Species: Tetrahymena
Alias: TTHERM_01220420, PreTt17306, 17306, 766, 279.m00031
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
17306.AA Protein None 620 None Fasta, JSON
17306.kin_dom Protein Kinase Domain None 208 None Fasta, JSON
17306.NA RNA None 1863 None Fasta, JSON

Protein domain

Protein domains of 17306.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17306.AA Ciliate-C7 69-228 36 5.7e-78 249.65 In-house 1-164 (164) Show / Hide 
Range on Protein: 69-228
Range on HMM: 1-164/164
Sequence Identity: 36% (60 aa)

IRFAGRGSFGTTIIGEDQNQN-RFAFKLIFIRTKHGQINQDIRGKALKEANLMSQ-MDHPNVVKFYKYYETQNYFIIQMEECK-GDLNQFMKS--YELLS
.||.|.|..|......||..| |.|.| ...|.|.|.|.|||......|.|...| .|.|.||......|.|........||. |.|||....  ...|.
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

IESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMNVAKIADFGLAAYVEQGSSRVKYSVQG
..|.|||...|..|..|.|....|..|||.||||||....|...|||||....|.| ........
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKS-KYQINQYM
S_TKc 17306.AA S_TKc 66-335 20 2.1e-34 121.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 66-335
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

YKSIRFAGRGSFGTTIIGEDQN-QNRFAFKLIFIRTKHGQINQDIRGKALKEANLMSQMDHPNVVKFYKYYETQNYFIIQMEECKG---DLNQFMKSYEL
|. .|  |.|.||.   . . . . ..| | |               ....| ..... .|||.||.| .... ... . || | |   || ...|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSIESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMNVAKIADFGLAAYVEQGSSRVKYSVQGAQLFRAPELQDELCQNLIQQLKKENPS
      ..     .| ..| ....| |..| . |||| .|||.|.  . ||.|||||. .        ... |   ..|||.                  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----------------

LVLQSK-KSDCFSLGLIFYSCLG--TPLSKFIKILQDGPASIDTPVMIEGQQEFQCIDQMLQLLCEHHPNKRMKISDVIQ--------QFK
    .| |.|  |.| |.| .|   .| .  .. . .                 ...| ... ...  |.||. . .. |        .. 
--GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase 17306.AA Pkinase 66-273 27 9.3e-30 106.3 Pfam 1-203 (293) Show / Hide 
Range on Protein: 66-273
Range on HMM: 1-203/293
Sequence Identity: 27% (61 aa)

YKSIRFAGRGSFGTTIIGEDQNQNR-FAFKLIFIRTKHGQINQ-DIRGKALKEANLMSQMDHPNVVKFYKYYETQNYFIIQMEECKG-----DLNQFMK-
|. .|  |.||||.  .. ... .. .| | |  |... . .| ..|     |. .|  ..|||.|..| ..|. ..  . || | |     ||  ... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-SYELL--SIESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMNVA----KIADFGLAAYVEQGSSRVKYSVQGAQLFRAPELQDELCQNLIQQLK
 ..  .  | .  ..|  .| .|..| |..| . |||| .|||||. ..     ||.|||||. ..  ...  ... |   ..|||.        |.   
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--------IR---

KENPSLVLQSKKSDCFSLGLIFY
    .    ..|.| .|.|.|.|
----GGQYYGPKVDMWSCGCILY
Kinase 17306.AA Ciliate-A2 73-215 32 1.1e-27 93.36 In-house 1-153 (272) Show / Hide 
Range on Protein: 73-215
Range on HMM: 1-153/272
Sequence Identity: 32% (50 aa)

GRGSFGTTIIGED---QNQNRFAFKLIFIRTKHGQ-INQDIRGKALKEANLMSQMDHPNVVKFYKYYETQNYFIIQMEEC-KGDLNQFMK----SYELLS
|.|.||. |. |.   .|   .| | . |  ...| |.|     . .|| ...  .|||.|| .. .   .|  |||| | ...|... .    .   ..
GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIP

IESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMNV-AKIADFGLAAYV
 . |... . |...|.| | .  |||||.  |||||| |.  |  |||||...
DHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKY
Kinase 17306.AA CAMKL 115-237 26 6.3e-25 76.35 In-house 61-204 (297) Show / Hide 
Range on Protein: 115-237
Range on HMM: 61-204/297
Sequence Identity: 26% (38 aa)

KEANLMSQMD---HPNVVKFYKYYETQNY------FIIQMEECKGD---LNQFM--KSYEL--LSIESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILI
.|...|....   |||..|.|  .||...      . . || | |    | ..   . .    .. .   .| . | ....| |..| | ||.| .|||.
REIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL

D-QMN-VAKIADFGLAAYVE---QGSSRVKYSVQGAQLFRAPEL
| ..| ..||.|||.... .    |. .      |   . |||.
DENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI
Kinase 17306.AA Ciliate-E2 66-276 20 9.2e-25 81.91 In-house 1-290 (365) Show / Hide 
Range on Protein: 66-276
Range on HMM: 1-290/365
Sequence Identity: 20% (60 aa)

YKSIRFAGRGSFGTTIIGED-QNQNRFA-------------------FKLIFIRTKHGQINQDIRGKA-LKEAN----------LMSQMDHPNVVKFYKY
|| |.  |.|.||.   ... ..|..||                   ..    . |. ||.|  . .  ..| |          ...|..|||..|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TQNYFIIQMEECKG-DLNQFMK-----------------SYELLSIESFIKYGQ---------EISEGIQYVHDQG-LVLRDLKQDNILIDQMNVA
..  ..|.. . || |.| || ...|                  .| . |   | .|.         .| ....| | ..  . ||.| .|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGLAAYVEQGSSRVKYSVQGAQLFRAPELQDELCQNLIQQ------------LKKENPSLVLQS-------------KKSDCFSLGLIFYSCL
||.||||. .. . . .  .  |.....     ... ..  ..|               . .  .|..             .|.| .||| |.| .|
KIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML
Kinase 17306.AA CAMK 73-237 18 9.3e-25 76.09 In-house 3-291 (425) Show / Hide 
Range on Protein: 73-237
Range on HMM: 3-291/425
Sequence Identity: 18% (55 aa)

GRGSFGTTIIGEDQNQNR-------------FAFKLIFIR--------------------TKHGQIN--QDIRGKALKEANLMSQ-------MDHPNVVK
||||||.   ... | ..             .| | |  .                    .||.. .  .  | . ..| ..|..       .||||..|
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

FYKYYE------------TQNY--------FIIQM---EECKG-----DLNQFMKSYEL---------------LSIESFIKYGQEISEGIQYVHDQGLV
.| .||            | ..        ... |   | | |     || .. .. .                .. .   .| . | ....| |... |
LYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIV

LRDLKQDNILIDQM-----------------NVAKIADFGLAAYVEQGS----------------------SRVKYSVQGAQLFRA-PEL
 |||| .|||.|.                  |  ||.|||.|.....|.                          . . |   . | ||.
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase 17306.AA STE 66-236 20 1.6e-23 80.03 In-house 1-232 (359) Show / Hide 
Range on Protein: 66-236
Range on HMM: 1-232/359
Sequence Identity: 20% (48 aa)

YKSIRFAGRGSFGTTIIGEDQN----------------QNRFAFKLIFIRTK-----------HGQINQDIRGKALKEANLMSQMD--HPNVVKFYKYYE
.. |.. |.|.|||.  . . .                ....| | . ....             ..|.... . ||| ..|....  |||.||.| .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TQ-------NYFIIQMEECK-GDLNQFMK-SYELLSI------------ESFI-KYGQEISEG-IQYVHDQGLVLRDLKQDNILIDQMNVAKIADFGLAA
         ..  | || .  | | ...|  |. .              || | .. ..| .|  .| |... . ||.| .|||.     .|..|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

YVEQG--------------SSR-VKYSVQGAQLFRAPE
 ...               ..    ... | . . |||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 17306.AA ULK 66-244 24 5.8e-23 77.07 In-house 1-231 (329) Show / Hide 
Range on Protein: 66-244
Range on HMM: 1-231/329
Sequence Identity: 24% (57 aa)

YKSIRFAGRGSFGTTIIGEDQNQN-----RFAFKLIFIRTKHGQIN----QDIRGKALKEANLMSQMD--------HPNVVKFYKYYETQ--NYFIIQME
|  ..  | ||||.   |......      .| | | . ..  . |    | .     .|  .| ...        |||.||.|...||.  |.. | ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

ECKG-DLNQFMKSYELLSIES----------FIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMN------------VAKIADFGLAAYVEQG--SSR
 | | || |..| .  |. .            |.. . | .| .. |... . ||.| .||||.  .            |.||||||.|  |. .  . .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VKYSVQ------GAQLFRAPELQDEL--CQN
. ..        |  |. ||..  ..  ...
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKP
Kinase 17306.AA Ciliate-E2-Unclassified 66-276 20 5.9e-22 72.97 In-house 1-264 (352) Show / Hide 
Range on Protein: 66-276
Range on HMM: 1-264/352
Sequence Identity: 20% (58 aa)

YKSIRFAGRGSFGTTIIGEDQNQNRFA-----------FKLIFIRTKHGQINQDIRGKALKEAN-------------LMSQMDHPNVVKFYKYYETQNYF
|| |.  |.|.||.    .. .|. ..           .|   |..|. .|.. .  |.... .             ......||..||.. . ......
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEM--KEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI

IIQMEECKG-DLNQFMKSY-----------------ELLSIESFI-----KYGQEISEGIQYVHDQG-LVLRDLKQDNILIDQMN---VAKIADFGLAAY
.| || |.| || |..|..                 . .. .  .     .|  .| .|..| | ..  . ||.| .|||.|. .     ||.|||.. .
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

VEQG--------------SSRVKYSVQGAQLFR----APELQDELCQNLIQQLKKENPSLVLQSKKSDCFSLGLIFYSCL
 .|               ..   ... |   .     |||.   |...   . |          .|.|..||| |.| .|
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV---LQGQNYDHSKA---------YKCDIWSLGVILYEML
Kinase 17306.AA CMGC 66-237 16 1.5e-21 66.77 In-house 1-296 (513) Show / Hide 
Range on Protein: 66-237
Range on HMM: 1-296/513
Sequence Identity: 16% (50 aa)

YKSIRFAGRGSFGTTIIGED---------------QNQNRFAFKLIFIRTKHGQINQDIRG--------KALKEANLMSQM-----------------DH
|. |.  |.|..|.   . |               ..... | | |. .  .    ..           .|| |  .. ..                 .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKS--TIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHH

PNVVKFYKYYETQN-----------------YFIIQMEECKGDLNQFMKSYE---------LLSIES------------FIKYG------QEISEGIQ--
.|.|| | .. . |                 .. . .| .  || |..|..           ||                 ..       . | .|.   
NNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

YVHDQG--LVLRDLKQDNILIDQMNVA--------------------KIADFGLAAYVEQGS--------------------SRVKYSVQGAQLFRAPEL
| | ..   . ||||  ||||.. .                      ||.||||| .... |                    .|  ..       ||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 17306.AA ULK 66-212 26 3.5e-21 71.94 In-house 1-185 (324) Show / Hide 
Range on Protein: 66-212
Range on HMM: 1-185/324
Sequence Identity: 26% (50 aa)

YKSIRFAGRGSFG-TTIIGEDQNQN--RFAFKLIFIR---TKHGQIN---QDIRGKALKEANLMSQMD---HPN--VVKFYKYYETQ--NYFIIQMEECK
|  ..  | |||| .   |.....|    ...   |     .  . .   | .  .  .| ..| ...   |||  .||.|...||.  |.. | || | 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-DLNQFMKSYELLSIES----------FIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMN------------VAKIADFGLA
| || |..| .  |.              |.. . | .| .. |... . ||.| .||||   .            |.||||||.|
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 17306.AA TyrKc 66-334 15 5.7e-10 -61.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-334
Range on HMM: 1-280/280
Sequence Identity: 15% (52 aa)

YKSIRFAGRGSFGTTIIGEDQNQNRFAFKLIFI-RTKHGQINQDIRGKALKEANLMSQM--DHPNVVKFYKYYETQ-------NYFIIQMEECK-GDLNQ
 . ..  |.| ||.   |.             .   |..      |   ..||..|..   .|||.|..| .  .|           | || .. |||..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FMKSYEL-LSIESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMNVAKIADFGLAAYVEQG----------------SSR------------VKYS
. ....  |. . ....   |..| .| |..... |||   |.|..  ...||.||||. ... .                ...             .|.
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

V-------------------QGAQLFRAP----ELQDELCQNLIQQLKKENPSL----VLQSKKSDCFSLGLIFYSCLGTPLSKFIKILQDGPASIDTPV
.                    |.|    .       .|. ... |    . |                                                
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------------

MIEGQQEFQCIDQMLQLL---CEHHPNKRMKISDVIQQF
         | | | |.    ... |..|   |.....|
-----F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 17306.AA Pkinase_Tyr 148-212 30 6.7e-07 23.99 Pfam 90-158 (270) Show / Hide 
Range on Protein: 148-212
Range on HMM: 90-158/270
Sequence Identity: 30% (21 aa)

CKGDLNQFMKSY----ELLSIESFIKYGQEISEGIQYVHDQGLVLRDLKQDNILIDQMNVAKIADFGLA
..|||  . ..     . |...  ... ..|..| .| ...... |||   |.|..  ||.||.|||||
PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 17306.AA Pkinase_Tyr 114-132 45 0.000153 16.01 Pfam 51-70 (270) Show / Hide 
Range on Protein: 114-132
Range on HMM: 51-70/270
Sequence Identity: 45% (9 aa)

LKEANLMSQM-DHPNVVKFY
..||..|.|. .|||.|..|
MREAKIMKQLGHHPNIVRLY
LRR_RI 17306.AA LRR_RI 438-465 39 0.024087 9.96 SMART 1-28 (28) Show / Hide 
Range on Protein: 438-465
Range on HMM: 1-28/28
Sequence Identity: 39% (11 aa)

NLTNLTIDLTDNKIGDEGTRALGLALVA
| . ....| .||.|||| |.|  .| .
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17306.AA LRR_RI 508-535 28 0.324312 1.99 SMART 1-28 (28) Show / Hide 
Range on Protein: 508-535
Range on HMM: 1-28/28
Sequence Identity: 28% (8 aa)

ANQFIKIYQSNNQIGEKGIEALGFGLAS
     ... ||| .|..|. .|  ||..
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17306.AA LRR_RI 538-565 39 4e-06 27.78 SMART 1-28 (28) Show / Hide 
Range on Protein: 538-565
Range on HMM: 1-28/28
Sequence Identity: 39% (11 aa)

YLSILTLYLRNNQIGDKGAIALSSSLKT
  |...|.|.|| .||.|...|...|| 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17306.AA LRR_RI 568-595 42 0.001364 18.76 SMART 1-28 (28) Show / Hide 
Range on Protein: 568-595
Range on HMM: 1-28/28
Sequence Identity: 42% (12 aa)

HLSNFELYLKSNEIGDEGALALCSALSA
. |  ||.| .| .||||. .||..|..
NCSLRELWLSNNKLGDEGCRQLCEGLKH